JP2002145742A - Hair tonic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a hair tonic having an excellent hair growth action. SOLUTION: It is found that the subject is solved by providing a hair tonic comprising an extract of a plant of the genus Malva of the family Malvaceae as an active ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is an invention belonging to the technical field related to hair restoration. More specifically, the present invention relates to a hair restorer containing an extract of a specific plant as an active ingredient. The hair restorer of the present invention is specifically used in the fields of pharmaceuticals, quasi-drugs, and cosmetics.

[0002]

2. Description of the Related Art In a modern society referred to as an aging society or a stressed society, there are more and more opportunities for head hair to be exposed to hair loss and baldness due to various causes.

[0003] Generally, the causes of hair loss and baldness are hair roots,
Activation of androgens in organs such as sebaceous glands, decreased blood flow to the dermal papilla and hair follicles, excessive secretion of sebum, abnormalities in the scalp due to generation of peroxide, malnutrition, and the like are considered.

[0004] For this reason, conventional hair nourishes are generally blended with components having an action of removing or reducing the above-mentioned causes. For example, in order to improve blood circulation in the scalp, a vasodilator such as assembly extract, vitamin E, and acetylcholine derivative and a skin function enhancer such as cepharanthin are blended, and scalp inflammation caused by excess secretion of sebum and the like is reduced. Anti-inflammatory agents such as purple root extract and hinokitiol are combined to suppress, female hormones such as estradiol are combined to suppress male hormones, and vitamin B etc. Vitamins and amino acids such as serine and methionine are compounded and used for prevention and treatment of hair loss (symptoms), promotion of hair growth, and the like.

[0005] In the prior art relating to the technical field, other natural ingredients other than those described above may be used, for example, medicinal plants such as pepper (pepper), shimatsurishi (purple mariko), and leopard (buoying). Sebum inhibitor containing at least one extract of lipase (see JP-A-3-220129)
And a hair restorer prepared by mixing 15 kinds of medicinal natural products such as pepper and ground yellow at a specific ratio and immersing the mixture in an aqueous solution containing ethanol and acetic acid (see JP-A-3-44312). .

However, in spite of various attempts as described above, conventional hair restorations have not always had sufficient hair restoration effects such as hair loss prevention and hair growth promotion. This is presumably due to various causes of hair loss and the very complex mechanism of hair growth. In view of the variety of causes of hair loss and the complexity of the mechanism of hair growth, it would be desirable to provide a novel hair restorer having an excellent hair restorer action.

[0007]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a new hair restorer having an excellent hair restorer in order to address the various causes of hair loss.

[0008]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have widely searched for and searched for effective substances and have studied them. As a result, it has been found that an extract of a Malvaceae mallow (Malva) plant, which is a plant extract, exhibits excellent hair-growing action (hair loss-preventing action and hair-growth promoting action). completed.

[0009] That is, the present invention relates to Malvaceae.
Provided is a hair restorer containing an extract of a mallow genus (Malva) plant as an active ingredient. In the hair restoration of the present invention, when the extract of the plant of the genus Malvaceae (Malva) is Malva spicata, the intended effect of the present invention can be particularly favorably exhibited.

[0010] In the present invention, the term "hair growth" is used in the concept including a hair loss preventing action, a hair growth promoting action and the like. Further, the hair restorer of the present invention can be used as an active ingredient of a composition for external use on the skin including a cosmeceutical for hair growth of head hair and the like.

[0011]

Embodiments of the present invention will be described below. As described above, the hair restorer of the present invention is a hair restorer containing a Malvaceae mallow genus (Malva) plant as an active ingredient.

The extract of Malvaceae mallow genus (Malva) plant, which is incorporated as an active ingredient in the hair restorer of the present invention, is obtained from Malvaceae / Malva genus Malvaceae.
a) An extract obtained from plants.

The Malvaceae mallow (Malvaceae)
a) Plants include musk mallow (Malva moschata), mallow (Malva sylvestris), and smelt (Malva verti
cillata), and preferably, Malva spicata.

The extract of this plant is a Malvaceae family (Malvacea
e) It can be produced by extracting from a plant of the genus Malva by a solvent according to a generally known method. For example,
After the plant is raw or dried as necessary,
As obtained or crushed, immersed in a solvent or heated under reflux with a solvent, or further immersed or heated under reflux to further evaporate the solvent, or immersed, heated under reflux or distilled off the solvent and further dried. Can be.

Malvaceae (Genus Malvaceae)
a) The part of the plant used for extraction does not impair the intended effect of the present invention, and as long as it contains a component having a hair-growing action, even if it is a whole plant, any of the plant such as leaves, fruits, roots, etc. It may be a component, but is preferably a fruit or root.

