JP2001206801A - Compound of bioactive substance-containing particulate and method of cultivation for agricultural product using the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a compound of bioactive substance-containing particulate having the following features: capable of improving the application efficiency of the bioactive substance and achieving the labor saving in application work; and especially in the case of a compound of agrochemical granules having a delayed releasing function of controlled release type, the growth disorder on the initial stage of cultivation is not caused, the whole or a large part of the agrochemical necessary for the cultivation period can be applied at the same time of seeding or transplanting, and thereby chemical injury is not caused and the burden of the application work for the agrochemical can be extremely reduced, and a method of cultivation for agricultural products using the compound. SOLUTION: The compound comprises >=2 kinds of bioactive substance- containing particulates which contain at least one kind of bioactive substances. The average weight of the particulates is 0.1-5 mg/particle.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a blend of bioactive substance-containing granules containing at least one bioactive substance and a cultivation method using the same. The biologically active substance in the present invention means a substance having activity on organisms related to agriculture, forestry, horticulture and the like.

[0002]

2. Description of the Related Art In order to reduce the cost and enhance the performance of agricultural materials, it is easier and more effective to combine materials having various effects than all-purpose materials having many functions with one material. Easy to name. It is generally well known to mix materials having various effects by mixing. When mixing these materials with a mixer, the selection of the model requires characteristic values such as particle size distribution, bulk specific gravity, true specific gravity, particle shape, surface condition, angle of repose, bulk tendency, and moisture. It is determined by performing a test based on the characteristic values. For example, in the production of insecticide sterilizing granules, extrusion granulation method, coating method, impregnation method and the like are employed, but pesticide components having an insecticidal effect and pesticide components having a bactericidal effect in terms of production costs and the like. It is generally manufactured by mixing with an extender or the like, and even in the case of other methods, the granules are manufactured so that the composition of one granule is the same.

[0003]

However, when a plurality of pesticidal ingredients are blended, the properties are generally different from each other. The release design had to be optimized for only the pesticide components. Therefore, even if an insecticide granule or a germicidal granule manufactured so as to exhibit the release behavior optimized for each active ingredient is put into a mixer, it is attempted to make the distribution of each granule uniform by convection, diffusion, shearing, etc. Depending on the properties of each granule before mixing, classification may occur and the granules may be separated. In general, pesticide granules are not uniform in particle shape and are not considered as a raw material for mixing. Therefore, in particular, mixing of pesticide granules often cannot make the distribution of the particles uniform. In addition, in view of recent changes in the agricultural environment, there has been a demand for the development of agricultural materials that have a high application efficiency and do not burden farmers.

[0004]

Means for Solving the Problems The present inventors have been engaged in the research and development of agricultural materials for the purpose of labor saving of agricultural work and improving the application efficiency of biologically active substances, particularly pesticides, and the coating containing at least one or more pesticide components. As for pesticide granules, data were collected and analyzed to construct a comprehensive labor-saving cultivation system using materials containing these, and the average weight per pesticide granule satisfies the range of 0.1 to 5 mg. Could be easily compounded. Further, in addition to the above-mentioned conditions, by mixing pesticide granules having an average value of the minimum diameter / maximum diameter ratio of the particles of 0.7 or more and cultivating agricultural crops using the same, labor saving of application work can be achieved. The inventors have found that this is achieved, and completed the present invention based on this finding.

The present invention has the following constitutions (1) to (9). (1) A blend of two or more biologically active substance-containing granules containing one or more biologically active substances, wherein the average weight per particle of the granules is 0.1 to 5 mg. Formulation of bioactive substance-containing granules. (2) The blend of the bioactive substance-containing granular material according to the above (1), wherein the bioactive substance is an agrochemical component having both or one of an insecticidal action and a bactericidal action. (3) The biologically active substance-containing granular material has a minimum diameter / maximum diameter ratio of 0.7 or more,
A blend of the biologically active substance-containing granules according to the above (1) or (2). (4) The method according to any one of the above (1) to (3), wherein at least one kind of the bioactive substance-containing granular material has a surface coated with a coating material containing a resin. A formulation of the biologically active substance-containing granules as described. (5) The bioactive substance-containing granular material according to the above (4), wherein the coating material contains one or more powders selected from the group consisting of a water-insoluble powder and a poorly water-soluble powder. The composition of. (6) A coating having a release function set so that the biologically active substance-containing granular material has a period during which the release of the biologically active substance is suppressed after application and a period during which the biologically active substance is gradually released after the passage of the period. The blend of the bioactive substance-containing granules according to any one of the above (1) to (5), which is a bioactive substance-containing granule. (7) The blend of granular materials containing a bioactive substance according to any one of the above (1) to (6), wherein the bioactive substance is osmotic. (8) A method for cultivating agricultural crops, which comprises applying the mixture of the biologically active substance-containing granular material according to any one of (1) to (7) before sowing or transplanting. (9) The above (8), wherein the crop is rice.
The cultivation method of the crop described in the paragraph.

