JP2001515359A5 - - Google Patents
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- Publication number
- JP2001515359A5 JP2001515359A5 JP1998541074A JP54107498A JP2001515359A5 JP 2001515359 A5 JP2001515359 A5 JP 2001515359A5 JP 1998541074 A JP1998541074 A JP 1998541074A JP 54107498 A JP54107498 A JP 54107498A JP 2001515359 A5 JP2001515359 A5 JP 2001515359A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- tuberculosis
- mycobacterium
- belonging
- ifn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000008827 tuberculosis Diseases 0.000 claims description 8
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims description 6
- 229920001184 polypeptide Polymers 0.000 claims 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims 38
- 102000004196 processed proteins & peptides Human genes 0.000 claims 38
- 210000004027 cell Anatomy 0.000 claims 10
- 102100037850 Interferon gamma Human genes 0.000 claims 6
- 108010074328 Interferon-gamma Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 6
- 239000000725 suspension Substances 0.000 claims 6
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 5
- 239000013598 vector Substances 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 claims 2
- 241001467553 Mycobacterium africanum Species 0.000 claims 2
- 241000186366 Mycobacterium bovis Species 0.000 claims 2
- 241001302239 Mycobacterium tuberculosis complex Species 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 208000035415 Reinfection Diseases 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 230000003362 replicative effect Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 210000004989 spleen cell Anatomy 0.000 claims 1
- 241001515965 unidentified phage Species 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK37697 | 1997-04-02 | ||
| US4462497P | 1997-04-18 | 1997-04-18 | |
| US60/044,624 | 1997-04-18 | ||
| DK127797 | 1997-11-10 | ||
| US7048898P | 1998-01-05 | 1998-01-05 | |
| US0376/97 | 1998-01-05 | ||
| US60/070,488 | 1998-01-05 | ||
| US1277/97 | 1998-01-05 | ||
| PCT/DK1998/000132 WO1998044119A1 (en) | 1997-04-02 | 1998-04-01 | NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS) |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007299636A Division JP4406024B2 (ja) | 1997-04-02 | 2007-11-19 | 結核菌由来の核酸フラグメント及びポリペプチドフラグメント |
| JP2008131389A Division JP4544434B2 (ja) | 1997-04-02 | 2008-05-19 | 結核菌由来の核酸フラグメント及びポリペプチドフラグメント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001515359A JP2001515359A (ja) | 2001-09-18 |
| JP2001515359A5 true JP2001515359A5 (https=) | 2008-07-10 |
| JP4172598B2 JP4172598B2 (ja) | 2008-10-29 |
Family
ID=47018662
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54107498A Expired - Lifetime JP4172598B2 (ja) | 1997-04-02 | 1998-04-01 | 結核菌由来の核酸フラグメント及びポリペプチドフラグメント |
| JP2007299636A Expired - Lifetime JP4406024B2 (ja) | 1997-04-02 | 2007-11-19 | 結核菌由来の核酸フラグメント及びポリペプチドフラグメント |
| JP2008131389A Expired - Lifetime JP4544434B2 (ja) | 1997-04-02 | 2008-05-19 | 結核菌由来の核酸フラグメント及びポリペプチドフラグメント |
| JP2010002535A Withdrawn JP2010154856A (ja) | 1997-04-02 | 2010-01-08 | 結核菌由来の核酸フラグメント及びポリペプチドフラグメント |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007299636A Expired - Lifetime JP4406024B2 (ja) | 1997-04-02 | 2007-11-19 | 結核菌由来の核酸フラグメント及びポリペプチドフラグメント |
| JP2008131389A Expired - Lifetime JP4544434B2 (ja) | 1997-04-02 | 2008-05-19 | 結核菌由来の核酸フラグメント及びポリペプチドフラグメント |
| JP2010002535A Withdrawn JP2010154856A (ja) | 1997-04-02 | 2010-01-08 | 結核菌由来の核酸フラグメント及びポリペプチドフラグメント |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1449922B1 (https=) |
| JP (4) | JP4172598B2 (https=) |
| AT (1) | ATE370236T1 (https=) |
| AU (1) | AU740545B2 (https=) |
| CA (1) | CA2285625C (https=) |
| DE (1) | DE69838268T2 (https=) |
| DK (1) | DK1449922T3 (https=) |
| ES (1) | ES2291810T3 (https=) |
| PT (1) | PT1449922E (https=) |
| WO (1) | WO1998044119A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6991797B2 (en) | 1993-07-02 | 2006-01-31 | Statens Serum Institut | M. tuberculosis antigens |
| US6982085B2 (en) | 1997-04-02 | 2006-01-03 | Statens Serum Institut | TB diagnostic based on antigens from M. tuberculosis |
| US7037510B2 (en) | 1997-04-18 | 2006-05-02 | Statens Serum Institut | Hybrids of M. tuberculosis antigens |
