JP2001523001A - 自己修正ベンドをもつ蛇行電気泳動チャネル - Google Patents

自己修正ベンドをもつ蛇行電気泳動チャネル

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Publication number
JP2001523001A
JP2001523001A JP2000519780A JP2000519780A JP2001523001A JP 2001523001 A JP2001523001 A JP 2001523001A JP 2000519780 A JP2000519780 A JP 2000519780A JP 2000519780 A JP2000519780 A JP 2000519780A JP 2001523001 A JP2001523001 A JP 2001523001A
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JP
Japan
Prior art keywords
channel
curved
section
sections
width
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000519780A
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English (en)
Japanese (ja)
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JP2001523001A5 (https=
Inventor
エリック エス. ノードマン,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems Inc
Original Assignee
PE Corp
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Publication date
Application filed by PE Corp filed Critical PE Corp
Publication of JP2001523001A publication Critical patent/JP2001523001A/ja
Publication of JP2001523001A5 publication Critical patent/JP2001523001A5/ja
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44791Microapparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/28Control of physical parameters of the fluid carrier
    • G01N2030/285Control of physical parameters of the fluid carrier electrically driven carrier
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/38Flow patterns
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6095Micromachined or nanomachined, e.g. micro- or nanosize
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S366/00Agitating
    • Y10S366/03Micromixers: variable geometry from the pathway influences mixing/agitation of non-laminar fluid flow

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Micromachines (AREA)
JP2000519780A 1997-11-12 1998-11-12 自己修正ベンドをもつ蛇行電気泳動チャネル Pending JP2001523001A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6510097P 1997-11-12 1997-11-12
US60/065,100 1997-11-12
PCT/US1998/024202 WO1999024828A1 (en) 1997-11-12 1998-11-12 Serpentine electrophoresis channel with self-correcting bends

Publications (2)

Publication Number Publication Date
JP2001523001A true JP2001523001A (ja) 2001-11-20
JP2001523001A5 JP2001523001A5 (https=) 2009-11-05

Family

ID=22060347

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000519780A Pending JP2001523001A (ja) 1997-11-12 1998-11-12 自己修正ベンドをもつ蛇行電気泳動チャネル

Country Status (8)

Country Link
US (1) US6176991B1 (https=)
EP (1) EP1031032B1 (https=)
JP (1) JP2001523001A (https=)
AT (1) ATE220456T1 (https=)
AU (1) AU747940B2 (https=)
CA (1) CA2307623C (https=)
DE (1) DE69806499T2 (https=)
WO (1) WO1999024828A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005024316A (ja) * 2003-06-30 2005-01-27 Kyocera Corp マイクロ化学チップおよびその製造方法
JP2008212814A (ja) * 2007-03-02 2008-09-18 Canon Inc 流体搬送路、流体処理装置および流体処理システム
WO2010113871A1 (ja) 2009-03-31 2010-10-07 信和化工株式会社 マイクロ流路デバイス及びマイクロ流路デバイスの作製方法
JP2013127468A (ja) * 2007-04-16 2013-06-27 The General Hospital Corporation Dba Massachusetts General Hospital マイクロチャネルにおける粒子集束のためのシステムおよび方法
JP2013537980A (ja) * 2010-09-26 2013-10-07 ダ・ユー・エンタープライジズ、エルエルシー 分析物の分離

