PT1449922E - Fragmentos de ácidos nucleicos e fragmentos polipeptídicos obtidos a partir de m. tuberculosis - Google Patents
Fragmentos de ácidos nucleicos e fragmentos polipeptídicos obtidos a partir de m. tuberculosis Download PDFInfo
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- PT1449922E PT1449922E PT04076605T PT04076605T PT1449922E PT 1449922 E PT1449922 E PT 1449922E PT 04076605 T PT04076605 T PT 04076605T PT 04076605 T PT04076605 T PT 04076605T PT 1449922 E PT1449922 E PT 1449922E
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- polypeptide
- fragment
- tuberculosis
- sequence
- vaccine
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- 229940049954 penicillin Drugs 0.000 description 1
- 229950009506 penicillinase Drugs 0.000 description 1
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- 230000000737 periodic effect Effects 0.000 description 1
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- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000001885 phytohemagglutinin Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- NXGWSWBWEQYMND-UHFFFAOYSA-N piperazine;prop-2-enamide Chemical compound NC(=O)C=C.NC(=O)C=C.C1CNCCN1 NXGWSWBWEQYMND-UHFFFAOYSA-N 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
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- 238000006116 polymerization reaction Methods 0.000 description 1
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- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
- 229960000885 rifabutin Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- YEENEYXBHNNNGV-XEHWZWQGSA-M sodium;3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoate;(2r,3r,4s,5s,6r)-2-[(2r,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound [Na+].CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I.O[C@H]1[C@H](O)[C@@H](CO)O[C@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 YEENEYXBHNNNGV-XEHWZWQGSA-M 0.000 description 1
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- 101150103075 ssr3 gene Proteins 0.000 description 1
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- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- 238000004613 tight binding model Methods 0.000 description 1
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- 230000002588 toxic effect Effects 0.000 description 1
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- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK37697 | 1997-04-02 | ||
| US4462497P | 1997-04-18 | 1997-04-18 | |
| DK127797 | 1997-11-10 | ||
| US7048898P | 1998-01-05 | 1998-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1449922E true PT1449922E (pt) | 2007-11-09 |
Family
ID=47018662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04076605T PT1449922E (pt) | 1997-04-02 | 1998-04-01 | Fragmentos de ácidos nucleicos e fragmentos polipeptídicos obtidos a partir de m. tuberculosis |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP0972045A1 (https=) |
| JP (4) | JP4172598B2 (https=) |
| AT (1) | ATE370236T1 (https=) |
| AU (1) | AU740545B2 (https=) |
| CA (1) | CA2285625C (https=) |
| DE (1) | DE69838268T2 (https=) |
| DK (1) | DK1449922T3 (https=) |
| ES (1) | ES2291810T3 (https=) |
| PT (1) | PT1449922E (https=) |
| WO (1) | WO1998044119A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6991797B2 (en) | 1993-07-02 | 2006-01-31 | Statens Serum Institut | M. tuberculosis antigens |
| US6982085B2 (en) | 1997-04-02 | 2006-01-03 | Statens Serum Institut | TB diagnostic based on antigens from M. tuberculosis |
| US7037510B2 (en) | 1997-04-18 | 2006-05-02 | Statens Serum Institut | Hybrids of M. tuberculosis antigens |
| CA2319380A1 (en) * | 1997-11-10 | 1999-05-20 | Statens Serum Institut | Nucleic acid fragments and polypeptide fragments derived from m. tuberculosis |
| CA2322505A1 (en) * | 1998-03-06 | 1999-09-10 | Statens Serum Institut | Production of mycobacterial polypeptides by lactic acid bacteria |
| AU2594500A (en) * | 1998-12-24 | 2000-07-31 | Corixa Corporation | Methods for using mycobacterium tuberculosis molecules as immunological adjuvants |
| ATE429245T1 (de) * | 1999-05-04 | 2009-05-15 | Univ New Jersey Med | Durch mycobacterium tuberculosis und nicht durch bcg exprimierte proteine und ihre verwendung als diagnostische reagenzien und impfstoffe |
| US6537552B1 (en) | 1999-10-19 | 2003-03-25 | Iowa State University Research Foundation | Vaccine adjuvant |
