JP2001518509A - グルココルチコイド関連機能不全に関連した精神病の処置のための方法。 - Google Patents

グルココルチコイド関連機能不全に関連した精神病の処置のための方法。

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Publication number
JP2001518509A
JP2001518509A JP2000514650A JP2000514650A JP2001518509A JP 2001518509 A JP2001518509 A JP 2001518509A JP 2000514650 A JP2000514650 A JP 2000514650A JP 2000514650 A JP2000514650 A JP 2000514650A JP 2001518509 A JP2001518509 A JP 2001518509A
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JP
Japan
Prior art keywords
psychosis
glucocorticoid receptor
receptor antagonist
psychotic
mifepristone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000514650A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001518509A5 (https=
Inventor
アラン エフ. シャッツバーグ,
ジョセフ ケイ. ベラノフ,
Original Assignee
ザ ボード オブ トラスティーズ オブ レランド スタンフォード ジュニア ユニバーシティ
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Application filed by ザ ボード オブ トラスティーズ オブ レランド スタンフォード ジュニア ユニバーシティ filed Critical ザ ボード オブ トラスティーズ オブ レランド スタンフォード ジュニア ユニバーシティ
Publication of JP2001518509A publication Critical patent/JP2001518509A/ja
Publication of JP2001518509A5 publication Critical patent/JP2001518509A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2000514650A 1997-10-06 1998-10-05 グルココルチコイド関連機能不全に関連した精神病の処置のための方法。 Withdrawn JP2001518509A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6097397P 1997-10-06 1997-10-06
US60/060,973 1997-10-06
PCT/US1998/020906 WO1999017779A1 (en) 1997-10-06 1998-10-05 Methods for treating psychosis associated with glucocorticoid related dysfunction

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2008271442A Division JP2009051858A (ja) 1997-10-06 2008-10-21 グルココルチコイド関連機能不全に関連した精神病の処置のための方法。
JP2009071039A Division JP5180125B2 (ja) 1997-10-06 2009-03-23 グルココルチコイド関連機能不全に関連した精神病の処置のための方法。

Publications (2)

Publication Number Publication Date
JP2001518509A true JP2001518509A (ja) 2001-10-16
JP2001518509A5 JP2001518509A5 (https=) 2006-01-05

Family

ID=22032889

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2000514650A Withdrawn JP2001518509A (ja) 1997-10-06 1998-10-05 グルココルチコイド関連機能不全に関連した精神病の処置のための方法。
JP2008271442A Withdrawn JP2009051858A (ja) 1997-10-06 2008-10-21 グルココルチコイド関連機能不全に関連した精神病の処置のための方法。
JP2009071039A Expired - Fee Related JP5180125B2 (ja) 1997-10-06 2009-03-23 グルココルチコイド関連機能不全に関連した精神病の処置のための方法。

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2008271442A Withdrawn JP2009051858A (ja) 1997-10-06 2008-10-21 グルココルチコイド関連機能不全に関連した精神病の処置のための方法。
JP2009071039A Expired - Fee Related JP5180125B2 (ja) 1997-10-06 2009-03-23 グルココルチコイド関連機能不全に関連した精神病の処置のための方法。

Country Status (17)

Country Link
US (2) US6150349A (https=)
EP (1) EP1023074B1 (https=)
JP (3) JP2001518509A (https=)
KR (2) KR100840957B1 (https=)
CN (3) CN1528315A (https=)
AT (1) ATE332696T1 (https=)
AU (1) AU747956B2 (https=)
CA (1) CA2302586C (https=)
CY (1) CY1106330T1 (https=)
DE (1) DE69835225T2 (https=)
DK (1) DK1023074T3 (https=)
ES (1) ES2268792T3 (https=)
IL (2) IL135469A0 (https=)
NO (1) NO327233B1 (https=)
NZ (1) NZ503250A (https=)
PT (1) PT1023074E (https=)
WO (1) WO1999017779A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005513024A (ja) * 2001-11-23 2005-05-12 アクゾ・ノベル・エヌ・ベー グルココルチコイド受容体アンタゴニストを用いる大うつ病性障害の治療
JP2005521637A (ja) * 2001-10-26 2005-07-21 アクゾ・ノベル・エヌ・ベー 大うつ病性障害の治療における(11β,17β)−11−(1,3−ベンゾジオキソール−5−イル)−17−ヒドロキシ−17−(1−プロピニル)エストラ−4,9−ジエン−3−オンの使用
JP2005526843A (ja) * 2002-04-29 2005-09-08 コーセプト セラピューティクス, インコーポレイテッド 電気痙攣療法(「ect」)に対する治療応答を増大させるための方法
JP2015007128A (ja) * 2007-06-15 2015-01-15 リサーチ トライアングル インスティテュート Gabaレセプタークロライドイオノフォアの潜在的アロステリック調節特性を有するアンドロスタンステロイドおよびプレグナンステロイド
JP2018507226A (ja) * 2015-03-02 2018-03-15 コーセプト セラピューティクス, インコーポレイテッド Acth分泌腫瘍を処置するための糖質コルチコイドレセプターアンタゴニストおよびソマトスタチンアナログの使用
JP2018127492A (ja) * 2011-02-03 2018-08-16 ポップ テスト オンコロジー エルエルシー 診断と治療のためのシステムおよび方法

