JP2001522605A5 - - Google Patents
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- Publication number
- JP2001522605A5 JP2001522605A5 JP2000520570A JP2000520570A JP2001522605A5 JP 2001522605 A5 JP2001522605 A5 JP 2001522605A5 JP 2000520570 A JP2000520570 A JP 2000520570A JP 2000520570 A JP2000520570 A JP 2000520570A JP 2001522605 A5 JP2001522605 A5 JP 2001522605A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- tir
- polynucleotide
- seq
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 46
- 229920001184 polypeptide Polymers 0.000 description 45
- 102000004196 processed proteins & peptides Human genes 0.000 description 45
- 238000000034 method Methods 0.000 description 28
- 108091033319 polynucleotide Proteins 0.000 description 28
- 102000040430 polynucleotide Human genes 0.000 description 28
- 239000002157 polynucleotide Substances 0.000 description 28
- 241000588724 Escherichia coli Species 0.000 description 14
- 239000000523 sample Substances 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 10
- 150000007523 nucleic acids Chemical group 0.000 description 9
- 108091028043 Nucleic acid sequence Proteins 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 101710167241 Intimin Proteins 0.000 description 6
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 6
- 239000002853 nucleic acid probe Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 108020001507 fusion proteins Proteins 0.000 description 4
- 102000037865 fusion proteins Human genes 0.000 description 4
- 210000004292 cytoskeleton Anatomy 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000000369 enteropathogenic effect Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 206010000050 Abdominal adhesions Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 238000010188 recombinant method Methods 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000021633 leukocyte mediated immunity Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6513097P | 1997-11-12 | 1997-11-12 | |
| US60/065,130 | 1997-11-12 | ||
| PCT/CA1998/001042 WO1999024576A1 (en) | 1997-11-12 | 1998-11-10 | Hp90: host membrane receptor for pathogenic bacteria, encoded by the bacterial tir gene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009071999A Division JP2009173667A (ja) | 1997-11-12 | 2009-03-24 | 病原菌のｔｉｒ遺伝子によってコードされる、病原菌の宿主の膜受容体、ｈｐ９０ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001522605A JP2001522605A (ja) | 2001-11-20 |
| JP2001522605A5 true JP2001522605A5 (https=) | 2006-01-12 |
| JP4410412B2 JP4410412B2 (ja) | 2010-02-03 |
Family
ID=22060539
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000520570A Expired - Fee Related JP4410412B2 (ja) | 1997-11-12 | 1998-11-10 | 病原菌のｔｉｒ遺伝子によってコードされる、病原菌の宿主の膜受容体、ｈｐ９０ |
| JP2009071999A Pending JP2009173667A (ja) | 1997-11-12 | 2009-03-24 | 病原菌のｔｉｒ遺伝子によってコードされる、病原菌の宿主の膜受容体、ｈｐ９０ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009071999A Pending JP2009173667A (ja) | 1997-11-12 | 2009-03-24 | 病原菌のｔｉｒ遺伝子によってコードされる、病原菌の宿主の膜受容体、ｈｐ９０ |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1029054B1 (https=) |
| JP (2) | JP4410412B2 (https=) |
| AT (1) | ATE438721T1 (https=) |
| AU (1) | AU1137399A (https=) |
| CA (1) | CA2309559A1 (https=) |
| DE (1) | DE69841042D1 (https=) |
| ES (1) | ES2333630T3 (https=) |
| PT (1) | PT1029054E (https=) |
| WO (1) | WO1999024576A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9901897D0 (en) * | 1999-01-29 | 1999-03-17 | Imp College Innovations Ltd | Biological material and use thereof |
| GB0013115D0 (en) * | 2000-05-31 | 2000-07-19 | Imp College Innovations Ltd | Biological materials and methods for use in the prevention or treatment of infections |
| AU2002218927B2 (en) | 2001-01-04 | 2007-08-30 | The University Of British Columbia | Enterohemorrhagic Escherichia coli vaccine |
| CA2339436A1 (fr) | 2001-03-15 | 2002-09-15 | Josee Harel | Production d'anticorps contre les facteurs de virulence associes aux souches d'escherichia coli aeec, et leur utilisation |
| BRPI0415816A (pt) | 2003-10-31 | 2006-12-26 | Univ British Columbia | composição, bactéria ou um preparado da mesma, método para detectar a presença de um patógeno de a/e em uma amostra, método para provocar uma resposta imunológica contra um patógeno de a/e ou um componente do mesmo em um animal, método para reduzir a colonização de um patógeno de a/e em um animal, método para reduzir a disseminação de um patógeno de a/e em um animal, método para o tratamento ou a prevenção da infecção por um patógeno de a/e, método para atenuar a virulência de um patógeno de a/e, método para a seleção de um composto que atenue a virulência de um patógeno e a/e, método para a produção de um polipeptìdio de patógeno de a/e, polipeptìdio recombinante, molécula de ácido nucléico isolada, vetor, célula hospedeira, uso da composição e kit |
| WO2008133659A2 (en) | 2006-11-29 | 2008-11-06 | Tufts University | Eschericia coli mutants and methods of use thereof |
| JP2012522522A (ja) | 2009-04-06 | 2012-09-27 | ユニバーシティー オヴ サスカチュワン | 志賀毒素産生大腸菌感染を処置及び予防するための方法並びに組成物 |
| EP2964240B1 (en) * | 2013-03-07 | 2018-10-24 | The General Hospital Corporation | Compositions and methods for bacterial delivery of polypeptides |
| US10702559B2 (en) | 2016-02-09 | 2020-07-07 | The General Hospital Corporation | Methods and compositions relating to engineered microbial cells |
| CN121537480B (zh) * | 2026-01-16 | 2026-04-17 | 湘潭大学 | 一种具有多靶点降脂活性的小球藻七肽tgplgsr及其制备方法和应用 |
-
1998
- 1998-11-10 AT AT98954076T patent/ATE438721T1/de active
- 1998-11-10 PT PT98954076T patent/PT1029054E/pt unknown
- 1998-11-10 AU AU11373/99A patent/AU1137399A/en not_active Abandoned
- 1998-11-10 ES ES98954076T patent/ES2333630T3/es not_active Expired - Lifetime
- 1998-11-10 DE DE69841042T patent/DE69841042D1/de not_active Expired - Lifetime
- 1998-11-10 CA CA002309559A patent/CA2309559A1/en not_active Abandoned
- 1998-11-10 JP JP2000520570A patent/JP4410412B2/ja not_active Expired - Fee Related
- 1998-11-10 EP EP98954076A patent/EP1029054B1/en not_active Expired - Lifetime
- 1998-11-10 WO PCT/CA1998/001042 patent/WO1999024576A1/en not_active Ceased
-
2009
- 2009-03-24 JP JP2009071999A patent/JP2009173667A/ja active Pending
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