JP2002128656A - Skin-bleaching cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin-bleaching cosmetic having an extremely high skin- bleaching effect. SOLUTION: This skin-bleaching cosmetic contains an extract of Tussilago farfafa L. together with one, two or more kinds of skin-bleaching components selected from the group consisting of L-ascorbic acid and its derivatives, hydroquinone derivatives, ellagic acid and its derivatives, resorcinol derivatives, an extract of the placenta, and an oil-soluble extract of licorice.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a whitening cosmetic comprising a coltsfoot extract and one or more selected from whitening ingredients,
More specifically, the present invention relates to a skin external preparation that enhances the whitening effect of a whitening component synergistically by using a coltsfoot extract in combination.

[0002]

2. Description of the Related Art In general, pigmentation of skin, such as spots, freckles, and dark skin, is caused by excessive production of melanin pigment by melanin-producing cells present in the skin. In order to improve or prevent this pigmentation, a whitening cosmetic containing a whitening component having a melanin pigment formation inhibitory action has been used.

[0003]

However, in order to improve pigmentation, it is not enough to simply use a skin external preparation containing a whitening component, and a prescription design excellent in whitening effect is required. Have been.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies in view of the above circumstances and found that synergistic whitening effect can be obtained by containing coltsfoot extract and one or more kinds selected from whitening components. The invention of a whitening cosmetic, which is to be improved, has been completed.

[0005] That is, the whitening cosmetic of the present invention contains a coltsfoot extract and one or more selected from whitening components, and is an external preparation for skin that enhances the whitening effect synergistically.

Hereinafter, the configuration of the present invention will be described in detail.

The coltsfoot (Tussi) used in the present invention
lago farfafa L. Subcommittee winter, Asteraceae (C
ompositae), Tussilag
o) plants of Europe, North Africa, India,
Native to China.

The coltsfoot extract is one or more selected from whole plants or colts of flowers, leaves, stems, roots and seeds, or crushed and extracted, or extracted with a solvent. is there.

The extraction solvent is not particularly restricted but includes, for example, water, alcohols (eg, methanol,
Lower alcohols such as anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, esters such as ethyl ether, acetonitrile and ethyl acetate, xylene, benzene and chloroform These solvents may be used alone or in combination of two or more selected from organic solvents, and the respective solvent extracts may be combined.

The production method is not particularly limited, but may be, for example, at or below the boiling point of the solvent at normal temperature and pressure. After extraction, the solvent is purified by filtration or by using an ion exchange resin to obtain a solution, paste, or the like. , Gel, or powder.

Further, if necessary, a purification treatment such as decolorization and deodorization may be added to the extent that the effect of the extract is not affected. It is also possible to arbitrarily select a usual means generally applied to the extract.

[0012] The coltsfoot extract used in the present invention is preferably such that the extraction solvent is water, propylene glycol,
One kind or a combination of two or more kinds selected from 3-butylene glycol. For example, a 30% by weight 1,3-butylene glycol solution extracted as a commercially available product at room temperature, "Fukitan Popo Extract" Ichimaru Falcos (stock)
Company.

[0013] The content of coltsfoot extract used in the present invention is not particularly limited, but may be from 0.01 to 0.01%.
When the content is less than 0.01% by weight, a synergistic whitening effect may not be expected in some cases, and it may be contained in an amount exceeding 20% by weight. Not recognized and not economic.

The L-ascorbic acid and its derivatives used in the present invention are generally referred to as vitamin C, and the L-ascorbic acid derivatives include L-ascorbic acid phosphate, L-ascorbic acid alkyl ester, Examples include L-ascorbic acid sulfate, L-ascorbic acid glycoside, and the like. Specifically, L-ascorbic acid-2-phosphate, L-ascorbic acid-3-phosphate, DL-α- Tocopherol-2
L-ascorbic acid phosphates such as L-ascorbic acid diester, L-ascorbyl palmitate, L-ascorbyl isostearate, L-ascorbic acid alkyl esters such as L-ascorbyl dioleate, L-ascorbic acid-2 -Sulfate, L-ascorbic acid sulfate such as L-ascorbic acid-3-sulfate, 2-O-α-D-glucopyranosyl-
L-ascorbic acid glycosides such as L-ascorbic acid and the like can be mentioned.

In the present invention, these salts can also be used, and alkali metal salts such as sodium salt and potassium salt, and alkaline earth metal salts such as calcium salt and magnesium salt are used.

Examples of the hydroquinone derivative include a condensate of hydroquinone and a sugar, a condensate of an alkylhydroquinone obtained by introducing an alkyl group into hydroquinone and a sugar, and a preferable example thereof includes arbutin.

Examples of ellagic acid and its derivatives include ellagic acid compounds and alkali metal salts thereof. Preferred examples thereof include ellagic acid.

