JP3890563B2 - Permanent wave agent - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a permanent wave agent that activates hair matrix cells and can be used without damaging hair and scalp.
[0002]
[Prior art]
In general, permanent wave is performed by mixing two liquids. First, cysteine disulfide bonds in hair are cleaved with a reducing agent mainly composed of thioglycolic acid or cysteine or a salt thereof. Subsequently, the reducing agent is neutralized using an oxidizing agent such as hydrogen peroxide or sodium bromate to repair the cysteine disulfide bond.
[0003]
Repeated use of a reducing agent such as thioglycolic acid may damage the hair. Therefore, Patent Document 1 and Patent Document 2 propose a permanent wave agent that prevents hair damage.
[0004]
Patent Document 1 states that skin irritation and hair damage can be prevented by mixing 0.1 to 15% by weight of 2-methyl-1,3-propanediol with a reducing agent.
[0005]
In Patent Document 2, 1,3-propanediol monothioglycolate is mixed with another reducing agent as a reducing agent. According to Patent Document 2, it acts at a pH value that does not damage hair, and the effect on the skin is reduced.
[0006]
On the other hand, the present inventor created an environment similar to the skin cell interstitial fluid on the skin surface to activate the skin cells and improve various diseases caused by the decrease in the cell functions of the skin cells, and to balance the electrolyte and osmotic pressure. By applying it, the inventors have invented aqueous skin and hair cosmetics that promote normalization of damaged cells from the surface of the skin (Patent Document 3). In this aqueous skin and hair cosmetic, in the case of stains and reddish face, the subcutaneous cells are stimulated and divided to lead to healing, and the hair matrix cells are stimulated by the osmotic effect on the scalp and squirrels. The effect of promoting hair growth and deodorizing action has been observed.
[0007]
Furthermore, the present inventor has no risk of side effects even when used as an external preparation for the oral cavity and nasal mucosa, and can be applied to various diseases in a wider range of cells such as stomatitis and hay fever. A possible cell activity promoting external preparation has been invented (Patent Document 4).
[0008]
[Patent Document 1]
JP 2002-220326 A [Patent Document 2]
JP-A-8-291031 [Patent Document 3]
Japanese Patent No. 1597430 [Patent Document 4]
Japanese Patent No. 2681527 [0009]
[Problems to be solved by the invention]
However, the permanent wave agents described in Patent Document 1 and Patent Document 2 are capable of reducing skin irritation and hair damage, but are capable of activating hair matrix cells and actively protecting the hair and scalp. It was not a drug.
[0010]
On the other hand, the components described in Patent Document 3 and Patent Document 4 stimulate hair matrix cells by osmotic pressure action, and are components that have no risk of side effects even when used as an external preparation for oral cavity and nasal mucosa. is there.
[0011]
Therefore, the present invention further improves the components described in Patent Document 3 and Patent Document 4, and provides a permanent wave agent that activates hair matrix cells and can be used without damaging hair and scalp. Objective.
[0012]
[Means for Solving the Problems]
In order to achieve the above object, the present invention provides a permanent wave agent containing thioglycolic acid or cysteine or a salt thereof as a main component alone or in combination with another reducing agent, xyloglucan, laminaran, krestin. , Pectin, dextran, glucose, pullulan, lentinan, cyclodextrin, trehalose, sodium chloride, calcium chloride, and potassium chloride are added as a means for solving the problem.
[0013]
Causes of various symptoms such as inflammation, pigmentation, and alopecia that are lesions in human skin are related to various factors such as ultraviolet rays and chemical substances, and their changes at the cellular level are limited. The root of this is a disorder of the mitochondrial membrane and cell membrane, one of the organelles. In other words, damage to the mitochondrial membrane results in inhibition of intracellular respiration, thereby reducing the production of ATP (adenosine triphosphate), which is the source of cellular activity. Such a deficiency in ATP reduces the function of active transport of the cell membrane, leading to a decrease in the ability to transport substances between cells and interstitial fluid. This causes a vicious circle in which intracellular deprivation substances such as glucose are deficient, leading to a decrease in the acidity of ATP.
[0014]
There are a variety of causes that cause changes at the cellular level as described above. In particular, in hair matrix cells, cells in the diseased part are activated by pulling up the cell interstitial fluid by osmotic pressure action. Can do. Furthermore, it is considered that by adding xyloglucan, laminaran, and krestin, the immunity and healing power of the hair matrix cells of the scalp can be enhanced.
[0015]
DETAILED DESCRIPTION OF THE INVENTION
The permanent wave agent of the present invention is applied to all permanent wave agents in which thioglycolic acid is used alone or mixed with another reducing agent as a reducing agent. It is also possible to apply to the following classified permanent wave agents. That is, cold two-bath type permanent wave agent, heated two-bath type permanent wave agent, cold one-bath type permanent wave agent, first-time adjustment exothermic type permanent wave agent, cold two-bath type hair straightener, warming A two-bath hair straightener, a cold two-bath hair straightener using a high-pressure hair-styling iron, and a warm two-bath hair straightener using a high-pressure hair-styling iron.