Hereinafter, the present invention will be described in detail. The term bioactive substance-containing granules used in the present invention means not only granules containing a bioactive substance but also granules composed of only a bioactive substance, unless otherwise specified.
The composition of the granular material containing the biologically active substance of the present invention contains two or more biologically active substances selected from the group consisting of a granular substance comprising one or more biologically active substances and a granular substance containing one or more biologically active substances. It is obtained by mixing granules. Further, the mixture may be subjected to post-processing such as coating, or at least one or more of the biologically active substance-containing granules previously coated may be used as a component of the blend.

The bioactive substance-containing granules used in the present invention have an average weight per grain of 0.1 to 5 mg, preferably 1 to 4 mg. If the water content is smaller than the lower limit, the particles become finer, and if water adheres to the feeder of the mixture of the particulates containing the biologically active substance, which is installed in a seeder, etc., the water is easily caught and accumulated on the water droplets. There are problems such as doing. If it is larger than the upper limit,
Since the amount of treatment per crop of the crop is reduced, it is difficult to uniformly treat the crop, and stable efficacy cannot be exhibited.

[0008] In order to obtain a mixture of the bioactive substance-containing granules of the present invention by mixing, it is preferable that the shapes of the bioactive substance-containing granules are as identical as possible. Grain shape has a significant effect on other physical properties, such as bulk specific gravity, angle of repose, and flow characteristics. The granular form of the bioactive substance-containing granular material in the present invention is generally a granular material (φ0.3 to 1.7) in the field of agricultural chemicals.
mm), pills or any other shape. In the present invention, the shape of the particles constituting the blend of the biologically active substance-containing granules is typically represented by a minimum diameter / maximum diameter ratio. To measure the ratio of the minimum diameter to the maximum diameter, enlarge the particles with a microscope or the like, and then take a picture or display them on a monitor connected to a personal computer or the like, and check the shortest distance between the parallel lines sandwiching the particles. The distance is measured by setting the minimum diameter and the long part as the maximum diameter. Thus, the ratio of the minimum diameter / maximum diameter of one grain is calculated, 100 grains are measured, and the average value is defined as the minimum diameter / maximum diameter ratio. The preferred shape in the present invention has a minimum diameter / maximum diameter ratio of 0.7 or more, more preferably 0.8 or more, as measured by the above-mentioned measuring method. When the minimum diameter / maximum diameter ratio is less than the lower limit, mixing becomes difficult, and release control by coating tends to be unstable.

In order to mix the bioactive substance-containing granules in a short time, the particle diameters are preferably uniform. Usually, the particle size range can be controlled by sieving, but the above-described minimum diameter is measured, the average value of 100 particles is taken as the average particle size, and the average particle size of the bioactive substance-containing granules before mixing is x ₁ , x ₂ (x ₁ ≧
x ₂ , when three or more types, x ₁ is the maximum value, x ₂ is the minimum value), and when the standard deviations are σ ₁ and σ ₂ , respectively, (x ₁
−3σ ₁ ) <(x ₂ + 3σ ₂ ). This relationship, (x ₁ -2σ ₁₎ <more preferably from (x ₂ + 2σ _2), even more preferably _{(x 1 -1.5σ 1) <(} x 2 + 1.5σ 2). Particle size distribution of the bioactive substance-containing granules can be regarded as a normal distribution, the better the difference between x ₁ and x ₂ is small. In the case of (x ₁ −3σ ₁ ) ≧ (x ₂ + 3σ ₂ ), the difference between x ₁ and x ₂ is too large, and it is difficult to homogenize by mixing.

[0010] The bulk specific gravity varies depending on the material composition when producing the bioactive substance-containing granules, the granulation method thereof, and the fluctuations in operating conditions during the production process. Problems with mixing. However, in the case of the material related to the present invention, since the approximate diameter is 1.0 to 1.5 mm at 3 mg / particle, particles having a desired weight may be prepared based on these particle diameters. .

The method for producing the biologically active substance-containing granules may be any of granulation methods such as extrusion granulation, tumbling granulation, coating granulation and crushing granulation. In the case of pesticides, generally, raw materials containing pesticide components are mixed and granulated by any granulation method,
It can be obtained through drying and sieving. Similar granules can be obtained by adsorbing or coating a raw material containing an agricultural chemical component on a granular material.