The resorcinol derivative is, for example, 4
-N-butyl resorcinol, 4-isoamyl resorcinol and the like.

The placenta extract is generally referred to as a water-soluble placenta extract. For example, the placenta of mammals such as cows, pigs, and humans is washed, blood removed, crushed, frozen, and the like. It is obtained by extracting impurities and then removing impurities.

The oil-soluble licorice extract is a licorice extract containing components such as glabridine, and specific licorice (Gly).
cyrrhiza graba Linne var.
It is an extract extracted from Russia, Afghanistan and Licorice.

The whitening component used in the present invention includes L-ascorbic acid and its derivatives, hydroquinone derivatives,
It is selected from ellagic acid and its derivatives, resorcinol derivatives, placenta extract, and oil-soluble licorice extract, preferably L-ascorbic acid and its derivatives, and more preferably L-ascorbic acid-2-phosphate. Salt, 2-O-α-D-glucopyranosyl-L-
It is ascorbic acid.

One or more of these whitening ingredients may be contained in order to improve the whitening effect or to ensure the stability of the preparation, and the content is not particularly limited. 0.1 to 10% by weight, and if less than 0.01% by weight, a synergistic whitening effect may not be expected. It is possible to contain more than 10% by weight, but the whitening effect is remarkable. No significant increase is observed and it is not economical.

The whitening cosmetic of the present invention may contain, in addition to the above essential components, various components used in ordinary cosmetics, quasi-drugs, pharmaceuticals, etc., such as oily components, emulsifiers, humectants, thickeners,
Pharmaceutical ingredients, preservatives, pigments, powders, pH adjusters, ultraviolet absorbers, antioxidants, fragrances and the like can be appropriately compounded.

Specifically, the oily components include, for example, liquid paraffin, vaseline, microcrystalline wax, squalane, jojoba oil, beeswax, carnauba wax, lanolin, olive oil, coconut oil, higher alcohols,
Examples include fatty acids, esters of higher alcohols and fatty acids, and silicone oils. Examples of the emulsifier include nonionic surfactants such as polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and polyoxyethylene hydrogenated castor oil. And anionic surfactants such as sodium stearoyl lactate; amphoteric surfactants such as soybean phospholipid; and cationic surfactants such as alkyltrimethylammonium chloride. Examples of the humectant include glycerin, sorbitol, xylitol, maltitol, propylene glycol, polyethylene glycol, 1,3-butylene glycol and the like. Examples of the thickener include carboxyvinyl polymer, xanthan gum, methylcellulose, polyvinylpyrrolidone, gelatin, clay minerals such as bentonite, and the like. Examples of the medicinal component include various vitamins and derivatives thereof, allantoin, glycyrrhizic acid and derivatives thereof, and various animal and plant extracts.

The whitening cosmetic of the present invention can be produced by a known method, and is not limited to general skin cosmetics, but includes quasi-drugs, external medicines, and the like. Can be arbitrarily selected according to the purpose, and can be in the form of cream, emulsion, liquid, gel, ointment, pack, stick, powder, and the like.

[0026]

The whitening cosmetic of the present invention relates to a whitening cosmetic characterized by containing a coltsfoot extract and one or more selected from whitening components. It has remarkably superior whitening effect compared to some whitening cosmetics.

Comparative Examples 1 to 9 in Table 1 and Examples 1 to 9 in Table 2
7. Samples shown in Examples 8 to 15 in Table 3 were prepared and evaluated. The results are shown in Tables 1 to 3. The compounding amount is% by weight. Prior to the examples, the method of manufacturing the sample used in the present invention,
The method for preparing pigmentation, the method for coating, the method for evaluation, and the criteria for determination will be described.

(Production method of sample) The components of each of Examples and Comparative Examples shown in Tables 1 to 3 are dissolved and mixed at 75 ° C, and emulsified under the same conditions by using a shearing force of a homogenizer. Thereafter, each sample was obtained by cooling to room temperature while continuing stirring.

(Method for producing pigmentation) Ten healthy male subjects were used as subjects, and biosolar simulators were used on the inner left and right upper arms, which are considered to be hardly exposed in daily life.
Irradiation equivalent to 1.5 MED (minimum erythema) of each subject was irradiated three times every other day in an area of 12 mm in diameter per part.

(Applying Method) An appropriate amount of each sample was continuously applied to the designated site three times a day in the morning, noon and evening for 28 days, and the whitening effect was examined.

(Evaluation method) The evaluation was made as the actual feeling of the effect of the subject. Effective: apparently thinner than the control. Somewhat effective: Feels thinner than the control. Disabled: No difference compared to control.

