JP2002114666A - Skin cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a skin cosmetic capable of keeping normal barrier function of the dermal horny layer, and having activities for recovering the reduction of the barrier function and enhancing the function, and in addition, capable of heightening water retention of the horny layer, and having excellent activities for ameliorating rough skin, or the like. SOLUTION: This skin cosmetic contains (A) a diamide compound represented by formula 1 (wherein, R1 is a 1-22C linear or branched hydrocarbon group which may be substituted with hydroxy group or an alkoxy group; R2 is a 1-12C linear or branched divalent hydrocarbon group; R3 is a 1-42C linear or branched divalent hydrocarbon group), and (B) following (B1) and/or (B2): (B1) a water-soluble humectant selected from a polyhydric alcohol, an organic acid or its salts or derivatives, and a plant essence; (B2) a lipid component among keratinocytes.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention has the effect of maintaining the normal barrier function of the stratum corneum of the skin, restoring and reinforcing the decrease in the barrier function, and further increasing the water retention of the stratum corneum and improving the rough skin. It relates to a skin cosmetic which is excellent in such properties.

[0002]

2. Description of the Related Art When the barrier function and moisture retention function of the stratum corneum decrease due to various internal factors or external factors,
Causes various skin problems such as promoting rough skin and aging. For example, atopy is a case in which the barrier function is remarkably reduced, and is accompanied by extreme swelling and itching, which impairs daily life. For this reason, maintenance and reinforcement of the barrier function and the water retention function of the stratum corneum are very important in performing healthy daily living. In recent years, it has been found that lipids existing between stratum corneum cells, such as ceramide, cholesterol, higher fatty acids, and cholesterol esters, play a particularly important role in the barrier function and water retention function of the stratum corneum. Above all, it has been revealed that ceramide, which accounts for about half of the intercellular lipids in the stratum corneum, has a high skin roughness-reducing effect, and blending into cosmetics or the like alone or in combination with other intercellular lipids in the stratum corneum has been attempted. However, ceramides or pseudoceramides have excellent skin barrier properties and excellent skin roughness improvement effects, but they do not always have sufficient solubility and stability with respect to the base, so that they are difficult to mix with cosmetics. It was not satisfactory in terms of blending stability. In addition, production of these ceramides or pseudoceramides requires multi-step reactions and complicated cultivation processes, which inevitably increases production costs. For these reasons, it has been difficult at present to mix ceramide or pseudoceramide into cosmetics at an effective concentration. On the other hand, many water-soluble humectants with high affinity for water, such as polyhydric alcohols such as glycerin, organic acids such as amino acids, and plant extracts, have been developed to maintain and reinforce the water retention function of the stratum corneum. It is used for the purpose of improving rough skin. However, the action of these water-soluble moisturizers is on the stratum corneum of the skin to supply moisture, and since the effect is temporary, it fundamentally improves the moisture retention ability of the stratum corneum itself and makes the skin rough. Was not essentially a prevention or cure. In addition, these water-soluble humectants
It was not very effective in maintaining and reinforcing the barrier function of the stratum corneum.

[0003]

SUMMARY OF THE INVENTION According to the present invention, the barrier function and moisture retention function of the stratum corneum are essentially improved, and the compoundability and compound stability are improved. An object of the present invention is to provide a skin cosmetic that maintains and reinforces a barrier function and a moisture retention function of a stratum corneum and prevents and improves skin troubles such as rough skin.

[0004]

DISCLOSURE OF THE INVENTION The present invention provides a skin cosmetic containing the following components (A) and (B): (A) The following general formula (1):