Examples of the solvent that can be used for extraction include:
Hot water; methanol, ethanol, isopropanol, n
Lower alcohols such as butanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol;
Examples include hydrates of these alcohols; hydrocarbon solvents such as n-hexane and toluene, and use of methanol or ethanol is convenient. When a lower alcohol is used, the resulting extract can be directly included in the hair restoration of the present invention.

The extract of the Malvaceae mallow (Malva) plant thus obtained has excellent hair-growing action,
That is, it has an excellent action of preventing hair loss and promoting hair growth. In the hair restoration of the present invention, the content of the extract of the Malvaceae mallow (Malva) plant may vary depending on the actually used extract, the form or the application method of the hair restoration of the present invention, and the like. And is not specified.

For example, when an extract obtained according to the method described in Examples described below is used, the content of the extract (based on dry matter) in the total mass of the hair restorer is generally 0.0001.
To 10.0 mass%, preferably 0.001 to 5.
0% by mass.

If the content of the plant extract is less than 0.0001% by mass based on the total mass of the hair growth agent, the desired effect of the present invention is not sufficiently exhibited, so that it is not preferable.
If the content exceeds 10.0% by mass, the tendency of causing troubles in the preparation becomes remarkable, which is not preferable.

The dosage form that can be taken by the hair restorer of the present invention is not particularly limited as long as it is a dosage form applicable to the scalp.
Emulsions, ointments and the like can be selected. Further, the form of the hair restorer of the present invention is arbitrary, and for example, it can take the form of hair tonic, hair cream, hair gel, water grease, hair spray, mousse, shampoo, rinse and the like.

The hair restoration according to the present invention includes Malvaceae.
Various components generally used in cosmetics, quasi-drugs, pharmaceuticals, and the like, as needed, in addition to the extract of the mallow genus (Malva) plant, and as long as the desired effects of the present invention are not impaired, such as oil components , Humectants, thickeners, preservatives, antioxidants, UV protection agents, fragrances, coloring agents, drugs, ethanol, water, and the like. In addition, components conventionally incorporated into hair restorations, for example, assembly extract, carpronium chloride, vitamin E, vasodilators such as acetylcholine derivatives, skin function enhancers such as cepharanthin,
Purple root extract, anti-inflammatory agents such as hinokitiol, female hormones such as estradiol, vitamins such as vitamin B, amino acids such as serine and methionine, as long as the intended effects of the present invention are not impaired, Can be blended. The specific formulation of the hair restorer of the present invention will be described later.

[0022]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples, but it should be understood that the technical scope of the present invention is not limited to these Examples.

In the following Examples, those indicated by "%" and indicating the contents are as follows unless otherwise specified.
% By mass. Example 1 Preparation of Malva spicata extract Malva sp.
picata) was immersed in 7 liters of methanol at room temperature for 5 days. The solvent was distilled off from the extract and then dried to obtain 42.0 g of Malva spica extract (dry product).

[Example 2] Hair growth test Using a C3H / HeNCrj mouse in the telogen phase of the hair cycle as an experimental animal, the method of Ogawa et al. (Normal and Abnormal / Epidermal Differentiation (Nor
mal and Abnormal Epidermal Differentiation), M. Se
Edited by iji and IABernstein, pp. 159-170, 1982
Year, Tokyo University Press).

That is, 60 mice are grouped into 10 mice, each for test samples 1 to 3 (a 70% ethanol solution containing 1%, 2% or 4% of the Malva spicata extract obtained in Example 1). And control sample 1 (75% ethanol solution containing 0.1% croton oil) and control sample 1
(70% ethanol solution), the back of the mouse was shaved with a hair clipper and a shaver, and the sample was applied to the shaved portion, 0.1 mL each, once a day. The hair regeneration area was measured after 17 days and 30 days. The results are shown in Table 1.

Table 1 ──────────────────────────────────── Sample Hair Regeneration Area Judgment After 17 Days 30 After day ──────────────────────────────────── Test sample 1 11% ethanol solution containing 1% extract 42 % Effective Test sample 2 Ethanol solution containing 2% extract 17 55 Effective Test sample 3 Ethanol solution containing 4% extract 25 69 Effective Comparative control Containing 0.1% croton oil 26 63 Effective Sample 1 Ethanol solution Control sample 1 70% ethanol solution 0 3 No effect ────────────────────────────────────

From the results shown in Table 1, it was clarified that the Malva spicata extract exhibited an excellent hair growth promoting action.

