JP2004256411A - Oxidation hair dye - Google Patents
Oxidation hair dye Download PDFInfo
- Publication number
- JP2004256411A JP2004256411A JP2003047126A JP2003047126A JP2004256411A JP 2004256411 A JP2004256411 A JP 2004256411A JP 2003047126 A JP2003047126 A JP 2003047126A JP 2003047126 A JP2003047126 A JP 2003047126A JP 2004256411 A JP2004256411 A JP 2004256411A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- hair dye
- liquid
- dye
- oxidative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000118 hair dye Substances 0.000 title claims abstract description 49
- 230000003647 oxidation Effects 0.000 title abstract description 13
- 238000007254 oxidation reaction Methods 0.000 title abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 33
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 22
- 150000004676 glycans Chemical class 0.000 claims abstract description 22
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 22
- 239000005017 polysaccharide Substances 0.000 claims abstract description 22
- 229920002000 Xyloglucan Polymers 0.000 claims abstract description 14
- 150000004985 diamines Chemical class 0.000 claims abstract description 11
- 239000000975 dye Substances 0.000 claims abstract description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 8
- 239000008103 glucose Substances 0.000 claims abstract description 8
- 239000001814 pectin Substances 0.000 claims abstract description 8
- 229920001277 pectin Polymers 0.000 claims abstract description 8
- 235000010987 pectin Nutrition 0.000 claims abstract description 8
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229920002307 Dextran Polymers 0.000 claims abstract description 7
- 229920001491 Lentinan Polymers 0.000 claims abstract description 7
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 7
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 7
- 229940115286 lentinan Drugs 0.000 claims abstract description 7
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 6
- 229920001218 Pullulan Polymers 0.000 claims abstract description 6
- 239000004373 Pullulan Substances 0.000 claims abstract description 6
- 235000019423 pullulan Nutrition 0.000 claims abstract description 6
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 230000001590 oxidative effect Effects 0.000 claims description 43
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- 239000002075 main ingredient Substances 0.000 claims description 11
- 108010001062 polysaccharide-K Proteins 0.000 claims description 11
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 10
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 7
- 239000001110 calcium chloride Substances 0.000 claims description 7
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 7
- 239000011780 sodium chloride Substances 0.000 claims description 7
- 239000001103 potassium chloride Substances 0.000 claims description 5
- 235000011164 potassium chloride Nutrition 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 abstract description 18
- 239000011159 matrix material Substances 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 11
- 210000004761 scalp Anatomy 0.000 abstract description 10
- 239000000243 solution Substances 0.000 abstract description 6
- 239000004615 ingredient Substances 0.000 abstract description 3
- 229920001543 Laminarin Polymers 0.000 abstract description 2
- DBTMGCOVALSLOR-VPNXCSTESA-N laminarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](O)C(O[C@H]2[C@@H]([C@@H](CO)OC(O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-VPNXCSTESA-N 0.000 abstract description 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000000203 mixture Substances 0.000 description 11
- 230000035876 healing Effects 0.000 description 7
- 230000003204 osmotic effect Effects 0.000 description 7
- 239000008213 purified water Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 210000004927 skin cell Anatomy 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 4