Embedded image (Wherein, R ¹ represents a linear or branched hydrocarbon group having 1 to 22 carbon atoms, which may be substituted by a hydroxy group or an alkoxy group, and R ² represents a straight-chain or branched hydrocarbon group having 1 to 12 carbon atoms. A chain or branched divalent hydrocarbon group, wherein R ³ has 1 to 4 carbon atoms;
2 represents a linear or branched divalent hydrocarbon group. (B1) a water-soluble humectant selected from the following (B1) and / or (B2), (B1) a polyhydric alcohol, an organic acid or a salt or a derivative thereof, and a plant extract; ) It provides a keratinocyte intercellular lipid component.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION One of the components (A) used in the present invention
R of the diamide compound represented by the general formula (1) ¹Is hid
Selected from a roxy group and an alkoxy group having 1 to 6 carbon atoms.
1 to 3 carbon atoms which may be substituted,
Is preferably a branched alkyl group,
Coxy groups may be simultaneously substituted. In addition, carbon number 1
To 18 alkyl groups, C1 to C18 mono or diphenyl
Droxyalkyl group, alkoxy having 1 to 6 carbon atoms substituted
C1-C18 alkyl groups and hydroxy and carbon
Alkyl having 1 to 18 carbon atoms substituted by alkoxy having 1 to 6 carbon atoms
Kill groups are preferred. Furthermore, an alkyl having 1 to 18 carbon atoms
A mono- or di-hydroxyalkyl having 2 to 12 carbon atoms
Kill group, carbon number 2 substituted by alkoxy having 1 to 6 carbon atoms
~ 12 alkyl groups, hydroxy and C1-6 alkyl
Alkyl groups having 2 to 12 carbon atoms substituted by koxy are more preferred.
Good. Specifically, methyl group, ethyl group, propyl group,
Butyl, hexyl, dodecyl, 2-methylpropyl
Group, 2-ethylhexyl group, methyl branched isostearyl
Group, 2-hydroxyethyl group, 9-hydroxynonyl
Group, 2,3-dihydroxypropyl group, 2-methoxy
Tyl group, 2-hydroxy-3-methoxypropyl group, 9
-Methoxynonyl group and the like. Of these, 2-hi
Droxyethyl group, methyl group, dodecyl group, 2-methoxy
Siethyl groups are more preferred.

R ² is preferably a linear or branched alkylene group having 1 to 12 carbon atoms, more preferably a linear or branched alkylene group having 2 to 6 carbon atoms. Specifically, an ethylene group,
Trimethylene group, tetramethylene group, pentamethylene group, hexamethylene group, methylmethylene group (ethylidene group), 1-methylethylene group, 2-methylethylene group,
Examples thereof include a 1-methyltrimethylene group, a 2-methyltrimethylene group, a 1,1-dimethylethylene group, and a 2-ethyltrimethylene group. Of these, an ethylene group and a trimethylene group are more preferred.

In the general formula (1), R ³ has 2 carbon atoms.
~ 34 linear or branched divalent hydrocarbon groups are preferred,
Further, a linear or branched alkylene group having 2 to 34 carbon atoms or an alkenylene group having 1 to 4 double bonds is preferable, and a linear or branched alkylene group having 2 to 24 carbon atoms or 1 to 4 is particularly preferable. Alkenylene groups having four double bonds are preferred. Specific examples include an ethylene group, a trimethylene group, a tetramethylene group, a hexamethylene group, a heptamethylene group, an octamethylene group, a decamethylene group, an undecamethylene group, a dodecamethylene group, a tridecamethylene group, a tetradecamethylene group, and a hexamethylene group. Decamethylene, octadecamethylene, tricosamethylene, hexacosamethylene, triacontamethylene, 1-methylethylene, 2-ethyltrimethylene, 1-methylheptamethylene, 2-methylheptamethylene , 1-butylhexamethylene, 2-methyl-5-ethylheptamethylene, 2,3,6-trimethylheptamethylene, 6
-Ethyldecamethylene group, 7-methyltetradecamethylene group, 7-ethylhexadecamethylene group, 7,12-dimethyloctadecamethylene group, 8,11-dimethyloctadecamethylene group, 7,10-dimethyl-7- Ethyl hexadecamethylene group, 1-octadecyl ethylene group,
9,10-dioctyloctadecamethylene group, 8,9-
Dinonylhexadecamethylene group, ethenylene group, 1-octadecenylethylene group, 7,11-octadecadienienylene group, 7-ethenyl-9-hexadecamethylene group,
7,12-dimethyl-7,11-octadecadienylene group, 8,11-dimethyl-7,11-octadecadienylene group, 9,10-dioctyl-7,11-octadecadienylene group, 8, And a 9-dinonyl-6,10-hexadecadienylene group. Of these, 7,12-
Dimethyloctadecamethylene group, 7,12-dimethyl-
A 7,11-octadecadienylene group, an octadecamethylene group, an octamethylene group, a decamethylene group, an undecamethylene group, and a tridecamethylene group are more preferred.