Example 3 Actual Use Test In order to examine the hair growth effect of the hair growth preparation of the present invention, such as the prevention of hair loss and the promotion of hair growth, a tricogram test was performed on humans by the following method.

As the samples, the hair restoration of the present invention (test sample 4) and the hair restoration of the comparative example (test sample 4) containing the Malva spica extract (dried product) obtained in Example 1 shown in Table 2 were used. Sample 2) and 70% ethanol (control sample 2) were used.

Table 2 ──────────────────────────────────── Compounding amount (% by mass) Compounding component毛 Hair restoration of the present invention Comparative hair restoration 例─────────────── (1) glycerin 2.0 2.0 (2) L-menthol 0.1 0.1 (3) decyltetradecyl 0.8 0.8 dimethyl Amine oxide (4) Malva spica extract 1.0-(4) Pepper extract ^* 1-1.0 (5) 95% ethanol 60.0 60.0 (6) Fragrance Appropriate amount Appropriate amount (7) Purification Water remaining amount ──────────────────────────────────── * 1: From pepper (Piper nigrum) And meta in the same manner as in Example 1. It is an extract (dry product) obtained by extraction with knol.

<Preparation method> (1), (2),
After adding (3), (4) and (6) and dissolving with stirring, (7) was added to obtain a hair restorer.

The above sample was applied to the scalp of 10 male subjects twice a day, 2 mL at a time, continuously for 4 months. Immediately before application and immediately after completion of application for 4 months, 100 hairs were removed per subject, and the roots of the removed hairs were observed under a microscope. The number of resting roots was counted from the form of the roots, and the percentage of resting roots was determined. I asked.

The hair nourishing effect of each sample was compared by increasing or decreasing the proportion of the telogen root. The telogen follicles are hair follicles that have stopped growing, and it has been recognized that humans who complain of hair loss have a higher percentage of these telogen follicles than normal humans.

In addition, the evaluation of the hair nourishing action was determined according to the following criteria. <Evaluation criteria> Effective: When the proportion of the telogen hair root decreased by 20% or more is 30% or more Slightly effective: When the proportion of the telogen hair root decreased by 20% or more is 20% or more and less than 30% Ineffective: Table 3 shows the results when the proportion of telogen roots decreased by 20% or more in less than 20% of the subjects.

Table 3 割 合 Ratio of test subjects (%) ──休止 Percentage of resting hair roots in hair nourishing sample evaluation 20% or more decrease Less than 20% decrease 20% or more increase ~ Less than 20% increase ─ ─────────────────────────────────── Test sample 4 60 30 10 Effective Hair restoration of the present invention Comparative sample 2 20 60 20 Slightly effective Hair restoration of comparative example Control sample 2 10 50 40 Ineffective 70% ethanol ──────────────────────────── ────────

As is evident from the results shown in Table 3, it was clarified that the hair restoration according to the present invention containing the Malva spicata extract exhibited an excellent hair restoration effect based on this extract.

[0037] Examples of the hair growth preparation of the present invention containing the Malva spicata extract (dried product) obtained in Example 1 are shown in Examples 4 to 20. [Example 4] Hair tonic blending component blending amount (% by mass) (1) Hardened castor oil EO (40 mol) adduct 2.0 (2) Malva spicata extract 0.1 (3) 95% ethanol 70. 0 (4) Appropriate amount of perfume (5) Residual amount of purified water <Preparation method> (1), (2) and (4) were added to (3), and dissolved by stirring. I got

Example 5 Hair Tonic Ingredients Incorporation Amount (% by Mass) (1) Glycerin 2.0 (2) L-Menthol 0.1 (3) Malva Spica Extract 0.5 (4) 95% Ethanol 60.0 (5) Appropriate amount of perfume (6) Residual purified water <Preparation method> (1), (2), (3) and (5) were added to (4), and dissolved by stirring. 6) was added to obtain a hair tonic.

Example 6 Hair Tonic Ingredient Compounding Amount (% by Mass) (1) Glycerin 2.0 (2) L-Menthol 0.1 (3) Decyltetradecyldimethylamine oxide 0.8 (4) Malva・ Spicata extract 0.001 (5) 95% ethanol 60.0 (6) Appropriate amount of perfume (7) Residual amount of purified water <Preparation method> (1), (2), (3), (3) After adding 4) and (6) and stirring and dissolving, (7) was added to obtain a hair tonic.

Example 7 Hair Tonic Ingredient Compounding Amount (% by Mass) (1) Glycerin 2.0 (2) L-Menthol 0.1 (3) Kudine Extraction Liquid 0.5 (4) Malva Spica Extraction Product 0.01 (5) 95% ethanol 60.0 (6) Appropriate amount of perfume (7) Residual amount of purified water <Preparation method> In (5), (1), (2), (3), (4) and After adding (6) and dissolving with stirring, (7) was added to obtain a hair tonic.

