JP2001510181A5 - - Google Patents

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Publication number
JP2001510181A5
JP2001510181A5 JP2000503054A JP2000503054A JP2001510181A5 JP 2001510181 A5 JP2001510181 A5 JP 2001510181A5 JP 2000503054 A JP2000503054 A JP 2000503054A JP 2000503054 A JP2000503054 A JP 2000503054A JP 2001510181 A5 JP2001510181 A5 JP 2001510181A5
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JP
Japan
Prior art keywords
polyamine
amino
polyamine analog
alkyl
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000503054A
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English (en)
Japanese (ja)
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JP2001510181A (ja
JP4044728B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1998/014896 external-priority patent/WO1999003823A2/en
Publication of JP2001510181A publication Critical patent/JP2001510181A/ja
Publication of JP2001510181A5 publication Critical patent/JP2001510181A5/ja
Application granted granted Critical
Publication of JP4044728B2 publication Critical patent/JP4044728B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2000503054A 1997-07-15 1998-07-15 治療および診断薬剤としての新規なポリアミンアナログ Expired - Fee Related JP4044728B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5258697P 1997-07-15 1997-07-15
US60/052,586 1997-07-15
US6572897P 1997-11-14 1997-11-14
US60/065,728 1997-11-14
US8553898P 1998-05-15 1998-05-15
US60/085,538 1998-05-15
PCT/US1998/014896 WO1999003823A2 (en) 1997-07-15 1998-07-15 Novel polyamine analogues as therapeutic and diagnostic agents

Publications (3)

Publication Number Publication Date
JP2001510181A JP2001510181A (ja) 2001-07-31
JP2001510181A5 true JP2001510181A5 (enExample) 2005-10-27
JP4044728B2 JP4044728B2 (ja) 2008-02-06

Family

ID=27368228

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000503054A Expired - Fee Related JP4044728B2 (ja) 1997-07-15 1998-07-15 治療および診断薬剤としての新規なポリアミンアナログ

Country Status (6)

Country Link
US (2) US6172261B1 (enExample)
EP (1) EP1001927A2 (enExample)
JP (1) JP4044728B2 (enExample)
AU (1) AU758570B2 (enExample)
CA (1) CA2297413A1 (enExample)
WO (1) WO1999003823A2 (enExample)