Families Citing this family (29)

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EP0903146A1 (en) * 1997-09-23 1999-03-24 Applied Research Systems ARS Holdings N.V. 21-Hydroy-6,19-oxidoprogesterone (210h-60p) as antiglucocorticoid
GB9915625D0 (en) * 1999-07-02 1999-09-01 Cortendo Ab Method
US6620802B1 (en) 1999-11-23 2003-09-16 Corcept Therapeutics, Inc. Methods of treating mild cognitive impairment using a glucocorticoid-specific receptor antagonist
US7071328B2 (en) * 2000-09-18 2006-07-04 Applied Research System Ars Holding N.V. Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21 oh-6op)
DE60232956D1 (de) 2001-03-23 2009-08-27 Corcept Therapeutics Inc Verfahren zur behandlung von stressbedingten erkrankungen unter verwendung von glucocorticoid-rezepto-spezifischen antagonisten
WO2002096433A1 (en) * 2001-05-04 2002-12-05 Corcept Therapeutics, Inc. Methods for treating delirium using glucocorticoid receptor-specific antagonists
US7163934B2 (en) 2001-05-04 2007-01-16 Corcept Therapeutics, Inc. Methods for treating delirium glucocorticoid receptor-specific antagonists
CA2454339C (en) 2001-07-23 2012-01-10 Corcept Therapeutics, Inc. Methods for preventing antipsychotic-induced weight gain
NZ531477A (en) * 2001-08-31 2006-10-27 Corcept Therapeutics Inc Use of a glucocorticoid receptor antagonist comprising a steroidal skeleton with at least one phenyl-containing moiety in the 11-beta position of the steroidal skeleton to decrease cognitive deterioration in adults with Down's syndrome
JP2005535664A (ja) * 2002-07-02 2005-11-24 コーセプト セラピューティクス, インコーポレイテッド インターフェロン−α治療に関連した精神病を処置するための方法
WO2004054587A1 (en) * 2002-12-18 2004-07-01 University Of Zurich Treatment of neuro-psychiatric disorders
JP2006516651A (ja) * 2003-02-04 2006-07-06 コーセプト セラピューティクス, インコーポレイテッド 産後精神病の処置のための抗糖質コルチコイド
US8097606B2 (en) * 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
GB0400031D0 (en) 2004-01-03 2004-02-04 Univ Sheffield Depression treatment
US20090156565A1 (en) * 2004-12-03 2009-06-18 The Children's Hospital Of Philadelphia Composition and use thereof in enhancing a therapeutic effect of an antiepileptic drug
CN100588393C (zh) * 2004-12-15 2010-02-10 上海三合生物技术有限公司 赛米司酮类用于治疗抑郁症的用途
US20060229505A1 (en) * 2005-04-08 2006-10-12 Mundt James C Method and system for facilitating respondent identification with experiential scaling anchors to improve self-evaluation of clinical treatment efficacy
WO2007131041A2 (en) * 2006-05-02 2007-11-15 Corcept Therapeutics, Inc. The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2
EP1987814A1 (en) * 2007-04-30 2008-11-05 Exelgyn Mifepristone pharmaceutical compositions and their methods of preparation
RU2327448C1 (ru) 2007-05-23 2008-06-27 Виктор Иванович Рощин Средство для лечения зависимости от этилового спирта и/или от наркотиков, фармацевтическая композиция, активный ингредиент фармацевтической композиции, способ лечения зависимости от этилового спирта и/или от наркотиков для лечения психосоматических и неврологических осложнений у алкоголиков и/или наркоманов
WO2011150209A1 (en) * 2010-05-26 2011-12-01 Corcept Therapeutics, Inc. Treatment of muscular dystrophy
US10500216B2 (en) 2011-11-18 2019-12-10 Corcept Therapeutics, Inc. Optimizing mifepristone absorption
US8986677B2 (en) * 2012-07-30 2015-03-24 Pop Test Cortisol Llc Therapeutic compositions and methods
US9943526B2 (en) 2015-04-21 2018-04-17 Corcept Therapeutics, Inc. Optimizing mifepristone levels for cushing's patients
KR20180008627A (ko) * 2015-05-18 2018-01-24 코어셉트 쎄라퓨틱스, 잉크. 쿠싱 증후군을 진단하고 이에 대한 치료를 평가하는 방법
CN114680890A (zh) * 2016-10-21 2022-07-01 西铁城时计株式会社 检测装置
EP4653047A3 (en) 2019-03-18 2026-02-18 Nieman, Lynnette K. Mifepristone for use in improving insulin sensitivity
JP7569492B2 (ja) 2019-12-11 2024-10-18 コーセプト セラピューティクス, インコーポレイテッド 抗精神病薬誘発性体重増加のミリコリラントによる治療方法
US11878025B2 (en) * 2021-09-06 2024-01-23 Slayback Pharma Llc Pharmaceutical compositions of mifepristone

