CA2309559A1 - Hp90: host membrane receptor for pathogenic bacteria, encoded by the bacterial tir gene - Google Patents

Hp90: host membrane receptor for pathogenic bacteria, encoded by the bacterial tir gene Download PDF

Info

Publication number
CA2309559A1
CA2309559A1 CA002309559A CA2309559A CA2309559A1 CA 2309559 A1 CA2309559 A1 CA 2309559A1 CA 002309559 A CA002309559 A CA 002309559A CA 2309559 A CA2309559 A CA 2309559A CA 2309559 A1 CA2309559 A1 CA 2309559A1
Authority
CA
Canada
Prior art keywords
tir
polypeptide
polynucleotide
coli
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002309559A
Other languages
English (en)
French (fr)
Inventor
B. Brett Finlay
Brendan Kenny
Rebekah Devinney
Marcus Stein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2309559A1 publication Critical patent/CA2309559A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002309559A 1997-11-12 1998-11-10 Hp90: host membrane receptor for pathogenic bacteria, encoded by the bacterial tir gene Abandoned CA2309559A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6513097P 1997-11-12 1997-11-12
US60/065,130 1997-11-12
PCT/CA1998/001042 WO1999024576A1 (en) 1997-11-12 1998-11-10 Hp90: host membrane receptor for pathogenic bacteria, encoded by the bacterial tir gene

Publications (1)

Publication Number Publication Date
CA2309559A1 true CA2309559A1 (en) 1999-05-20

Family

ID=22060539

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002309559A Abandoned CA2309559A1 (en) 1997-11-12 1998-11-10 Hp90: host membrane receptor for pathogenic bacteria, encoded by the bacterial tir gene

Country Status (9)

Country Link
EP (1) EP1029054B1 (https=)
JP (2) JP4410412B2 (https=)
AT (1) ATE438721T1 (https=)
AU (1) AU1137399A (https=)
CA (1) CA2309559A1 (https=)
DE (1) DE69841042D1 (https=)
ES (1) ES2333630T3 (https=)
PT (1) PT1029054E (https=)
WO (1) WO1999024576A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9901897D0 (en) * 1999-01-29 1999-03-17 Imp College Innovations Ltd Biological material and use thereof
GB0013115D0 (en) * 2000-05-31 2000-07-19 Imp College Innovations Ltd Biological materials and methods for use in the prevention or treatment of infections
AU2002218927B2 (en) 2001-01-04 2007-08-30 The University Of British Columbia Enterohemorrhagic Escherichia coli vaccine
CA2339436A1 (fr) 2001-03-15 2002-09-15 Josee Harel Production d'anticorps contre les facteurs de virulence associes aux souches d'escherichia coli aeec, et leur utilisation
BRPI0415816A (pt) 2003-10-31 2006-12-26 Univ British Columbia composição, bactéria ou um preparado da mesma, método para detectar a presença de um patógeno de a/e em uma amostra, método para provocar uma resposta imunológica contra um patógeno de a/e ou um componente do mesmo em um animal, método para reduzir a colonização de um patógeno de a/e em um animal, método para reduzir a disseminação de um patógeno de a/e em um animal, método para o tratamento ou a prevenção da infecção por um patógeno de a/e, método para atenuar a virulência de um patógeno de a/e, método para a seleção de um composto que atenue a virulência de um patógeno e a/e, método para a produção de um polipeptìdio de patógeno de a/e, polipeptìdio recombinante, molécula de ácido nucléico isolada, vetor, célula hospedeira, uso da composição e kit
WO2008133659A2 (en) 2006-11-29 2008-11-06 Tufts University Eschericia coli mutants and methods of use thereof
JP2012522522A (ja) 2009-04-06 2012-09-27 ユニバーシティー オヴ サスカチュワン 志賀毒素産生大腸菌感染を処置及び予防するための方法並びに組成物
EP2964240B1 (en) * 2013-03-07 2018-10-24 The General Hospital Corporation Compositions and methods for bacterial delivery of polypeptides
US10702559B2 (en) 2016-02-09 2020-07-07 The General Hospital Corporation Methods and compositions relating to engineered microbial cells
CN121537480B (zh) * 2026-01-16 2026-04-17 湘潭大学 一种具有多靶点降脂活性的小球藻七肽tgplgsr及其制备方法和应用

Also Published As

Publication number Publication date
PT1029054E (pt) 2009-11-11
JP4410412B2 (ja) 2010-02-03
JP2001522605A (ja) 2001-11-20
DE69841042D1 (de) 2009-09-17
AU1137399A (en) 1999-05-31
WO1999024576A1 (en) 1999-05-20
EP1029054A1 (en) 2000-08-23
ATE438721T1 (de) 2009-08-15
ES2333630T3 (es) 2010-02-24
EP1029054B1 (en) 2009-08-05
JP2009173667A (ja) 2009-08-06

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20150417