[0016]
The present invention includes all such conventionally used permanent wave agents such as xyloglucan, laminaran, krestin, pectin, dextran, glucose, pullulan, lentinan, cyclodextrin, trehalose, sodium chloride, calcium chloride, and potassium chloride. Is a mixture of aqueous polysaccharide solutions to which is added.
[0017]
0.1 to 30% of the aqueous polysaccharide solution to which the above components are added is mixed with the permanent wave agent in a total weight ratio. The mixing ratio of the polysaccharide aqueous solution is arbitrarily changed according to the classification of the permanent wave agent.
[0018]
On the other hand, the components added to the polysaccharide aqueous solution are 1-50% xyloglucan, 1-50% laminaran, and 1-50% krestin in the total weight ratio of the aqueous solution dissolving the polysaccharide. To do.
[0019]
Xyloglucan is a constituent sugar chain that exists universally on the wall (primary wall) of plant cells that are elongated and enlarged. Plant species specificity arises from the binding of galactose or fucosyl-galactose to xylose residues. Lectins can bind to these galactose and fucose residues, but the functions of these branched sugar chains are not known. Plant cell growth is caused by a water absorption phenomenon derived from the osmotic pressure of the cell, and water absorption is caused by a decrease in wall pressure due to loosening of the cell wall. This loosening of the cell wall has not yet been elucidated, but cell elongation is always accompanied by degradation and solubilization of xyloglucan, and is attracting attention as one of the polysaccharides that control the physiological activity of cells.
[0020]
Laminaran is one of the carbohydrates and is classified as a β-glucan laminaran. It is contained in seaweeds such as shiitake mushrooms and kelp and has the effect of enhancing immunity.
[0021]
Krestin is used as an immunotherapeutic drug that enhances the expression of HLA class I antigens in human cancer cells, and is extracted from chopped mycelium. This krestin has been shown to have an immunotherapeutic effect on neoplastic diseases such as gastric cancer, colorectal cancer, and small cell lung cancer.
[0022]
As a result of researching ingredients suitable for external preparations from among many polysaccharides, the inventor has combined these xyloglucan, laminaran, and krestin to immunize and heal cellular tissues such as the oral cavity and nasal mucosa. This is a preparation for external use that increases strength. This immunity and healing power has been found to have an effect of healing scalp skin damage and hair damage caused by permanent wave agents.
[0023]
In an aqueous solution in which these polysaccharides are dissolved, 1 to 50% pectin, 1 to 30% dextran, 1 to 30% glucose, and 1 to 30% in weight ratio of the whole aqueous solution in advance. It contains lentinan and 1-50% trehalose.
[0024]
Pectin functions to connect plant cells by binding to other components such as cellulose as a component of plant cell walls. It is a component having a gelling action and is suitable as an additive for the external preparation of the present invention.
[0025]
Moreover, sodium chloride, calcium chloride, and potassium chloride are added to the aqueous solution in which the polysaccharide is dissolved. The amount of sodium chloride is 0.1 to 1% in the total weight ratio so that the osmotic pressure balance and the electrolyte balance on the skin, that is, the skin cells can be activated. Similarly, in calcium chloride and potassium chloride Also, 0.1 to 1% of each component is dissolved in the aqueous phase component.
[0026]
【Example】
Next, the prescription of the permanent wave agent for mixing the polysaccharide aqueous solution of the present invention will be specifically described. In addition, an Example is only an example of a permanent wave agent, and this invention is not limited to these Examples.
[0027]
First, the polysaccharide aqueous solution mixed with the permanent wave agent of the present invention will be specifically described.
[0028]
-Aqueous polysaccharide solution 1-
Dextran 18.0
Glucose 10.0
Cyclodextrin 2.0
Trehalose 3.0
Pullulan 7.0
Lentinan 7.0
Lamina Run 2.0
Krestin 1.0
Pectin 3.0
Xyloglucan 1.0
Sodium chloride 0.9
Calcium chloride 0.3
Potassium chloride 0.3
Purified water 44.5
Total weight (%) 100.0
[0029]
The aqueous phase component (purified water) is produced only with pure water. And when mixing each of these components and an aqueous phase component, in order to complete melt | dissolution of each component, it implements at the temperature of 50-100 degreeC.
[0030]
Furthermore, the polysaccharide aqueous solution which consists of another mixing ratio was prepared.