The mixing ratio of the bioactive substance-containing granules used as the blending raw material is not particularly limited. However, if the ratio is too large, the effect of small amounts of application is likely to occur, so that the most bioactive substance-containing granules with respect to the least bioactive substance-containing granules The mixing ratio of the contained particulate matter is preferably 50 times or less by weight, more preferably 20 times or less, and further preferably 15 times or less. For example, if the required amount of the pesticide component is largely different, the ratio of the pesticide component to the smaller bioactive substance-containing particulate matter is adjusted to be small, and the amount used as the blending material is increased. It is desirable to set the mixing ratio to the above.

[0013] The biologically active substance in the present invention means a substance which is active against organisms related to agriculture, forestry, horticulture, etc. as described above. It is used for the purpose of breeding and protecting the body, increasing the yield according to the purpose of use, increasing the quality of crops, controlling disease, controlling pests, controlling pests, controlling weeds, further promoting the growth of crops, suppressing growth And an effect such as dwarfing, and specific examples include pesticides, fertilizers, and microorganisms.

As pesticides, disease control agents, pest control agents,
Pest control agents, weed control agents, and plant growth regulators can be used, and any of these can be used without limitation. Disease control agents are agents used to protect agricultural crops and the like from harmful effects of pathogenic microorganisms, and mainly include fungicides. Pest control agents are agents that control pests such as crops, and mainly include insecticides. Pest control agents are agents used to control plant parasitic mites, plant parasitic nematodes, wild rats, birds, and other pests that damage crops and the like. A weed control agent is an agent used for controlling plant plants that are harmful to crops, trees, and the like, and is also called a herbicide. A plant growth regulator is a drug used for the purpose of promoting or suppressing the physiological function of a plant.

Preferably, the pesticide has both insecticidal and / or bactericidal actions, and can be used without any limitation. The pesticide granule composition of the present invention includes a pesticide granule containing at least one pesticide component having both insecticidal action and / or bactericidal action (hereinafter, the term "pesticide granule" has the same meaning). ) Are obtained by blending two or more kinds. The composition may be subjected to post-processing of coating the particle surface, or two or more kinds of pre-coated pesticide granules may be mixed to form a pesticide granule composition.

The agricultural chemical component used in the present invention is preferably in the form of a solid powder at room temperature, but may be liquid at room temperature. Further, in the present invention, it is possible to use water-soluble, hardly water-soluble, or water-insoluble pesticide components, which are not particularly limited.
A penetrative agrochemical component that migrates into a plant to be protected by contact or the like and exhibits a medicinal effect is preferable. Specific examples of the pesticidal components that can be used in the present invention are shown below, but the present invention is not limited to these. In addition, the pesticide component may be a single component or a combination of two or more composite components.

The pesticidal component having an insecticidal action includes (E)
-N ¹ -[(6-chloro-3-pyridyl) methyl] -N ²
-Cyano-N ¹ -methylacetamidine (generic name: acetamiprid), 1- (6-chloro-3-pyridylmethyl) -N-nitroimidazolidine-2-ylideneamine (generic name: imidacloprid), O, O-diethyl-S
-2- (ethylthio) ethyl phosphorodithioate (generic name: ethylthiomethone), 2,3-dihydro-2,2
-Dimethyl-7-benzo [b] furanyl = N-dibutylaminothio-N-methylcarbamate (generic name: carbosulfan), (E) -N- (6-chloro-3-pyridylmethyl) -N- Ethyl-N'-methyl-2-nitrovinylidenediamine (generic name: nitenpyram),

(±) -5-amino- (2,6-dichloro-α, α, α-trifluoro-p-toluyl) -4-trifluoromethylsulfinylpyrazole-3-carbonitrile (generic name: fipronil) , Butyl = 2,3-
Dihydro-2,2-dimethylbenzofuran-7-yl =
N, N'-dimethyl-N, N'-thiodicarbamate (general name: furatiocarb), ethyl = N- [2,3-
Dihydro-2,2-dimethylbenzofuran-7-yloxycarbonyl (methyl) aminothio] -N-isopropyl-β-alaninate (generic name: benflacarb);
And 1-naphthyl-N-methyl carbamate (generic name: NAC) and the like,

As the pesticidal component having a bactericidal action, (1R
S, 3SR) -2,2-Dichloro-N- [1- (4-chlorophenyl) ethyl] -1-ethyl-3-methylcyclopropanecarboxamide (general name: carpropamide), 5-methyl-1,2,4 -Triazolo [3,4-
b] benzothiazole (generic name: tricyclazole),
1,2,5,6-tetrahydropyrrolo [3,2,1-i
j] quinolin-4-one (generic name: pyroquilon), (R
S) -5-Chloro-N- (1,3-dihydro-1,1,1
3-trimethylisobenzofuran-4-yl) -1,3
-Dimethylpyrazole-4-carboxamide (generic name:
Furametopyr) and 3-allyloxy-1,2-benzisothiazole-1,1-dioxide (generic name: probenazole).

