JP2001524948A5 - - Google Patents

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Publication number
JP2001524948A5
JP2001524948A5 JP1998539593A JP53959398A JP2001524948A5 JP 2001524948 A5 JP2001524948 A5 JP 2001524948A5 JP 1998539593 A JP1998539593 A JP 1998539593A JP 53959398 A JP53959398 A JP 53959398A JP 2001524948 A5 JP2001524948 A5 JP 2001524948A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998539593A
Other languages
English (en)
Japanese (ja)
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JP4339411B2 (ja
JP2001524948A (ja
Filing date
Publication date
Priority claimed from US08/816,551 external-priority patent/US5773430A/en
Application filed filed Critical
Publication of JP2001524948A publication Critical patent/JP2001524948A/ja
Publication of JP2001524948A5 publication Critical patent/JP2001524948A5/ja
Application granted granted Critical
Publication of JP4339411B2 publication Critical patent/JP4339411B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP53959398A 1997-03-13 1998-02-26 疎水性テトラサイクリンによるセリンプロテイナーゼ阻害活性 Expired - Fee Related JP4339411B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/816,551 US5773430A (en) 1997-03-13 1997-03-13 Serine proteinase inhibitory activity by hydrophobic tetracycline
US08/816,551 1997-03-13
PCT/US1998/003782 WO1998040079A1 (en) 1997-03-13 1998-02-26 Serine proteinase inhibitory activity by hydrophobic tetracycline

Publications (3)

Publication Number Publication Date
JP2001524948A JP2001524948A (ja) 2001-12-04
JP2001524948A5 true JP2001524948A5 (https=) 2005-12-02
JP4339411B2 JP4339411B2 (ja) 2009-10-07

Family

ID=25220936

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53959398A Expired - Fee Related JP4339411B2 (ja) 1997-03-13 1998-02-26 疎水性テトラサイクリンによるセリンプロテイナーゼ阻害活性

Country Status (13)

Country Link
US (1) US5773430A (https=)
EP (1) EP0975349B1 (https=)
JP (1) JP4339411B2 (https=)
KR (1) KR100530683B1 (https=)
AT (1) ATE292972T1 (https=)
AU (1) AU733308B2 (https=)
CA (1) CA2283071C (https=)
DE (1) DE69829748T2 (https=)
DK (1) DK0975349T3 (https=)
ES (1) ES2241124T3 (https=)
NZ (1) NZ337578A (https=)
PT (1) PT975349E (https=)
WO (1) WO1998040079A1 (https=)

