JP2001226242A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for oral cavity containing a surfactant and slightly harmful to the mucosa. SOLUTION: This composition for oral cavity is characterized by containing a surfactant and fibroin as well.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an oral composition having little harm to mucous membranes.

[0002]

2. Description of the Related Art Conventionally, a surfactant is generally used in a toothpaste, a mouthwash or the like to improve foaming during use or to emulsify a drug. However, although surfactants are excellent in emulsification and dispersion, they have the property of easily causing mucosal exfoliation. Therefore, some surfactants use nonionic surfactants that are relatively less harmful to mucous membranes, but their effect is not sufficient, and it is not possible to formulate a formulation using only nonionic surfactants. Often difficult.

[0003]

SUMMARY OF THE INVENTION It is an object of the present invention to provide an oral composition containing a surfactant, which has less harm to mucous membranes.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies in order to solve the above-mentioned problems, and as a result, have found that fibroin reduces mucosal damage, and have accomplished the present invention. That is, according to the present invention, together with a surfactant,
An oral composition comprising fibroin is provided.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Fibroin is one of the proteins constituting silk, but the method for producing fibroin used in the present invention is not particularly limited, and is usually prepared as the following aqueous solution. First, boil silk materials such as eyebrows, raw silk, and silk fabric with an aqueous alkaline solution such as sodium carbonate,
After washing with water, sericin is removed by immersion in hot water. Next, the de-sericin silk material thus obtained is dissolved in water containing a dissolution aid such as calcium chloride or ethanol. This is dialyzed using a semipermeable membrane tube. Thereby, an aqueous fibroin solution from which the dissolution aid has been removed can be obtained. The fibroin used in the present invention does not necessarily need to be in the form of an aqueous solution, but can be in the form of a colloid. Colloidal fibroin can be obtained from an aqueous fibroin solution by selecting an appropriate additive according to a conventionally known method.

The oral composition of the present invention can be obtained by adding fibroin to an oral composition containing a surfactant in the form of an aqueous solution or colloid. The proportion of fibroin in the composition is 0.1% by weight.
001 to 10% is preferable, and more preferably 0.01 to 10%.
5%. When the ratio is below the above range, the mucous membrane cannot be sufficiently protected, while when the ratio exceeds the above range, the flavor may be very bad.

The oral composition of the present invention contains a surfactant. In this case, the surfactant includes an anionic surfactant, a cationic surfactant, a nonionic surfactant and an amphoteric surfactant. Surfactants are included. Specific examples thereof include sodium lauryl sulfate, sodium α-olefin sulfonate, N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, N-acyl taurate, sucrose fatty acid ester , Alkylol amide, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester,
Pluronic, polyoxyethylene sorbitan monostearate and the like. In the oral composition of the present invention,
Examples include toothpastes, lubricating toothpastes, liquid dentifrices, mouthwashes, mouth fresheners, and base compositions for preparing the same. Various abrasives, thickeners, binders, sweeteners, fragrances, coloring agents, preservatives, active ingredients, and the like can be added to the composition of the present invention as necessary. As abrasives, precipitated silica,
Silica-based abrasives such as silica gel, aluminosilicate, zirconosilicate, dibasic calcium phosphate dihydrate and anhydride, calcium pyrophosphate, calcium carbonate,
Aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, insoluble sodium metaphosphate,
Insoluble potassium metaphosphate, titanium oxide, zeolite,
Examples include aluminum silicate, zirconium silicate, and synthetic resin-based abrasives. As a thickener, glycerin,
Sorbitol, propylene glycol, polyethylene glycol and the like. Examples of the binder include carrageenan, sodium hydroxyethyl cellulose, sodium alginate, propylene glycol alginate, xanthan gum, polyacrylic acid, sodium polyacrylate, tarragant gum, guar gum, locusting gum, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, gellan gum, Gelatin, curdlan, gum arabic, agar, pectin,
Polyvinyl alcohol, polyvinyl pyrrolidone, pullulan and the like can be mentioned. Examples of the sweetener include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, and perillartin. Examples of the flavor include terpenes such as 1-menthol, carvone, anethole, limonene, and derivatives thereof. Coloring agents include Blue No. 1, Yellow No. 4, and titanium dioxide.