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000004043 dyeing Methods 0.000 description 4
- 210000003722 extracellular fluid Anatomy 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- CBCKQZAAMUWICA-UHFFFAOYSA-N 1,4-phenylenediamine Chemical compound NC1=CC=C(N)C=C1 CBCKQZAAMUWICA-UHFFFAOYSA-N 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 210000002421 cell wall Anatomy 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 210000001700 mitochondrial membrane Anatomy 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 210000002850 nasal mucosa Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- -1 2-hydroxylethyl Chemical group 0.000 description 2
- OBCSAIDCZQSFQH-UHFFFAOYSA-N 2-methyl-1,4-phenylenediamine Chemical compound CC1=CC(N)=CC=C1N OBCSAIDCZQSFQH-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 229930182830 galactose Natural products 0.000 description 2
- 230000003700 hair damage Effects 0.000 description 2
- 239000003676 hair preparation Substances 0.000 description 2
- 230000001024 immunotherapeutic effect Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- QMDPAEWMWMZYOS-YWSMWOPSSA-N (2R,3S,4S,5R)-2,3,4,5,6-pentahydroxy-1-[(3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]hexan-1-one Chemical compound C[C@@H]1OC([C@@H](O)[C@H](O)[C@@H]1O)C(=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO QMDPAEWMWMZYOS-YWSMWOPSSA-N 0.000 description 1
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- HQCHAOKWWKLXQH-UHFFFAOYSA-N 2,6-Dichloro-para-phenylenediamine Chemical compound NC1=CC(Cl)=C(N)C(Cl)=C1 HQCHAOKWWKLXQH-UHFFFAOYSA-N 0.000 description 1
- WFXLRLQSHRNHCE-UHFFFAOYSA-N 2-(4-amino-n-ethylanilino)ethanol Chemical compound OCCN(CC)C1=CC=C(N)C=C1 WFXLRLQSHRNHCE-UHFFFAOYSA-N 0.000 description 1
- RCANFVUNFLBTJG-UHFFFAOYSA-N 2-bromo-6-chlorobenzene-1,4-diamine Chemical compound NC1=CC(Cl)=C(N)C(Br)=C1 RCANFVUNFLBTJG-UHFFFAOYSA-N 0.000 description 1
- MPUYRZSQOVOWER-UHFFFAOYSA-N 2-chloro-6-methylbenzene-1,4-diamine Chemical compound CC1=CC(N)=CC(Cl)=C1N MPUYRZSQOVOWER-UHFFFAOYSA-N 0.000 description 1
- KNRVAYVZVIKHHL-UHFFFAOYSA-N 2-methoxy-5-methylbenzene-1,4-diamine Chemical compound COC1=CC(N)=C(C)C=C1N KNRVAYVZVIKHHL-UHFFFAOYSA-N 0.000 description 1
- HGUYBLVGLMAUFF-UHFFFAOYSA-N 2-methoxybenzene-1,4-diamine Chemical compound COC1=CC(N)=CC=C1N HGUYBLVGLMAUFF-UHFFFAOYSA-N 0.000 description 1
- NFCPRRWCTNLGSN-UHFFFAOYSA-N 2-n-phenylbenzene-1,2-diamine Chemical class NC1=CC=CC=C1NC1=CC=CC=C1 NFCPRRWCTNLGSN-UHFFFAOYSA-N 0.000 description 1
- YOJKEVXNAVNUGW-UHFFFAOYSA-N 4-n-chlorobenzene-1,4-diamine Chemical compound NC1=CC=C(NCl)C=C1 YOJKEVXNAVNUGW-UHFFFAOYSA-N 0.000 description 1
- IHWPTLPROWODBQ-UHFFFAOYSA-N 4-n-methoxybenzene-1,4-diamine Chemical compound CONC1=CC=C(N)C=C1 IHWPTLPROWODBQ-UHFFFAOYSA-N 0.000 description 1
- VVYWUQOTMZEJRJ-UHFFFAOYSA-N 4-n-methylbenzene-1,4-diamine Chemical compound CNC1=CC=C(N)C=C1 VVYWUQOTMZEJRJ-UHFFFAOYSA-N 0.000 description 1
- 230000002407 ATP formation Effects 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical group C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 240000000599 Lentinula edodes Species 0.000 description 1
- BZORFPDSXLZWJF-UHFFFAOYSA-N N,N-dimethyl-1,4-phenylenediamine Chemical compound CN(C)C1=CC=C(N)C=C1 BZORFPDSXLZWJF-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 241000555745 Sciuridae Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009056 active transport Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- TTWYZDPBDWHJOR-IDIVVRGQSA-L adenosine triphosphate disodium Chemical compound [Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O TTWYZDPBDWHJOR-IDIVVRGQSA-L 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 208000002029 allergic contact dermatitis Diseases 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical class C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- AXKVOSSFZLZIDC-UHFFFAOYSA-N n,n-diaminoaniline Chemical class NN(N)C1=CC=CC=C1 AXKVOSSFZLZIDC-UHFFFAOYSA-N 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229960003893 phenacetin Drugs 0.000 description 1