As the fertilizer, nitrogenous fertilizer, phosphate fertilizer,
In addition to potassium fertilizers, fertilizers containing calcium, magnesium, sulfur, iron, trace elements, silicon and the like, which are essential components of plants, can be mentioned. Specific examples of the nitrogenous fertilizer include ammonium sulfate, urea, and ammonium nitrate, as well as isobutyraldehyde condensed urea and acetaldehyde condensed urea. The potassium fertilizer includes potassium sulfate, potassium chloride, and silicic acid fertilizer, and the form thereof is not particularly limited. Advanced chemical fertilizers, compound fertilizers, and organic fertilizers in which the total amount of the three components of the fertilizer is 30% or more may be used. Further, a fertilizer to which a nitrification inhibitor or an agricultural chemical is added may be used.

The composition of the bioactive substance-containing granules is not particularly limited as long as the composition contains the bioactive substance.
It may be a granular substance composed of only the biologically active substance, or a granular substance composed of the biologically active substance and auxiliary agents such as a bulking agent and a binder. Mineral substance fine powder or water-soluble powder can be used as the extender. Examples of the mineral substance fine powder include diatomaceous earth, talc, clay, bentonite, zeolite, and calcium carbonate. Examples of the water-soluble powder include lactose, fructose, sucrose, glucose, saccharides such as dextrin and starch, urea or sulfuric acid, phosphoric acid, and the like. Examples of the binder include polyvinyl alcohol, lignin sulfonates, molasses, carboxymethyl cellulose, polyacrylates, polyethylene glycol, surfactants, and liquid paraffin. These extenders may be used alone or in combination of two or more. Also, if necessary, other auxiliary agents such as absorbent fine powder, grinding aid, decomposition inhibitor, colorant,
An antifoaming agent or the like can be added.

In the present invention, it is preferable to use a bioactive substance-containing granular material whose surface is coated with a coating material containing a resin since the release of each bioactive substance can be arbitrarily controlled. As such, for example,
Commercially available LP coats (manufactured by Chisso Corporation) and long coats (manufactured by Asahi Chemical Industry Co., Ltd.) are exemplified. In this case, the resin may be either a thermoplastic resin or a thermosetting resin, and an auxiliary component may be added. When the coated bioactive substance-containing granules are used in the present invention, those coated with a thermoplastic resin, particularly an olefin resin such as polyethylene or polypropylene, are preferable.

Auxiliary components used for coating the biologically active substance-containing granules include, for example, fine powders of mineral substances such as talc and mica, sugar polymer powders such as starch, sulfur, iron acetylacetone iron, and nickel such as dibutyldithiocarbamate nickel. It is preferable to add a complex or the like, and the particle size is 0.1 to 10
It is preferably 0 μm, more preferably 20 μm or less. However, the particle size only needs to be completely contained in the coating film, and is not particularly limited. Select in consideration of the thickness of the coating, etc.
It is preferred that they are uniformly distributed in the coating. Among these, it is more preferable to use one or more powders selected from the group consisting of water-insoluble powders and poorly water-soluble powders. These powders are not particularly limited as long as they have a solubility in water at 25 ° C. of 0.1 g / 100 mL or less. Examples thereof include talc, clay, kaolin, muscovite, phlogopite, mica-like iron oxide, metal oxides, siliceous substances, carbonates and sulfates of glass and alkaline earth metals. It is preferably a flat fine powder, and talc, muscovite, seriteite and the like are typical examples. These shapes are in the form of flakes. Specifically, the particle size / thickness is 2 or more, and when the particle size / thickness is 10 or more, the precision of release control tends to be high, which is more preferable. .

The content of the above powder is not particularly limited, but is preferably in the range of 5 to 98% by weight in the coating. When the content is less than 5% by weight, the influence of the external temperature on the release function is large, and the release control becomes unstable, especially over a long period of use, which is not practical.
On the other hand, if the content is more than 98% by weight, it becomes difficult to form a complete film without pinholes or cracks on the particle surface, and the function of suppressing release cannot be obtained. In order to minimize undesired fluctuations in release and to reliably form a complete film, the content of the powder is preferably in the range of 50 to 95% by weight, more preferably 85 to 95% by weight. Range. By adding and dispersing these auxiliary components to the coating material and coating, various functions such as decomposition of the coating and various release patterns can be added to the coated bioactive substance-containing granules.