Among the diamide compounds, preferred compounds are those in which R ¹ , R ² and R ^{3 in} the general formula (1) are each a combination of the above-mentioned more preferred groups. Among the diamide compounds used in the external preparation composition of the present invention, particularly preferred are the following compounds.

[0009]

Embedded image

[0010]

Embedded image

The diamide compound used in the external preparation composition of the present invention can be produced, for example, by the following known amide synthesis method.

[0012]

Embedded image

(Wherein, R ¹ , R ² and R ³ have the same meanings as described above). That is, the corresponding dicarboxylic acid (2) or its reactive derivative (ester, acid halide, acid anhydride, etc.) And the amine (3), the desired diamide compound can be efficiently obtained.

As the component (A), two or more kinds may be used in combination. The content of the component (A) in the skin cosmetic of the present invention is 0.01 to 50% by weight (hereinafter simply referred to as%),
In particular, it is preferably 0.1 to 20%.

The component (B) (B1) used in the present invention
Is a water-soluble humectant selected from polyhydric alcohols, organic acids or salts thereof or derivatives thereof, and plant extracts.
Examples of polyhydric alcohols include polyglycerin such as glycerin, diglycerin, triglycerin, and tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, , 3-propanediol, glucose, maltose, maltitol, sucrose, fructose, xylitol, sorbitol, maltotriose, threitol,
Erythritol, amylolytic sugar-reducing alcohol, sorbite, polyoxyalkylene alkyl glucoside, and the like. Among these, glycerin, 1,3-
Butylene glycol and dipropylene glycol are preferred.

[0016] Two or more polyhydric alcohols may be used in combination. The content in the skin cosmetic of the present invention is 0.0
01-50%, preferably 0.01-40, especially 0.1
When it is set to と 30%, the water retention function of the stratum corneum is increased additively, and the effect of improving skin roughness is further enhanced.

The organic acids and organic acid derivatives include oxycarboxylic acids having 2 to 28 carbon atoms such as glycolic acid, lactic acid, citric acid and 2-hydroxyoctanoic acid; succinic acid, fumaric acid, maleic acid, malonic acid, C2-C12 dicarboxylic acids such as 2,3-propanedicarboxylic acid; amino acids such as aspartic acid, asparagine, glycine, glutamic acid, glutamine, γ-aminobutyric acid, arginine, cysteine, and alanine and derivatives thereof; octyl succinate;
Dicarboxylic acid monoesters such as methyl maleate and the general formula (4)

[0018]

Embedded image

The sterine derivative represented by

As the above sterine derivative, those having 1 to 2 in the general formula (4), R ⁶ is preferably hexadecenyl or octadecenyl, and R ⁵ is preferably cholesteryl or sitosteryl.

Nicotinic acid, methyl nicotinate, ethyl nicotinate, benzyl nicotinate, nicotinamide, nicameta citrate, tocopherol nicotinate, quinolinic acid, pyridine-3,5-dicarboxylic acid, nicotinamide adenine dinucleotide Acid (NAD
Nicotinic acid such as P), nicotinic acid mononucleotide, nicotinyl alcohol, and nicotinyl tartrate, or a salt or derivative thereof.

Such organic acids and organic acid derivatives include α
-Hydroxycarboxylic acid, amino acid, nicotinic acid and derivatives thereof are preferable, and glycolic acid, lactic acid, citric acid, succinic acid, aspartic acid, glycine, arginine, nicotinamide, tocopherol nicotinate, and glycine betaine are particularly preferable.

The salts of organic acids include, for example, lactic acid,
Examples include potassium, sodium, magnesium, calcium, aluminum, and basic amino acid salts such as citric acid and succinic acid.When the organic acid has a basic group, for example, acid addition such as hydrochloric acid, sulfuric acid, nitric acid, and phosphoric acid Salts.

The organic acid or salt or derivative thereof is
Two or more kinds may be used in combination. The content in the skin cosmetic of the present invention is 0.0001 to 10%, especially 0.001.
It is preferable to contain 〜5%.