- 150000004986 phenylenediamines Chemical class 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000001026 semi permanent hair color Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 239000011973 solid acid Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000001027 temporary hair color Substances 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 125000000969 xylosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)CO1)* 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【０００１】
【発明の属する技術分野】
本発明は、毛母細胞を活性化すると共に、毛髪や頭皮を傷めることなく使用することが可能な酸化染毛剤に関する。
【０００２】
【従来の技術】
酸化染毛剤は、一般に、ジアミン系酸化染料を第１液の主剤とし、過酸化水素を第２液の主剤とする染毛剤である。この種の染毛剤は、毛髪内部の皮質で発色し、定着するために色持ちが良く、しかも脱色しながら染色することによって、望んだ色に染めることが可能になっている。ところが、第１液の主成分になっているジアミン系化合物は、アレルギー性の接触性皮膚炎を起こすことが知られている。一方、第２液の主成分である過酸化水素は、毛髪を脱水する作用があるので毛髪がぱさつき、染毛時に発生する酸素により毛髪が酸化することから、毛髪を傷めることになる。
【０００３】
そこで、特許文献１及び特許文献２において、毛髪の損傷を防止する酸化染毛剤が提案されている。
【０００４】
特許文献１は、第２液として用いる過酸化水素の代わりに、固体酸触媒を酸化剤として用いる酸化染毛剤であり、ジアミン系酸化染料の使用量をできるだけ低減したものである。
【０００５】
特許文献２は、酸化染毛剤用組成物にサクシノグリカンを配合したもので、この酸化染毛剤用組成物によると、染着性が一段と向上し、毛髪の損傷が少なくなるというものである。
【０００６】
一方、当発明者は、皮膚細胞を活性化し、皮膚細胞の細胞機能低下による諸疾患を改善するものとして、皮膚細胞間質液と同様な環境を皮膚表面に作り出し、電解質バランス、浸透圧バランスを応用することで、皮膚の表面からも障害細胞の正常化を促進することが可能になった水性皮膚及び毛髪化粧料を発明している（特許文献３）。この水性皮膚及び毛髪化粧料にあっては、シミ、赤ら顔の場合は皮下細胞を刺激、分裂させ、治癒に導びき、また、頭皮、ワキガ等に対しては浸透圧作用により毛母細胞を刺激し、発毛及び脱臭作用を促進させる効果が見られている。
【０００７】
更に、当発明者は、口腔や鼻粘膜用の外用剤として使用しても副作用の虞が全く無く、例えば、口内炎や花粉症などといった、より広範囲な細胞レベルにおける諸疾患にも適用することが可能な細胞活性促進外用剤を発明している（特許文献４）。
【０００８】
【特許文献１】
特公平６−６００９０号公報
【特許文献２】
特開平１０−２７９４５２号公報
【特許文献３】
特許第１５９７４３０号公報
【特許文献４】
特許第２６８１５２７号公報
【０００９】
【発明が解決しようとする課題】
ところが、特許文献１及び特許文献２に記載された酸化染毛剤では、いずれも、皮膚刺激や毛髪の損傷を少なくすることは可能でも、毛母細胞を活性化して頭髪や頭皮を積極的に保護する酸化染毛剤ではなかった。
【００１０】
一方、特許文献３及び特許文献４に記載された成分は、浸透圧作用により毛母細胞を刺激するもので、口腔や鼻粘膜用の外用剤として使用しても副作用の虞が全く無い成分である。
【００１１】
そこで本発明は、特許文献３及び特許文献４に記載された成分をさらに改良し、毛母細胞を活性化すると共に、毛髪や頭皮を傷めることなく使用することが可能な酸化染毛剤の提供を目的とする。
【００１２】
【課題を解決するための手段】
上述の目的を達成すべく本発明の第１の手段は、ジアミン系酸化染料を第１液の主剤とし、過酸化水素を第２液の主剤とする酸化染毛剤において、キシログルカン、ラミラナン、クレスチンのいずれか又は全てを添加した多糖類水溶液を第１液に配合することにある。
【００１３】
また、前記酸化染毛剤に、ペクチン、デキストラン、ブドウ糖、プルラン、レンチナン、サイクロデキストリン、トレハロースのいずれか又は全てを添加する。
【００１４】
さらに、前記酸化染毛剤に、塩化ナトリウム、塩化カルシウム、塩化カリウムのいずれか又は全てを添加することを課題解消のための手段とする。
【００１５】
人間の皮膚における病変である炎症、色素沈着、脱毛症等の各種症状の原因は、紫外線、化学物質等の種々の因子が関連したものとなっており、その細胞レベルでの変化が限られているその根本は、細胞内小器官の一つであるミトコンドリアの膜や細胞膜の障害といえるものである。つまり、ミトコンドリアの膜の障害によって細胞内呼吸の阻害が生じ、これによって、細胞の活動源たるＡＴＰ（アデノシン３リン酸）の産生が低下する。このようなＡＴＰの不足によって細胞膜の能動輸送の機能が低下し、細胞と間質液との間において物質の輸送能力の低下が起る。すると、細胞内におけるグルコース等の栄奏物質の不足を生じさせ、ひいてはＡＴＰの酸性の低下につながるといった悪循環をなすものである。
【００１６】
以上のような細胞レベルでの変化を生じさせる原因は多様なものがあり、特に、毛母細胞においては、浸透圧作用で細胞問質液を引き上げることで、疾患部分の細胞を活性化することができる。更に、キシログルカンと、ラミラナンと、クレスチンとを添加することにより、頭皮の毛母細胞組織の免疫力や治癒力を高めることが可能になると考えられる。
【００１７】
【発明の実施の形態】
本発明酸化染毛剤は、ジアミン系酸化染料を第１液の主剤とし、過酸化水素を第２液の主剤とし、染毛処理の直前に第１液と第２液を混合して毛髪に塗布する酸化染毛剤である。
【００１８】
第１液の主剤とするジアミン系酸化染料として、フェニレンジアミン類、トルイレンジアミン類、ジアミノフェニルアミン類、Ｎ−フェニルフェニレンジアミン類、ジフェニルアミン類がある。具体的な酸化染料としては、例えば、パラフェニレンジアミン、パラトルイレンジアミン、Ｎ−メチルパラフェニレンジアミン、Ｎ，Ｎ−ジメチルパラフェニレンジアミン、トルエン−２，５−ジアミン、Ｎ，Ｎ−ジメチル−２−メチルパラフェニレンジアミン、Ｎ−エチル−Ｎ−ヒドロキシエチル−パラフェニレンジアミン、クロルパラフェニレンジアミン、Ｎ，Ｎ−ビス−（２−ヒドロキシルエチル）パラフェニレンジアミン、メトキシパラフェニレンジアミン、２，６−ジクロルパラフェニレンジアミン、２−クロル−６−ブロムパラフェニレンジアミン、２−クロル−６−メチルパラフェニレンジアミン、６−メトキシ−３−メチルパラフェニレンジアミン、２，５−ジアミノアニソール、Ｎ−（２−ヒドロキシプロピル）パラフェニレンジアミン、ｐ−フェニレンジアミンなどがある。この第１液には、必要により、界面活性剤、保湿剤、アンモニア又はアルカノールアミン等のアルカリ剤、高級アルコール及び香料等を必要に応じて適宜配合する。
【００１９】
一方、第２液としては、過酸化水素を主剤とし、必要により、フェナセチン、界面活性剤、油脂類、高級アルコール、香料等を配合する。
【００２０】
本発明は、このような従来から使用されている酸化染毛剤の第１液に、キシログルカン、ラミラナン、クレスチンのいずれか又は全てを添加した多糖類水溶液を配合したものである。
【００２１】
また、前記酸化染毛剤に、ペクチン、デキストラン、ブドウ糖、プルラン、レンチナン、サイクロデキストリン、トレハロースのいずれか又は全てを添加してもよく、さらに、前記パーマネントウェーブ剤に、塩化ナトリウム、塩化カルシウム、塩化カリウムのいずれか又は全てを添加することも能である。
【００２２】
前記成分を添加した多糖類水溶液を用意し、酸化染毛剤の第１液に対し、全体の重量比で、０．１〜３０％配合する。この多糖類水溶液の配合率は第１液の成分により任意に変更するものである。
【００２３】