The bioactive substance-containing granules of the present invention have a slow-release or sustained-release function (hereinafter referred to as "sustained-release function") in which the release of the bioactive substance is maintained for at least one day after application. It is preferred to have. More preferably, a release suppression period in which the release of the biologically active substance is suppressed for a certain period after application,
This is a bioactive substance-containing particulate material having a release pattern consisting of a period in which the bioactive substance is gradually released after the elapse of the period, that is, a time-release type sustained release function. For example, a period (0 to 10%) until 10% of pesticide granules start releasing pesticide components after application is defined as a release suppression period, and until 90% of the coated pesticide granules start releasing pesticide components thereafter. (10 to 90%) is the release period, the release ratio of the release suppression period / release period is 0.2 or more, preferably 0.4 or more and 10 or less, more preferably 0.5 or more and 5 or less. Has a pattern.

The timed release type sustained release function may be based on any mechanism. Practically, a method of controlling the disintegration of particles by a granulation technique, a method of bonding to or being contained in a polymer, a method of coating with a resin, and the like can be mentioned. Examples of timed release by coating include JP-A-6-9303, JP-A-6-9304,
Coating compositions disclosed in JP-A-6-72805 and JP-A-6-80514 can be exemplified. Each of these coatings is composed of two coating layers, and it is preferable that the coating be a single layer from the viewpoint of the complexity of the coating operation and the cost of capital investment for manufacturing equipment.

Examples of coated pesticide granules which achieve a time-release type sustained release function by a single layer film include, for example, those disclosed by the present applicant in JP-A-9-77608.
A coated pesticide granule in which the surface of a pesticide core particle (hereinafter, referred to as a core material) composed of at least one kind of pesticide component and at least one kind of water-swellable substance is coated with a film containing a resin as a main component. Can be. After the coated pesticide granule of this composition is applied to a field or the like, the water supplied to the field acts on the water-swellable substance of the core material due to the moisture permeability of the film, and the core material starts to swell. Due to the stress caused by the swelling of the water-swellable substance, the coating collapses after a certain period of time, and the core material is directly exposed to the environment (soil, water, etc.) outside the coating.

Examples of the coating method include a fluidized-bed coating method, a spouted-bed coating method, and a rolling coating method, and any of these methods may be used. Spray-bed coating method of spray-coating a coating solution obtained by dissolving and suspending in a solvent onto a pesticide granule surface is preferable.

The cultivation method of the agricultural crop of the present invention is a cultivation method using the composition of the biologically active substance-containing granular material of the present invention. The application time of the composition is not limited, and it may be applied to a seedling container such as a seedling box at the time of sowing or at the start of seedling raising, or applied to a gutter or the like at the time of transplanting or sowing seedlings or seeds in this field. Is also good. Since the application efficiency becomes better as the plant and the pesticide granule formulation are closer to each other, the application is preferably performed before sowing or transplantation. The crop cultivation method of the present invention is most effective particularly in the case of rice transplant cultivation among crops. For example, release control of pesticide granules containing pesticide components that show medicinal properties against pests and diseases that are expected to occur in advance is performed so that the effect is most effective for each component, and seedlings are seeded or seeded before transplantation By applying in a container, it becomes possible to omit the application | coating operation of a pesticide several times. Furthermore, since the efficacy of the applied agricultural chemical component is improved, a high effect can be obtained with a small amount. If the product contains pesticide components that may cause phytotoxicity at the time of application, avoid phytotoxicity by coating, etc. Otherwise, if the release design is made with consideration of residual effects, a safe, low-cost, highly effective pesticide granule A formulation can be obtained. Hereinafter, the present invention will be described with reference to examples, but the present invention is not limited thereto.

[0030]

EXAMPLES Production Example 1 of Granules (Production of Insecticide Granules) 1- (6-Chloro-3-pyridylmethyl) -N-nitroimidazolidin-2-ylideneamine (hereinafter referred to as CPNI) is used as an agrochemical component having an insecticidal action.
Abbreviated as A. (3 parts by weight) (purity: 70 parts by weight), 65 parts by weight of bentonite, 31 parts by weight of clay, and 1 part by weight of sodium ligninsulfonate were uniformly mixed, kneaded by kneading with a kneader. The mixture was extruded and granulated by a screw extrusion granulator (diameter of a die: 0.8 mm), and the granulated product was rotated using a rotary disk-type granulator (Fuji Paudal, Marumeraizer QJ400). The granulated product was obtained by sizing under the following operating conditions. Next, the granulated product was dried at 100 ° C. using a circulating hot air drier, and then sieved to 1.0 to 1.4 m.
m (open mesh) was obtained. Operating conditions of sizing machine Operating method: Batch type Operating time: 1 min Plate pitch: 1 mm Number of rotations: 788 r / min Charge: 1.5 kg (per time)

