JP2008214236A - Skin-lightening cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic having a markedly high skin-lightening effect. <P>SOLUTION: The skin lightening cosmetic contains an aqueous extract of the leaves of Lilium japonicum and L-ascorbic acid or its derivative. The L-ascorbic acid derivative is magnesium L-ascorbyl phosphate. The content of the aqueous extract of the Lilium japonicum is 0.0005 to 0.1 wt.%, and the content of the L-ascorbic acid and its derivative is 0.001 to 0.1 wt.%. Since the cosmetic exhibits skin-lightening effect by the use of a small amount of it, it is excellent in use feeling and also it is a skin preparation for external use being synergistically improved in the skin-lightening effect. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a whitening cosmetic comprising a water-soluble extract of Sasayuri leaves and L-ascorbic acid or a derivative thereof, and more specifically, by using these in combination, The present invention relates to a cosmetic that synergistically enhances the whitening effect.

In general, skin pigmentation observed in spots, freckles, dark blacks, etc. is caused by excessive production of melanin pigments by melanin-producing cells present in the skin. In order to improve or prevent this pigmentation, cosmetics containing a whitening component having a melanin pigment formation inhibitory action such as L-ascorbic acid have been used.
JP 2006-225359 A

  However, in order to improve pigmentation, it is not sufficient to simply use a cosmetic containing a whitening component, and a prescription design with an excellent whitening effect has been demanded. In addition, high-concentration blending of L-ascorbic acid and its derivatives has problems such as cost, stickiness, feeling of use such as creaking, and insufficient storage stability.

  As a result of diligent study in view of such circumstances, the present inventors have synergistically enhanced the whitening effect by containing a water-soluble extract of Sasayuri leaves and L-ascorbic acid or a derivative thereof, and in a small amount. The inventors have completed the invention of cosmetics with a good feeling of use.

  The whitening cosmetic of the present invention relates to a cosmetic comprising a water-soluble extract of Sasayuri leaves and L-ascorbic acid or a derivative thereof, and compared with a whitening cosmetic that is conventionally used in general, The feeling of use is good and the whitening effect is remarkably excellent. That is, the whitening cosmetic composition of the present invention contains a water-soluble extract of Sasayuri leaves and L-ascorbic acid or a derivative thereof, and is a cosmetic composition that synergistically enhances the whitening effect.

The lily used in the present invention is a lily family, a lily genus, and a lily. The scientific name is Lilium japonicum (reference document: primary color world plant encyclopedia, Hokuryukan), for example, cultivated products can be used.

  The water-soluble extract of Sasayuri leaves used in the present invention is a product obtained by extracting plant leaves with a water-soluble solvent. For example, water, alcohols (methanol, ethanol, 1,3-butylene glycol, And a solvent such as acetone. What was extracted using the 1 type, or 2 or more types of mixed solvent of these water-soluble solvents may be used. Moreover, what was heat-extracted may be sufficient and what was extracted at normal temperature may be sufficient. If necessary, it can be concentrated or diluted and used as a cosmetic.

  The L-ascorbic acid and derivatives thereof used in the present invention are generally referred to as vitamin C. Examples of L-ascorbic acid derivatives include L-ascorbic acid phosphate, L-ascorbic acid alkyl ester, and L-ascorbine. Acid sulfate ester, L-ascorbic acid glycoside and the like, specifically, L-ascorbic acid-2-phosphate ester, L-ascorbic acid-3-phosphate ester, DL-α-tocopherol-2 L-ascorbic acid phosphoric acid esters such as L-ascorbic acid phosphoric diester, L-ascorbic acid alkyl esters such as L-ascorbyl palmitate, L-ascorbyl isostearate, L-ascorbyl isoleate, L-ascorbic acid-2 -Sulfate ester, L-ascorbic acid-3-sulfate ester Roh L- ascorbic acid sulfuric ester, 2-O-α-D- glucopyranosyl L- ascorbic acid glycosides such as -L- ascorbic acid.

  In the present invention, these salts can also be used, and alkali metal salts such as sodium salt and potassium salt, and alkaline earth metal salts such as calcium salt and magnesium salt are used.

  In addition, the addition method may be added in advance or during the production, and may be appropriately selected in consideration of workability.

