JP2002275046A - Agent for enhancing barrier against penetration through epidermis, and skin care composition - Google Patents
Agent for enhancing barrier against penetration through epidermis, and skin care compositionInfo
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- JP2002275046A JP2002275046A JP2001084349A JP2001084349A JP2002275046A JP 2002275046 A JP2002275046 A JP 2002275046A JP 2001084349 A JP2001084349 A JP 2001084349A JP 2001084349 A JP2001084349 A JP 2001084349A JP 2002275046 A JP2002275046 A JP 2002275046A
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- Prior art keywords
- skin
- epidermis
- pakiman
- agent
- enhancing
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- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、日焼け等の環境か
ら受ける影響に対し表皮透過バリア機能を強化し、肌荒
れ等の表皮透過バリア崩壊に対しても速やかにこれを改
善し、皮膚を皮膚科学的及び美容的に健やかな状態に保
つ表皮透過バリア強化剤及び該剤を含有する皮膚外用組
成物に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention enhances the skin permeability barrier function against the influence of the environment such as sunburn, improves the skin permeability barrier collapse such as rough skin quickly, and improves skin dermatology. The present invention relates to an agent for enhancing an epidermal permeation barrier which keeps a healthy state in a healthy and cosmetic manner, and an external composition for skin containing the agent.
【０００２】[0002]
【従来の技術及び発明が解決しようとする課題】ヒトを
はじめとするすべての生体は、まわりの環境から影響を
受けている。しかしながら、ほ乳類等の高等動物は、生
命を維持するために必要な各器官への環境からの影響を
極力小さくするための器官を持っている。それが皮膚で
あり、その最も重要な機能の一つが、物質の生体内への
侵入と生体内部からの水分の過剰蒸散を防ぐ、表皮透過
バリア機能である。2. Description of the Related Art All living organisms, including humans, are affected by the surrounding environment. However, higher animals such as mammals have organs for minimizing environmental influences on organs necessary for sustaining life. It is the skin, and one of its most important functions is a skin permeation barrier function that prevents substances from entering the living body and preventing excessive evaporation of water from inside the living body.
【０００３】表皮透過バリア機能は、有機溶媒、界面活
性剤、紫外線等で一時的に崩壊し、皮膚内部環境を乱
す。この状態が続くと、病原菌や有害な化学物質等が皮
膚及び生体内部に侵入する危険性があり、速やかに表皮
透過バリア機能を回復させる必要がある。また、表皮透
過バリアが崩壊している状態は、皮膚表面が乾燥し、鱗
屑が表面を覆い、美容上も好ましくない状態となる。[0003] The epidermis permeation barrier function is temporarily disintegrated by an organic solvent, a surfactant, ultraviolet rays or the like, and disturbs the environment inside the skin. If this state continues, there is a risk that pathogens, harmful chemical substances, and the like may enter the skin and the living body, and it is necessary to quickly restore the epidermal penetration barrier function. In addition, the state in which the epidermal transmission barrier is collapsed is a state in which the skin surface is dried, scales cover the surface, and the cosmetic is not preferable.
【０００４】しかしながら、これまでに表皮透過バリア
を強化する物質として、様々な物質が提案されてきた
が、充分に満足するに足りるものはなかった。[0004] However, various substances have been proposed as a substance that enhances the epidermal permeability barrier, but none of them have been sufficiently satisfactory.
【０００５】本発明の目的は、環境から受ける影響に対
し表皮透過バリア機能を強化し、表皮透過バリアの崩壊
も迅速に改善し、美容学的にも健やかな皮膚に保つ効果
に優れた表皮透過バリア強化剤及び皮膚外用組成物を提
供することにある。[0005] It is an object of the present invention to enhance the skin permeation barrier function against the influence of the environment, quickly improve the collapse of the skin permeation barrier, and have an excellent skin permeation excellent effect for keeping the skin healthy cosmetically. An object of the present invention is to provide a barrier enhancer and a composition for external use on the skin.
