JP2001518304A - アンギオスタチン成分を含む融合タンパク質及び抗腫瘍療法におけるその使用 - Google Patents
アンギオスタチン成分を含む融合タンパク質及び抗腫瘍療法におけるその使用Info
- Publication number
- JP2001518304A JP2001518304A JP2000513958A JP2000513958A JP2001518304A JP 2001518304 A JP2001518304 A JP 2001518304A JP 2000513958 A JP2000513958 A JP 2000513958A JP 2000513958 A JP2000513958 A JP 2000513958A JP 2001518304 A JP2001518304 A JP 2001518304A
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- seq
- protein
- multifunctional protein
- angiostatin
- interferon
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6060997P | 1997-10-01 | 1997-10-01 | |
| US60/060,609 | 1997-10-01 | ||
| PCT/US1998/020464 WO1999016889A1 (en) | 1997-10-01 | 1998-09-30 | Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001518304A true JP2001518304A (ja) | 2001-10-16 |
| JP2001518304A5 JP2001518304A5 (enExample) | 2006-01-05 |
Family
ID=22030604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000513958A Withdrawn JP2001518304A (ja) | 1997-10-01 | 1998-09-30 | アンギオスタチン成分を含む融合タンパク質及び抗腫瘍療法におけるその使用 |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1019515A1 (enExample) |
| JP (1) | JP2001518304A (enExample) |
| AU (1) | AU9673998A (enExample) |
| CA (1) | CA2303401A1 (enExample) |
| WO (1) | WO1999016889A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69833794D1 (de) * | 1997-12-08 | 2006-05-04 | Beth Israel Hospital | Verfahren zur herstellung von anti-angiogene proteine; endostatin, angiostatin oder restin, mit einem expressions-system für hefe pichia |
| US6797488B1 (en) | 1997-12-08 | 2004-09-28 | Beth Israel Deaconess Medical Center | Methods of producing anti-angiogenic proteins |
| WO1999061464A1 (en) * | 1998-05-28 | 1999-12-02 | Korea Green Cross Corporation | Process of purifying angiogenesis inhibitors |
| US6500431B1 (en) * | 1998-07-13 | 2002-12-31 | University Of Southern California | Inhibitors of angiogenesis and tumor growth |
| WO2000054813A2 (en) * | 1999-03-15 | 2000-09-21 | Chiron Corporation | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| US6943153B1 (en) | 1999-03-15 | 2005-09-13 | The Regents Of The University Of California | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| AU2004240199B2 (en) * | 1999-04-30 | 2007-05-17 | Novartis Vaccines And Diagnostics S.R.L. | Conserved Neisserial antigens |
| MXPA02008014A (es) * | 2000-02-18 | 2004-04-05 | New York Medical College | Composiciones inhibidoras de tumores de 1-nitroacridina. |
| CA2421251A1 (en) * | 2000-09-05 | 2002-03-14 | Karolinska Innovations Ab | Recombinant endothelial cell growth inhibitors derived from a mammalian plasminogen |
| US7420036B2 (en) | 2000-11-28 | 2008-09-02 | Waisman David M | Anti-angiogenic polypeptides |
| US20030086903A1 (en) | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
| US20030158112A1 (en) | 2002-02-15 | 2003-08-21 | Johns Hopkins University School Of Medicine | Selective induction of apoptosis to treat ocular disease |
| EP1501861A4 (en) * | 2002-05-06 | 2007-06-20 | Univ Texas | TARGETED BINDING PROTEINS FOR THE ADMINISTRATION OF THERAPEUTIC OR DIAGNOSTIC REAGENTS |
| JP4511108B2 (ja) * | 2002-05-31 | 2010-07-28 | オンコリクス インコーポレイテッド | ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質 |
