JP2001520189A - 抗腫瘍剤の毒性を低減するための調合物及び方法 - Google Patents
抗腫瘍剤の毒性を低減するための調合物及び方法Info
- Publication number
- JP2001520189A JP2001520189A JP2000516661A JP2000516661A JP2001520189A JP 2001520189 A JP2001520189 A JP 2001520189A JP 2000516661 A JP2000516661 A JP 2000516661A JP 2000516661 A JP2000516661 A JP 2000516661A JP 2001520189 A JP2001520189 A JP 2001520189A
- Authority
- JP
- Japan
- Prior art keywords
- antitumor agent
- agent
- antitumor
- pharmaceutical composition
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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| PCT/US1998/021814 WO1999020264A1 (en) | 1997-10-17 | 1998-10-16 | Formulations and methods for reducing toxicity of antineoplastic agents |
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| JP2009237143A Pending JP2010043117A (ja) | 1997-10-17 | 2009-10-14 | 抗腫瘍剤の毒性を低減するための調合物及び方法 |
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| US (11) | US5919816A (https=) |
| EP (1) | EP1033981B1 (https=) |
| JP (3) | JP2001520189A (https=) |
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| AT (1) | ATE262329T1 (https=) |
| AU (1) | AU750521B2 (https=) |
| CA (1) | CA2304704C (https=) |
| DE (1) | DE69822659T2 (https=) |
| DK (1) | DK1033981T3 (https=) |
| ES (1) | ES2213922T3 (https=) |
| PT (1) | PT1033981E (https=) |
| WO (1) | WO1999020264A1 (https=) |
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| JP2011514356A (ja) * | 2008-03-14 | 2011-05-06 | バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド | 化学的保護方法及び組成物 |
| JP2011140521A (ja) * | 2002-04-30 | 2011-07-21 | Bionumerik Pharmaceuticals Inc | タキサンにより惹起される神経毒性を予防又は軽減するための薬剤 |
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| US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| US8853260B2 (en) * | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US20020155999A1 (en) * | 1998-04-30 | 2002-10-24 | Han In Suk | Method of using a porphyrin-like molecule conjugated with an anti-cancer drug for the treatment of cancer |
| US7314637B1 (en) | 1999-06-29 | 2008-01-01 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
| US6197831B1 (en) * | 1999-02-09 | 2001-03-06 | Bionumerik Pharmaceuticals, Inc. | Method of treating septic shock |
| US6075053A (en) * | 1999-02-09 | 2000-06-13 | Bionumerik Pharmaceuticals, Inc. | Method of reducing or reversing neuropathy |
| US6395481B1 (en) * | 1999-02-16 | 2002-05-28 | Arch Development Corp. | Methods for detection of promoter polymorphism in a UGT gene promoter |
| US20030036513A1 (en) * | 1999-02-16 | 2003-02-20 | Yurkow Edward J. | Method for treating cancer |
| GB9904386D0 (en) * | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
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- 1998-10-16 JP JP2000516661A patent/JP2001520189A/ja active Pending
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| US12006319B2 (en) | 2018-05-25 | 2024-06-11 | Cardurion Pharmaceuticals, Inc. | Monohydrate and crystalline forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one |
| US12466832B2 (en) | 2018-05-25 | 2025-11-11 | Cardurion Pharmaceuticals, Inc. | Monohydrate and crystalline forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one |
| US12213975B2 (en) | 2018-08-31 | 2025-02-04 | Cardurion Pharmaceuticals, Inc. | PDE9 inhibitors for treating sickle cell disease |
Also Published As
| Publication number | Publication date |
|---|---|
| PT1033981E (pt) | 2004-08-31 |
| EP1033981B1 (en) | 2004-03-24 |
| DE69822659D1 (de) | 2004-04-29 |
| US6046234A (en) | 2000-04-04 |
| US6066668A (en) | 2000-05-23 |
| US6040312A (en) | 2000-03-21 |
| EP1033981A1 (en) | 2000-09-13 |
| US6046159A (en) | 2000-04-04 |
| US6066645A (en) | 2000-05-23 |
| ES2213922T3 (es) | 2004-09-01 |
| DK1033981T3 (da) | 2004-07-12 |
| US6040304A (en) | 2000-03-21 |
| CN1276720A (zh) | 2000-12-13 |
| WO1999020264A1 (en) | 1999-04-29 |
| US5919816A (en) | 1999-07-06 |
| AU1090899A (en) | 1999-05-10 |
| US6040294A (en) | 2000-03-21 |
| JP2006070041A (ja) | 2006-03-16 |
| EP1033981A4 (en) | 2001-10-04 |
| ATE262329T1 (de) | 2004-04-15 |
| CA2304704A1 (en) | 1999-04-29 |
| CA2304704C (en) | 2009-01-13 |
| JP2010043117A (ja) | 2010-02-25 |
| US6057361A (en) | 2000-05-02 |
| AU750521B2 (en) | 2002-07-18 |
| US6048849A (en) | 2000-04-11 |
| DE69822659T2 (de) | 2004-08-12 |
| US6043249A (en) | 2000-03-28 |
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