| EP1278769A2 (en) * | 2000-04-19 | 2003-01-29 | Statens Serum Institut | Tuberculosis antigens and methods of use thereof |
| US7288261B2 (en) * | 2000-07-10 | 2007-10-30 | Colorado State University Research Foundation | Mid-life vaccine and methods for boosting anti-mycobacterial immunity |
| WO2004099771A1 (en) | 2003-05-08 | 2004-11-18 | Statens Serum Institut | A new specific epitope based immunological diagnosis of tuberculosis |
| SG159555A1 (en) | 2004-11-16 | 2010-03-30 | Crucell Holland Bv | Multivalent vaccines comprising recombinant viral vectors |
| EP2441493B1 (en) | 2006-03-14 | 2014-05-07 | Oregon Health and Science University | Methods for producing an immune response to tuberculosis |
| GB0618127D0 (en) * | 2006-09-14 | 2006-10-25 | Isis Innovation | Biomarker |
| CA2668100C (en) | 2006-11-01 | 2014-12-23 | Immport Therapeutics, Inc. | Compositions and methods for immunodominant antigens |
| CA2769645A1 (en) * | 2009-07-29 | 2011-02-03 | Bernd Helmut Adam Rehm | Polymer particles and uses thereof |
| WO2011159814A2 (en) * | 2010-06-15 | 2011-12-22 | The Regents Of The University Of California | Novel live recombinant booster vaccine against tuberculosis |
| IN2014DN08675A (https=) * | 2012-04-16 | 2015-05-22 | Aeras Global Tb Vaccine Found | |
| CN104897838B (zh) * | 2015-06-10 | 2016-08-17 | 重庆医科大学 | 一种强极性有机酸碱混合物的同时提取分离分析方法 |
| US20220213461A1 (en) * | 2019-05-07 | 2022-07-07 | Nanyang Technological University | Asx-specific protein ligases and uses thereof |
| CN113373162A (zh) * | 2020-03-09 | 2021-09-10 | 北京蛋白质组研究中心 | 结核分枝杆菌H37Rv新基因Rv0229A及其编码蛋白和应用 |
| CA3176303A1 (en) * | 2020-04-20 | 2021-10-28 | Antonio FACCIUOLO | Compositions and methods for preventing, controlling and diagnosing mycobacterial infections |
| CN116082514B (zh) * | 2021-11-05 | 2024-02-13 | 安博智联(北京)生物科技有限公司 | 结核分枝杆菌特异性的重组融合蛋白em及其应用 |
| WO2025250534A1 (en) * | 2024-05-28 | 2025-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | T cell targets for tuberculosis vaccines |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK79893D0 (da) * | 1993-07-02 | 1993-07-02 | Statens Seruminstitut | New vaccine |
| JPH11506320A (ja) * | 1995-05-23 | 1999-06-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 豊富な細胞外産物、ならびにそれらを産生および使用するための方法 |
| DE69636075D1 (de) * | 1995-09-01 | 2006-06-01 | Corixa Corp | Verbindungen und verfahren zur diagnose von tuberkulose |
| TR200901109T1 (tr) * | 1995-09-01 | 2012-02-21 | Corixa Corporation | Tüberkülozun teşhisi ve immünoterapi yolu ile önlenmesine mahsus yöntemler ve bileşikler |
-
1998
- 1998-04-01 CA CA2285625A patent/CA2285625C/en not_active Expired - Lifetime
- 1998-04-01 ES ES04076605T patent/ES2291810T3/es not_active Expired - Lifetime
- 1998-04-01 DK DK04076605T patent/DK1449922T3/da active
- 1998-04-01 EP EP98913536A patent/EP0972045A1/en not_active Withdrawn
- 1998-04-01 DE DE69838268T patent/DE69838268T2/de not_active Expired - Lifetime
- 1998-04-01 AU AU68204/98A patent/AU740545B2/en not_active Ceased
- 1998-04-01 EP EP04076605A patent/EP1449922B1/en not_active Expired - Lifetime
- 1998-04-01 AT AT04076605T patent/ATE370236T1/de active
- 1998-04-01 WO PCT/DK1998/000132 patent/WO1998044119A1/en not_active Ceased
- 1998-04-01 PT PT04076605T patent/PT1449922E/pt unknown
- 1998-04-01 JP JP54107498A patent/JP4172598B2/ja not_active Expired - Lifetime
-
2007
- 2007-11-19 JP JP2007299636A patent/JP4406024B2/ja not_active Expired - Lifetime
-
2008
- 2008-05-19 JP JP2008131389A patent/JP4544434B2/ja not_active Expired - Lifetime
-
2010
- 2010-01-08 JP JP2010002535A patent/JP2010154856A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2285625C (en) | 2015-06-30 |
| DE69838268D1 (de) | 2007-09-27 |
| JP2010154856A (ja) | 2010-07-15 |
| JP2008301817A (ja) | 2008-12-18 |
| EP1449922B1 (en) | 2007-08-15 |
| ES2291810T3 (es) | 2008-03-01 |
| EP1449922A2 (en) | 2004-08-25 |
| EP0972045A1 (en) | 2000-01-19 |
| AU740545B2 (en) | 2001-11-08 |
| JP2008142079A (ja) | 2008-06-26 |
| WO1998044119A1 (en) | 1998-10-08 |
| JP2001515359A (ja) | 2001-09-18 |
| AU6820498A (en) | 1998-10-22 |
| JP4406024B2 (ja) | 2010-01-27 |
| DK1449922T3 (da) | 2007-12-03 |
| ATE370236T1 (de) | 2007-09-15 |
| JP4172598B2 (ja) | 2008-10-29 |
| DE69838268T2 (de) | 2008-05-08 |
| CA2285625A1 (en) | 1998-10-08 |
| EP1449922A3 (en) | 2004-11-17 |
| JP4544434B2 (ja) | 2010-09-15 |
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