The active ingredients include chlorohexidine, benzethonium chloride, benzalkonium chloride,
Cationic germicides such as cetylpyridinium chloride and decanium chloride; phenolic compounds such as triclosan, hinokitiol and biosol; enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, superoxide dismutase, and vitamin E , Vitamins such as vitamin C, alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate, fluorides such as sodium fluoride and stannous fluoride, tranexamic acid, epsilon aminocaproic acid, Aluminum chlorohydroxyalantoin, dihydrocholesterol, glycyrrhizic acid, glycyrrhetinic acid, bisabolol, glycerophosphate, chlorophyll, sodium chloride, water-soluble inorganic phosphate compounds, etc. Active ingredients of the may be formulated alone or in combination.

[0009]

EXAMPLES The present invention will now be described specifically with reference to examples and comparative examples, but the present invention is not limited to the following examples.

Reference Example 1 <Production method of fibroin aqueous solution> Silk thread was boiled with a 0.5% sodium carbonate aqueous solution for 1 hour, washed with water, and placed in hot water of 60 ° C.
It was immersed for 0 minutes and dried except for sericin and sodium carbonate. The purified silk yarn thus obtained was dissolved in a mixed solution of calcium chloride: ethanol: water = 1: 2: 8 (molar ratio) by heating at 70 ° C. for 2 hours. In this case, the weight ratio between the silk thread and the aqueous solution was 1: 7. This aqueous solution was dialyzed against ion-exchanged water for 3 days using a cellulose semipermeable membrane tube to obtain a 7% aqueous fibroin solution.

Comparative Example 1 and Example 1 A test dentifrice having the component composition (%) shown in Table 1 was prepared, and each tooth was brushed with the dentifrice for 3 minutes, and then the mouth was washed four times with 10 ml of distilled water. The turbidity of the fourth discharge was measured. Table 1 shows the results. In addition, SDS shown in Table 1 means sodium dodecyl sulfate. The turbidity is SP
It was measured by ECTRONIC 20A (manufactured by Shimadzu Corporation).

[0012]

[Table 1]

As can be seen from the results shown in Table 1, it is found that Example 1 containing fibroin has a lower turbidity, that is, is more effective in suppressing mucosal exfoliation.

Next, specific formulation examples of various oral compositions are shown below. Example 2 (Jun Toothpaste) (%) Sodium Pyrophosphate 3.0 Butylparaben 0.02 Calcium Carbonate 70.0 Sorbitol 2.0 Glycerin 8.0 7% Fibroin Aqueous Solution 0.2 Saccharin Sodium 0.08 Lauroyl Sarcosine Sodium 2 2.0 Purified water balance

Example 3 (Mouthwash) (%) Sodium pyrophosphate 1.0 Ethanol 5.0 Glycerin 10.0 Saccharin sodium 0.1 Polyoxyethylene hydrogenated castor oil 0.1 7% aqueous fibroin solution 75.0 Benzoic acid Sodium 0.3 Fragrance 0.5 Purified water Balance

Example 4 (Mouth freshener) (%) Sodium pyrophosphate 2.0 Ethanol 30.0 Glycerin 15.0 7% Fibroin aqueous solution 1.0 Saccharin sodium 0.3 Sucrose fatty acid ester 3.0 Fragrance 1.0 Purified water balance

[0017]

According to the present invention, by incorporating fibroin into an oral composition containing a surfactant, it is possible to alleviate the mucosal damage caused by the surfactant.

 ──────────────────────────────────────────────────の Continuing on the front page (72) Inventor Haruo Tsukuya 1-3-7 Honjo, Sumida-ku, Tokyo F-term in Lion Corporation (reference) 4C083 AB282 AB322 AB432 AC102 AC122 AC132 AC312 AC432 AC482 AC662 AC782 AC862 AD272 AD451 AD452 BB01 CC41 DD22 DD23 EE09 EE31

Claims (2)

[Claims] 1. An oral composition comprising fibroin together with a surfactant. 2. The composition for oral cavity according to claim 1, wherein the fibroin is in the form of a solution or a colloid.