JP2001511349A - Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａｅｒｙｔｈｒａｅａ及びＳｔｒｅｐｔｏｍｙｃｅｓａｎｔｉｂｉｏｔｉｃｕｓにおける６−デオキシヘキソースの生合成及び移送のための遺伝子 - Google Patents

Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａｅｒｙｔｈｒａｅａ及びＳｔｒｅｐｔｏｍｙｃｅｓａｎｔｉｂｉｏｔｉｃｕｓにおける６−デオキシヘキソースの生合成及び移送のための遺伝子

Info

Publication number
JP2001511349A
JP2001511349A JP2000504257A JP2000504257A JP2001511349A JP 2001511349 A JP2001511349 A JP 2001511349A JP 2000504257 A JP2000504257 A JP 2000504257A JP 2000504257 A JP2000504257 A JP 2000504257A JP 2001511349 A JP2001511349 A JP 2001511349A
Authority
JP
Japan
Prior art keywords
sequence
seq
nucleotides
dtdp
deoxyhexose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000504257A
Other languages
English (en)
Japanese (ja)
Inventor
フロマンタン クロード
ミシェル ジャンマルク
レイナル マリーセシル
サラウベイ カディジャ
コルテス イエスス
ガイザー ザビーネ
リードレイ ピーター
メンデス カルメン
ア．サラス ホセ
Original Assignee
ヘキスト・マリオン・ルセル
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9709458A external-priority patent/FR2766496B1/fr
Priority claimed from FR9807411A external-priority patent/FR2786200A1/fr
Application filed by ヘキスト・マリオン・ルセル filed Critical ヘキスト・マリオン・ルセル
Publication of JP2001511349A publication Critical patent/JP2001511349A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2000504257A 1997-07-25 1998-07-21 Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａｅｒｙｔｈｒａｅａ及びＳｔｒｅｐｔｏｍｙｃｅｓａｎｔｉｂｉｏｔｉｃｕｓにおける６−デオキシヘキソースの生合成及び移送のための遺伝子 Withdrawn JP2001511349A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9709458A FR2766496B1 (fr) 1997-07-25 1997-07-25 Genes de biosynthese et de transfert des 6-desoxyhexoses chez saccharopolyspora erythraea et leur utilisation
FR97/09458 1998-06-12
FR9807411A FR2786200A1 (fr) 1998-06-12 1998-06-12 Genes de biosynthese et de transfert des 6-desoxy-hexoses chez saccharopolyspora erythraea et chez streptomyces antibioticus et leur utilisation
FR98/07411 1998-06-12
PCT/FR1998/001593 WO1999005283A2 (fr) 1997-07-25 1998-07-21 Genes de biosynthese et de transfert des 6-desoxyhexoses chez saccharopolyspora erythraea et chez streptomyces antibioticus et leur utilisation

Publications (1)

Publication Number Publication Date
JP2001511349A true JP2001511349A (ja) 2001-08-14

Family

ID=26233703

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000504257A Withdrawn JP2001511349A (ja) 1997-07-25 1998-07-21 Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａｅｒｙｔｈｒａｅａ及びＳｔｒｅｐｔｏｍｙｃｅｓａｎｔｉｂｉｏｔｉｃｕｓにおける６−デオキシヘキソースの生合成及び移送のための遺伝子

Country Status (3)

Country Link
EP (1) EP1032679A2 (fr)
JP (1) JP2001511349A (fr)
WO (1) WO1999005283A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017536820A (ja) * 2014-11-14 2017-12-14 浙江海正薬業股▲ふん▼有限公司Ｚｈｅｊｉａｎｇ Ｈｉｓｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ ＣＯ．，ＬＴＤ． スピノサド異種発現株およびその構築方法ならびに使用