  The content of the water-soluble extract of Sasayuri leaves and L-ascorbic acid or a derivative thereof used in the present invention is 0.0005 to 0.1% by weight of the water-soluble extract of Sasayuri leaves, and L-ascorbic acid Or the combination whose content of the derivative is 0.001-0.1 weight% is good. More preferably, the water-soluble extract of Sasayuri leaves is 0.0005 to 0.01% by weight, and the content of L-ascorbic acid or a derivative thereof is 0.001 to 0.01% by weight.

  In addition to the above essential components, the whitening cosmetics of the present invention are various components used in normal cosmetics, quasi drugs, pharmaceuticals, etc., such as oily components, emulsifiers, moisturizers, thickeners, medicinal components, preservatives. Pigments, powders, pH adjusters, ultraviolet absorbers, antioxidants, fragrances, and the like can be appropriately blended.

  Specific examples of the oil component include liquid paraffin, petrolatum, microcrystalline wax, squalane, jojoba oil, beeswax, carnauba wax, lanolin, olive oil, coconut oil, higher alcohol, fatty acid, ester of higher alcohol and fatty acid, silicone oil, and the like. Is mentioned. Examples of the emulsifier include nonionic surfactants such as polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and polyoxyethylene hydrogenated castor oil. And anionic surfactants such as sodium stearoyl lactate, amphoteric surfactants such as soybean phospholipid, and cationic surfactants such as alkyltrimethylammonium chloride. Examples of the humectant include glycerin, sorbitol, xylitol, maltitol, propylene glycol, polyethylene glycol, 1,3-butylene glycol and the like. Examples of the thickening agent include clay minerals such as carboxyvinyl polymer, xanthan gum, methyl cellulose, polyvinyl pyrrolidone, gelatin, and bentonite. Examples of medicinal ingredients include various vitamins and derivatives thereof, allantoin, glycyrrhizic acid and derivatives thereof, and various animal and plant extracts.

  The whitening cosmetic of the present invention can be produced by a known method, and is not limited to general skin cosmetics, but includes quasi-drugs, external medicines, etc. It can be arbitrarily selected according to the form, and can be in the form of cream, emulsion, liquid, gel, ointment, pack, stick, powder, etc.

  The present invention will be described more specifically with reference to the following examples. However, the present invention is not limited to these examples. In addition,% shown in an Example shows weight%.

Production Example-1
50 g of dried lily leaves were shredded, heated and extracted with 1500 ml of water for 2 hours, and further concentrated to obtain 15 g of extract.

Production example-2
20 g of dried Sasayuri leaves were shredded, heated and extracted with 600 ml of a water-ethanol mixture (1: 1) for 5 hours, and further concentrated to obtain 2.5 g of an extract.

Production Example-3
30 g of dried lily leaves were shredded, 600 ml of ethanol was added, extracted at room temperature for 1 week, and further concentrated to obtain 3.5 g of extract.

Production Example-4
30 g of dried lily leaves are shredded, 900 ml of a 50% aqueous solution of 1,3-butylene glycol is added, and extraction is performed at room temperature for one month to obtain 850 ml of an extract (including about 0.5% solids). It was.

  Samples shown in Comparative Examples 1 to 9 in Table 1 and Examples 1 to 7 in Table 2 were prepared and evaluated. The results are shown in Tables 1 and 2. The blending amount is% by weight. Prior to the examples, the sample production method, pigmentation induction method, coating method, evaluation method, and judgment criteria used in the present invention will be described.

(Sample manufacturing method)
The components of each Example and Comparative Example shown in Tables 1 and 2 are dissolved and mixed at 75 ° C., and emulsified under the same conditions using the shearing force of a homogenizer. Then, it cooled to room temperature, continuing stirring, and obtained each sample.

(Induction method of pigmentation)
Using 10 healthy male subjects as subjects and using a biosolar simulator on the inner side of the left and right upper arms, which is considered difficult to be exposed in daily life, the irradiation dose corresponding to 1.5 MED (minimum erythema amount) of each subject is 12 mm in diameter per part Was irradiated three times every other day.

(Application method)
An appropriate amount of each sample was applied to the designated site three times a day in the morning, noon and evening for 28 days, and the whitening effect and feeling of use were examined.

(Whitening evaluation method)
The evaluation was evaluated as the actual feeling of the effect of the subject.
Effective: Clearly thinner than the control.
Slightly effective: Feels thinner than the control.
Invalid: No difference compared to control.