| WO2004054517A2 (en) | 2002-12-13 | 2004-07-01 | Mediomics, Llc | Compositions and methods for inhibiting tumor growth and metastasis |
| WO2008124086A2 (en) * | 2007-04-05 | 2008-10-16 | President And Fellows Of Harvard College | Chimeric activators: quantitatively designed protein therapeutics and uses thereof |
| EP2628748A1 (en) | 2012-02-14 | 2013-08-21 | Szilak Laboratories Bioinformatics & Molecule-Design Ltd. | Angiostatin chimeras and uses thereof |
| TWI775096B (zh) | 2012-05-15 | 2022-08-21 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| EP2995626B1 (en) * | 2013-05-06 | 2018-07-11 | China Pharmaceutical University | Bifunctional fusion proteins to inhibit angiogenesis in tumour microenvironment and to activate adaptive immune responses and the genes and uses thereof |
| CA2942776C (en) | 2014-03-17 | 2023-01-24 | Adverum Biotechnologies, Inc. | Polyneucleotide cassette and expression vector for expression of a gene in cone cells using truncated m-opsin promoter |
| WO2015168474A1 (en) | 2014-04-30 | 2015-11-05 | President And Fellows Of Harvard College | Fusion proteins for treating cancer and related methods |
| KR20170137730A (ko) | 2015-03-02 | 2017-12-13 | 애드베룸 바이오테크놀로지스, 인코포레이티드 | 망막 추상체에 폴리뉴클레오타이드의 유리체 내 전달을 위한 조성물 및 방법 |
| GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
| CN114058636A (zh) * | 2021-11-16 | 2022-02-18 | 大连润生康泰医学检验实验室有限公司 | 一种转甲状腺素蛋白基因的克隆、表达与纯化方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8315980D0 (en) * | 1983-06-10 | 1983-07-13 | Biogen Nv | Producing hybrid dna sequences |
| DE3883453T2 (de) * | 1987-07-01 | 1994-03-17 | Beecham Group Plc | Hybride Plasminogenaktivatoren. |
| ATE240740T1 (de) * | 1991-03-15 | 2003-06-15 | Amgen Inc | Pegylation von polypeptiden |
| CN1636594B (zh) * | 1994-04-26 | 2012-08-29 | 儿童医学中心公司 | 血管生成抑制素和用于抑制血管生成的方法 |
| ATE368051T1 (de) * | 1995-04-26 | 2007-08-15 | Childrens Medical Center | Angiostatinfragmente und verfahren für deren verwendung |
| US5824299A (en) * | 1995-06-22 | 1998-10-20 | President & Fellows Of Harvard College | Modulation of endothelial cell proliferation with IP-10 |
| CN1202932A (zh) * | 1995-10-23 | 1998-12-23 | 儿童医学中心公司 | 治疗用抗血管生成的组合物和方法 |
| US5837680A (en) * | 1996-02-16 | 1998-11-17 | Children's Medical Center Corporation | Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis |
| HUP0103329A3 (en) * | 1998-08-25 | 2003-09-29 | Lexigen Pharmaceuticals Corp L | Expression and export of angiostatin and endostatin as immunofusis |
-
1998
- 1998-09-30 AU AU96739/98A patent/AU9673998A/en not_active Abandoned
- 1998-09-30 EP EP98950775A patent/EP1019515A1/en not_active Withdrawn
- 1998-09-30 WO PCT/US1998/020464 patent/WO1999016889A1/en not_active Ceased
- 1998-09-30 EP EP05019787A patent/EP1705248A1/en not_active Withdrawn
- 1998-09-30 JP JP2000513958A patent/JP2001518304A/ja not_active Withdrawn
- 1998-09-30 CA CA002303401A patent/CA2303401A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1705248A1 (en) | 2006-09-27 |
| AU9673998A (en) | 1999-04-23 |
| CA2303401A1 (en) | 1999-04-08 |
| WO1999016889A1 (en) | 1999-04-08 |
| EP1019515A1 (en) | 2000-07-19 |
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