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6388099B2 (en) 1998-10-29 2002-05-14 Kosan Biosciences, Inc. Production of 8,8a-dihydroxy-6-deoxyerythronolide B
JP2003504006A (ja) * 1999-04-16 2003-02-04 コーサン バイオサイエンシーズ， インコーポレイテッド ポリケチドおよび非リボソームペプチドの大きなライブラリーを調製するための複数プラスミド方法
ES2165278B1 (es) * 1999-06-24 2003-06-16 Univ Oviedo Un procedimiento de obtencion de productos glicosilados mediante la biosintesis de los desoxiazucares: l-olivosa, l-oleandrosa y l-ramnosa.
US7033818B2 (en) 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
US6524841B1 (en) * 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
DK1278881T3 (da) 2000-04-13 2010-05-10 Biotica Tech Ltd Glycosylerede hybrid-produkter og deres fremstilling og anvendelse
JP2004534502A (ja) * 2000-10-05 2004-11-18 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 糖部分を変更するための方法
FR2851773A1 (fr) * 2003-02-27 2004-09-03 Aventis Pharma Sa Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leurs applications
MXPA05002852A (es) * 2002-10-08 2005-10-05 Aventis Pharma Sa Polipeptidos implicados en la biosintesis de espiramicinas, secuencias de nucleotidos que codifican estos polipeptidos y sus aplicaciones.
US7579167B2 (en) 2002-10-08 2009-08-25 Aventis Pharma S. Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof
FR2845394A1 (fr) * 2002-10-08 2004-04-09 Aventis Pharma Sa Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leurs applications
GB0327721D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Polyketides and their synthesis
US20120196770A1 (en) 2011-01-28 2012-08-02 Amyris, Inc. Gel-encapsulated microcolony screening
CN103518136A (zh) 2011-05-13 2014-01-15 阿迈瑞斯公司 用于检测水不混溶性化合物的微生物生成的方法和组合物
CA2879178C (fr) 2012-08-07 2020-11-24 Amyris, Inc. Methodes de stabilisation de la production de composes derives de l'acetyl-coenzyme a
MY171958A (en) 2013-03-15 2019-11-08 Amyris Inc Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds
CN105934517A (zh) 2013-08-07 2016-09-07 阿迈瑞斯公司 用于稳定生产乙酰辅酶a衍生化合物的方法
US10808015B2 (en) 2015-06-25 2020-10-20 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141926A (en) * 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
US5801032A (en) * 1995-08-03 1998-09-01 Abbott Laboratories Vectors and process for producing high purity 6,12-dideoxyerythromycin A by fermentation
US5998194A (en) * 1995-12-21 1999-12-07 Abbott Laboratories Polyketide-associated sugar biosynthesis genes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017536820A (ja) * 2014-11-14 2017-12-14 浙江海正薬業股▲ふん▼有限公司Ｚｈｅｊｉａｎｇ Ｈｉｓｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ ＣＯ．，ＬＴＤ． スピノサド異種発現株およびその構築方法ならびに使用

Also Published As

Publication number Publication date
WO1999005283A2 (fr) 1999-02-04
EP1032679A2 (fr) 2000-09-06
WO1999005283A3 (fr) 1999-05-27

Similar Documents

Publication Publication Date Title
JP2001511349A (ja) Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａｅｒｙｔｈｒａｅａ及びＳｔｒｅｐｔｏｍｙｃｅｓａｎｔｉｂｉｏｔｉｃｕｓにおける６−デオキシヘキソースの生合成及び移送のための遺伝子
US10047363B2 (en) NRPS-PKS gene cluster and its manipulation and utility
JP2000515390A (ja) 新規ポリケチド誘導体およびそれを製造するための組換え方法
CA2405958C (fr) Produits hybrides glycosyles, production et utilisation
EP0769555B1 (fr) Gene codant la glycosyl-transferase et utilisation de ce gene
US5786181A (en) Process for producing high purity 6, 12-dideoxyerythromycin A by fermentation
AU7753800A (en) Recombinant megalomicin biosynthetic genes and uses thereof
Arisawa et al. Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae
MXPA97002451A (en) Vectors and procedure for the production of 6,12-didesoxieritromycin a, of high purity, through fermentac
US20050287587A1 (en) Production of glycosylated macrolides in E. coli
Stassi et al. A genetically engineered strain of Saccharopolyspora erythraea that produces 6, 12-dideoxyerythromycin A as the major fermentation product
EP0792285B1 (fr) Procedes de production des anthracyclines et de leurs intermediaires
EP0846175A1 (fr) Procede de preparation de daunorubicine
FR2766496A1 (fr) Genes de biosynthese et de transfert des 6-desoxyhexoses chez saccharopolyspora erythraea et leur utilisation
FR2786200A1 (fr) Genes de biosynthese et de transfert des 6-desoxy-hexoses chez saccharopolyspora erythraea et chez streptomyces antibioticus et leur utilisation
Hong et al. Cloning and sequencing of a gene cluster for the resistance to doxorubicin from Streptomyces peucetius subsp. caesius ATCC 27952
FR2786201A1 (fr) Genes de biosynthese et de transfert des 6-desoxy-hexoses chez saccharopolyspora erythraea et chez streptomyces antibioticus et leur utilisation
FR2786189A1 (fr) Genes de biosynthese et de transfert des 6-desoxy-hexoses chez saccharopolyspora erythraea et chez streptomyces antibioticus et leur utilisation
WO2004003169A2 (fr) Genes de recombinaison destines a des enzymes modifiant des polyketides
Inventi-Solari et al. Doxorubicin Overproduction in
WO2001023578A1 (fr) Groupe de genes intervenant dans la biosynthese de l'aclacinomycine et son utilisation en genie genetique

Legal Events

Date Code Title Description
A300 Withdrawal of application because of no request for examination

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20051004