【０００６】[0006]
【課題を解決するための手段】本発明者等は、上記のよ
うなことを鑑みて鋭意研究を行った結果、β−１，３−
グルコシド結合を主鎖とする多糖体であるパキマン、パ
ヒマラン、レンチナン、シゾフィラン、クレスチン、ロ
イコシン、キシラン、ダルキシラン、スクレロタン、ス
クレログルカン、ザンタンガム、ラミナランおよびペン
デュランが表皮透過バリア強化作用及び美容的にも皮膚
を健やかに保つ効果に優れることを見出し、本発明を完
成するに至った。すなわち、本発明は、パキマン、パヒ
マラン、レンチナン、シゾフィラン、クレスチン、ロイ
コシン、キシラン、ダルキシラン、スクレロタン、スク
レログルカン、ザンタンガム、ラミナランからなる化合
物群のうち、1種または２種以上を有効成分とする表皮透
過バリア強化剤及び該表皮透過バリア強化剤を配合した
皮膚外用組成物にある。Means for Solving the Problems The inventors of the present invention have conducted intensive studies in view of the above, and as a result, have obtained β-1,3-
Pakiman, pahimaran, lentinan, schizophyllan, crestine, leucosine, xylan, dalxylan, sclerotan, scleroglucan, xanthan gum, laminaran and penduran, which are polysaccharides having a glucoside bond as a main chain, also have an epidermal permeation barrier enhancing effect and cosmetically. They found that the effect of keeping the skin healthy was excellent, and completed the present invention. That is, the present invention relates to a skin comprising one or more active ingredients of a compound group consisting of pakiman, pahimaran, lentinan, schizophyllan, krestin, leucosine, xylan, dalxylan, sclerotan, scleroglucan, xanthan gum, and laminaran. A skin barrier composition comprising the permeation barrier enhancer and the epidermal permeability barrier enhancer.
【０００７】[0007]
【発明の実施の形態】以下、本発明の実施の形態を詳述
する。本発明を構成する多糖体は、Poria cocos （ブク
リョウ）が産生するパキマン、パキマンの化学修飾によ
り得られるパヒマラン、Lentinus edodes （シイタケ）
が産生するレンチナン、Schizophyllum commune Fries
（スエヒロタケ）が産生するシゾフィラン、 Coriolus
versicolor（カワラタケ）が産生するクレスチン、Phyl
um crysophyta （ケイ藻の一種）が産生するロイコシ
ン、Canlerpa sp. （イワズタ）やBryopsis maxima
（オオハネモ）などの海草が産生するキシラン及びダル
キシラン、スクレロタン、スクレログルカン、ザンタン
ガム、ラミナラン、及びペンデュランからなるが、特に
好ましくはパキマン及びパヒマランがあげられる。Embodiments of the present invention will be described below in detail. The polysaccharides constituting the present invention include Pakiman produced by Poria cocos (Bukryo), Pahimaran obtained by chemical modification of Pakiman, Lentinus edodes (Shiitake)
Lentinan, Schizophyllum commune Fries
(Shihirotake mushroom) produced by schizophyllan, Coriolus
Kristin, Phyl produced by versicolor
Leucosin produced by um crysophyta (a type of diatom), Canlerpa sp. (Iwata) and Bryopsis maxima
It consists of xylan and darxylan, sclerotan, scleroglucan, xanthan gum, laminaran, and penduran, which are produced by seaweeds such as (Coleoptera) and particularly preferably Pakiman and Pahimaran.