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HUP0400494A3 (en) 2000-03-24 2004-08-30 Mediquest Therapeutics Inc Sea Polyamine analogues as cytotoxic agents and pharmaceutical compositions containing them
US7432302B2 (en) 2001-01-08 2008-10-07 Mediquest Therapeutics, Inc. Composition containing polyamine transport inhibitor and use thereof
AU2008201086B2 (en) * 2001-01-08 2011-06-09 Aminex Theapeutics, Inc. Hydrophobic Polyamine Analogs and Methods for their Use
WO2002053519A2 (en) * 2001-01-08 2002-07-11 Mediquest Therapeutics, Inc. Hydrophobic polyamine analogs and methods for their use
USRE43327E1 (en) * 2001-01-08 2012-04-24 Aminex Therapeutics, Inc. Hydrophobic polyamine analogs and methods for their use
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CA2456269A1 (en) * 2001-08-23 2003-03-06 The Government Of The United States Of America Methods of inhibiting formation of vascular channels and profileration using pyridinone derivatives
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US20030129208A1 (en) * 2002-01-07 2003-07-10 Alberts David S. Topical application of alpha-DFMO and anti-inflammatory drug for treatment of actinic keratoses
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MXPA04007584A (es) 2002-02-07 2004-12-06 Wisconsin Alumni Res Found Compuestos de poliamina y composiciones para su uso en conjunto con una terapia contra el cancer.
JP4709552B2 (ja) * 2003-02-19 2011-06-22 邦康 早田 Ｌｆａ−１抑制剤、及びその用途
WO2005014524A2 (en) * 2003-08-07 2005-02-17 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
US7146203B2 (en) 2003-12-18 2006-12-05 Elliot Botvinick Implantable biosensor and methods of use thereof
WO2005120451A1 (en) * 2004-06-14 2005-12-22 Unilever Plc Method of decreasing sebum production and pore size
US20060078580A1 (en) * 2004-10-08 2006-04-13 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US7740875B2 (en) * 2004-10-08 2010-06-22 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US7199267B1 (en) * 2005-10-21 2007-04-03 Mediquest Therapeutics, Inc. Recognition of oligiosaccaride molecular targets by polycationic small molecule inhibitors and treatment of immunological disorders and infectious diseases
US7411002B2 (en) * 2006-06-07 2008-08-12 The University Of Kansas Polycationic sulfonamides and use thereof
EP2096106B1 (en) * 2006-11-15 2014-06-18 Nihon University Novel polyamine derivatives
US8497398B1 (en) * 2007-05-02 2013-07-30 University Of Central Florida Research Foundation, Inc. Polyamine transporter selective compounds as anti-cancer agents
FR2919287B1 (fr) * 2007-07-26 2012-10-12 Pf Medicament Nouveaux derives fluorescents de polyamines, leur procede de preparation et leurs applications en tant qu'outils de diagnostic dans le traitement des tumeurs cancereuses.
CA2985271A1 (en) * 2007-09-06 2009-03-12 Ohr Pharmaceutical, Inc. A method for treating diabetes
US9285320B2 (en) * 2008-05-01 2016-03-15 University Of Central Florida Research Foundation, Inc. Fluorescent cytotoxic compounds specific for the cellular polyamine transport system
GB0904842D0 (en) * 2009-03-20 2009-05-06 Univ Nottingham Protein labelling
US8258186B2 (en) 2009-07-16 2012-09-04 Pathologica, Llc Pharmaceutical for oral delivery comprising MGBG
FR2967675B1 (fr) * 2010-11-24 2015-02-27 Pf Medicament Derives fluorescents de cyanines polyamines en tant que sonde de diagnostic
CN105163730B (zh) 2013-01-08 2018-10-30 帕萨罗杰卡有限公司 用于治疗脱髓鞘疾病的方法和组合物
JP6670503B2 (ja) * 2014-09-24 2020-03-25 国立大学法人弘前大学 生体由来細胞を用いたがん細胞の検出方法
CN113786195A (zh) 2015-09-02 2021-12-14 梅特罗诺姆中国Ip控股公司 使用光-酶分析物传感器进行连续健康监测的系统和方法
DK3432914T3 (da) 2016-03-25 2020-11-30 Aminex Therapeutics Inc Biotilgængelige polyaminer
WO2018111934A1 (en) * 2016-12-12 2018-06-21 University Of South Florida Polyamine compounds targeting the efflux pumps of multi-drug resistant bacterial pathogens and methods of using the same
WO2020033944A2 (en) 2018-08-10 2020-02-13 University Of Central Florida Research Foundation, Inc. Non-polyamine based polyamine transport inhibitors and their use in the treatment of human cancers
EP4221698A1 (en) 2020-09-30 2023-08-09 Aminex Therapeutics, Inc. Combination drug substance of polyamine transport inhibitor and dfmo
CN115074118B (zh) * 2022-06-27 2024-10-18 山东理工大学 一种基于芘基荧光探针分子的对硝基苯胺检测方法
WO2024130693A1 (zh) * 2022-12-23 2024-06-27 中国医学科学院基础医学研究所 精胺衍生物及其在疾病中的治疗用途
US12605349B2 (en) 2024-09-05 2026-04-21 Orbus Therapeutics, Inc. Methods of treating grade 3 astrocytoma

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WO1996022962A1 (en) * 1995-01-23 1996-08-01 The Trustees Of Columbia University In The City Of New York Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
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JPH09235271A (ja) * 1996-02-29 1997-09-09 Suntory Ltd ポリアミン誘導体
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WO2000034226A1 (en) 1998-12-10 2000-06-15 Universite Laval Polyamine transport inhibitors
AU778343B2 (en) 1999-02-05 2004-12-02 Mediquest Therapeutics, Inc. Antizyme modulators and their use

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