As the plant extract, for example, Japanese Patent Application Laid-Open No. 9-1
65313 gazette. Of these, especially eucalyptus, hops, ginger, gambi bean, noibara, sycamore, lily, adlay,
Cattail, loquat, gardenia, panax ginseng, saponosa,
Extracts, steam distillates or pressed products derived from birch, seaweed, clove, safflower, waremokou, iris and Clara are preferred. Examples of the extraction solvent include water, ethanol, 1,3-butylene glycol and the like. Two or more plant extracts may be used in combination. The content in the skin cosmetic of the present invention is converted to a dry solid component,
The content is preferably 0.0001 to 10%, particularly preferably 0.0001 to 5%.

The component (B1) may be used in combination with an anti-inflammatory substance. Anti-inflammatory substances include glycyrrhetinic acid and its salts, allantoin and its salts, epsilon aminocaproic acid and its salts, lysozyme chloride, guaiazulene, methyl salicylate, γ-oryzanol, etc., among these, dipotassium glycyrrhizinate, glycyrrhetinic acid Stearyl and allantoin are preferred. Two or more anti-inflammatory substances may be used in combination. This anti-inflammatory substance is preferably contained in the skin cosmetic in an amount of 0.001 to 5%, particularly preferably 0.01 to 2%.

The (B2) intercellular lipid component of the component (B) used in the present invention is a substance released from the inside of a cell to an intercellular cell and a related substance thereof in a process in which an epidermal cell becomes a keratinocyte. Ceramides, pseudoceramides, glycosphingolipids, sphingolipids, sphingosine and its derivatives, sphinganine and its derivatives, higher fatty acids, cholesterol and its derivatives, and the like.

Among these components (B2), ceramides, pseudoceramides, glycosphingolipids, and sphingolipids (hereinafter sometimes referred to as component (B2-1)) are preferable. Furthermore, sphingosine and its derivatives, sphingosine and its derivatives (these may be collectively described as sphingosines), higher fatty acids or cholesterol and its derivatives may be combined with those selected from these components (B2-1). This is preferable because the water retention of the stratum corneum is further increased, and the effect of improving skin roughness is further improved.

The ceramides include natural ceramides extracted and purified from brain and skin and synthetic ceramides synthesized by microbiological or chemical methods. Examples of the natural ceramide include ceramides of type I to type VII, N-oleoyl sphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, bovine brain ceramide and the like. . As a method for synthesizing a synthetic ceramide, for example, JP-A-59-7118, JP-A-4-342553
And the methods described in WO 93/22281 can be used.

On the other hand, pseudoceramide is disclosed in, for example, JP-A-62-228048 and JP-A-63-216852.
It can be manufactured according to the method described in Japanese Patent Publication No. Particularly preferred pseudoceramides include compounds represented by the following formula (5).

[0031]

Embedded image

(Wherein, R ⁷ represents an alkyl group having 9 to 17 carbon atoms, and R ⁸ represents an alkyl group having 10 to 18 carbon atoms)

Glycosphingolipids and phosphosphingolipids, like the ceramides described above, include those of natural origin and those of synthetic origin. Glycosphingolipids include, for example, those whose constituent sugars are composed of glucose, mannose, galactose, glucuronic acid, glucosamine and the like, and also include cerebroside and its sulfate. The sphingomyelin is exemplified by sphingomyelin.

Examples of sphingosines preferably used in combination with the component (B2-1) include sphingosines disclosed in JP-A-5-85924 and JP-A-6-27.
The compound represented by the general formula (4) disclosed in JP-A-1446 and the compound represented by the general formula (4 ') disclosed in JP-A-5-194185 are preferred.

The sphingosines disclosed in JP-A-5-85924 include sphingosine (sphingenin), dihydrosphingosine (sphinganine),
Phytosphingosine, dehydrosphingosine, dehydrophytosphingosine, sphingdienin, and their N-methyl or N, N-dimethyl forms. The carbon number of the hydrocarbon group of these compounds is 12 to 2
4 is preferable, and it may be either linear or branched saturated or unsaturated.