| CA2319380A1 (en) * | 1997-11-10 | 1999-05-20 | Statens Serum Institut | Nucleic acid fragments and polypeptide fragments derived from m. tuberculosis |
| WO1999045119A2 (en) * | 1998-03-06 | 1999-09-10 | Statens Serum Institut | Production of mycobacterial polypeptides by lactic acid bacteria |
| AU2594500A (en) * | 1998-12-24 | 2000-07-31 | Corixa Corporation | Methods for using mycobacterium tuberculosis molecules as immunological adjuvants |
| EP2087906A1 (en) | 1999-05-04 | 2009-08-12 | The University of Medicine and Dentistry of New Jersey | Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines |
| US6537552B1 (en) | 1999-10-19 | 2003-03-25 | Iowa State University Research Foundation | Vaccine adjuvant |
| AU2001250294A1 (en) * | 2000-04-19 | 2001-10-30 | Statens Serum Institut | Tuberculosis antigens and methods of use thereof |
| WO2002004018A2 (en) * | 2000-07-10 | 2002-01-17 | Colorado State University Research Foundation | Mid-life vaccine and methods for boosting anti-mycobacterial immunity |
| WO2004099771A1 (en) | 2003-05-08 | 2004-11-18 | Statens Serum Institut | A new specific epitope based immunological diagnosis of tuberculosis |
| CN102220357B (zh) | 2004-11-16 | 2013-12-25 | 克鲁塞尔荷兰公司 | 包含重组病毒载体的多价疫苗 |
| EP2441469A1 (en) * | 2006-03-14 | 2012-04-18 | Oregon Health and Science University | Methods for producing an immune response to tuberculosis |
| GB0618127D0 (en) * | 2006-09-14 | 2006-10-25 | Isis Innovation | Biomarker |
| US9297803B2 (en) | 2006-11-01 | 2016-03-29 | Immport Therapeutics, Inc. | Compositions and methods for immunodominant antigens |
| KR20140015127A (ko) * | 2009-07-29 | 2014-02-06 | 베른드 헬무트 아담 렘 | 폴리머 입자 및 이의 용도 |
| WO2011159814A2 (en) * | 2010-06-15 | 2011-12-22 | The Regents Of The University Of California | Novel live recombinant booster vaccine against tuberculosis |
| EP2838990A4 (en) * | 2012-04-16 | 2016-08-10 | Aeras Global Tb Vaccine Found | RECOMBINANT MYCOBACTERIUM FOR THE CODING OF A HEPARIN-BINDING HEMAGGLUTININE (HBHA) FUSION PROTEIN AND USES THEREOF |
| CN104897838B (zh) * | 2015-06-10 | 2016-08-17 | 重庆医科大学 | 一种强极性有机酸碱混合物的同时提取分离分析方法 |
| EP3966321A4 (en) * | 2019-05-07 | 2023-09-06 | Nanyang Technological University | Asx-specific protein ligases and uses thereof |
| CN113373162A (zh) * | 2020-03-09 | 2021-09-10 | 北京蛋白质组研究中心 | 结核分枝杆菌H37Rv新基因Rv0229A及其编码蛋白和应用 |
| BR112022021258A2 (pt) * | 2020-04-20 | 2023-01-17 | Univ Saskatchewan | Composições e métodos para prevenir, controlar e diagnosticar infecções micobacterianas |
| CN116082514B (zh) * | 2021-11-05 | 2024-02-13 | 安博智联(北京)生物科技有限公司 | 结核分枝杆菌特异性的重组融合蛋白em及其应用 |
| WO2025250534A1 (en) * | 2024-05-28 | 2025-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | T cell targets for tuberculosis vaccines |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK79893D0 (da) * | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | New vaccine |
| NZ309945A (en) * | 1995-05-23 | 2001-04-27 | Univ California | Abundant extracellular products and their use as vaccines |
| AU727602B2 (en) * | 1995-09-01 | 2000-12-14 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
| CA2230927A1 (en) * | 1995-09-01 | 1997-03-13 | Corixa Corporation | Compounds and methods for diagnosis of tuberculosis |
-
1998
- 1998-04-01 AT AT04076605T patent/ATE370236T1/de active
- 1998-04-01 PT PT04076605T patent/PT1449922E/pt unknown
- 1998-04-01 EP EP04076605A patent/EP1449922B1/en not_active Expired - Lifetime
- 1998-04-01 ES ES04076605T patent/ES2291810T3/es not_active Expired - Lifetime
- 1998-04-01 DK DK04076605T patent/DK1449922T3/da active
- 1998-04-01 EP EP98913536A patent/EP0972045A1/en not_active Withdrawn
- 1998-04-01 DE DE69838268T patent/DE69838268T2/de not_active Expired - Lifetime
- 1998-04-01 AU AU68204/98A patent/AU740545B2/en not_active Ceased
- 1998-04-01 WO PCT/DK1998/000132 patent/WO1998044119A1/en not_active Ceased
- 1998-04-01 CA CA2285625A patent/CA2285625C/en not_active Expired - Lifetime
- 1998-04-01 JP JP54107498A patent/JP4172598B2/ja not_active Expired - Lifetime
-
2007
- 2007-11-19 JP JP2007299636A patent/JP4406024B2/ja not_active Expired - Lifetime
-
2008
- 2008-05-19 JP JP2008131389A patent/JP4544434B2/ja not_active Expired - Lifetime
-
2010
- 2010-01-08 JP JP2010002535A patent/JP2010154856A/ja not_active Withdrawn
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