[0031]
-Aqueous polysaccharide solution 2-
Dextran 4.0
Glucose 3.0
Cyclodextrin 2.0
Trehalose 3.0
Pullulan 3.0
Lentinan 3.0
Lamina Run 2.0
Krestin 1.0
Pectin 3.0
Xyloglucan 50.0
Sodium chloride 0.4
Calcium chloride 0.3
Potassium chloride 0.3
Purified water 25.0
Total weight (%) 100.0
[0032]
As a result, if the concentration of xyloglucan is increased beyond that of Formulation Example 2, it will be separated after dissolution, which is inappropriate. In addition to xyloglucan, in both laminaran and krestin, it is necessary to have a concentration of at least 1% in each case, and each concentration should be within 50%.
[0033]
Next, the component prescribed by the polysaccharide aqueous solution 1 is mixed with the following permanent wave agent (cold two-bath type) to make the first agent.
Example 1
(weight%)
Aqueous polysaccharides 28.00
Ammonium thioglycolate salt solution (50%) 18.42
Monoethanolamine 1.70
Ammonia water reagent special grade (28%)-Adjusted to PH9.1 1.00
Ammonium bicarbonate 0.50
Edetate tetrasodium 0.10
Fragrance 0.30
Purified water balance
Total 100.00
[0034]
The prescription of the second agent of the permanent wave agent is as follows.
(weight%)
Sodium bromate 7.0
Phosphate buffer (PH6.5) Appropriate amount Sodium benzoate 0.1
Purified water balance
Total 100.0
[0035]
The hair treatment was carried out for 15 minutes using the second agent at room temperature (about 22 ° C.) after 20 minutes treatment with a dryer (about 40 ° C.) using the first agent of Example 1.
[0036]
As a comparative example, the same treatment was performed by replacing the aqueous polysaccharide solution of the first agent with purified water.
[0037]
As samples, pre-treatment hair and post-treatment hair were collected, and the state of each hair matrix cell was confirmed. As a result, the sample using the permanent wave agent of the present invention was in almost the same state before and after treatment. On the other hand, in the sample using the conventional permanent wave agent, it was found that the treated hair matrix cells were atrophied compared to the state before the treatment.
[0038]
Next, the component prescribed with the polysaccharide aqueous solution 2 is mixed with the following permanent wave agent (heated two-bath type) to form the first agent.
(Example 2) (wt%)
Polysaccharide aqueous solution 30.00
DL cysteine hydrochloride monohydrate 6.00
Ammonium thioglycolate salt solution (50%) 2.00
Monoethanolamine 3.80
Ammonia water reagent special grade (28%) adjusted to PH9.2 2.20
L-Arginine 0.10
Edetate tetrasodium 0.10
Fragrance 0.50
Purified water balance
Total 100.00
[0039]
The prescription of the second agent of the permanent wave agent is as follows.
(weight%)
Sodium bromate 7.0
Phosphate buffer (PH6.5) Appropriate amount Sodium benzoate 0.1
Purified water balance
Total 100.0
[0040]
The hair treatment was performed for 15 minutes using the second agent at room temperature (about 22 ° C.) after 20 minutes treatment with a dryer (about 40 ° C.) using the first agent of Example 2.
[0041]
As a comparative example, the same treatment was performed by replacing the polysaccharide aqueous solution of the first agent in Example 2 with purified water.
[0042]
As samples, pre-treatment hair and post-treatment hair were collected, and the state of each hair matrix cell was confirmed. As a result, the sample using the permanent wave agent of the present invention was in almost the same state before and after treatment. In addition, some samples show activated hair matrix cells. This is considered that the permanent wave agent of the present invention exhibited a healing effect more positively. On the other hand, in the sample using the conventional permanent wave agent, it was found that the treated hair matrix cells were atrophied compared to the state before the treatment.
[0043]
【The invention's effect】
According to the present invention, a permanent wave agent containing thioglycolic acid or cysteine or a salt thereof as a main component as a main component alone or mixed with another reducing agent is a combination of xyloglucan, laminaran and krestin. By mixing the aqueous saccharide solution, the hair matrix cells are activated and can be used without damaging the hair and scalp.
[0044]
In addition, it can create an environment similar to that of skin cell interstitial fluid while enhancing the immunity and healing power of cellular tissues, so that inhibition of intracellular respiration caused by mitochondrial membrane damage and ATP as the source of cellular activity It is possible to prevent a decrease in production of (adenosine triphosphate), maintain an electrolyte balance and an osmotic pressure balance, and promote normalization of damaged cells from the surface layer of skin cells and mucosal cells. As a result, there is also an effect of healing already damaged hair and scalp.

Claims (1)

Permanent wave agent containing thioglycolic acid or cysteine or a salt thereof as a main component, alone or mixed with other reducing agents, xyloglucan, laminaran, krestin , pectin, dextran, glucose, pullulan, lentinan, cyclodextrin A permanent waving agent comprising a polysaccharide aqueous solution to which all of trehalose, sodium chloride, calcium chloride and potassium chloride are added.