Subsequently, using a spouted bed coating apparatus shown in FIG. 1, low-density polyethylene (MFR = 6.6-7.
4 g / 10 min) 25% by weight, talc (average particle size 5μ)
m) The above-mentioned granules were coated with a coating material having a composition of 74% by weight and 1% by weight of ferric acetylacetone to obtain an insecticide granule so that the coverage was 20%. The coverage is the ratio of the weight (b) of the coating to the coated pesticide granules when the sum of the weight (a) of the uncoated insecticide granules (a) and the weight (b) of the coating is 100, and is expressed by the formula [b × 100 / (a + b)]
Is the value obtained in The production was performed according to the following method. For coating, a uniform coating material suspension having a concentration of 5.0% by weight in which the coating material was dissolved and suspended in tetrachloroethylene was used. (In the following examples,
The coating material suspension was prepared under the same conditions unless otherwise specified. One-fluid nozzle: 0.4 mm opening, full cone type Uncoated insecticide granules: 3 kg Hot air temperature: 100 ± 2 ° C. Hot air volume: 4 m ³ / min Spray flow rate: 0.2 kg / min The spraying was started from the time when the temperature of the insecticide granules reached 70 ° C., sprayed for a predetermined time, and then dried for 10 minutes.

Granule Production Example 2 (Production of insecticide granule) 2.5 parts by weight of CPNIA (purity: 70 parts by weight), 45 parts by weight of bentonite, 51.5 parts by weight of clay, 1 part by weight of urea as pesticidal ingredients having an insecticidal action Were uniformly mixed, kneaded by adding water with a kneader. The mixture was extruded with a screw extruder (a die having a hole diameter of 1.2 m).
m), the granulated product was granulated in the same manner as in Granule Production Example 1 using a rotating disk-type granulator (made by Fuji Paudal, Malmerizer QJ400) to obtain a granulated product. . Next, the granulated product is dried with a hot air circulating drier, sieved, and
An insecticide granule having a diameter of 2.0 mm (mesh opening) was obtained.

Granule Production Example 3 (Production of insecticide granule) 3 parts by weight of CPNIA (purity: 70% by weight) and bentonite 7 as pesticidal components having an insecticidal action
0 parts by weight, 26 parts by weight of clay, and 1 part by weight of magnesium ligninsulfonate were uniformly mixed, kneaded by adding water with a kneader. The mixture was extruded and granulated by a screw extruder (a hole diameter of a die of 1.4 mm), and the granulated product was dried by a fluidized-bed dryer and sieved.
mm (mesh opening) granular material was obtained. Subsequently, low density polyethylene (MFR = 6.6-7.4 g / 10 mi)
n) A coating material having a composition consisting of 27% by weight, talc (average particle size: 5 μm), 72% by weight, and ferric acetylacetone, 1% by weight, was coated with the above-mentioned granules in the same manner as in Granule Production Example 1. And an insecticide granule was obtained.

Granule Production Example 4 (Production of pesticide granule) 2.5 parts by weight of CPNIA (purity 70 parts by weight), 70 parts by weight of bentonite, 26.5 parts by weight of clay, and lignin sulfonic acid as pesticidal ingredients having an insecticidal action One part by weight of magnesium was uniformly mixed, and water was kneaded with a kneader. This mixture was extruded and granulated by a screw extrusion granulator (hole diameter of a die: 0.3 mm), and then the granulated product was dried by a fluidized bed drier and sieved to obtain a mixture of 0.09 to 0.85 mm. (Sieve opening) insecticide granules were obtained.

Granule Production Example 5 (Production of sterilized granules) 7-weight of 5-methyl-1,2,4-triazolo [3,4-b] benzothiazole (containing 75% by weight) as a pesticidal component having a bactericidal action. Parts, 70 parts by weight of bentonite, 22 parts by weight of clay, and 1 part by weight of sodium ligninsulfonate were uniformly mixed, kneaded by adding water in a kneader. The mixture was extruded and granulated by a screw extruder (diameter 0.8 mm), and the granulated product was sized in the same manner as in Granule Production Example 1. Next, the granulated product was dried by a fluidized bed drier, and then sieved to obtain a particle having a diameter of 1.
A granular material of 0 to 1.4 mm (mesh opening) was obtained. Using the granulated product and the spouted bed coating apparatus shown in FIG. 1, the granulated product was converted into low-density polyethylene (MFR = 6.6 to
A coating material composition consisting of 27% by weight (7.4 g / 10 min) and 72% by weight of talc (average particle size: 5 μm) was coated to a coverage of 20% to obtain a sterilizing granule. The manufacturing conditions are shown below. One-fluid nozzle: opening 0.4 mm full cone type Uncoated bioactive substance-containing granules: 3 kg Hot air temperature: 110 ± 2 ° C. Hot air volume: 4 m ³ / min Spray flow rate: 0.2 kg / min Starting from the point when the material temperature reached 70 ° C., spraying was performed for a predetermined time, and then drying was performed for 10 minutes.