【０００８】パキマンはPoria cocos （ブクリョウ）の
乾燥質量の約９０％を占める成分であるが、水に不溶で
あり、またメタノール、エタノールなどほとんどの有機
溶剤に難溶であることからその単離方法は限られてお
り、ブクリョウをアルカリ溶液、尿素水溶液などで抽出
することで、最も効率的にパキマンを得ることができ
る。市販のブクリョウエキスは水、エタノール、１，３
−ブチレングリコール、あるいはこれら混液により常温
で抽出して得られるが、不溶性のパキマンは極く少量し
か含まれていない。またパキマンは高分子であり水に難
溶であることから、多糖体の基本構造を変えることな
く、適宜低分子化してもよく、酸加水分解処理して誘導
されるパヒマランでもよい。パキマン及びパヒマランは
水や各種有機溶剤に難溶なことから、水溶性のブクリョ
ウエキスとは異なり、皮膚に適用した公知事例は殆ど無
く、本願発明の適用が新規であると思われる。[0008] Pakiman is a component occupying about 90% of the dry mass of Poria cocos, and is insoluble in water and hardly soluble in most organic solvents such as methanol and ethanol. Is limited, and pakiman can be obtained most efficiently by extracting bukuro with an alkaline solution, an aqueous urea solution, or the like. Commercially available black liquorice extract is water, ethanol, 1,3
It is obtained by extraction with butylene glycol or a mixture thereof at room temperature, but contains only a small amount of insoluble pakiman. Since pakiman is a polymer and is hardly soluble in water, it may be appropriately reduced in molecular weight without changing the basic structure of the polysaccharide, or may be pahimarane derived by acid hydrolysis. Pakiman and pahimalane are hardly soluble in water and various organic solvents, so unlike water-soluble botanical extract, there are few known cases of application to skin, and it is considered that the application of the present invention is novel.
【０００９】本発明を構成する多糖体の配合量は、表皮
透過バリア強化剤または皮膚外用組成物の総量を基準と
して抽出乾燥物換算で０．０００１〜２．０質量％が好
ましく、さらに好ましくは０．００１〜１．０質量％で
あり、より好ましくは０．０１〜１．０質量％である。
０．０００１質量％未満の配合量では、本発明の目的と
する効果が十分でない場合があり、一方、上限（２．０
質量％）を越えて配合してもその増加分に見合った効果
の向上がない場合があり、好ましくない。The amount of the polysaccharide constituting the present invention is preferably 0.0001 to 2.0% by mass, more preferably 0.0001 to 2.0% by mass, based on the total amount of the epidermal penetration barrier enhancer or the composition for external use on the skin. It is 0.001 to 1.0% by mass, and more preferably 0.01 to 1.0% by mass.
If the amount is less than 0.0001% by mass, the intended effect of the present invention may not be sufficient.
(% By mass) is not preferred because the effect may not be improved in proportion to the increase.
【００１０】本発明の表皮透過バリア強化剤は、基礎化
粧料、メイクアップ化粧料、頭髪化粧料及び入浴剤等の
皮膚外用組成物に適用でき、剤型的には例えばローショ
ン、乳液、クリーム、パック、顆粒、粉末等、種々のも
のとすることができる。The skin permeation barrier enhancer of the present invention can be applied to external skin compositions such as basic cosmetics, makeup cosmetics, hair cosmetics, and bath preparations. Various types such as packs, granules, and powders can be used.
【００１１】本発明の表皮透過バリア強化剤には上記の
他に化粧品、医薬部外品、医薬品等に一般に用いられる
色素、香料、防腐剤、界面活性剤、顔料、抗酸化剤等を
本発明の目的を達成する範囲内で適宜配合することがで
きる。The skin permeation barrier enhancer of the present invention includes, in addition to the above, dyes, fragrances, preservatives, surfactants, pigments, antioxidants and the like generally used in cosmetics, quasi-drugs, pharmaceuticals and the like. Can be appropriately compounded within a range that achieves the above object.
【００１２】[0012]
【実施例】以下、実施例及び比較例に基づいて本発明を
詳説する。尚、本発明は以下の実施例に限定されるもの
ではない。The present invention will be described below in detail with reference to examples and comparative examples. The present invention is not limited to the following embodiments.
【００１３】実施例１〜４、比較例１ 本発明を表皮透過バリアを崩壊させた皮膚に適用したと
きの、表皮透過バリア強化効果を次の試験方法により調
べた。Examples 1-4, Comparative Example 1 When the present invention was applied to skin in which the epidermal permeation barrier was disintegrated, the effect of enhancing the epidermal permeation barrier was examined by the following test method.
【００１４】１．本実施例及び比較例で使用した実験動
物 試験開始時１０週齢のヘアレスマウス１群５匹を用い
た。1. Experimental Animals Used in Examples and Comparative Examples Five groups of hairless mice 10 weeks old at the start of the test were used.
