JP2001526222A - アリールおよびヘテロアリール置換複素環尿素を使用するｐ３８キナーゼ活性の阻害 - Google Patents
アリールおよびヘテロアリール置換複素環尿素を使用するｐ３８キナーゼ活性の阻害Info
- Publication number
- JP2001526222A JP2001526222A JP2000525101A JP2000525101A JP2001526222A JP 2001526222 A JP2001526222 A JP 2001526222A JP 2000525101 A JP2000525101 A JP 2000525101A JP 2000525101 A JP2000525101 A JP 2000525101A JP 2001526222 A JP2001526222 A JP 2001526222A
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- substituted
- group
- alkyl
- twenty
- perhalo
- Prior art date
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- Pending
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- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
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- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
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- WMSCYGTVHFMKNS-UHFFFAOYSA-N tributyl(methyl)stannane Chemical group CCCC[Sn](C)(CCCC)CCCC WMSCYGTVHFMKNS-UHFFFAOYSA-N 0.000 description 1
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- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 description 1
- COHOGNZHAUOXPA-UHFFFAOYSA-N trimethyl(phenyl)stannane Chemical compound C[Sn](C)(C)C1=CC=CC=C1 COHOGNZHAUOXPA-UHFFFAOYSA-N 0.000 description 1
- LYRCQNDYYRPFMF-UHFFFAOYSA-N trimethyltin Chemical compound C[Sn](C)C LYRCQNDYYRPFMF-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99575197A | 1997-12-22 | 1997-12-22 | |
| US08/995,751 | 1997-12-22 | ||
| PCT/US1998/026079 WO1999032110A1 (en) | 1997-12-22 | 1998-12-22 | INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001526222A true JP2001526222A (ja) | 2001-12-18 |
| JP2001526222A5 JP2001526222A5 (https=) | 2006-01-05 |
Family
ID=25542169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000525101A Pending JP2001526222A (ja) | 1997-12-22 | 1998-12-22 | アリールおよびヘテロアリール置換複素環尿素を使用するｐ３８キナーゼ活性の阻害 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1043995B9 (https=) |
| JP (1) | JP2001526222A (https=) |
| AT (1) | ATE346600T1 (https=) |
| AU (1) | AU762077B2 (https=) |
| CA (1) | CA2315647C (https=) |
| CY (1) | CY1107995T1 (https=) |
| DE (2) | DE69836563T2 (https=) |
| DK (1) | DK1043995T3 (https=) |
| ES (1) | ES2155817T3 (https=) |
| GR (1) | GR20010300018T1 (https=) |
| IL (2) | IL136768A0 (https=) |
| PT (1) | PT1043995E (https=) |
| WO (1) | WO1999032110A1 (https=) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007302687A (ja) * | 2002-02-11 | 2007-11-22 | Bayer Pharmaceuticals Corp | 脈管形成阻害活性を有するアリール尿素 |
| JP2008526804A (ja) * | 2005-01-10 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | キナーゼ阻害剤としてのジ置換ウレア |
| JP2009504582A (ja) * | 2005-08-09 | 2009-02-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | チロシンキナーゼ活性を有するピラゾール誘導体 |
| JP2009513649A (ja) * | 2005-10-28 | 2009-04-02 | イーライ リリー アンド カンパニー | キナーゼ阻害剤 |
| JP2012504591A (ja) * | 2008-10-02 | 2012-02-23 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| JP2012511563A (ja) * | 2008-12-11 | 2012-05-24 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| WO2013100208A1 (ja) | 2011-12-28 | 2013-07-04 | 京都府公立大学法人 | 角膜内皮細胞の培養正常化 |
| WO2015072580A1 (ja) | 2013-11-14 | 2015-05-21 | 学校法人同志社 | 細胞増殖促進または細胞障害抑制による角膜内皮治療薬 |
Families Citing this family (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| EP1028953A1 (en) * | 1997-11-03 | 2000-08-23 | Boehringer Ingelheim Pharmaceuticals Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
| EP1473292A1 (en) * | 1997-11-03 | 2004-11-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
| ATE529109T1 (de) * | 1997-12-22 | 2011-11-15 | Bayer Healthcare Llc | Hemmung der p38 kinase aktivität durch substituierte heterocyclische harnstoffe |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| PT1056725E (pt) * | 1997-12-22 | 2006-09-29 | Bayer Pharmaceuticals Corp | Inibicao da raf-quinase usando ureias heterociclicas substituidas com arilo e heteroarilo |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| DE69914357T2 (de) | 1998-11-04 | 2004-11-11 | Smithkline Beecham Corp. | Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine |
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- 2007-01-16 CY CY20071100063T patent/CY1107995T1/el unknown
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007302687A (ja) * | 2002-02-11 | 2007-11-22 | Bayer Pharmaceuticals Corp | 脈管形成阻害活性を有するアリール尿素 |
| JP2008526804A (ja) * | 2005-01-10 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | キナーゼ阻害剤としてのジ置換ウレア |
| JP2009504582A (ja) * | 2005-08-09 | 2009-02-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | チロシンキナーゼ活性を有するピラゾール誘導体 |
| JP2009513649A (ja) * | 2005-10-28 | 2009-04-02 | イーライ リリー アンド カンパニー | キナーゼ阻害剤 |
| JP2012504591A (ja) * | 2008-10-02 | 2012-02-23 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| JP2012511563A (ja) * | 2008-12-11 | 2012-05-24 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| JP2012511564A (ja) * | 2008-12-11 | 2012-05-24 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| JP2015013890A (ja) * | 2008-12-11 | 2015-01-22 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| WO2013100208A1 (ja) | 2011-12-28 | 2013-07-04 | 京都府公立大学法人 | 角膜内皮細胞の培養正常化 |
| EP3553169A1 (en) | 2011-12-28 | 2019-10-16 | Kyoto Prefectural Public University Corporation | Normalization of culture of corneal endothelial cells |
| WO2015072580A1 (ja) | 2013-11-14 | 2015-05-21 | 学校法人同志社 | 細胞増殖促進または細胞障害抑制による角膜内皮治療薬 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2155817T3 (es) | 2007-06-16 |
| AU1997099A (en) | 1999-07-12 |
| EP1043995B1 (en) | 2006-11-29 |
| DK1043995T3 (da) | 2007-03-05 |
| PT1043995E (pt) | 2007-01-31 |
| WO1999032110A1 (en) | 1999-07-01 |
| IL136768A0 (en) | 2001-06-14 |
| IL136768A (en) | 2006-10-31 |
| CY1107995T1 (el) | 2013-09-04 |
| DE69836563T2 (de) | 2007-05-16 |
| ATE346600T1 (de) | 2006-12-15 |
| HK1031832A1 (en) | 2001-06-29 |
| DE69836563D1 (de) | 2007-01-11 |
| EP1043995A1 (en) | 2000-10-18 |
| ES2155817T1 (es) | 2001-06-01 |
| AU762077B2 (en) | 2003-06-19 |
| EP1043995B9 (en) | 2008-10-08 |
| GR20010300018T1 (en) | 2001-05-31 |
| CA2315647A1 (en) | 1999-07-01 |
| DE1043995T1 (de) | 2001-06-07 |
| CA2315647C (en) | 2009-09-29 |
| EP1043995A4 (en) | 2003-05-07 |
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