Granule Production Example 6 (Production of sterilized granules) After extrusion granulation according to the above-mentioned production of the sterilized granules (granulation step), the granulated product was subjected to granulation without a melmerizer. Was dried in a fluidized bed drier and then sieved to obtain a sterilized granule of 0.85 to 1.4 mm (mesh size).

<Measurement of Particle Weight and Shape> The weight per particle of each of the insecticide granules and the bactericidal granules was determined by measuring the weight of 1,000 particles and dividing the value by 1,000. The value was determined and defined as the weight per grain.
The measurement of the minimum diameter / maximum diameter ratio of the insecticide granules and the sterilizing granules was performed using PIAS-IV manufactured by Pierce Co., Ltd. The measurement was carried out using 100 randomly picked particles, and the average value was defined as the ratio of minimum diameter / maximum diameter. Table 1 shows the measurement results of the weight per particle and the ratio of the minimum diameter to the maximum diameter.

[0038]

[Table 1]

Examples 1-4 and Comparative Examples 1-2 (Production of pesticide granule composition) The pesticide granules obtained in granule production examples 1-6 were mixed at the following ratios, and And the pesticide granule composition of Comparative Examples 1-2 was manufactured. Figure 1 for mixing
The apparatus was operated under a condition without spraying using a spouted bed coating apparatus. Prepared so that the total weight is 5kg, 20-30
C. was blown at a rate of 4 m ³ / min for 3 minutes to mix the air. After the completion of the mixing, it was extracted from the lower part of the jet tower.

Example 1 Insecticide granules: disinfectant granules = 1: 1 Example 2 Insecticide granules: disinfectant granules = 1: 1 Example 3 Insecticide granules: disinfectant granules = 1: 1 Example 4 Insecticide granules Agent: disinfecting granules = 1: 3 Comparative Example 1 Insecticide granules: disinfectant granules = 1: 1 Comparative Example 2 Insecticide granules: disinfectant granules = 1: 1

<Measurement of Pesticide Content> Pesticide components of CPNIA contained in Examples 1 to 4 and Comparative Examples 1 and 2 were analyzed before and after mixing. Prior to mixing, an analysis was performed on insecticide granules containing CPNIA. Table 1 shows the results. Then, using the analysis values, a proportional calculation based on the mixing ratio of the example and the comparative example was performed to obtain the content before mixing. Table 2 shows the results. Next, 10 samples of 10 g were randomly sampled and analyzed for each compound of each example and comparative example. The arithmetic mean value X and standard deviation S of the result are shown in Table 2 as values after mixing. In the analysis, the collected sample was extracted with a solvent after grinding,
The measurement was performed using a high-performance liquid chromatograph (486 tunable UV / VIS detector manufactured by Waters).

[0042]

[Table 2]

As is clear from the results of Tables 1 and 2, Examples 1 to 4 were practical with little change in the pesticide content before and after mixing. On the other hand, Comparative Examples 1 to 3 do not seem to fluctuate much when viewed from the average, but the standard deviation is twice or more as large as Examples 1 to 6, and the pesticide components are unevenly distributed. From this, it was found that there was a problem in practical use.

Example 5 (Test for confirming release function) A test for confirming the release function of the insecticide granules and the germicidal granules obtained in the above granule production examples was performed. The release confirmation test measures the time (release start time) until the pesticide is released from the particles inside to the outside due to the destruction of the coating. The test was performed as follows. Test tube with cap (12mm × 72m
1.5 mL of water was added to m), and one granule was charged per test tube, followed by capping. This is 100 for each insecticidal grain.
Using a tube (granules), the number of film collapses of each granule was counted under a constant water temperature of 25 ° C. Observation was performed daily from the start of the test, and the cumulative release rate was defined as the cumulative release rate.
Take the cumulative release rate on the vertical axis and the elapsed days on the horizontal axis,
A graph was created by plotting each data. Using this graph, the number of days from the start of the test to the 10% release (release suppression period) is set to “d1”, and 90 days thereafter.
The number of days until the% release (release period) is "d2",
The results are shown in Table 3.

[Table 3] Separately, 1 g of pesticide granules is poured into a certain amount of water,
It was immersed in water at a constant water temperature of 25 ° C., and after a certain period of time, the amount of the pesticide dissolved in the water was determined. The concentration of the pesticide in the aqueous solution was determined by high-performance liquid chromatography (48
6 tunable UV / VIS detector). As a result, the pesticide was not detected when the coating of the granule was not disintegrated, in other words, when the release rate was 0%,
It was confirmed that the pesticide did not elute through the coating.