水溶液に添加する多糖類の成分は、多糖類水溶液を全体として、重量比１〜５０％のキシログルカンと、１〜５０％のラミラナンと、１〜５０％のクレスチンとを添加するものである。
【００２４】
キシログルカンは、伸長・肥大している植物細胞の壁（一次壁）に普遍的に存在する構成糖鎖である。植物種特異性は、キシロース残基にガラクトースまたはフコシル−ガラクトースが結合することによって生じる。このガラクトース残基及びフコース残基にはそれぞれレクチンが結合できるが、これら分岐糖鎖の機能は分かっていない。植物細胞の成長は、細胞の持っている浸透圧に由来する吸水現象によって生じ、吸水力は、細胞壁のゆるみによる壁圧の減少によって生じる。この細胞壁のゆるみは、未だ解明されていないが、細胞伸長は常にキシログルカンの分解と可溶化を伴って生じており、細胞の生理活性をつかさどる多糖類のひとつとして注目されている。
【００２５】
ラミラナンは、炭水化物の一でβグルカンのラミラナンとして分類される。椎茸をはじめとした茸類や昆布などの海草類に含まれるもので、免疫力を高める効果がある。
【００２６】
クレスチンは、ヒト癌細胞のＨＬＡクラスＩ抗原の発現を増強する免疫治療医薬品として使用されるもので、かわらたけ菌糸体より抽出される。このクレスチンは、胃癌、結腸・直腸癌、小細胞肺癌等の腫瘍性疾患に免疫治療作用が認められている。
【００２７】
発明者は、数多くの多糖類の中から、外用剤に適した成分を研究した結果、これらのキシログルカン、ラミラナン、クレスチンを組合せることで、口腔や鼻粘膜等の細胞組織の免疫力や治癒力を高める外用剤を調製したものである。そして、この免疫力や治癒力は、酸化染毛剤によって生じる頭皮の皮膚障害や、頭髪のダメージを治癒する効果があることを発見したものである。
【００２８】
これらの多糖類を溶解した水溶液中には、予め、水溶液の重量比で、１〜５０％のペクチンと、１〜３０％のデキストランと、１〜３０％のブドウ糖と、１〜３０％のレンチナンと、１〜５０％のトレハロースとを含有せしめてある。
【００２９】
ペクチンは、植物の細胞壁の構成成分としてセルロース等、他の成分と結合することで植物細胞をつなぎ合わせる働きをしている。ゲル化作用を持つ成分であり、本発明外用剤の添加剤として好適である。
【００３０】
また、多糖類を溶解した水溶液中に、塩化ナトリウムと、塩化カルシウムと、塩化カリウムとを添加している。塩化ナトリウムの配合量は、皮膚に対する浸透圧バランス、電解質バランスの有効性、すなわち、皮膚細胞を活性化できるよう、水溶液の重量比で０．１〜１％とし、同様に、塩化カルシウムと、塩化カリウムにおいても０．１〜１％の各成分を水相成分に溶解する。
【００３１】
【実施例】
次に、本発明の多糖類水溶液を処方する酸化染毛剤を具体的に説明する。尚、実施例は、酸化染毛剤の一例にすぎず、本発明はこれらの実施例に限定されるものではない。
【００３２】
まず、本発明の酸化染毛剤に配合する多糖類水溶液を具体的に説明する。
【００３３】
−多糖類水溶液１−
デキストラン １８．０
ブドウ糖 １０．０
サイクロデキストリン ２．０
トレハロース ３．０
プルラン ７．０
レンチナン ７．０
ラミナラン ２．０
クレスチン １．０
ペクチン ３．０
キシログルカン １．０
塩化ナトリウム ０．９
塩化カルシウム ０．３
塩化カリウム ０．３
精製水 ４４．５
計 重量（％） １００．０
【００３４】
水相成分（精製水）は、純水のみで製造するノンオイルのものである。そして、これらの各成分と水相成分との配合に際しては、各成分の溶解を完全にするために、５０〜１００℃の温度で実施する。
【００３５】
更に、別の配合比からなる多糖類水溶液を調合した。
【００３６】
−多糖類水溶液２−
デキストラン ４．０
ブドウ糖 ３．０
サイクロデキストリン ２．０
トレハロース ３．０
プルラン ３．０
レンチナン ３．０
ラミナラン ２．０
クレスチン １．０
ペクチン ３．０
キシログルカン ５０．０
塩化ナトリウム ０．４
塩化カルシウム ０．３
塩化カリウム ０．３
精製水 ２５．０
計 重量（％） １００．０
【００３７】
この結果、処方例２以上にキシログルカンの濃度を上げると、溶解後分離するようになり不適当である。また、キシログルカンの他、ラミナラン、クレスチンのいずれにおいても有効性が認められるのは少なくとも夫々１％以上の濃度が必要であり、また夫々の濃度が５０％以内の範囲とする。
【００３８】
次に、多糖類水溶液１の成分を、次の酸化染毛剤に配合して第１液とする。
酸化染毛剤の第２液は、過酸化水素６．０重量％を精製水に配合したものである。
【００４０】
実施例１の第１液と同量の前記第２液とを混合して毛髪の一部に塗布した。その後、室温で２０分経過後、約４０℃の湯で洗い流し、乾燥させた。
【００４１】
比較例として、前記第１液の多糖類水溶液を精製水に代えたもので同じ処理を行った。
【００４２】
サンプルとして、染毛した毛髪と染毛しなかった毛髪とを採取し、それぞれの毛母細胞の状態を確認した。この結果、本発明酸化染毛剤を使用したサンプルと処理しなかったサンプルとにおいて、毛母細胞の状態は、ほとんど同じ状態であった。また、サンプルによっては、処理後の毛母細胞が活性化しているものも見られる。これは、本発明酸化染毛剤が、より積極的に治癒効果を表したものと思われる。一方、従来の酸化染毛剤を使用したサンプルでは、処理していない毛髪に比べて毛母細胞が萎縮していることが判明した。
【００４３】
次に、前記多糖類水溶液２で処方した成分を、次の酸化染毛剤に配合して第１液とする。
酸化染毛剤の第２液は、３５％の過酸化水素２０．０重量％を精製水に配合したものである。
【００４５】
実施例２の第１液と同量の前記第２液とを混合して毛髪の一部に塗布した。その後、室温で２０分経過後、約４０℃の湯で洗い流し、乾燥させた。
【００４６】
比較例として、実施例２における第１液の多糖類水溶液を精製水に代えたもので同じ処理を行った。
【００４７】
サンプルとして、染毛した毛髪と染毛しなかった毛髪とを採取し、それぞれの毛母細胞の状態を確認した。この結果、本発明酸化染毛剤を使用したサンプルと処理しなかったサンプルとにおいて、毛母細胞の状態は、ほとんど変化はみとめられなかった。一方、従来の酸化染毛剤を使用したサンプルでは、処理していない毛髪に比べて毛母細胞が萎縮していた。
【００４８】
尚、本発明酸化染毛剤に処方する多糖類水溶液は、ジアミン系酸化染料を第１液の主剤とする酸化染毛剤のほか、ヘアブリーチ、ヘアライトナー、ダカラライザーなどの脱色剤・脱染剤や、オハグロ式の非酸化染毛剤、あるいはヘアマニュキュア、酸性ヘアカラー、カラーリンスなどの半永久染毛料、カラースプレー、カラーフォーム、カラースティックなどの一時染毛料などに配合して用いることも可能である。
【００４９】
【発明の効果】
本発明によると、ジアミン系酸化染料を第１液の主剤とし、過酸化水素を第２液の主剤とする酸化染毛剤において、キシログルカン、ラミラナン、クレスチンのいずれか又は全てを添加した多糖類水溶液を配合することにより、毛母細胞を活性化し、毛髪や頭皮を傷めることなく使用することが可能になる。
【００５０】
また、細胞組織の免疫力や治癒力を高めながら皮膚細胞間質液と同様な環境を作り出すことができるので、ミトコンドリアの膜の障害によって生じる、細胞内呼吸の阻害や、細胞の活動源たるＡＴＰ（アデノシン３リン酸）の産生の低下を防止することができ、電解質バランス、浸透圧バランスを保ち、皮膚細胞や粘膜細胞の表層からも障害細胞の正常化を促進することが可能になる。この結果、既に傷んだ毛髪や頭皮を治癒する効果もある。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an oxidative hair dye that activates hair matrix cells and can be used without damaging hair and scalp.
[0002]
[Prior art]
The oxidative hair dye is generally a hair dye having a diamine-based oxidative dye as the main ingredient of the first liquid and hydrogen peroxide as the main ingredient of the second liquid. This type of hair dye develops color in the cortex inside the hair and has good color for fixing, and it can be dyed to the desired color by dyeing while decolorizing. However, it is known that the diamine-based compound which is the main component of the first liquid causes allergic contact dermatitis. On the other hand, hydrogen peroxide, which is the main component of the second liquid, has an action of dehydrating the hair, so that the hair becomes clumsy and the hair is oxidized by oxygen generated at the time of hair dyeing, so that the hair is damaged.
