CA2307623C - Serpentine electrophoresis channel with self-correcting bends - Google Patents
Serpentine electrophoresis channel with self-correcting bends Download PDFInfo
- Publication number
- CA2307623C CA2307623C CA002307623A CA2307623A CA2307623C CA 2307623 C CA2307623 C CA 2307623C CA 002307623 A CA002307623 A CA 002307623A CA 2307623 A CA2307623 A CA 2307623A CA 2307623 C CA2307623 C CA 2307623C
- Authority
- CA
- Canada
- Prior art keywords
- channel
- alpha
- curved
- segments
- channel portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 title claims abstract description 12
- 238000001962 electrophoresis Methods 0.000 title abstract description 16
- 239000012491 analyte Substances 0.000 claims abstract description 22
- 238000000926 separation method Methods 0.000 claims description 16
- 239000000758 substrate Substances 0.000 claims description 8
- 230000037361 pathway Effects 0.000 claims description 6
- 230000002250 progressing effect Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 230000007423 decrease Effects 0.000 claims description 2
- 238000013508 migration Methods 0.000 abstract description 10
- 230000005012 migration Effects 0.000 abstract description 10
- 108091006146 Channels Proteins 0.000 description 143
- 238000012937 correction Methods 0.000 description 6
- 230000005684 electric field Effects 0.000 description 5
- 239000012530 fluid Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000005530 etching Methods 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000001712 DNA sequencing Methods 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010329 laser etching Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N2030/285—Control of physical parameters of the fluid carrier electrically driven carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S366/00—Agitating
- Y10S366/03—Micromixers: variable geometry from the pathway influences mixing/agitation of non-laminar fluid flow
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Devices For Indicating Variable Information By Combining Individual Elements (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Micromachines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6510097P | 1997-11-12 | 1997-11-12 | |
| US60/065,100 | 1997-11-12 | ||
| PCT/US1998/024202 WO1999024828A1 (en) | 1997-11-12 | 1998-11-12 | Serpentine electrophoresis channel with self-correcting bends |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2307623A1 CA2307623A1 (en) | 1999-05-20 |
| CA2307623C true CA2307623C (en) | 2004-03-16 |
Family
ID=22060347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002307623A Expired - Fee Related CA2307623C (en) | 1997-11-12 | 1998-11-12 | Serpentine electrophoresis channel with self-correcting bends |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6176991B1 (https=) |
| EP (1) | EP1031032B1 (https=) |
| JP (1) | JP2001523001A (https=) |
| AT (1) | ATE220456T1 (https=) |
| AU (1) | AU747940B2 (https=) |
| CA (1) | CA2307623C (https=) |
| DE (1) | DE69806499T2 (https=) |
| WO (1) | WO1999024828A1 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2320296A1 (en) * | 1998-05-18 | 1999-11-25 | University Of Washington | Liquid analysis cartridge |
| US6830729B1 (en) | 1998-05-18 | 2004-12-14 | University Of Washington | Sample analysis instrument |
| US6913679B1 (en) * | 1999-02-11 | 2005-07-05 | The Regents Of The University Of California | Apparatus and methods for high resolution separation of sample components on microfabricated channel devices |
| US6270641B1 (en) | 1999-04-26 | 2001-08-07 | Sandia Corporation | Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems |
| US7538237B2 (en) * | 1999-07-02 | 2009-05-26 | Kreido Laboratories | Process for high shear gas-liquid reactions |
| US6742774B2 (en) | 1999-07-02 | 2004-06-01 | Holl Technologies Company | Process for high shear gas-liquid reactions |
| US6471392B1 (en) * | 2001-03-07 | 2002-10-29 | Holl Technologies Company | Methods and apparatus for materials processing |
| JP2001281233A (ja) * | 2000-03-28 | 2001-10-10 | Inst Of Physical & Chemical Res | 水性分配用マイクロチップおよびそれを用いた水性分配方法 |
| US6902313B2 (en) * | 2000-08-10 | 2005-06-07 | University Of California | Micro chaotic mixer |
| US20020060153A1 (en) * | 2000-11-06 | 2002-05-23 | Dna Sciences, Inc. | Microchannel turn design |