【００１５】２．表皮透過バリア強度の測定 ２−１．測定装置及び条件 経皮水分蒸散量（以下、ＴＥＷＬと略記する）は、連続
発汗測定装置ハイドログラフＡＭＵ−１００（ケイアン
ドエス社製）を用いて次の通りに測定した。１平方セン
チメートルのカプセルを皮膚に密着させ、カプセル内に
窒素ガスを導入（３００ｍｌ／ｍｉｎ）し、カプセルに
送り出す前とカプセルから回収した後の窒素ガス中の水
蒸気量を測定した。この値の差から、１分あたり皮膚１
平方センチメートルから蒸散する水分量（ｍｇ／ｃ
ｍ2）を算出し、ＴＥＷＬとした。2. Measurement of epidermal transmission barrier strength 2-1. Measurement apparatus and conditions The transepidermal water loss (hereinafter abbreviated as TEWL) was measured using a continuous perspiration measuring apparatus Hydrograph AMU-100 (manufactured by K & S Corporation) as follows. A 1 square centimeter capsule was brought into close contact with the skin, nitrogen gas was introduced into the capsule (300 ml / min), and the amount of water vapor in the nitrogen gas before being sent to the capsule and after being recovered from the capsule was measured. From the difference of this value, 1 skin per minute
Moisture evaporating from square centimeter (mg / c
m 2 ) was calculated and used as TEWL.
【００１６】２−２．試料と実験方法 本発明を構成する多糖体としてパキマン（Megazyme製）
を用いた。パキマンはグリセロールに分散ゲル状化さ
せ、下記記載の濃度に調製した。この調製後の試料０．
０５ｍｌを予めＴＥＷＬを測定したヘアレスマウスの背
部皮膚（直径約２．５ｃｍ）に１日１回、一週間に５回
の頻度で４週間連続の塗布を行った。その後、事前塗布
の最終塗布から３日目に紫外線Ｂ波長（ＵＶＢ）を０．
１５Ｊ／ｃｍ2、１回照射した。ＵＶＢ照射前、照射後
３及び４日目のＴＥＷＬを測定し、基剤群と各群の平均
値を比較した。2-2. Sample and Experimental Method Pakiman (Megazyme) as a polysaccharide constituting the present invention
Was used. Pakiman was dispersed and gelled in glycerol and adjusted to the concentration described below. Sample 0.
05 ml was applied to the back skin (about 2.5 cm in diameter) of a hairless mouse whose TEWL was measured in advance, once a day, five times a week for four consecutive weeks. Then, on the third day from the final application of the pre-application, the ultraviolet B wavelength (UVB) was set to 0.
Irradiation was performed once at 15 J / cm 2 . TEWL was measured before and after UVB irradiation and on the third and fourth days after irradiation, and the average value of the base group and each group was compared.
【００１７】[0017]
【表１】 [Table 1]
【００１８】本試験の結果より実施例１〜４の塗布で、
比較例１と比較して、明らかにＵＶＢによる表皮透過バ
リアの崩壊が小さく、表皮透過バリアが強化された。From the results of this test, the coatings of Examples 1 to 4
Compared with Comparative Example 1, the breakdown of the epidermal transmission barrier due to UVB was clearly smaller, and the epidermal transmission barrier was enhanced.
【００１９】実施例５〜１１ 本発明の表皮強化バリア剤を含む下記皮膚化粧料につい
て、朝夕２回適当量を塗布する連用試験を、乾燥肌被験
者２０名に２週間実施し、肌荒れの改善効果を見た。な
お入浴剤については、比較例としてパキマンを除いた組
成を用いた試験も行った。Examples 5 to 11 The following skin cosmetics containing the skin-enhancing barrier agent of the present invention were subjected to a continuous test of applying an appropriate amount twice a day in the morning and evening to 20 subjects with dry skin for 2 weeks to improve skin roughness. I saw In addition, about the bath agent, the test using the composition except Pakiman was also performed as a comparative example.