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CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
US6913679B1 (en) * 1999-02-11 2005-07-05 The Regents Of The University Of California Apparatus and methods for high resolution separation of sample components on microfabricated channel devices
US6270641B1 (en) 1999-04-26 2001-08-07 Sandia Corporation Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems
US7538237B2 (en) * 1999-07-02 2009-05-26 Kreido Laboratories Process for high shear gas-liquid reactions
US6742774B2 (en) 1999-07-02 2004-06-01 Holl Technologies Company Process for high shear gas-liquid reactions
US6471392B1 (en) * 2001-03-07 2002-10-29 Holl Technologies Company Methods and apparatus for materials processing
JP2001281233A (ja) * 2000-03-28 2001-10-10 Inst Of Physical & Chemical Res 水性分配用マイクロチップおよびそれを用いた水性分配方法
US6902313B2 (en) * 2000-08-10 2005-06-07 University Of California Micro chaotic mixer
US20020060153A1 (en) * 2000-11-06 2002-05-23 Dna Sciences, Inc. Microchannel turn design
US6830806B2 (en) * 2001-04-12 2004-12-14 Kreido Laboratories Methods of manufacture of electric circuit substrates and components having multiple electric characteristics and substrates and components so manufactured
US6596140B2 (en) 2001-05-01 2003-07-22 Applera Corporation Multi-channel capillary electrophoresis device and method
KR100442680B1 (ko) * 2001-05-10 2004-08-02 주식회사 디지탈바이오테크놀러지 미세 혼합 채널 장치
KR100442681B1 (ko) * 2001-05-10 2004-08-02 주식회사 디지탈바이오테크놀러지 채널 유닛 및 이 유닛을 이용한 혼합 채널 장치
US6919058B2 (en) * 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US20030066624A1 (en) * 2001-09-13 2003-04-10 Holl Richard A. Methods and apparatus for transfer of heat energy between a body surface and heat transfer fluid
US6787246B2 (en) 2001-10-05 2004-09-07 Kreido Laboratories Manufacture of flat surfaced composites comprising powdered fillers in a polymer matrix
KR100473364B1 (ko) * 2001-10-17 2005-03-08 주식회사 디지탈바이오테크놀러지 미세 채널을 이용하여 유체를 혼합하는 미세 채널 장치 및그 방법
US7459127B2 (en) * 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US7005301B2 (en) * 2002-06-10 2006-02-28 Sandia National Laboratories Piecewise uniform conduction-like flow channels and method therefor
US20050238506A1 (en) * 2002-06-21 2005-10-27 The Charles Stark Draper Laboratory, Inc. Electromagnetically-actuated microfluidic flow regulators and related applications
US7098360B2 (en) * 2002-07-16 2006-08-29 Kreido Laboratories Processes employing multiple successive chemical reaction process steps and apparatus therefore
KR20050054935A (ko) * 2002-09-11 2005-06-10 크레이도 래버러토리즈 재료의 높은 전단혼합과 반응을 위한 방법 및 장치
WO2004030802A2 (en) * 2002-10-03 2004-04-15 Kreido Laboratories Apparatus for transfer of heat energy between a body surface and heat transfer fluid
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7094354B2 (en) * 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
DE10303107B3 (de) * 2003-01-27 2004-09-16 Sls Micro Technology Gmbh Trennsäule, insbesondere für einen miniaturisierten Gaschromatographen
US8142630B2 (en) * 2003-05-19 2012-03-27 Protasis Corporation Electrophoresis devices and methods for focusing charged analytes
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US7160025B2 (en) * 2003-06-11 2007-01-09 Agency For Science, Technology And Research Micromixer apparatus and methods of using same
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US20080257754A1 (en) * 2003-06-27 2008-10-23 Pugia Michael J Method and apparatus for entry of specimens into a microfluidic device
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
EP2541239B1 (en) * 2003-09-05 2019-05-01 Caliper Life Sciences, Inc. Isotachophoresis method
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
WO2005072793A1 (en) * 2004-01-29 2005-08-11 The Charles Stark Draper Laboratory, Inc. Implantable drug delivery apparatus
US20060285433A1 (en) * 2005-06-20 2006-12-21 Jing-Tang Yang Fluidic mixer of serpentine channel incorporated with staggered sudden-expansion and convergent cross sections
WO2007024485A2 (en) * 2005-08-11 2007-03-01 Eksigent Technologies, Llc Microfluidic reduction of diffusion and complience effect in a fluid mixing region
US20070246106A1 (en) 2006-04-25 2007-10-25 Velocys Inc. Flow Distribution Channels To Control Flow in Process Channels
US9046192B2 (en) 2007-01-31 2015-06-02 The Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
JP4411661B2 (ja) * 2007-10-26 2010-02-10 セイコーエプソン株式会社 生体物質検出方法
US8430558B1 (en) * 2008-09-05 2013-04-30 University Of Central Florida Research Foundation, Inc. Microfluidic mixer having channel width variation for enhanced fluid mixing
US8377277B2 (en) 2008-10-22 2013-02-19 General Electric Company System and method for performing microfluidic manipulation
DE112010002222B4 (de) 2009-06-04 2024-01-25 Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) Mehr-Proben-Mikrofluidchip fur DNA-Analyse
GB2497501A (en) 2010-10-15 2013-06-12 Lockheed Corp Micro fluidic optic design
CA2825757C (en) 2011-02-02 2019-09-03 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US8795605B2 (en) * 2012-01-12 2014-08-05 Fred C. Senftleber Apparatus and methods for transferring materials between locations possessing different cross-sectional areas with minimal band spreading and dispersion due to unequal path-lengths
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
CN102788831B (zh) * 2012-08-13 2014-07-30 中国科学院研究生院 分离后可调节pH的微流控芯片电泳-电化学检测装置及其应用
US20140065034A1 (en) * 2012-08-31 2014-03-06 Yun Zheng Microfluidic device and method of fabricating microfluidic devices
WO2018089953A1 (en) * 2016-11-14 2018-05-17 Orca Biosystems, Inc. Methods and apparatuses for sorting target particles
CN106596692B (zh) * 2017-01-14 2018-12-28 常州大学 一种弯曲毛细管电泳检测抗体多肽相互作用的方法
WO2022241247A1 (en) * 2021-05-13 2022-11-17 Fluid-Screen, Inc. Microfluidic device with improved flow profile