Compound (4) disclosed in JP-A-6-271446 is

[0037]

Embedded image

(Wherein, R ⁹ represents a hydrocarbon group having 1 to 40 carbon atoms which may have a hydroxyl group, and Z represents —CH ₂ O
H, -CO ₂ H or

[0039]

Embedded image

Compound (4 ') disclosed in JP-A-5-194185 is

[0041]

Embedded image

(Wherein R ¹⁰ represents a linear, branched or cyclic, saturated or unsaturated hydrocarbon group having 4 to 40 carbon atoms. R ¹¹ , R ¹² , R ¹³ , R ¹⁴ and R ¹⁵ Represents a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms which may be substituted by one or more hydroxyl groups.)

As the higher fatty acids, those having 12 or more carbon atoms, particularly those having 12 to 24 carbon atoms are preferable, and examples thereof include myristic acid, palmitic acid, palmitooleic acid, stearic acid, oleic acid, linoleic acid, and behenic acid. . Also,
Monoglycerides, diglycerides and triglycerides rich in these higher fatty acids may be blended.

The cholesterol ester is preferably composed of a higher fatty acid having 12 or more carbon atoms, particularly 12 to 24 carbon atoms. Cholesterol palmitate, cholesterol isostearate, di-N-lauroyl-L-glutamate (cholesterol, 2-octyldodecyl) are preferred. ), Lanolin fatty acid cholesterol and the like.

As the component (B2), two or more kinds may be used in combination. The content in the skin cosmetic of the present invention is 0.001.
-20%, especially 0.005-10%.

By combining the diamide compound of the component (A) with a high obstructive polymer compound or an oil agent, the barrier function and the water retention function can be further improved. The components (A) and (B) of the present invention may be used in combination with these highly obstructive polymer compounds or oils.

As the high obstructive polymer compound, JISZ150 described in JP-A-9-194342 can be used.
The moisture permeability coefficient measured according to the method of 3 is 7.5 × 10 ⁻¹⁰ m ³
(STP) Polymer compound having a molecular weight of m / m ² · sec · kPa or less, having a molecular weight of 50 described in JP-A-11-147808.
A perfluoropolymer compound of 00 to 1,000,000 (measurement method: gel permeation chromatography, in terms of polystyrene) is exemplified.

Preferred high-occlusive polymer compounds include polyvinyl alcohol, polyvinyl pyrrolidone, polyoxyethylene, collagen, pullulan, chitin, perfluoropolyether, perfluoroalkyl methacrylate / alkyl methacrylate copolymer, fluorine-modified Silicone and the like can be mentioned.

[0049] Two or more kinds of high obstructive polymer compounds may be used in combination. The high occlusive polymer compound is preferably contained in the skin cosmetic in an amount of 0.01 to 30%, particularly preferably 0.1 to 10%.

As an oil agent having a high blocking property, an oil agent having a water permeability of 30% or less is preferable. The moisture permeability is measured by placing a moisture-permeable cup conforming to JISZ0208 in a desiccator saturated with water vapor, measuring the amount of moisture permeating the oil film having the thickness of the filter paper, and calculating the moisture permeability from the measured value and the blank test value. This is the calculated value. Oils with high occlusive properties include petrolatum, lanolin, heavy liquid paraffin, heavy liquid isoparaffin, solid paraffin, microcrystalline wax,
Ceresin, candelilla wax, carnauba wax, mokuro, hardened tallow, rice wax, beeswax, hardened jojoba oil such as extremely hydrogenated jojoba, higher alcohols such as stearyl alcohol and cetanol, alkyl-modified silicones such as dimethyl stearyl polysiloxane, and 25 ° C. Viscosity is 5
Solid or semi-solid oils such as highly polymerized methyl polysiloxane of 000 cSt or more, cross-linked methyl polysiloxane, silicone resin, silicone rubber, etc., perfluoropolyether,
Fluorinated oils such as fluorine compounds such as 2- (perfluorohexyl) ethyl 1,3-dimethylbutyl ether and perfluorooctylethyl octanoate, and fluorine-modified silicones such as perfluoroalkyl ether silicone are preferred.

Two or more oil agents having a high blocking property may be used in combination. This highly obstructive oil agent contains 0.0
The content is preferably 1 to 30%, particularly 0.1 to 10%.