| US6830806B2 (en) * | 2001-04-12 | 2004-12-14 | Kreido Laboratories | Methods of manufacture of electric circuit substrates and components having multiple electric characteristics and substrates and components so manufactured |
| US6596140B2 (en) | 2001-05-01 | 2003-07-22 | Applera Corporation | Multi-channel capillary electrophoresis device and method |
| KR100442680B1 (ko) * | 2001-05-10 | 2004-08-02 | 주식회사 디지탈바이오테크놀러지 | 미세 혼합 채널 장치 |
| KR100442681B1 (ko) * | 2001-05-10 | 2004-08-02 | 주식회사 디지탈바이오테크놀러지 | 채널 유닛 및 이 유닛을 이용한 혼합 채널 장치 |
| US6919058B2 (en) * | 2001-08-28 | 2005-07-19 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
| US20030066624A1 (en) * | 2001-09-13 | 2003-04-10 | Holl Richard A. | Methods and apparatus for transfer of heat energy between a body surface and heat transfer fluid |
| US6787246B2 (en) | 2001-10-05 | 2004-09-07 | Kreido Laboratories | Manufacture of flat surfaced composites comprising powdered fillers in a polymer matrix |
| KR100473364B1 (ko) * | 2001-10-17 | 2005-03-08 | 주식회사 디지탈바이오테크놀러지 | 미세 채널을 이용하여 유체를 혼합하는 미세 채널 장치 및그 방법 |
| US7459127B2 (en) * | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
| US7005301B2 (en) * | 2002-06-10 | 2006-02-28 | Sandia National Laboratories | Piecewise uniform conduction-like flow channels and method therefor |
| US20050238506A1 (en) * | 2002-06-21 | 2005-10-27 | The Charles Stark Draper Laboratory, Inc. | Electromagnetically-actuated microfluidic flow regulators and related applications |
| US7098360B2 (en) * | 2002-07-16 | 2006-08-29 | Kreido Laboratories | Processes employing multiple successive chemical reaction process steps and apparatus therefore |
| KR20050054935A (ko) * | 2002-09-11 | 2005-06-10 | 크레이도 래버러토리즈 | 재료의 높은 전단혼합과 반응을 위한 방법 및 장치 |
| WO2004030802A2 (en) * | 2002-10-03 | 2004-04-15 | Kreido Laboratories | Apparatus for transfer of heat energy between a body surface and heat transfer fluid |
| US7125711B2 (en) | 2002-12-19 | 2006-10-24 | Bayer Healthcare Llc | Method and apparatus for splitting of specimens into multiple channels of a microfluidic device |
| US7094354B2 (en) * | 2002-12-19 | 2006-08-22 | Bayer Healthcare Llc | Method and apparatus for separation of particles in a microfluidic device |
| DE10303107B3 (de) * | 2003-01-27 | 2004-09-16 | Sls Micro Technology Gmbh | Trennsäule, insbesondere für einen miniaturisierten Gaschromatographen |
| US8142630B2 (en) * | 2003-05-19 | 2012-03-27 | Protasis Corporation | Electrophoresis devices and methods for focusing charged analytes |
| US7435381B2 (en) * | 2003-05-29 | 2008-10-14 | Siemens Healthcare Diagnostics Inc. | Packaging of microfluidic devices |
| US7160025B2 (en) * | 2003-06-11 | 2007-01-09 | Agency For Science, Technology And Research | Micromixer apparatus and methods of using same |
| US20040265171A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method for uniform application of fluid into a reactive reagent area |
| US20040265172A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method and apparatus for entry and storage of specimens into a microfluidic device |
| US20080257754A1 (en) * | 2003-06-27 | 2008-10-23 | Pugia Michael J | Method and apparatus for entry of specimens into a microfluidic device |
| JP2005024316A (ja) * | 2003-06-30 | 2005-01-27 | Kyocera Corp | マイクロ化学チップおよびその製造方法 |
| US7347617B2 (en) * | 2003-08-19 | 2008-03-25 | Siemens Healthcare Diagnostics Inc. | Mixing in microfluidic devices |
| EP2541239B1 (en) * | 2003-09-05 | 2019-05-01 | Caliper Life Sciences, Inc. | Isotachophoresis method |
| US7867194B2 (en) | 2004-01-29 | 2011-01-11 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
| WO2005072793A1 (en) * | 2004-01-29 | 2005-08-11 | The Charles Stark Draper Laboratory, Inc. | Implantable drug delivery apparatus |
| US20060285433A1 (en) * | 2005-06-20 | 2006-12-21 | Jing-Tang Yang | Fluidic mixer of serpentine channel incorporated with staggered sudden-expansion and convergent cross sections |
| WO2007024485A2 (en) * | 2005-08-11 | 2007-03-01 | Eksigent Technologies, Llc | Microfluidic reduction of diffusion and complience effect in a fluid mixing region |
| US20070246106A1 (en) | 2006-04-25 | 2007-10-25 | Velocys Inc. | Flow Distribution Channels To Control Flow in Process Channels |