Example 8 Hair Tonic Ingredient Compounding Amount (% by Mass) (1) Glycerin 2.0 (2) L-Menthol 0.1 (3) Panax Ginseng Extract 1.0 (4) Malva spica extract 0.01 (5) 95% ethanol 60.0 (6) Appropriate amount of perfume (7) Residual purified water <Preparation method> (1), (2), (3), (4) and (4) After adding 6) and dissolving with stirring, (7) was added to obtain a hair tonic.

Example 9 Hair Tonic Compounding Component Blending Amount (% by Mass) (1) Glycerin 2.0 (2) L-Menthol 0.1 (3) Decyltetradecyldimethylamine oxide 0.8 (4) Kuzin Extracted liquid 0.5 (5) Quacharate extract 0.1 (6) Malva spicata extract 0.0001 (7) 95% ethanol 60.0 (8) Perfume proper amount (9) Purified water residue <Preparation Method> (7) to (1), (2), (3), (4),
After adding (5), (6) and (8) and stirring and dissolving, (9) was added to obtain a hair tonic.

Example 10 Hair Tonic Ingredients Incorporation Amount (% by Mass) (1) Polyethylene glycol 200 2.0 (2) L-menthol 0.2 (3) Malva spicata extract 1.0 (4) 95% ethanol 50.0 (5) Appropriate amount of fragrance (6) Residual purified water <Preparation method> (1), (2), (3) and (5) were added to (4), and the mixture was stirred and dissolved. , (6) was added to obtain a hair tonic.

Example 11 Hair Liquid Compounding Component Blending Amount (% by mass) (1) Polyoxypropyl butyl ether (40PO) 15.0 (2) Polyoxypropyl butyl ether phosphoric acid (40PO) 15.0 (3) Malva -Spica extract 2.0 (4) 1,3-butylene glycol 5.0 (5) 95% ethanol 50.0 (6) Appropriate amount of fragrance (7) Appropriate amount of pigment and edetic acid (8) Residual amount of purified water <Preparation method> Prepared in the same manner as in Example 4.

[Example 12] Scalp treatment compounding ingredients (mass%) (1) 1,3-propylene glycol 0.5 (2) pentaerythritol tetra-2-ethylhexanate 1.2 (3) 95% Ethanol 60.0 (4) Malva spica extract 2.0 (5) Assembly extract 1.0 (6) Appropriate amount of perfume (7) DME / LPG (95/5) balance <Preparation method> Prepared in a similar manner.

Example 13 Hair Cream Compounding Components (% by mass) Phase A (1) Liquid paraffin 5.0 (2) Cetostearyl alcohol 5.5 (3) Vaseline 5.5 (4) Glyceryl monostea Rate 3.0 (5) EO (20 mole addition) -2-octyldodecyl ether 3.0 (6) Vitamin E acetate 0.05 (7) Propylparaben 0.3 (8) Fragrance 0.05 B phase (9 ) Malva spicata extract 0.01 (10) Glycerin 7.0 (11) Dipropylene glycol 20.0 (12) Polyoxyethylene glycol 4000 5.0 (13) Sodium hexametaphosphate 0.005 (14) Purified water Residual amount <Preparation method> Heat dissolve and mix phase A, add the hot melt mixture of phase B to this, emulsify with a homomixer, and add I got

[Example 14] Hair gel compounding component compounding amount (% by mass) (1) Carboxyvinyl polymer 0.7 (2) Polyvinylpyrrolidone 2.0 (3) Glycerin 4.0 (4) Malva spica extract 0 0.05 (5) Sodium hydroxide suitable amount (6) Ethanol 20.0 (7) Polyoxyethylene octyl dodecyl ether suitable amount (8) Flavor, chelating agent (EDTA) proper amount (9) Purified water residue <Preparation method The carboxyvinyl polymer was dispersed in a mixture of glycerin and some purified water. Here, a solution obtained by dissolving the other components in the remaining purified water was added with stirring to obtain a hair gel.

[Example 15] Water grease compounding component compounding amount (% by mass) (1) Carboxyvinyl polymer 0.5 (2) Glycerin 50.0 (3) Sodium hydroxide proper amount (4) Ethanol 10.0 ( 5) Malva spicata extract 3.0 (6) Polyoxyethylene octyl dodecyl ether suitable amount (7) Flavor, chelating agent (EDTA) proper amount (8) Residual purified water <Preparation method> Same as in Example 8 Prepared by the method.