(Criteria)
A: Effective and slightly effective ratio is 80% or more.
○: Effective and slightly effective ratio is 50% or more and less than 80%.
Δ: Effective and slightly effective ratio is 20% or more and less than 50%.
X: The ratio which shows effectiveness and some effectiveness is less than 20%.

(Usage feeling evaluation method)
Evaluation was evaluated as the actual feeling of the subject.
Good: Use feeling is good.
Slightly good: Slightly good feeling.
Slightly bad: The feeling of use is slightly bad.
Bad: The feeling of use is bad.

(Criteria)
A: The ratio indicating good and slightly good is 80% or more.
○: The ratio of good and slightly good is 50% or more and less than 80%.
(Triangle | delta): The ratio which shows good and a little good is 20% or more and less than 50%.
X: The ratio which shows good and slightly good is less than 20%.

  As described above, according to the present invention, 0.0005 to 0.01% by weight of a water-soluble extract of Sasayuri leaves and 0.001 to 0.01% by weight of L-ascorbic acid or a derivative thereof are contained. Thus, it is possible to provide a cosmetic material with a remarkably high whitening effect and good usability. Moreover, since the amount of ascorbic acid used is small, the cost can be reduced.

Example 8 Moisturizing Cream A Squalane 10.0% by weight
Adsorption refined lanolin 4.5
Vaseline 4.5
Stearyl alcohol 2.5
Cetanol 2.5
POE (20) sorbitan monostearate 2.2
POE (20) cetyl ether 2.0
Perfume appropriate amount B Polyethylene glycol 8.0
Magnesium ascorbate phosphate 0.01
Water-soluble extract of Sasayuri leaves (Production Example-2) 0.001
Preservative appropriate amount pH adjuster appropriate amount Purified water Residual

  The raw material of the oil phase part of A and the raw material of the water phase part of B are each heated to 75 ° C. and completely dissolved, then the oil phase part is mixed into the aqueous phase part, emulsified, and cooled to room temperature. The obtained cream was a good emulsion having an average particle size of about 1 to 2 μm and was excellent in stability over time. Also, good results were obtained in the whitening evaluation test.

Example 9 Sunscreen Emulsion A Neopentyl glycol dicaprate 7.0% by weight
Isononyl isononanoate 7.0
2-Ethylhexyl paramethoxycinnamate 7.0
Fine particle titanium oxide 6.0
POE (20) glyceryl oleate 2.0
Perfume proper amount B 1,3-butylene glycol 5.0
Magnesium ascorbate phosphate 0.01
Water-soluble extract of Sasayuri leaves (Production Example-4) 0.001
Carboxyvinyl polymer 0.1
AMPD 0.05
Preservative Appropriate amount Purified water Residual

  The raw material of the oil phase part of A and the raw material of the water phase part of B are heated to 75 ° C. and completely dissolved, and then the oil phase part is mixed into the aqueous phase part, emulsified using a homogenizer, and cooled to room temperature. The obtained emulsion was a good emulsion having an average particle size of 1 μm or less, and the stability over time was good. Moreover, the feeling of use was refreshing and there was no stickiness. Also, good results were obtained in the whitening evaluation test.

Example 10 lotion ethanol 10.0% by weight
Dipropylene glycol 5.0
Water-soluble extract of Sasayuri leaves (Production Example-2) 0.001
Magnesium ascorbate phosphate 0.01
POE (9) lauryl ether 0.5
Vitamin E acetate 0.3
Perfume Appropriate amount Preservative Appropriate amount pH adjuster Appropriate amount Purified water Residue

Mix and completely dissolve all ingredients at room temperature. The obtained lotion had good stability over time. Moreover, the feeling of use was refreshing and it was comfortable to use without stickiness. Also, good results were obtained in the whitening evaluation test.

Claims (3)

A whitening cosmetic comprising a water-soluble extract of Sasayuri leaves and L-ascorbic acid or a derivative thereof. The whitening cosmetic composition according to claim 1, wherein the L-ascorbic acid derivative is magnesium ascorbate phosphate. The content of the water-soluble extract of Sasayuri leaves is 0.0005 to 0.1% by weight, and the content of L-ascorbic acid and its derivatives is 0.001 to 0.1% by weight. The whitening cosmetic according to claim 1 or 2.