| US9046192B2 (en) | 2007-01-31 | 2015-06-02 | The Charles Stark Draper Laboratory, Inc. | Membrane-based fluid control in microfluidic devices |
| JP2008212814A (ja) * | 2007-03-02 | 2008-09-18 | Canon Inc | 流体搬送路、流体処理装置および流体処理システム |
| US8186913B2 (en) * | 2007-04-16 | 2012-05-29 | The General Hospital Corporation | Systems and methods for particle focusing in microchannels |
| JP4411661B2 (ja) * | 2007-10-26 | 2010-02-10 | セイコーエプソン株式会社 | 生体物質検出方法 |
| US8430558B1 (en) * | 2008-09-05 | 2013-04-30 | University Of Central Florida Research Foundation, Inc. | Microfluidic mixer having channel width variation for enhanced fluid mixing |
| US8377277B2 (en) | 2008-10-22 | 2013-02-19 | General Electric Company | System and method for performing microfluidic manipulation |
| JP5008690B2 (ja) * | 2009-03-31 | 2012-08-22 | 信和化工株式会社 | マイクロ流路デバイス及びマイクロ流路デバイスの作製方法 |
| DE112010002222B4 (de) | 2009-06-04 | 2024-01-25 | Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) | Mehr-Proben-Mikrofluidchip fur DNA-Analyse |
| JP6049621B2 (ja) * | 2010-09-26 | 2016-12-21 | ダ・ユー・エンタープライジズ、エルエルシー | 分析物の分離 |
| GB2497501A (en) | 2010-10-15 | 2013-06-12 | Lockheed Corp | Micro fluidic optic design |
| CA2825757C (en) | 2011-02-02 | 2019-09-03 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
| US8795605B2 (en) * | 2012-01-12 | 2014-08-05 | Fred C. Senftleber | Apparatus and methods for transferring materials between locations possessing different cross-sectional areas with minimal band spreading and dispersion due to unequal path-lengths |
| US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
| CN102788831B (zh) * | 2012-08-13 | 2014-07-30 | 中国科学院研究生院 | 分离后可调节pH的微流控芯片电泳-电化学检测装置及其应用 |
| US20140065034A1 (en) * | 2012-08-31 | 2014-03-06 | Yun Zheng | Microfluidic device and method of fabricating microfluidic devices |
| WO2018089953A1 (en) * | 2016-11-14 | 2018-05-17 | Orca Biosystems, Inc. | Methods and apparatuses for sorting target particles |
| CN106596692B (zh) * | 2017-01-14 | 2018-12-28 | 常州大学 | 一种弯曲毛细管电泳检测抗体多肽相互作用的方法 |
| WO2022241247A1 (en) * | 2021-05-13 | 2022-11-17 | Fluid-Screen, Inc. | Microfluidic device with improved flow profile |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68927019T2 (de) * | 1988-04-29 | 1997-01-23 | Beckman Instruments Inc | Kassette mit einem kapillaren Detektor für Elektroforese |
| JPH03223674A (ja) * | 1989-11-30 | 1991-10-02 | Mochida Pharmaceut Co Ltd | 反応容器 |
| SE470347B (sv) * | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
| CA2134474C (en) * | 1992-05-01 | 1999-07-06 | The Trustees Of The University Of Pennsylvania | Microfabricated sperm handling devices |
| EP0653631B1 (de) | 1993-11-11 | 2003-05-14 | Aclara BioSciences, Inc. | Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen |
| US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| US5658413A (en) * | 1994-10-19 | 1997-08-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
| JP3839524B2 (ja) * | 1995-06-07 | 2006-11-01 | アジレント・テクノロジーズ・インク | 小型化全分析システム |
| US5993750A (en) * | 1997-04-11 | 1999-11-30 | Eastman Kodak Company | Integrated ceramic micro-chemical plant |
| US5958694A (en) * | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
-
1998
- 1998-11-12 JP JP2000519780A patent/JP2001523001A/ja active Pending
- 1998-11-12 CA CA002307623A patent/CA2307623C/en not_active Expired - Fee Related
- 1998-11-12 DE DE69806499T patent/DE69806499T2/de not_active Expired - Lifetime
- 1998-11-12 AT AT98958561T patent/ATE220456T1/de not_active IP Right Cessation
- 1998-11-12 EP EP98958561A patent/EP1031032B1/en not_active Expired - Lifetime
- 1998-11-12 WO PCT/US1998/024202 patent/WO1999024828A1/en not_active Ceased
- 1998-11-12 AU AU14580/99A patent/AU747940B2/en not_active Ceased
- 1998-11-12 US US09/191,417 patent/US6176991B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69806499D1 (de) | 2002-08-14 |
| WO1999024828A1 (en) | 1999-05-20 |
| AU1458099A (en) | 1999-05-31 |
| EP1031032A1 (en) | 2000-08-30 |
| US6176991B1 (en) | 2001-01-23 |
| CA2307623A1 (en) | 1999-05-20 |
| ATE220456T1 (de) | 2002-07-15 |
| AU747940B2 (en) | 2002-05-30 |
| DE69806499T2 (de) | 2003-02-27 |
| JP2001523001A (ja) | 2001-11-20 |
| EP1031032B1 (en) | 2002-07-10 |
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| Publication | Publication Date | Title |
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