Example 16 Hair Spray Component Ingredients (mass%) (stock solution formulation) (1) Acrylic resin alkanolamine solution (50%) 7.0 (2) Cetyl alcohol 0.1 (3) Silicone oil (Methylphenylpolysiloxane) 0.3 (4) Ethanol residue (5) Malva spicata extract 4.0 (6) Appropriate amount of perfume (filling formulation) (7) Stock solution 50.0 (8) Dimethyl ether 45.0 (9) LPG 5.0 <Preparation method> (1), (2) and (3) were uniformly emulsified with a homomixer. This was added to the mixed solution of (4), (5) and (6) to prepare a stock solution. This undiluted solution was filled in a can, a valve was attached, and then gas was charged to obtain a hair spray.

[0050] Example 17 Lotion Ingredients Amount (wt%) (1) 1,3-butylene glycol 6.0 (2) Glycerin 4.0 (3) oleyl alcohol 0.1 (4) POE ( 20) Sorbitan monolaurate 0.5 (5) POE (15) Lauryl alcohol ether 0.5 (6) Malva spica extract 1.0 (7) Ethanol 10.0 (8) Fragrance, coloring matter, preservative, Appropriate amount of anti-fading agent and buffer solution (9) Residual amount of purified water <Preparation method> In (9), dissolve the buffer agent and anti-fading agent of (1), (2) and (8) at room temperature, and did.
In (7), the fragrance of (8), (3), (4), (5) and (6) were dissolved and mixed with the aqueous phase to solubilize. The obtained solubilized product was toned with the coloring agent of (8) to obtain a lotion.

[0051] Example 18 Emollient lotion Ingredients Amount (wt%) (1) Stearic acid 2.0 (2) Cetyl alcohol 1.5 (3) Vaseline 4.0 (4) Squalane 5.0 (5 2.) Malva spicata extract 5.0 (6) Glycerol tri-2-ethylhexanoate 2.0 (7) Sorbitan monooleate 2.0 (8) Dipropylene glycol 5.0 (9) PEG 1500 0 (10) Triethanolamine 1.0 (11) Appropriate amount of fragrance and preservative (12) Residual amount of purified water <Preparation method> Prepared by a conventional method.

[0052] Example 19 Emollient Cream Ingredients Amount (wt%) (1) cetyl alcohol 5.0 (2) Stearic acid 3.0 (3) Vaseline 5.0 (4) Squalane 10.0 (5 7.) Glycerol tri-2-ethylhexanoate 7.0 (6) Malva spicata extract 0.5 (7) Dipropylene glycol 5.0 (8) Glycerin 5.0 (9) Propylene glycol monostearate 0 (10) POE (20) cetyl alcohol ether 3.0 (11) Triethanolamine 1.0 (12) Appropriate amount of fragrance, preservative, antioxidant (13) Residual amount of purified water <Preparation method> Prepared.

[Example 20] Moisture gel blending component blending amount (% by mass) (1) Dipropylene glycol 7.0 (2) PEG 1500 8.0 (3) Malva spicata extract 0.1 (4) Carboxyvinyl Polymer 0.4 (5) Methylcellulose 0.2 (6) POE (15) Oleyl alcohol ether 1.0 (7) Potassium hydroxide 0.1 (8) Perfume, pigment, preservative, anti-fading agent, chelating agent Amount (9) Remaining amount of purified water <Preparation method> Prepared by a conventional method.

[0054]

Industrial Applicability According to the present invention, a hair restorer having excellent hair restorer action is provided.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Masahiro Tajima 2-2-1 Hayabuchi, Tsuzuki-ku, Yokohama-shi, Kanagawa Prefecture Inside Shiseido Research Center (Shinyokohama) (72) Inventor Masahiro Ota Tsuzuki, Yokohama-shi, Kanagawa 2-2-1 Hayabuchi-ku Shiseido Research Center Co., Ltd. (Shin-Yokohama) F-term (reference) 4C083 AA111 AA112 AB032 AB282 AC012 AC022 AC072 AC102 AC122 AC182 AC242 AC422 AC432 AC442 AC482 AC542 AC642 AC902 AD042 AD072 AD092 AD162 AD392 AD532 AD662 CC37 DD08 DD23 DD31 DD41 EE22 4C088 AB13 BA08 BA10 MA63 ZA92

Claims (2)

[Claims] 1. The genus Malvaceae (Malayaceae)
lva) Hair restoration containing a plant extract as an active ingredient. 2. The genus Malvaceae (Malayaceae)
2. The hair restorer according to claim 1, wherein the lva) plant is Malva spicata.