(Judgment Criteria) 有効: The ratio showing validity and somewhat validity is 80% or more. ：: The ratio indicating effective and somewhat effective is 50% or more and 80%
Less than. Δ: Effective and slightly effective ratio of 20% or more and 50%
Less than. X: The ratio showing effective and somewhat effective is less than 20%.

[0033]

[Table 1]

[0034]

[Table 2]

[0035]

[Table 3]

As described above, according to the present invention, a whitening cosmetic having a remarkably high whitening effect can be provided by containing a coltsfoot extract and one or more selected from whitening components. It becomes possible.

[0037]

EXAMPLES The present invention will be described below in more detail with reference to Examples, but it should not be construed that the invention is limited thereto.

Example 16 Moisturizing Cream A Squalane 10.0% by Weight Adsorbed and Purified Lanolin 4.5 Vaseline 4.5 Stearyl Alcohol 2.5 Cetanol 2.5 POE (20) Sorbitan Monostearate 2.2 POE (20) Cetyl Ether 2.0 Perfume Appropriate amount B Polyethylene glycol 8.0 Magnesium ascorbate 3.0 Phosphorus poppy extract (* 1) 3.0 Preservatives Appropriate pH adjuster Appropriate amount Purified water Residue

The raw material of the oil phase portion of A and the raw material of the aqueous phase portion of B are heated to 75 ° C. and completely dissolved, and then the oil phase portion is mixed with the aqueous phase, emulsified, and cooled to room temperature. The obtained cream was a good emulsion having an average particle diameter of about 1 to 2 μm, and was excellent in stability over time.

Example 17 Sunscreen Emulsion A Neopentyl glycol dicaprate 7.0% by weight isononyl isononanoate 7.0 2-Ethylhexyl paramethoxycinnamate 7.0 Fine particle titanium oxide 6.0 POE (20) Glyceryl oleate 2.0 Appropriate amount of fragrance B 1,3-butylene glycol 5.0 Water-soluble placenta extract 5.0 Extraction of coltsfoot extract (water, room temperature extraction) 1.0 Carboxyvinyl polymer 0.1 AMPD 0.05 Preservative Appropriate amount Purified water residue

After the raw material of the oil phase of A and the raw material of the aqueous phase of B are heated to 75 ° C. and completely dissolved, the oil phase is mixed with the aqueous phase, emulsified using a homogenizer, and cooled to room temperature. The obtained emulsion was a good emulsion having an average particle size of 1 μm or less, and the stability over time was good. The feeling of use was refreshing and non-sticky.

Example 18 Lotion Ethanol 10.0% by weight Dipropylene glycol 5.0 Coltsfoot extract (hot water extraction) 5.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 2.0 POE ( 9) Lauryl ether 0.5 Vitamin E acetate 0.3 Perfume proper amount Preservative proper amount pH adjuster proper amount Purified water residue

At room temperature, all components are mixed and completely dissolved. The obtained lotion had good stability over time. In addition, the feeling of use was refreshing and comfortable without stickiness.

 ────────────────────────────────────────────────── ─── Continuing from the front page (72) Inventor Jiro Kitahara 2-7 Tomicho, Nishi-ku, Nagoya, Aichi Japan Research Institute for Menard Cosmetics Co., Ltd. (72) Inventor Satoru Nakata 2- Tomicho, Nishi-ku, Nagoya, Aichi 7 Japan Menard Cosmetics Research Institute F-term (reference) 4C083 AA071 AA072 AA082 AA111 AA112 AB242 AC022 AC072 AC102 AC122 AC182 AC311 AC312 AC342 AC392 AC442 AC491 AD042 AD092 AD112 AD641 AD642 CC04 CC05 CC19 DD32 DD33 EE12EE

Claims (5)

[Claims] 1. A coltsfoot (Tussilago fa)
rfafa L. Sub-winter) An extract and a whitening component (hereinafter, referred to as “whitening component”) consisting of L-ascorbic acid and its derivatives, hydroquinone derivatives, ellagic acid and its derivatives, resorcinol derivatives, placental extracts, and oil-soluble licorice extracts. A whitening cosmetic comprising one or more of the above. 2. The whitening cosmetic according to claim 1, comprising a coltsfoot extract and L-ascorbic acid and its derivatives. 3. The whitening cosmetic according to claim 2, wherein the L-ascorbic acid derivative is an L-ascorbic acid-2-phosphate ester salt. 4. The method according to claim 1, wherein the L-ascorbic acid derivative is 2-O-α
The whitening cosmetic according to claim 2, which is -D-glucopyranosyl-L-ascorbic acid. 5. The content of coltsfoot extract in a range from 0.01 to 0.01.
20% by weight, one or two selected from whitening ingredients
The content of at least one species is 0.01 to 10% by weight.
The whitening cosmetic according to claim 4.