[0003]
Thus, in Patent Document 1 and Patent Document 2, oxidative hair dyes that prevent hair damage have been proposed.
[0004]
Patent Document 1 is an oxidative hair dye that uses a solid acid catalyst as an oxidizing agent instead of hydrogen peroxide used as the second liquid, and reduces the amount of diamine-based oxidative dye used as much as possible.
[0005]
Patent Document 2 is a composition in which succinoglycan is blended with a composition for oxidative hair dye, and according to this composition for oxidative hair dye, the dyeing property is further improved and hair damage is reduced. is there.
[0006]
On the other hand, the present inventor created an environment similar to the skin cell interstitial fluid on the skin surface to activate the skin cells and improve various diseases caused by the decrease in the cell functions of the skin cells, and to balance the electrolyte and osmotic pressure. It has invented aqueous skin and hair cosmetics that can promote normalization of damaged cells from the surface of the skin by applying (Patent Document 3). In this aqueous skin and hair cosmetics, in the case of stains and red face, the subcutaneous cells are stimulated and divided to lead to healing, and the hair matrix cells are stimulated by osmotic action on the scalp, squirrels, etc. However, the effect of promoting hair growth and deodorizing action has been observed.
[0007]
Furthermore, the present inventor has no risk of side effects even when used as an external preparation for the oral cavity and nasal mucosa, and can be applied to various diseases in a wider range of cells such as stomatitis and hay fever. A possible cell activity promoting external preparation has been invented (Patent Document 4).
[0008]
[Patent Document 1]
Japanese Patent Publication No. 6-60090 [Patent Document 2]
Japanese Patent Laid-Open No. 10-279552 [Patent Document 3]
Japanese Patent No. 1597430 [Patent Document 4]
Japanese Patent No. 2681527 [0009]
[Problems to be solved by the invention]
However, with the oxidative hair dyes described in Patent Document 1 and Patent Document 2, it is possible to reduce skin irritation and damage to the hair, but it is possible to activate hair matrix cells and actively treat hair and scalp. It was not an oxidative hair dye to protect.
[0010]
On the other hand, the components described in Patent Document 3 and Patent Document 4 stimulate hair matrix cells by osmotic pressure action, and are components that have no risk of side effects even when used as an external preparation for oral cavity and nasal mucosa. is there.
[0011]
Therefore, the present invention provides an oxidative hair dye that further improves the components described in Patent Document 3 and Patent Document 4, activates hair matrix cells, and can be used without damaging hair and scalp. With the goal.
[0012]
[Means for Solving the Problems]
In order to achieve the above-mentioned object, the first means of the present invention is an oxidative hair dye having a diamine-based oxidative dye as the main ingredient of the first liquid and hydrogen peroxide as the main ingredient of the second liquid, xyloglucan, lamiranan, It is to mix | blend the polysaccharide aqueous solution which added any or all of krestin with the 1st liquid.
[0013]
In addition, any or all of pectin, dextran, glucose, pullulan, lentinan, cyclodextrin, and trehalose are added to the oxidative hair dye.
[0014]
Furthermore, adding any or all of sodium chloride, calcium chloride, and potassium chloride to the oxidative hair dye is a means for solving the problem.