The skin cosmetic composition of the present invention may contain a surfactant such as a nonionic surfactant, an anionic surfactant, a cationic surfactant, and an amphoteric surfactant. Among them, polyoxyethylene alkyl ether,
Nonionic surfactants such as polyoxyethylene fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, fatty acid monoglyceride and glyceryl ether are preferred. The content is preferably 0.01 to 20%, particularly preferably 0.1 to 10% in the composition.

The skin cosmetics of the present invention include aqueous solutions, ethanol solutions, emulsions, suspensions, gels, solids,
It can be in the form of an aerosol, a powder or the like.

[0054]

EXAMPLES Production Example of Diamide Compound Production of Compound (A) 150 g of dimethyl 8,13-dimethyl-eicosadioate (IPS-22MM manufactured by Okamura Oil Co., Ltd.) was placed in a flask equipped with a stirrer, a nitrogen inlet tube and a distillation apparatus. 159 g of diglycolamine and 7.5 g of sodium methoxide were charged and stirred at 140 ° C. under reduced pressure (2.6 kPa) for 5 hours while distilling off by-product methanol. After the reaction,
Excess diglycolamine was distilled off under reduced pressure, followed by washing with water to obtain 200 g (yield 98%) of the title compound. Physical properties of compound 1 (A) obtained are as described below. Colorless paste ¹ H-NMR (CDCl ₃ , δ); 0.67-0.91 (m, 6H), 0.93-1.58 (m, 26
H), 1.59-1.76 (m, 4H), 2.17 (t, J = 7.2Hz, 4H), 2.72-3.12
(m, 2H), 3.33-3.52 (m, 4H), 3.52-3.64 (m, 8H), 3.65-3.85
(m, 4H), 6.13-6.56 (m, 2H).

Examples 1 to 13 O / W emulsion skin cosmetics described in Tables 1 and 2 were prepared, and the effects of maintaining and reinforcing the barrier function and moisture retaining function of the stratum corneum were measured. And Table 2.

(Test Method 1) Ten women aged 20 to 50 who had rough skin on their cheeks in winter were subjected to different skin cosmetics on the left and right cheeks for two weeks. The following items were tested on the day after the two-week application was completed. (1) Skin conductance After washing the face with warm water of 37 ° C. and resting in a room at a temperature of 20 ° C. and a humidity of 40% for 20 minutes, the water content of the stratum corneum was measured with a skin conductance meter (manufactured by IBS). . (2) Rough skin score Rough skin was observed with the naked eye and judged according to the following criteria. The score was shown as an average value. 0: No rough skin is recognized. 1: Slight skin roughness is recognized. 2: Skin roughness is recognized. 3: Severe rough skin is recognized.

(Test Method 2) Wistar male rats were bred only with a diet containing no essential fatty acid, and rats having symptoms of essential fatty acid deficiency were used in this test. After carefully shaving the back of these essential fatty acid deficiency rats, the skin cosmetic for evaluation was applied once a day for 2 weeks. In addition, 5 groups of each skin cosmetic were subjected to this test. Two weeks later, the following items were tested. (1) Transepidermal water loss The back of the test rat was washed with warm water and allowed to stand for 1 hour (room temperature 2).
(3 ° C., 45% humidity), and the amount of water evaporated from the skin was measured with an evaporator. In addition, the measured value was shown by the average value. (2) Percutaneous absorption The back of the rat was washed with warm water at 37 ° C., and the back skin was cut off and fixed in a percutaneous absorption chamber with the epidermis side up. The lower receiver was filled with a phosphate buffered saline solution, and 1 mL of a phosphate buffered saline solution containing 37 KBq of ¹⁴ C-salicylic acid was added to the upper part of the epidermis and allowed to stand. Two hours later, 1 mL of the phosphate buffered saline was withdrawn from the lower receiver, and the permeated ¹⁴ C
-Evaluated by measuring the amount of radioactivity of salicylic acid. In addition, the measured value was shown by the average value.

[0058]

[Table 1]

[0059]

[Table 2]

The O / W emulsion skin cosmetics of the present invention were all excellent in the effect of increasing the water content of the stratum corneum and the effect of improving the rough skin.

Examples 14 to 25 O / W emulsions described in Tables 3 to 5 were prepared.
In the same manner as in Example 1, the effects of maintaining and reinforcing the barrier function and the water retention function of the stratum corneum were measured, and the results are shown in Tables 3 to 5.