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US4814333A (en) * 1987-07-28 1989-03-21 The Trustees Of Dartmouth College Method for treatment of hypercortisolemic, depressed patients
US5348729A (en) * 1988-11-30 1994-09-20 The United States Of America As Represented By The Department Of Health And Human Services Evaluative means for detecting inflammatory reactivity
FR2696934B1 (fr) * 1992-10-20 1995-06-02 Conservatoire Nal Arts Metiers Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir.
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
FR2739029B1 (fr) * 1995-09-21 1997-11-21 Roussel Uclaf Nouvelle application therapeutique des composes antimineralo-corticoides
EP0954317B1 (en) * 1996-04-09 2007-06-06 The University Of Edinburgh Use of 7 apha-substituted steroids to treat neuropsychiatric disorders
FR2757400B1 (fr) * 1996-12-19 1999-12-17 Hoechst Marion Roussel Inc Application des composes antiglucocorticoides dans le traitement des psychoses ou des comportements addictifs

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005521637A (ja) * 2001-10-26 2005-07-21 アクゾ・ノベル・エヌ・ベー 大うつ病性障害の治療における(11β,17β)−11−(1,3−ベンゾジオキソール−5−イル)−17−ヒドロキシ−17−(1−プロピニル)エストラ−4,9−ジエン−3−オンの使用
JP2005513024A (ja) * 2001-11-23 2005-05-12 アクゾ・ノベル・エヌ・ベー グルココルチコイド受容体アンタゴニストを用いる大うつ病性障害の治療
JP2005526843A (ja) * 2002-04-29 2005-09-08 コーセプト セラピューティクス, インコーポレイテッド 電気痙攣療法(「ect」)に対する治療応答を増大させるための方法
JP2011116771A (ja) * 2002-04-29 2011-06-16 Corcept Therapeutics Inc 電気痙攣療法(「ect」)に対する治療応答を増大させるための方法
JP2015007128A (ja) * 2007-06-15 2015-01-15 リサーチ トライアングル インスティテュート Gabaレセプタークロライドイオノフォアの潜在的アロステリック調節特性を有するアンドロスタンステロイドおよびプレグナンステロイド
JP2018127492A (ja) * 2011-02-03 2018-08-16 ポップ テスト オンコロジー エルエルシー 診断と治療のためのシステムおよび方法
JP2018507226A (ja) * 2015-03-02 2018-03-15 コーセプト セラピューティクス, インコーポレイテッド Acth分泌腫瘍を処置するための糖質コルチコイドレセプターアンタゴニストおよびソマトスタチンアナログの使用

Also Published As

Publication number Publication date
NO327233B1 (no) 2009-05-18
PT1023074E (pt) 2006-12-29
CA2302586C (en) 2008-06-10
DE69835225T2 (de) 2007-07-05
KR100840957B1 (ko) 2008-06-24
AU9683298A (en) 1999-04-27
KR100804558B1 (ko) 2008-02-20
JP5180125B2 (ja) 2013-04-10
US6362173B1 (en) 2002-03-26
CA2302586A1 (en) 1999-04-15
DE69835225D1 (de) 2006-08-24
DK1023074T3 (da) 2006-11-06
CN1528315A (zh) 2004-09-15
KR20010024431A (ko) 2001-03-26
NO20001744L (no) 2000-04-05
IL135469A0 (en) 2001-05-20
NO20001744D0 (no) 2000-04-05
CN1919199A (zh) 2007-02-28
CN1272788A (zh) 2000-11-08
AU747956B2 (en) 2002-05-30
IL135469A (en) 2007-03-08
KR20070032822A (ko) 2007-03-22
ATE332696T1 (de) 2006-08-15
EP1023074B1 (en) 2006-07-12
US6150349A (en) 2000-11-21
JP2009132743A (ja) 2009-06-18
JP2009051858A (ja) 2009-03-12
NZ503250A (en) 2001-09-28
CY1106330T1 (el) 2011-10-12
WO1999017779A1 (en) 1999-04-15
CN1187053C (zh) 2005-02-02
EP1023074A1 (en) 2000-08-02
ES2268792T3 (es) 2007-03-16

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