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US6608112B1 (en) * 1997-05-20 2003-08-19 The Trustees Of Columbia University In The City Of New York Use of metalloproteinase inhibitors in the treatment and prevention of pulmonary emphysema
US5977091A (en) * 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
US5998390A (en) * 1998-09-28 1999-12-07 The Research Foundation Of State University Of New York Combination of bisphosphonate and tetracycline
US6946453B2 (en) 1998-11-18 2005-09-20 Collagenex Pharmaceuticals, Inc. 4-dedimethylaminotracycline derivatives
US6506740B1 (en) 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
US6887678B2 (en) * 1998-12-02 2005-05-03 Cindy L. Bristow Method for the quantitative determination of proteinase inhibitors
JP2002543122A (ja) * 1999-04-30 2002-12-17 エイピーティー ファーマスーティカルズ エルエルスィー 抗マラリア治療剤についての新規使用
GB0004531D0 (en) * 2000-02-25 2000-04-19 Richards Andrew J M The treatment of respiratory diseases
US6627785B1 (en) * 2000-02-29 2003-09-30 Virginia Commwealth University Wound dressings with protease-lowering activity
US6503892B2 (en) * 2000-04-26 2003-01-07 New England Medical Center Hospitals Inc. Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7247704B2 (en) * 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
EP2311440A1 (en) * 2001-04-05 2011-04-20 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
EP1801240A1 (en) * 2001-06-05 2007-06-27 Auckland Uniservices Limited Methods and compositions for assessment of pulmonary function and disorders
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2327409A1 (en) 2001-07-13 2011-06-01 Paratek Pharmaceuticals, Inc. Tetracycline compound having target therapeutic activities
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
ES2551708T3 (es) 2002-01-08 2015-11-23 Paratek Pharmaceuticals, Inc. Compuestos de 4-desdimetilamino tetraciclina
EP2311451A1 (en) 2002-03-08 2011-04-20 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
EP1503981A4 (en) 2002-03-21 2007-08-15 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS
AU2003261161B2 (en) 2002-07-12 2009-09-10 Paratek Pharmaceuticals, Inc 3, 10, and 12a substituted tetracycline compounds
US20040092491A1 (en) * 2002-11-09 2004-05-13 The Research Foundation Of State University Of New York Method of treating sepsis-induced ARDS
WO2004091483A2 (en) 2003-04-07 2004-10-28 Shire Laboratories, Inc. Once daily formulations of tetracyclines
AU2004240629B2 (en) * 2003-05-16 2010-02-25 Arriva Pharmaceuticals, Inc. Treatment of respiratory disease by inhalation of synthetic matrix metalloprotease inhibitors
US20050143352A1 (en) 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2004259661B2 (en) 2003-07-09 2011-11-10 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
EP2033950A1 (en) 2004-10-25 2009-03-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP1805134B1 (en) 2004-10-25 2012-06-20 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US20060269946A1 (en) * 2005-05-10 2006-11-30 Young Robert P Methods and compositions for assessment of pulmonary function and disorders
KR20080011292A (ko) * 2005-05-19 2008-02-01 시너젠즈 바이오사이언스 리미티드 유전자 다형 분석을 사용하여 폐암 발생 위험을 평가하는방법
EP1888779A4 (en) * 2005-05-20 2009-06-10 Synergenz Bioscience Ltd METHOD FOR THE ANALYSIS OF POLYMORPHISMS AND USES THEREOF
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
US8795730B2 (en) * 2006-01-31 2014-08-05 David John Vachon Compositions and methods for promoting the healing of tissue of multicellular organisms
WO2008079339A2 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
CA2892739A1 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
EP2216323A3 (en) * 2007-04-27 2010-12-29 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EP2176216B1 (en) * 2007-07-06 2012-04-25 Paratek Pharmaceuticals, Inc. Methods for synthesizing 9-substituted minocycline
TWI680117B (zh) 2008-05-19 2019-12-21 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
KR101746795B1 (ko) 2008-08-08 2017-06-13 테트라페이즈 파마슈티컬스, 인코포레이티드 Ｃ７-플루오로 치환된 테트라시클린 화합물
JP2012501456A (ja) 2008-08-28 2012-01-19 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
WO2010129057A2 (en) 2009-05-08 2010-11-11 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
NO2470500T3 (https=) 2009-08-28 2018-03-03
DK2552890T3 (en) 2010-03-31 2017-04-03 Tetraphase Pharmaceuticals Inc POLYCYCLIC TETRACYCLINE COMPOUNDS
CA2883238C (en) 2012-08-31 2021-11-23 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
HUE066360T2 (hu) 2016-10-19 2024-07-28 Tetraphase Pharmaceuticals Inc Eravaciklin kristályformái
US12570604B2 (en) 2018-11-09 2026-03-10 Tetraphase Pharmaceuticals, Inc. Polymorphic forms of a tetracycline compound and uses thereof
US20250177318A1 (en) * 2022-01-04 2025-06-05 The Research Foundation For The State University Of New York Cmt-3 formulations and methods of using the same

Family Cites Families (16)

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US4704383A (en) * 1983-12-29 1987-11-03 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4666897A (en) * 1983-12-29 1987-05-19 Research Foundation Of State University Inhibition of mammalian collagenolytic enzymes by tetracyclines
US4935412A (en) * 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
USRE34656E (en) * 1983-12-29 1994-07-05 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency
US4925833A (en) * 1983-12-29 1990-05-15 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
US5308839A (en) * 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
JP3016587B2 (ja) * 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク 非ステロイド抗炎症剤及びテトラサイクリンの配合
US5045538A (en) * 1990-06-28 1991-09-03 The Research Foundation Of State University Of New York Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines
US5223248A (en) * 1991-02-11 1993-06-29 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing antiplaque properties
US5258371A (en) * 1992-05-29 1993-11-02 Kuraray Co., Ltd. Method to reduce connective tissue destruction
DK0599397T3 (da) * 1992-11-17 1996-09-16 Univ New York State Res Found Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
CA2170030A1 (en) * 1993-09-14 1995-03-23 Robert A. Lazarus Pharmaceutical compositions containing ecotin and homologs thereof
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
GB9502152D0 (en) * 1995-02-03 1995-03-29 Zeneca Ltd Proline derivatives
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production

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