Example 6 (Cultivation Example 1) 3000 g of black cultivated soil (made by Kumiai Kyoyusha Co., Ltd.) was used as floor soil for raising seedlings, and the inside size was 58 in length.
cm, 28cm wide, 3cm deep in a rice seedling raising box,
The surface is flattened and the pesticide granule formulation 100 of Example 1 is prepared.
g and 150 g of germinated seed rice (variety: Mori no Kuma) were sowed and applied uniformly and in layers. On this, cultivation soil 1 same as floor soil
The soil was covered with 000 g and well watered. The seedling raising boxes were raised at a temperature of 18 to 28 ° C for 20 days. Nursery management was in accordance with the conventional method except that watering was appropriately performed so that the surface layer did not dry.

Comparative Example 3 (Cultivation Example 2) Seedlings were grown in the same manner as in Example 6 except that 100 g of the pesticide granule composition of Comparative Example 1 was used.

Reference Example A seedling was grown in the same manner as in Cultivation Example 1 except that no pesticide granule formulation was added. After raising the seedlings, they were transplanted to miniature paddy fields in Minamata City, Kumamoto Prefecture, and cultivated according to the conventional cultivation method.

Example 7 (Cultivation Example 3) Using the seedling box of the reference example, immediately before transplanting, apply 100 g of the pesticide granule composition of Example 2 / the seedling raising box from the top of the seedling raising box, and transplant the seedling. Cultivation was carried out according to.

Comparative Example 4 (Cultivation Example 4) The seedling box of the Reference Example was used, and immediately after transplanting, 100 g of the pesticide granule composition of Comparative Example 1 / the seedling raising box was applied from above the seedling raising box, and transplanted. Cultivation was carried out according to.

As a result of observing the seedling growth in Example 6, Comparative Example 3 and Reference Example, Example 6 was able to grow uniform seedlings similar to the Reference Example, whereas Comparative Example 3 was able to raise seedlings. And some showed signs of phytotoxicity. Also,
When the state of rice during the cultivation period was observed for Example 7, Comparative Example 4, and Reference Example, the Reference Example in which control was performed in accordance with the conventional method with Example 7 showed the same growth, but the Comparative Example Sample No. 4 showed signs of insect damage from around one month after transplantation, and was presumed to be affected by variations in the pesticide components. In addition,
The seedling of Example 6 was also transplanted at the same time, but the rice grew as in Reference Example and Example 7.

[0051]

According to the present invention, the application efficiency of the biologically active substance can be improved and the labor of the application operation can be reduced. In particular, if it is a mixture of pesticide granules having a time release type sustained release function, without causing growth disorders in the early stage of cultivation,
Since the whole or most of the pesticide required during the cultivation period can be applied simultaneously with sowing or transplanting, the application of the pesticide can be significantly reduced without causing harm. In addition, the pesticide granule formulation having the optimized release characteristics can be provided at a low cost by covering the pesticide which may cause phytotoxicity at the same time of sowing and not covering the pesticide which has little effect.

[Brief description of the drawings]

FIG. 1 is an explanatory view of a spouted bed coating apparatus.

[Explanation of Signs] 1: Jet tower 2: Spray nozzle 3: Core material 4: Hot air supply pipe 5: Coating material introduction pipe 6: Guide pipe 7: Extraction port

Claims (9)

[Claims] 1. A blend of two or more biologically active substance-containing granules containing one or more biologically active substances, wherein one of said granules is
A formulation of granules containing a biologically active substance, characterized in that the average weight per grain is 0.1 to 5 mg. 2. The blend of granules containing a bioactive substance according to claim 1, wherein the bioactive substance is an agrochemical component having both an insecticidal action and / or a bactericidal action. 3. The bioactive substance-containing granule according to claim 1, wherein the bioactive substance-containing granule has a minimum diameter / maximum diameter ratio of 0.7 or more. The composition of. 4. The method according to claim 1, wherein at least one of the bioactive substance-containing granules has a surface coated with a coating material containing a resin. Formulation of bioactive substance-containing granules. 5. The bioactive substance-containing granular material according to claim 4, wherein the coating material contains one or more powders selected from the group consisting of a water-insoluble powder and a poorly water-soluble powder. The composition of. 6. The release function is set so that the bioactive substance-containing particulate has a period during which the release of the bioactive substance is suppressed after application and a period during which the bioactive substance is gradually released after the elapse of the period. 6. A blend of bioactive substance-containing granules according to any of the preceding claims, characterized in that they are coated bioactive substance-containing granules. 7. The formulation of granules containing a bioactive substance according to claim 1, wherein the bioactive substance is systemic. 8. A method for cultivating agricultural crops, which comprises applying the blend of the biologically active substance-containing granules according to any one of claims 1 to 7 before sowing or transplanting. 9. The method according to claim 8, wherein the crop is rice.