[0062]

[Table 3]

[0063]

[Table 4]

[0064]

[Table 5]

Each of the O / W emulsion skin cosmetics of the present invention was excellent in the effect of increasing the water content of the stratum corneum and the effect of improving the rough skin.

Example 28 A W / O cream having the following composition was prepared. The obtained W / O cream maintains the normal barrier function of the stratum corneum of the skin, has the effect of restoring and reinforcing the decrease in the barrier function, and further enhances the water retention of the stratum corneum, and is excellent in the effect of improving rough skin and the like. Was something. Composition% Diamide compound (A) or (D) or (F) 10 Ceramide 2 (Takasago flavor) 1 Bovine brain lipid (Kewpie) 0.5 Softcare ceramide SLE (Kao) 3 N-Lauroyl-L-glutamic acid di (cholesterol) 2-octyldodecyl) (Ajinomoto) 2 Dimethylpolysiloxane 10 cSt 5 Polyether-modified silicone 2 Polyoxyethylene hydrogenated castor oil 1 Cyclic silicone 7 Glycerin 3 Magnesium sulfate 0.5 Nicotinamide 0.2 Dipotassium glycyrrhizinate 0.1 Obak Extract 0.1 Heavy liquid isoparaffin 0.5 Polyvinyl alcohol 0.3 Methyl parahydroxybenzoate qs Perfume qs Purified water balance

Example 29 A sunscreen emulsion shown below was prepared. The obtained sunscreen emulsion improved the barrier function and moisture retention function of the stratum corneum, and was excellent in the effect of improving skin roughness. Composition% Diamide compound (A) or (D) or (F) 3 Cethyloxypropyl glyceryl methoxypropyl myristamide (Example 1 of JP-A-08-319263) 1 Phytosphingosine (Cosmoferm) 0.1 Stearic acid 0.2 Palmitic acid 0.3 lanolin fatty acid cholesterol 0.5 p-methoxycinnamate 2-ethylhexyl 5 silicone-coated titanium dioxide 7 silicone-coated zinc oxide 3 polyether-modified silicone 2 alkyl-modified silicone 2 cyclic silicone 15 sodium citrate 1 glycerin 21 3-butylene glycol 3 chitin 1 cysteine 0.2 warmoko extract 0.3 stearyl glycyrrhetinate 0.2 methyl paraoxybenzoate qs perfume qs purified water remaining

[0068]

EFFECT OF THE INVENTION The skin cosmetic of the present invention has the effect of maintaining the normal barrier function of the stratum corneum of the skin, restoring and reinforcing the decrease in the barrier function, and further enhancing the water retention of the stratum corneum, and roughening the skin. Excellent improvement effect.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 G (72) Inventor Kenji Kodama 2-1-3 Bunka, Sumida-ku, Tokyo F-term in Kao Corporation (reference) 4C083 AA111 AA112 AB212 AB242 AB362 AC122 AC241 AC242 AC302 AC342 AC432 AC482 AC541 AC582 AC641 AC642 AC852 AD112 AD152 AD162 AD172 AD322 AD391 AD492 AD532 AD571 CC02 CC05 CC19 DD32 EE12 EE17

Claims (3)

[Claims] 1. A skin cosmetic comprising the following components (A) and (B): (A) the following general formula (1): (Wherein, R ¹ represents a linear or branched hydrocarbon group having 1 to 22 carbon atoms, which may be substituted by a hydroxy group or an alkoxy group, and R ² represents a straight-chain or branched hydrocarbon group having 1 to 12 carbon atoms. A chain or branched divalent hydrocarbon group, wherein R ³ has 1 to 4 carbon atoms;
2 represents a linear or branched divalent hydrocarbon group. (B1) a water-soluble humectant selected from the following (B1) and / or (B2), (B1) a polyhydric alcohol, an organic acid or a salt or a derivative thereof, and a plant extract; ) Keratin intercellular lipid components. 2. The skin cosmetic according to claim 1, wherein the component (B) is the component (B2) and is selected from ceramides, pseudoceramides, glycosphingolipids, and phosphosphingolipids. 3. The skin cosmetic according to claim 2, further comprising a substance selected from sphingosine and its derivatives, sphinganine and its derivatives, higher fatty acids, cholesterol and its derivatives.