【００２０】 実施例５（化粧水） [組成 ] 原 料 成 分 配合量（質量％） エタノール １０．０ ポリオキシエチレン硬化ヒマシ油（６０ＥＯ） １．０ グリセリン ３．０ １、３−ブチレングリコール ２．０ ジプロピレングリコール ３．０ ポリエチレングリコール１５００ １．０ リン酸塩 ０．５ メチルパラベン ０．１ パキマン ０．１ 精製水 残量Example 5 (Lotion) [Composition] Raw material component Content (% by mass) Ethanol 10.0 Polyoxyethylene hydrogenated castor oil (60EO) 1.0 Glycerin 3.0 1, 3-butylene glycol 2 2.0 Dipropylene glycol 3.0 Polyethylene glycol 1500 1.0 Phosphate 0.5 Methyl paraben 0.1 Pakiman 0.1 Purified water
【００２１】 実施例６（乳液） [組成] 原 料 成 分 配合量（質量％） Ａ成分 ステアリン酸 １．０ ステアリン酸グリセルエステル ２．０ セタノール １．０ コレステロール ０．５ ワセリン ２．０ スクワレン ５．０ 流動パラフィン ５．０ シリコーン油 １．０ プチルパラベン ０．１ パキマン ０．５ Ｂ成分 アシルグルタミン酸塩 １．０ アルキル変性カルボキシビニルポリマー ０．２ グリセリン ２．０ ジプロピレングリコール ３．０ 精製水 総量を１００と する残量 Example 6 (Emulsion) [Composition] Ingredients Ingredients Amount (% by mass) A component Stearic acid 1.0 Glyceryl stearate 2.0 Cetanol 1.0 Cholesterol 0.5 Vaseline 2.0 Squalene 5.0 liquid paraffin 5.0 silicone oil 1.0 butyl paraben 0.1 pakiman 0.5 B component acyl glutamate 1.0 alkyl-modified carboxyvinyl polymer 0.2 glycerin 2.0 dipropylene glycol 3.0 purified water Remaining amount with total amount as 100
【００２２】調製法 上記に示す、成分Ｂを成分Ａに添加し攪拌することによ
り、乳液を調製した。Preparation Method An emulsion was prepared by adding the above component B to the component A and stirring the mixture.
【００２３】 実施例７（クリーム） [組成] 原 料 成 分 配合量（質量％） Ａ成分 ステアリン酸 ２．０ ステアリン酸グリセリンエステル ２．０ セタノール ３．０ コレステロール ０．５ ワセリン ２．０ スクワレン ５．０ 流動パラフィン １０．０ シリコーン油 １．０ ブチルパラベン ０．１ パキマン １．０ Ｂ成分 アシルグルタミン酸塩 １．０ カルボキシビニルポリマー ０．１５ アルキル変性カルボキシビニルポリマー ０．１５ グリセリン ５．０ ジプロピレングリコール ３．０ 精製水 残量Example 7 (Cream) [Composition] Ingredients Ingredients Amount (% by mass) A component Stearic acid 2.0 Glycerin stearate 2.0 Cetanol 3.0 Cholesterol 0.5 Vaseline 2.0 Squalene 5 0.0 Liquid paraffin 10.0 Silicone oil 1.0 Butyl paraben 0.1 Pakiman 1.0 B component Acyl glutamate 1.0 Carboxyvinyl polymer 0.15 Alkyl-modified carboxyvinyl polymer 0.15 Glycerin 5.0 Dipropylene glycol 3.0 Purified water
【００２４】調製法 上記に示したＡ，Ｂ成分を各々８０℃に加熱溶解した
後、混合して撹拌しつつ、３０℃まで冷却して各スキン
クリ−ムを調製した。Preparation Method Each of the components A and B shown above was heated and dissolved at 80 ° C., and then cooled to 30 ° C. while mixing and stirring to prepare each skin cream.
【００２５】 実施例８ （シート状パック） [組成] 原 料 成 分 配合量（質量％） パキマン ０．１ ポリアクリル酸ナトリウム ２．０ ポリビニルピロリドン ０．５ グリセリン ２５．０ １、3−ブチレングリコール １０．０ パラベン ０．１ 香料 ０．１ Ｌ−メントール ０．１ 含浸不織布 １０．０ 精製水 残量Example 8 (Sheet-shaped pack) [Composition] Raw material component Content (% by mass) Pakiman 0.1 Sodium polyacrylate 2.0 Polyvinylpyrrolidone 0.5 Glycerin 25.0 1,3-butylene glycol 10.0 Paraben 0.1 Fragrance 0.1 L-Menthol 0.1 Impregnated non-woven fabric 10.0 Purified water
【００２６】 実施例９（粉末状パック） [組成] 原 料 成 分 配合量（質量％） パキマン ０．１ アルギン酸ナトリウム １５．０ タルク ２０．０ クエン酸 ０．２ クエン酸ナトリウム ０．６ パラベン ０．１ 香料 微量 焼セッコウ 残量Example 9 (powder pack) [Composition] Raw material component Ingredient amount (% by mass) Pakiman 0.1 Sodium alginate 15.0 Talc 20.0 Citric acid 0.2 Sodium citrate 0.6 Paraben 0 Amount of perfume trace amount of gypsum
【００２７】 実施例１０（入浴剤） [組成] 原 料 成 分 配合量（質量％） パキマン ０．５ ジオウエキス ０．１ ニンジンエキス ０．０５ チンピ末 １．０ マカデミアナッツ油 ０．０５ ヒバ油 ０．１ １、3−ブチレングリコール １．０ キシリトール ０．５ モノラウリン酸ポリオキシエチレンソルビタン １．５ 無水硫酸ナトリウム 残量Example 10 (bath additive) [Composition] Ingredients Ingredients Compounding amount (% by mass) Pakiman 0.5 Diou extract 0.1 Carrot extract 0.05 Thick powder 1.0 Macadamia nut oil 0.05 Hiba oil 0. 1 1,3-butylene glycol 1.0 xylitol 0.5 polyoxyethylene sorbitan monolaurate 1.5 anhydrous sodium sulfate
【００２８】 実施例１１（入浴剤） [組成] 原 料 成 分 配合量（質量％） パヒマラン ０．５ ジオウエキス ０．１ ニンジンエキス ０．０５ チンピ末 １．０ マカデミアナッツ油 ０．０５ ヒバ油 ０．１ １、3−ブチレングリコール １．０ キシリトール ０．５ モノラウリン酸ポリオキシエチレンソルビタン １．５ 無水硫酸ナトリウム 残量Example 11 (bath additive) [Composition] Raw material component Ingredient amount (% by mass) Pahimaran 0.5 Jiao extract 0.1 Carrot extract 0.05 Chimney powder 1.0 Macadamia nut oil 0.05 Hiba oil 0. 1 1,3-butylene glycol 1.0 xylitol 0.5 polyoxyethylene sorbitan monolaurate 1.5 anhydrous sodium sulfate
【００２９】上記の実施例５〜１１の皮膚外用組成物に
ついて連用試験を実施した結果、肌荒れが改善されたと
のアンケート結果を得た。入浴剤については、実施例１
０及び実施例１１とも比較例の効果を上回った。A continuous test was conducted on the external composition for skin of Examples 5 to 11, and as a result, a questionnaire was obtained indicating that the skin roughness was improved. Example 1 for bath agent
0 and Example 11 exceeded the effect of the comparative example.
【００３０】[0030]
【発明の効果】以上記載のごとく、本発明は、表皮透過
バリア強度を強化する効果に優れた皮膚透過バリア強化
剤及び皮膚外用組成物を提供することができる。As described above, the present invention can provide a skin permeation barrier enhancer and a skin external composition which are excellent in the effect of enhancing the epidermal permeation barrier strength.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） // Ｃ０８Ｂ 37/00 Ｃ０８Ｂ 37/00 Ｃ Ｂ Ｆターム(参考） 4C083 AA112 AA122 AB282 AB352 AB432 AC012 AC022 AC072 AC102 AC122 AC132 AC242 AC302 AC422 AC432 AC442 AC482 AC662 AD042 AD072 AD092 AD112 AD152 AD211 AD212 AD302 AD351 AD492 AD532 CC04 CC05 CC07 CC25 DD27 DD33 EE12 4C086 AA01 AA02 EA20 MA01 MA04 NA14 ZA89 4C090 AA08 BA23 BA36 BA93 BD41 DA23 DA26 ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (reference) // C08B 37/00 C08B 37/00 CB F term (reference) 4C083 AA112 AA122 AB282 AB352 AB432 AC012 AC022 AC072 AC102 AC122 AC132 AC242 AC302 AC422 AC432 AC442 AC482 AC662 AD042 AD072 AD092 AD112 AD152 AD211 AD212 AD302 AD351 AD492 AD532 CC04 CC05 CC07 CC25 DD27 DD33 EE12 4C086 AA01 AA02 EA20 MA01 MA04 NA14 ZA89 4C090 AA08 BA23 BA36 BA93 BD41 DA23 DA26
Claims (4)
ゾフィラン、クレスチン、ロイコシン、キシラン、ダル
キシラン、スクレロタン、スクレログルカン、ザンタン
ガム、ラミナランおよびペンデュランからなる化合物群
のうち、1種または２種以上を有効成分とする表皮透過バ
リア強化剤。1. An active ingredient comprising one or more compounds of the group consisting of pakiman, pahimaran, lentinan, schizophyllan, krestin, leucosine, xylan, dalxylan, sclerotan, scleroglucan, xanthan gum, laminaran and penduran. Skin permeation barrier enhancer.
配合した皮膚外用組成物。2. A composition for external use on the skin, comprising the epidermal penetration barrier enhancer according to claim 1.
した皮膚外用組成物。3. An external composition for skin containing pakiman and / or pahimalan.
００１〜２．０質量％配合した皮膚外用組成物。4. Pakiman and / or pahimaran is added at 0.0.
An external composition for skin containing 001 to 2.0% by mass.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001084349A JP2002275046A (en) | 2001-03-23 | 2001-03-23 | Agent for enhancing barrier against penetration through epidermis, and skin care composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001084349A JP2002275046A (en) | 2001-03-23 | 2001-03-23 | Agent for enhancing barrier against penetration through epidermis, and skin care composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002275046A true JP2002275046A (en) | 2002-09-25 |
Family
ID=18940033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001084349A Pending JP2002275046A (en) | 2001-03-23 | 2001-03-23 | Agent for enhancing barrier against penetration through epidermis, and skin care composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2002275046A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003086421A1 (en) * | 2002-04-16 | 2003-10-23 | Cac Corporation | External preparations for enhancing cell activity |
| JP2004256410A (en) * | 2003-02-25 | 2004-09-16 | Cac:Kk | Permanent waving agent |
| JP2004256411A (en) * | 2003-02-25 | 2004-09-16 | Cac:Kk | Oxidation hair dye |
| WO2006015627A1 (en) * | 2004-08-13 | 2006-02-16 | Symrise Gmbh & Co. Kg | β-(1,3)-β-(1,4)-GLUCAN AS CARRIER FOR CHEMICAL SUBSTANCES |
| US7648714B2 (en) | 2004-08-05 | 2010-01-19 | Kao Corporation | Food for skin moisture retention |
| CN102399299A (en) * | 2011-12-05 | 2012-04-04 | 武汉回盛生物科技有限公司 | Preparation method for tuckahoe acidic polysaccharide extract and application of tuckahoe acidic polysaccharide extract |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2003086421A1 (en) * | 2002-04-16 | 2003-10-23 | Cac Corporation | External preparations for enhancing cell activity |
| JP2004256410A (en) * | 2003-02-25 | 2004-09-16 | Cac:Kk | Permanent waving agent |
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| CN102399299A (en) * | 2011-12-05 | 2012-04-04 | 武汉回盛生物科技有限公司 | Preparation method for tuckahoe acidic polysaccharide extract and application of tuckahoe acidic polysaccharide extract |
| CN102399299B (en) * | 2011-12-05 | 2013-05-22 | 湖北泱盛生物科技有限公司 | Preparation method for tuckahoe acidic polysaccharide extract and application of tuckahoe acidic polysaccharide extract |
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