JP2001524829A5 - - Google Patents

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Publication number
JP2001524829A5
JP2001524829A5 JP1998547413A JP54741398A JP2001524829A5 JP 2001524829 A5 JP2001524829 A5 JP 2001524829A5 JP 1998547413 A JP1998547413 A JP 1998547413A JP 54741398 A JP54741398 A JP 54741398A JP 2001524829 A5 JP2001524829 A5 JP 2001524829A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1998547413A
Other languages
English (en)
Japanese (ja)
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JP2001524829A (ja
Filing date
Publication date
Priority claimed from US08/846,247 external-priority patent/US6391594B1/en
Application filed filed Critical
Priority claimed from PCT/US1998/008792 external-priority patent/WO1998049315A2/en
Publication of JP2001524829A publication Critical patent/JP2001524829A/ja
Publication of JP2001524829A5 publication Critical patent/JP2001524829A5/ja
Withdrawn legal-status Critical Current

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JP54741398A 1997-04-30 1998-04-30 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー Withdrawn JP2001524829A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/846,247 1997-04-30
US08/846,247 US6391594B1 (en) 1993-09-20 1997-04-30 Modified modular PKS with retained scaffold
US7691998P 1998-03-05 1998-03-05
US60/076,919 1998-03-05
PCT/US1998/008792 WO1998049315A2 (en) 1997-04-30 1998-04-30 Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008061922A Division JP2008169226A (ja) 1997-04-30 2008-03-11 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー

Publications (2)

Publication Number Publication Date
JP2001524829A JP2001524829A (ja) 2001-12-04
JP2001524829A5 true JP2001524829A5 (enExample) 2005-12-02

Family

ID=26758639

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54741398A Withdrawn JP2001524829A (ja) 1997-04-30 1998-04-30 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー

Country Status (7)

Country Link
EP (1) EP0979286B1 (enExample)
JP (1) JP2001524829A (enExample)
AU (1) AU732909B2 (enExample)
CA (1) CA2288030A1 (enExample)
IL (1) IL132590A0 (enExample)
NZ (1) NZ500693A (enExample)
WO (1) WO1998049315A2 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6066721A (en) * 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
GB9814006D0 (en) * 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
JP2002525026A (ja) 1998-07-02 2002-08-13 ザ ボード オブ リージェンツ オブ ザ レランド スタンフォード ジュニア ユニバーシティ ポリケチドを作製するための方法
CA2343880C (en) * 1998-10-02 2008-08-26 Kosan Biosciences, Inc. Polyketide synthase enzymes and recombinant dna constructs therefor
JP2002528467A (ja) * 1998-10-28 2002-09-03 コーサン バイオサイエンシーズ, インコーポレイテッド 新規な「不自然な(unnatural)」天然生成物のライブラリ
EP1135470A2 (en) 1998-11-20 2001-09-26 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
EP1141275B1 (en) 1999-01-05 2009-08-12 Trustees Of Boston University Improved nucleic acid cloning
WO2000044717A2 (en) * 1999-01-27 2000-08-03 Kosan Biosciences, Inc. Synthesis of oligoketides
EP1754700A3 (en) * 1999-01-27 2007-05-09 Kosan Biosciences, Inc. Synthesis of oligoketides
CA2359801A1 (en) * 1999-02-09 2000-08-17 Rajesh S. Gokhale Methods to mediate polyketide synthase module effectiveness
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
CN1373767A (zh) * 1999-04-16 2002-10-09 奥索-麦克尼尔药品公司 酮式大环内酯抗菌剂
DE60028956T2 (de) * 1999-04-16 2006-11-30 Kosan Biosciences, Inc., Hayward Multi-plasmid verfahren zur herstellung von grossen bibliotheken von polyketiden und nicht-ribosomalen peptiden
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
GB9913694D0 (en) * 1999-06-11 1999-08-11 Simper Adrian M DNA manipulation methods and applications for synthetic enzymes
US6569867B2 (en) 1999-10-01 2003-05-27 Kosan Biosciences, Inc. Polyketide derivatives
US7033818B2 (en) 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
US6524841B1 (en) 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
DE60026563D1 (de) 1999-10-25 2006-05-04 Kosan Biosciences Inc Herstellung von polyketiden
MXPA02004153A (es) 1999-10-27 2002-10-17 Kosan Biosciences Inc Produccion heterologa de policetidos.
ATE356880T1 (de) 1999-10-29 2007-04-15 Kosan Biosciences Inc Rapamycin analoge
WO2001059126A2 (en) 2000-02-08 2001-08-16 Norges Teknisk Naturvitenskapelige Universitet Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility
WO2001079520A1 (en) * 2000-04-13 2001-10-25 Biotica Technology Limited Hybrid glycosylated products and their production and use
US6838265B2 (en) 2000-05-02 2005-01-04 Kosan Biosciences, Inc. Overproduction hosts for biosynthesis of polyketides
AU2001275012A1 (en) 2000-05-30 2001-12-11 Kosan Biosciences, Inc. Design of polyketide synthase genes
WO2002099113A1 (en) * 2001-06-01 2002-12-12 Ajinomoto Co., Inc. Macrolide compounds, antifungal agents using the same, macrolide compound-producing bacterium belonging to the genus sorangium and process for producing macrolide compounds using the same
US7189549B2 (en) * 2002-06-14 2007-03-13 Kosan Biosciences, Inc. Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
KR100549690B1 (ko) 2003-10-23 2006-02-07 상하이 지아오통 대학 에프알-008 폴리케타이드 합성에 관여하는 유전자
EP1751279A4 (en) 2004-05-05 2008-03-19 Univ Minnesota NUCLEIC ACIDS AND POLYPEPTIDES INVOLVED IN THE PREPARATION OF CRYPTOPHYCIN
US20050272166A1 (en) * 2004-05-06 2005-12-08 Li Jin Methods and systems for detection, identification and quantitation of macrolides and their impurities
US7566558B2 (en) 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
US8759031B2 (en) 2007-04-12 2014-06-24 Wisconsin Alumni Research Foundation Type I polyketide synthase extender units
WO2009121066A1 (en) 2008-03-28 2009-10-01 The Regents Of The University Of California Producing dicarboxylic acids using polyketide synthases
CN102014623A (zh) * 2008-04-29 2011-04-13 加利福尼亚大学董事会 使用聚酮化物合酶制备生物燃料
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
GB201312318D0 (en) * 2013-07-09 2013-08-21 Isomerase Therapeutics Ltd Novel methods and compounds
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN112301005B (zh) * 2020-11-09 2023-01-24 浙江大学 一种6-脱氧赤酮酸内酯b合酶复合体3的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
EP0910633B1 (en) 1996-07-05 2009-12-09 Biotica Technology Limited Hybrid polyketide synthase I gene

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