Citations (5)

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JPH02140355U (https=) * 1988-04-29 1990-11-22
JPH03223674A (ja) * 1989-11-30 1991-10-02 Mochida Pharmaceut Co Ltd 反応容器
JPH05507793A (ja) * 1990-05-10 1993-11-04 フアーマシア・ビオテク・アクチエボラーグ ミクロ液体構造およびその製造方法
JPH07506430A (ja) * 1992-05-01 1995-07-13 トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 微細加工した検出構造体
JPH08334505A (ja) * 1995-06-07 1996-12-17 Hewlett Packard Co <Hp> 小型化全分析システム

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EP0653631B1 (de) 1993-11-11 2003-05-14 Aclara BioSciences, Inc. Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
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JPH02140355U (https=) * 1988-04-29 1990-11-22
JPH03223674A (ja) * 1989-11-30 1991-10-02 Mochida Pharmaceut Co Ltd 反応容器
JPH05507793A (ja) * 1990-05-10 1993-11-04 フアーマシア・ビオテク・アクチエボラーグ ミクロ液体構造およびその製造方法
JPH07506430A (ja) * 1992-05-01 1995-07-13 トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 微細加工した検出構造体
JPH08334505A (ja) * 1995-06-07 1996-12-17 Hewlett Packard Co <Hp> 小型化全分析システム

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005024316A (ja) * 2003-06-30 2005-01-27 Kyocera Corp マイクロ化学チップおよびその製造方法
JP2008212814A (ja) * 2007-03-02 2008-09-18 Canon Inc 流体搬送路、流体処理装置および流体処理システム
JP2013127468A (ja) * 2007-04-16 2013-06-27 The General Hospital Corporation Dba Massachusetts General Hospital マイクロチャネルにおける粒子集束のためのシステムおよび方法
WO2010113871A1 (ja) 2009-03-31 2010-10-07 信和化工株式会社 マイクロ流路デバイス及びマイクロ流路デバイスの作製方法
JP2010237053A (ja) * 2009-03-31 2010-10-21 Shinwa Kako Kk マイクロ流路デバイス及びマイクロ流路デバイスの作製方法
JP2013537980A (ja) * 2010-09-26 2013-10-07 ダ・ユー・エンタープライジズ、エルエルシー 分析物の分離

Also Published As

Publication number Publication date
DE69806499D1 (de) 2002-08-14
WO1999024828A1 (en) 1999-05-20
AU1458099A (en) 1999-05-31
EP1031032A1 (en) 2000-08-30
US6176991B1 (en) 2001-01-23
CA2307623A1 (en) 1999-05-20
ATE220456T1 (de) 2002-07-15
AU747940B2 (en) 2002-05-30
DE69806499T2 (de) 2003-02-27
EP1031032B1 (en) 2002-07-10
CA2307623C (en) 2004-03-16

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