[0015]
Causes of various symptoms such as inflammation, pigmentation, and alopecia that are lesions in human skin are related to various factors such as ultraviolet rays and chemical substances, and their changes at the cellular level are limited. The root of this is a disorder of the mitochondrial membrane and cell membrane, one of the organelles. In other words, inhibition of intracellular respiration is caused by damage to the mitochondrial membrane, thereby reducing the production of ATP (adenosine triphosphate), which is a cell activity source. Such a lack of ATP reduces the function of active transport of the cell membrane, leading to a decrease in the ability to transport substances between cells and interstitial fluid. This causes a vicious circle in which a deprivation substance such as glucose is deficient in the cell, leading to a decrease in the acidity of ATP.
[0016]
There are a variety of causes that cause changes at the cellular level as described above. In particular, in hair matrix cells, cells in the diseased part are activated by pulling up the cell interstitial fluid by osmotic pressure action. Can do. Furthermore, it is considered that by adding xyloglucan, lamiranan and krestin, the immunity and healing power of the hair matrix cell tissue of the scalp can be enhanced.
[0017]
DETAILED DESCRIPTION OF THE INVENTION
The oxidative hair dye of the present invention uses a diamine-based oxidative dye as the main ingredient of the first liquid, hydrogen peroxide as the main ingredient of the second liquid, and mixes the first liquid and the second liquid just before the hair dyeing treatment to form hair. It is an oxidative hair dye to be applied.
[0018]
Examples of the diamine-based oxidative dye as the main component of the first liquid include phenylenediamines, toluylenediamines, diaminophenylamines, N-phenylphenylenediamines, and diphenylamines. Specific examples of the oxidation dye include paraphenylenediamine, paratoluylenediamine, N-methylparaphenylenediamine, N, N-dimethylparaphenylenediamine, toluene-2,5-diamine, and N, N-dimethyl-2. -Methylparaphenylenediamine, N-ethyl-N-hydroxyethyl-paraphenylenediamine, chloroparaphenylenediamine, N, N-bis- (2-hydroxylethyl) paraphenylenediamine, methoxyparaphenylenediamine, 2,6-di Chloroparaphenylenediamine, 2-chloro-6-bromoparaphenylenediamine, 2-chloro-6-methylparaphenylenediamine, 6-methoxy-3-methylparaphenylenediamine, 2,5-diaminoanisole, N- (2- Hydroxypropyl) parafe Diamine, and the like p- phenylenediamine. In the first liquid, a surfactant, a humectant, an alkaline agent such as ammonia or alkanolamine, a higher alcohol, a fragrance, and the like are appropriately blended as necessary.
[0019]
On the other hand, as the second liquid, hydrogen peroxide is a main ingredient, and if necessary, phenacetin, a surfactant, fats and oils, higher alcohols, fragrances and the like are blended.
[0020]
This invention mix | blends the polysaccharide aqueous solution which added any or all of xyloglucan, lamiranan, and krestin to the 1st liquid of the oxidative hair dye used conventionally.
[0021]
In addition, any or all of pectin, dextran, glucose, pullulan, lentinan, cyclodextrin, trehalose may be added to the oxidative hair dye, and sodium chloride, calcium chloride, chloride may be added to the permanent wave agent. It is also possible to add any or all of the potassium.
[0022]
The polysaccharide aqueous solution which added the said component is prepared, and 0.1-30% is mix | blended by the whole weight ratio with respect to the 1st liquid of an oxidative hair dye. The mixing ratio of the polysaccharide aqueous solution is arbitrarily changed depending on the components of the first liquid.
[0023]
The polysaccharide component added to the aqueous solution is a mixture of 1 to 50% xyloglucan, 1 to 50% lamiranan, and 1 to 50% krestin as a whole.
[0024]
Xyloglucan is a constituent sugar chain that exists universally on the wall (primary wall) of plant cells that are elongated and enlarged. Plant species specificity arises from the binding of galactose or fucosyl-galactose to xylose residues. Lectins can bind to these galactose and fucose residues, but the functions of these branched sugar chains are not known. Plant cell growth is caused by a water absorption phenomenon derived from the osmotic pressure of the cell, and water absorption is caused by a decrease in wall pressure due to loosening of the cell wall. This loosening of the cell wall has not yet been elucidated, but cell elongation is always accompanied by degradation and solubilization of xyloglucan, and is attracting attention as one of the polysaccharides that control the physiological activity of cells.
[0025]
Ramilanan is one of the carbohydrates and is classified as a β-glucan lamiranan. It is contained in seaweeds such as shiitake mushrooms and kelp and has the effect of enhancing immunity.
[0026]
Krestin is used as an immunotherapeutic drug that enhances the expression of HLA class I antigens in human cancer cells, and is extracted from chopped mycelium. This krestin has been shown to have an immunotherapeutic effect on neoplastic diseases such as gastric cancer, colorectal cancer, and small cell lung cancer.
[0027]
As a result of researching ingredients suitable for external preparations from among many polysaccharides, the inventor has combined these xyloglucans, lamiranans, and krestins to immunize and heal cellular tissues such as the oral cavity and nasal mucosa. This is a preparation for external use that increases strength. And it discovered that this immunity and healing power had the effect of healing the skin damage of the scalp caused by the oxidative hair dye and the damage of the hair.
[0028]
In an aqueous solution in which these polysaccharides are dissolved, 1 to 50% pectin, 1 to 30% dextran, 1 to 30% glucose, and 1 to 30% lentinan in a weight ratio of the aqueous solution in advance. And 1 to 50% trehalose.
[0029]
Pectin functions to connect plant cells by binding to other components such as cellulose as a component of plant cell walls. It is a component having a gelling action and is suitable as an additive for the external preparation of the present invention.
[0030]
Moreover, sodium chloride, calcium chloride, and potassium chloride are added to the aqueous solution in which the polysaccharide is dissolved. The amount of sodium chloride is 0.1 to 1% by weight of the aqueous solution so that the osmotic pressure balance and the electrolyte balance on the skin, that is, the skin cells can be activated. Similarly, calcium chloride and chloride Also in potassium, 0.1 to 1% of each component is dissolved in the aqueous phase component.
