JP2001511450A - チアガビンを含有する制御放出性の医薬組成物 - Google Patents
チアガビンを含有する制御放出性の医薬組成物Info
- Publication number
- JP2001511450A JP2001511450A JP2000504859A JP2000504859A JP2001511450A JP 2001511450 A JP2001511450 A JP 2001511450A JP 2000504859 A JP2000504859 A JP 2000504859A JP 2000504859 A JP2000504859 A JP 2000504859A JP 2001511450 A JP2001511450 A JP 2001511450A
- Authority
- JP
- Japan
- Prior art keywords
- tiagabine
- formulation
- hours
- rate controlling
- plasma concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229960002036 phenytoin Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical class O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 229960002410 tiagabine hydrochloride Drugs 0.000 description 1
- YUKARLAABCGMCN-PKLMIRHRSA-N tiagabine hydrochloride Chemical compound Cl.C1=CSC(C(=CCCN2C[C@@H](CCC2)C(O)=O)C2=C(C=CS2)C)=C1C YUKARLAABCGMCN-PKLMIRHRSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 150000003611 tocopherol derivatives Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 125000005591 trimellitate group Chemical group 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
- 150000003772 α-tocopherols Chemical class 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 150000003781 β-tocopherols Chemical class 0.000 description 1
- 150000003789 δ-tocopherols Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5443297P | 1997-08-01 | 1997-08-01 | |
| IE970588 | 1997-08-08 | ||
| IE19970588A IE970588A1 (en) | 1997-08-01 | 1997-08-08 | Controlled release pharmaceutical compositions containing tiagabine |
| IE60/054,432 | 1997-08-08 | ||
| PCT/IE1998/000067 WO1999006045A1 (en) | 1997-08-01 | 1998-07-30 | Controlled release pharmaceutical compositions containing tiagabine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001511450A true JP2001511450A (ja) | 2001-08-14 |
| JP2001511450A5 JP2001511450A5 (enExample) | 2006-01-05 |
Family
ID=26320083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000504859A Pending JP2001511450A (ja) | 1997-08-01 | 1998-07-30 | チアガビンを含有する制御放出性の医薬組成物 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0991409B1 (enExample) |
| JP (1) | JP2001511450A (enExample) |
| AT (1) | ATE212550T1 (enExample) |
| AU (1) | AU8643698A (enExample) |
| CA (1) | CA2299464C (enExample) |
| DE (1) | DE69803670T2 (enExample) |
| DK (1) | DK0991409T3 (enExample) |
| ES (1) | ES2172179T3 (enExample) |
| PT (1) | PT991409E (enExample) |
| WO (1) | WO1999006045A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006520390A (ja) * | 2003-03-14 | 2006-09-07 | ムルイェ、ニルマル | 徐放性錠剤の製造方法 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002325404B2 (en) * | 1998-01-22 | 2006-02-02 | Abbott Laboratories | Extended Release Tiagabine Formulations with Reduced Side-effects |
| ZA99407B (en) * | 1998-01-22 | 1999-07-20 | Abbott Lab | Extended release tiagabine formulations with reduced side-effects. |
| PT1205190E (pt) * | 1999-08-04 | 2006-09-29 | Astellas Pharma Inc | Composicoes medicinais estaveis para uso oral utilizando oxidos de ferro |
| KR100510270B1 (ko) * | 2002-11-29 | 2005-08-26 | 센츄론(주) | 펠렛타이저를 이용한 서방성 제제의 제조방법 |
| US7442387B2 (en) * | 2003-03-06 | 2008-10-28 | Astellas Pharma Inc. | Pharmaceutical composition for controlled release of active substances and manufacturing method thereof |
| US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| CN105431144A (zh) | 2013-06-05 | 2016-03-23 | 思康脑侒股份有限公司 | 阿坎酸制剂、使用阿坎酸制剂的方法以及包含阿坎酸制剂的组合 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK288385D0 (da) * | 1985-06-26 | 1985-06-26 | Novo Industri As | Aminosyrederivater |
| ZA953078B (en) * | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| US5750140A (en) * | 1994-05-20 | 1998-05-12 | Novo Nordisk A/S | Transdermal delivery of tiagabine |
| US5866590A (en) * | 1995-05-05 | 1999-02-02 | Novo Nordisk A/S | Pharmaceutical composition containing tiagabine hydrochloride and the process for its preparation |
| DE19525598C2 (de) * | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
| ES2297859T3 (es) * | 1996-05-24 | 2008-05-01 | Smithkline Beecham Corporation | Uso de inhibidores de la captacion de gaba como agentes antitusivos. |
| UA52661C2 (uk) * | 1996-06-14 | 2003-01-15 | Ново Нордіск А/С | Безводна кристалічна форма гідрохлориду r(-)-n-(4,4-ди(3-метилтієн-2-іл)бут-3-еніл) ніпекотинової кислоти |
| US5914333A (en) * | 1996-07-31 | 1999-06-22 | Novo Nordisk A/S | Treatment of psychotic disorders |
-
1998
- 1998-07-30 AU AU86436/98A patent/AU8643698A/en not_active Abandoned
- 1998-07-30 DK DK98937738T patent/DK0991409T3/da active
- 1998-07-30 CA CA002299464A patent/CA2299464C/en not_active Expired - Fee Related
- 1998-07-30 JP JP2000504859A patent/JP2001511450A/ja active Pending
- 1998-07-30 EP EP98937738A patent/EP0991409B1/en not_active Expired - Lifetime
- 1998-07-30 PT PT98937738T patent/PT991409E/pt unknown
- 1998-07-30 ES ES98937738T patent/ES2172179T3/es not_active Expired - Lifetime
- 1998-07-30 WO PCT/IE1998/000067 patent/WO1999006045A1/en not_active Ceased
- 1998-07-30 AT AT98937738T patent/ATE212550T1/de active
- 1998-07-30 DE DE69803670T patent/DE69803670T2/de not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006520390A (ja) * | 2003-03-14 | 2006-09-07 | ムルイェ、ニルマル | 徐放性錠剤の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0991409B1 (en) | 2002-01-30 |
| EP0991409A1 (en) | 2000-04-12 |
| CA2299464A1 (en) | 1999-02-11 |
| ATE212550T1 (de) | 2002-02-15 |
| ES2172179T3 (es) | 2002-09-16 |
| PT991409E (pt) | 2002-06-28 |
| AU8643698A (en) | 1999-02-22 |
| CA2299464C (en) | 2009-02-17 |
| DE69803670D1 (de) | 2002-03-14 |
| WO1999006045A1 (en) | 1999-02-11 |
| DK0991409T3 (da) | 2002-03-25 |
| DE69803670T2 (de) | 2002-11-21 |
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