JP2001508788A - 1,4−ジヒドロピリジン誘導体および治療におけるその使用 - Google Patents
1,4−ジヒドロピリジン誘導体および治療におけるその使用Info
- Publication number
- JP2001508788A JP2001508788A JP53383198A JP53383198A JP2001508788A JP 2001508788 A JP2001508788 A JP 2001508788A JP 53383198 A JP53383198 A JP 53383198A JP 53383198 A JP53383198 A JP 53383198A JP 2001508788 A JP2001508788 A JP 2001508788A
- Authority
- JP
- Japan
- Prior art keywords
- mol
- dihydropyridine
- dimethyl
- methoxycarbonyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.下記式 (式中、nは1または2であり、そして、 R1は2,4,6−トリメトキシフェニル、2−チエニルおよび2−ピローリ ル基から選ばれた基である)の化合物、および、薬理上許容される酸とのその付 加塩。 2.(4S,3’R)(−)N−〔4−(2−チエノイル)ブチル〕ピペリジ −3’ −イル2,6−ジメチル−4−(3−ニトロフェニル)−5−メトキシ カルボニル−1,4−ジヒドロピリジン−3−カルボキシレートである請求項1 記載の化合物、および、薬理上許容される酸とのその付加塩。 3.(4S,3’R)(−)N−〔4−(2,4,6−トリメトキシベンゾイ ル)ブチル〕ピロリジン−3’−イル2,6−ジメチル−4−(3−ニトロフェ ニル)−5−メトキシカルボニル−1,4−ジヒドロピリジン−3−カルボキシ レートである請求項1記載の化合物、および、薬理上許容される酸とのその付加 塩。 4.(4S,3’R)(−)N−〔5−(1H−2−ピローリル)−5−オキ ソペンチル〕ピペリジ−3’−イル2,6−ジメチル−4−(3−ニトロフェニ ル)−5−メトキシカルボニル−1,4 −ジヒドロピリジン−3−カルボキシレートである請求項1記載の化合物、およ び、薬理上許容される酸とのその付加塩。 5.下記式の酸と、下記式 (式中、nおよびR1は上記の通りである)のアルコールとを反応させることを 含む、請求項1記載の化合物の製造法。 6.請求項1〜4のいずれか1項記載の化合物を有効成分として含む治療用組 成物。 7.下記式 (式中、nおよびR1は請求項1記載の通りである)の化合物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR97/00577 | 1997-01-21 | ||
FR9700577A FR2758558B1 (fr) | 1997-01-21 | 1997-01-21 | Nouveaux derives de la 1,4-dihydropyridine et leur utilisation en therapeutique |
PCT/FR1998/000042 WO1998031680A1 (fr) | 1997-01-21 | 1998-01-12 | Derives de la 1,4-dihydropyridine et leur utilisation en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001508788A true JP2001508788A (ja) | 2001-07-03 |
JP4163260B2 JP4163260B2 (ja) | 2008-10-08 |
Family
ID=9502803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53383198A Expired - Lifetime JP4163260B2 (ja) | 1997-01-21 | 1998-01-12 | 1,4−ジヒドロピリジン誘導体および治療におけるその使用 |
Country Status (14)
Country | Link |
---|---|
US (1) | US6166035A (ja) |
EP (1) | EP0958290B1 (ja) |
JP (1) | JP4163260B2 (ja) |
AT (1) | ATE221528T1 (ja) |
AU (1) | AU727876B2 (ja) |
CA (1) | CA2278223C (ja) |
DE (1) | DE69806902T2 (ja) |
DK (1) | DK0958290T3 (ja) |
ES (1) | ES2181160T3 (ja) |
FR (1) | FR2758558B1 (ja) |
NO (1) | NO315853B1 (ja) |
NZ (1) | NZ336585A (ja) |
PT (1) | PT958290E (ja) |
WO (1) | WO1998031680A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6391881B2 (en) * | 2000-05-19 | 2002-05-21 | Bristol-Myers Squibb Company | Thiourea derivatives of dihydropyridine NPY antagonists |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2671349B1 (fr) * | 1991-01-09 | 1993-04-23 | Lafon Labor | Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant. |
-
1997
- 1997-01-21 FR FR9700577A patent/FR2758558B1/fr not_active Expired - Fee Related
-
1998
- 1998-01-12 ES ES98902058T patent/ES2181160T3/es not_active Expired - Lifetime
- 1998-01-12 DE DE69806902T patent/DE69806902T2/de not_active Expired - Lifetime
- 1998-01-12 AU AU58702/98A patent/AU727876B2/en not_active Expired
- 1998-01-12 JP JP53383198A patent/JP4163260B2/ja not_active Expired - Lifetime
- 1998-01-12 US US09/341,120 patent/US6166035A/en not_active Expired - Lifetime
- 1998-01-12 WO PCT/FR1998/000042 patent/WO1998031680A1/fr active IP Right Grant
- 1998-01-12 AT AT98902058T patent/ATE221528T1/de active
- 1998-01-12 PT PT98902058T patent/PT958290E/pt unknown
- 1998-01-12 EP EP98902058A patent/EP0958290B1/fr not_active Expired - Lifetime
- 1998-01-12 DK DK98902058T patent/DK0958290T3/da active
- 1998-01-12 CA CA002278223A patent/CA2278223C/fr not_active Expired - Lifetime
- 1998-01-12 NZ NZ336585A patent/NZ336585A/xx not_active IP Right Cessation
-
1999
- 1999-07-19 NO NO19993546A patent/NO315853B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT958290E (pt) | 2002-11-29 |
ATE221528T1 (de) | 2002-08-15 |
US6166035A (en) | 2000-12-26 |
AU5870298A (en) | 1998-08-07 |
FR2758558A1 (fr) | 1998-07-24 |
ES2181160T3 (es) | 2003-02-16 |
CA2278223A1 (fr) | 1998-07-23 |
FR2758558B1 (fr) | 1999-04-16 |
NZ336585A (en) | 2000-09-29 |
NO993546L (no) | 1999-09-21 |
EP0958290B1 (fr) | 2002-07-31 |
DE69806902T2 (de) | 2002-12-12 |
WO1998031680A1 (fr) | 1998-07-23 |
NO993546D0 (no) | 1999-07-19 |
JP4163260B2 (ja) | 2008-10-08 |
AU727876B2 (en) | 2001-01-04 |
DE69806902D1 (de) | 2002-09-05 |
DK0958290T3 (da) | 2002-12-02 |
CA2278223C (fr) | 2008-07-22 |
EP0958290A1 (fr) | 1999-11-24 |
NO315853B1 (no) | 2003-11-03 |
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