[0031]
【Example】
Next, the oxidative hair dye which prescribes the polysaccharide aqueous solution of the present invention will be specifically described. In addition, an Example is only an example of an oxidation hair dye, and this invention is not limited to these Examples.
[0032]
First, the polysaccharide aqueous solution mix | blended with the oxidation hair dye of this invention is demonstrated concretely.
[0033]
-Aqueous polysaccharide solution 1-
Dextran 18.0
Glucose 10.0
Cyclodextrin 2.0
Trehalose 3.0
Pullulan 7.0
Lentinan 7.0
Lamina Run 2.0
Krestin 1.0
Pectin 3.0
Xyloglucan 1.0
Sodium chloride 0.9
Calcium chloride 0.3
Potassium chloride 0.3
Purified water 44.5
Total weight (%) 100.0
[0034]
The aqueous phase component (purified water) is a non-oil produced only with pure water. And when mix | blending each of these each component and an aqueous phase component, in order to melt | dissolve each component completely, it implements at the temperature of 50-100 degreeC.
[0035]
Furthermore, the polysaccharide aqueous solution which consists of another compounding ratio was prepared.
[0036]
-Aqueous polysaccharide solution 2-
Dextran 4.0
Glucose 3.0
Cyclodextrin 2.0
Trehalose 3.0
Pullulan 3.0
Lentinan 3.0
Lamina Run 2.0
Krestin 1.0
Pectin 3.0
Xyloglucan 50.0
Sodium chloride 0.4
Calcium chloride 0.3
Potassium chloride 0.3
Purified water 25.0
Total weight (%) 100.0
[0037]
As a result, if the concentration of xyloglucan is increased beyond that of Formulation Example 2, it will be separated after dissolution, which is inappropriate. In addition to xyloglucan, in both laminaran and krestin, it is necessary to have a concentration of at least 1% in each case, and each concentration should be within 50%.
[0038]
Next, the component of the polysaccharide aqueous solution 1 is mixed with the following oxidative hair dye to form a first liquid.
The second solution of oxidative hair dye is obtained by blending 6.0% by weight of hydrogen peroxide in purified water.
[0040]
The same amount of the second liquid as the first liquid in Example 1 was mixed and applied to a part of the hair. Thereafter, after 20 minutes at room temperature, it was washed with hot water at about 40 ° C. and dried.
[0041]
As a comparative example, the same treatment was performed with the polysaccharide solution of the first liquid replaced with purified water.
[0042]
As samples, hair that was dyed and hair that was not dyed were collected, and the state of each hair matrix cell was confirmed. As a result, the state of the hair matrix cells was almost the same in the sample using the oxidative hair dye of the present invention and the sample not treated. In addition, some samples show activated hair matrix cells. This is considered that the oxidative hair dye of the present invention more positively expressed the healing effect. On the other hand, in the sample using the conventional oxidative hair dye, it was found that the hair matrix cells were atrophied compared to the untreated hair.
[0043]
Next, the component prescribed by the polysaccharide aqueous solution 2 is mixed with the following oxidative hair dye to form a first liquid.
The second solution of the oxidative hair dye is obtained by blending 20.0% by weight of 35% hydrogen peroxide into purified water.
[0045]
The same amount of the second liquid as the first liquid of Example 2 was mixed and applied to a part of the hair. Thereafter, after 20 minutes at room temperature, it was washed with hot water at about 40 ° C. and dried.
[0046]
As a comparative example, the same treatment was performed by replacing the polysaccharide aqueous solution of the first liquid in Example 2 with purified water.
[0047]
As samples, hair that was dyed and hair that was not dyed were collected, and the state of each hair matrix cell was confirmed. As a result, the state of the hair matrix cells hardly changed between the sample using the oxidative hair dye of the present invention and the sample not treated. On the other hand, in the sample using the conventional oxidative hair dye, the hair matrix cells were contracted as compared with the untreated hair.
[0048]
In addition, the polysaccharide aqueous solution prescribed in the present invention oxidation hair dye is not only an oxidation hair dye mainly composed of a diamine-based oxidation dye, but also a bleaching agent such as hair bleach, hair lightener, dakaralizer, and decolorizer. It can also be used in combination with hair dyes, Ohagro non-oxidative hair dyes, semi-permanent hair dyes such as hair manicure, acidic hair color, color rinse, and temporary hair dyes such as color spray, color foam, and color stick. It is.
[0049]
【The invention's effect】
According to the present invention, a polysaccharide in which any or all of xyloglucan, lamiranan, and krestin is added to an oxidative hair dye having a diamine-based oxidative dye as the main ingredient of the first liquid and hydrogen peroxide as the main ingredient of the second liquid. By blending the aqueous solution, the hair matrix cells are activated and can be used without damaging the hair and scalp.
