JP2001504820A5 - - Google Patents
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- Publication number
- JP2001504820A5 JP2001504820A5 JP1998522746A JP52274698A JP2001504820A5 JP 2001504820 A5 JP2001504820 A5 JP 2001504820A5 JP 1998522746 A JP1998522746 A JP 1998522746A JP 52274698 A JP52274698 A JP 52274698A JP 2001504820 A5 JP2001504820 A5 JP 2001504820A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Description
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3060496P | 1996-11-13 | 1996-11-13 | |
| US60/030,604 | 1996-11-13 | ||
| US4298997P | 1997-04-14 | 1997-04-14 | |
| US60/042,989 | 1997-04-14 | ||
| US08/964,791 | 1997-11-05 | ||
| US08/964,791 US5786488A (en) | 1996-11-13 | 1997-11-05 | Synthetic methods for the preparation of indolyquinones |
| PCT/US1997/020557 WO1998020874A1 (en) | 1996-11-13 | 1997-11-12 | Synthetic methods for the preparation of indolylquinones and mono- and bis-indolylquinones prepared therefrom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001504820A JP2001504820A (ja) | 2001-04-10 |
| JP2001504820A5 true JP2001504820A5 (ja) | 2005-07-14 |
Family
ID=27363680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52274698A Withdrawn JP2001504820A (ja) | 1996-11-13 | 1997-11-12 | インドリルキノンを製造するための合成法およびそれから製造されるモノ―およびビス―インドリルキノン |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5786488A (ja) |
| EP (1) | EP0959881B1 (ja) |
| JP (1) | JP2001504820A (ja) |
| AT (1) | ATE305000T1 (ja) |
| AU (1) | AU5177098A (ja) |
| CA (1) | CA2271737A1 (ja) |
| DE (1) | DE69734246T2 (ja) |
| ES (1) | ES2251035T3 (ja) |
| WO (1) | WO1998020874A1 (ja) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6376529B1 (en) * | 1995-06-07 | 2002-04-23 | Peng Cho Tang | Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof |
| US5786488A (en) * | 1996-11-13 | 1998-07-28 | Sugen, Inc. | Synthetic methods for the preparation of indolyquinones |
| US6147106A (en) * | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
| US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
| US6051597A (en) * | 1997-06-13 | 2000-04-18 | Merck & Co., Inc. | Indolylquinones as antidiabetic agents |
| US6114371A (en) * | 1997-06-20 | 2000-09-05 | Sugen, Inc. | 3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors |
| JP2002510623A (ja) * | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | 抗糖尿病薬 |
| CA2332806A1 (en) * | 1998-05-22 | 1999-12-02 | Natalie Dales | Bioreductive cytotoxic agents |
| SK287132B6 (sk) | 1998-05-29 | 2009-12-07 | Sugen, Inc. | Farmaceutická kompozícia obsahujúca pyrolom substituovaný 2-indolinón, súprava obsahujúca uvedenú kompozíciu a použitie pyrolom substituovaného 2-indolinónu |
| US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| ES2290117T3 (es) | 2000-02-15 | 2008-02-16 | Sugen, Inc. | Inhibidores de proteina quinasa 2-indolina sustituida con pirrol. |
| AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| US6642232B2 (en) | 2001-10-10 | 2003-11-04 | Sugen, Inc. | 3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors |
| US7057052B2 (en) * | 2002-09-26 | 2006-06-06 | Duke University | Heterocyclic quinones as pharmaceutical agents |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3917820A (en) * | 1969-05-29 | 1975-11-04 | Canadian Patents Dev | Antibiotic cochliodinol and production by chaetomium, cochliodes and chaetomium globsum |
| DE3364419D1 (en) * | 1982-04-30 | 1986-08-14 | Ici Plc | Delignification of lignocellulosic material |
| JPS6360966A (ja) * | 1986-08-29 | 1988-03-17 | Kyoto Yakuhin Kogyo Kk | キノン誘導体 |
| JPH11503519A (ja) | 1995-03-31 | 1999-03-26 | メルク エンド カンパニー インコーポレーテッド | インシュリンの擬似剤及び増強剤のアッセイ |
| US6376529B1 (en) * | 1995-06-07 | 2002-04-23 | Peng Cho Tang | Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof |
| US5786488A (en) * | 1996-11-13 | 1998-07-28 | Sugen, Inc. | Synthetic methods for the preparation of indolyquinones |
| IL122427A0 (en) * | 1995-06-07 | 1998-06-15 | Sugen Inc | Pharmaceutical compositions and methods for inhibition of adaptor protein/tyrosine kinase interactions |
| US6051597A (en) * | 1997-06-13 | 2000-04-18 | Merck & Co., Inc. | Indolylquinones as antidiabetic agents |
| JP2002510623A (ja) | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | 抗糖尿病薬 |
| US20030073837A1 (en) * | 1998-12-31 | 2003-04-17 | Langecker Peter J. | 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy |
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1997
- 1997-11-05 US US08/964,791 patent/US5786488A/en not_active Expired - Fee Related
- 1997-11-12 ES ES97946641T patent/ES2251035T3/es not_active Expired - Lifetime
- 1997-11-12 JP JP52274698A patent/JP2001504820A/ja not_active Withdrawn
- 1997-11-12 AU AU51770/98A patent/AU5177098A/en not_active Abandoned
- 1997-11-12 WO PCT/US1997/020557 patent/WO1998020874A1/en active IP Right Grant
- 1997-11-12 EP EP97946641A patent/EP0959881B1/en not_active Expired - Lifetime
- 1997-11-12 CA CA002271737A patent/CA2271737A1/en not_active Abandoned
- 1997-11-12 DE DE69734246T patent/DE69734246T2/de not_active Expired - Fee Related
- 1997-11-12 AT AT97946641T patent/ATE305000T1/de not_active IP Right Cessation
-
1998
- 1998-05-05 US US09/072,861 patent/US6110957A/en not_active Expired - Fee Related
-
2000
- 2000-05-03 US US09/563,424 patent/US6750240B2/en not_active Expired - Fee Related