[0050]
In addition, it can create an environment similar to skin cell interstitial fluid while enhancing the immunity and healing power of cellular tissues, thus inhibiting intracellular respiration caused by mitochondrial membrane damage and cell activity source ATP. It is possible to prevent a decrease in production of (adenosine triphosphate), maintain an electrolyte balance and an osmotic pressure balance, and promote normalization of damaged cells from the surface layer of skin cells and mucosal cells. As a result, there is also an effect of healing already damaged hair and scalp.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003047126A JP3890564B2 (en) | 2003-02-25 | 2003-02-25 | Oxidative hair dye |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003047126A JP3890564B2 (en) | 2003-02-25 | 2003-02-25 | Oxidative hair dye |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004256411A true JP2004256411A (en) | 2004-09-16 |
| JP3890564B2 JP3890564B2 (en) | 2007-03-07 |
Family
ID=33113453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003047126A Expired - Fee Related JP3890564B2 (en) | 2003-02-25 | 2003-02-25 | Oxidative hair dye |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3890564B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008208120A (en) * | 2007-02-02 | 2008-09-11 | Hayashibara Biochem Lab Inc | Oxidizing agent-containing composition for use as hair treatment preparation |
| JP2013511512A (en) * | 2009-11-19 | 2013-04-04 | アモーレパシフィック コーポレイション | Composition for alleviating skin irritation with dyes |
| US20160074292A1 (en) * | 2013-05-22 | 2016-03-17 | Henkel Ag & Co. Kgaa | Mineral salts for reducing the content of cysteic acid in keratin fibres |
| JP2017155028A (en) * | 2016-03-01 | 2017-09-07 | 有限会社岡田技研 | Scalp protective agent |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6028912A (en) * | 1983-07-25 | 1985-02-14 | Shiseido Co Ltd | First liquid composition of hairdye |
| JPH0491015A (en) * | 1990-08-03 | 1992-03-24 | Japan Happy:Kk | Raw material for hair cosmetic and cosmetic for hair |
| JPH06287110A (en) * | 1993-04-02 | 1994-10-11 | Ichimaru Pharcos Co Ltd | Hair cosmetic |
| JP2001342120A (en) * | 2000-03-30 | 2001-12-11 | Shiseido Co Ltd | Hair dye, immobilizing agent of hair dye and method for dyeing hair |
| JP2002275046A (en) * | 2001-03-23 | 2002-09-25 | Kanebo Ltd | Agent for enhancing barrier against penetration through epidermis, and skin care composition |
-
2003
- 2003-02-25 JP JP2003047126A patent/JP3890564B2/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6028912A (en) * | 1983-07-25 | 1985-02-14 | Shiseido Co Ltd | First liquid composition of hairdye |
| JPH0491015A (en) * | 1990-08-03 | 1992-03-24 | Japan Happy:Kk | Raw material for hair cosmetic and cosmetic for hair |
| JPH06287110A (en) * | 1993-04-02 | 1994-10-11 | Ichimaru Pharcos Co Ltd | Hair cosmetic |
| JP2001342120A (en) * | 2000-03-30 | 2001-12-11 | Shiseido Co Ltd | Hair dye, immobilizing agent of hair dye and method for dyeing hair |
| JP2002275046A (en) * | 2001-03-23 | 2002-09-25 | Kanebo Ltd | Agent for enhancing barrier against penetration through epidermis, and skin care composition |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008208120A (en) * | 2007-02-02 | 2008-09-11 | Hayashibara Biochem Lab Inc | Oxidizing agent-containing composition for use as hair treatment preparation |
| JP2013511512A (en) * | 2009-11-19 | 2013-04-04 | アモーレパシフィック コーポレイション | Composition for alleviating skin irritation with dyes |
| US20160074292A1 (en) * | 2013-05-22 | 2016-03-17 | Henkel Ag & Co. Kgaa | Mineral salts for reducing the content of cysteic acid in keratin fibres |
| JP2017155028A (en) * | 2016-03-01 | 2017-09-07 | 有限会社岡田技研 | Scalp protective agent |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3890564B2 (en) | 2007-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0829258B1 (en) | Oxidative composition in gel form and uses for dyeing, for permanent deformation or for decoloration of hair | |
| EP0754449B1 (en) | Skin whitening composition and/or anti-aging composition and uses thereof | |
| JP5974407B2 (en) | Cosmetic, bathing agent and pharmaceutical composition containing chitin nanofiber or chitosan nanofiber | |
| CH654482A5 (en) | THERAPEUTIC COMPOSITION OF DIMETHYLSULFOXIDE. | |
| PT87123B (en) | PROCESS OF COLORATION OF 5,6-DIHYDROXY-INDOLE CERATINAL FIBERS ASSOCIATED WITH AN IODIDE AND WITH A COMPOSITION OF HYDROGEN PEROXIDE WITH ALKALINE PH | |
| JP4827856B2 (en) | Destaining agent composition | |
| KR102404932B1 (en) | Method for manufacturing spicule coated with diamond and ingredients effective for skin improvement, and diamond spicule cosmetic composition including the same | |
| JP2023097373A (en) | Schizophyllan composition as well as preparation method and application thereof | |
| EP1173149A1 (en) | Cosmetic and/or dietetic composition comprising a mixture of lycopene and olive leaf extract | |
| KR20170099656A (en) | Cosmetic compositions for moisturizing | |
| Morganti | Chitin Nanofibrils in skin treatment | |
| JP3885204B2 (en) | External agent for promoting cell activity | |
| KR102124583B1 (en) | Hair treatment agent and method of permanent wave using thereof | |
| TWI278318B (en) | External preparations for treating dermatitis | |
| JP3890564B2 (en) | Oxidative hair dye | |
| KR101339841B1 (en) | Treatment composition of human hair | |
| JP2005041826A (en) | Hair-growth stimulant/hair restorer with hair-dyeing effect | |
| KR101292828B1 (en) | Hair dye containing snail mucus extract and preparation method therof | |
| JP3890563B2 (en) | Permanent wave agent | |
| FR2741266A1 (en) | Cosmetic and therapeutic compositions contg a haemocyanin | |
| CA2747860C (en) | Cosmetic composition containing a locust bean gum hydrolysate | |
| KR20090099164A (en) | Hair permanent composition comprising black mud | |
| JPH0432046B2 (en) | ||
| KR102081974B1 (en) | Mask pack composition comprising for moisturizing effect and enhancing elasticity on the skin | |
| JPS59106409A (en) | Cosmetic containing chitin compound |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041203 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20051201 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060711 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060911 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20061031 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20061124 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 3890564 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101215 Year of fee payment: 4 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20111215 Year of fee payment: 5 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121215 Year of fee payment: 6 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131215 Year of fee payment: 7 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |