JP2001139489A - Cosmetic composition - Google Patents
Cosmetic compositionInfo
- Publication number
- JP2001139489A JP2001139489A JP32624999A JP32624999A JP2001139489A JP 2001139489 A JP2001139489 A JP 2001139489A JP 32624999 A JP32624999 A JP 32624999A JP 32624999 A JP32624999 A JP 32624999A JP 2001139489 A JP2001139489 A JP 2001139489A
- Authority
- JP
- Japan
- Prior art keywords
- genus
- extract
- acid
- fruit
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- GNBVPFITFYNRCN-UHFFFAOYSA-M sodium thioglycolate Chemical compound [Na+].[O-]C(=O)CS GNBVPFITFYNRCN-UHFFFAOYSA-M 0.000 description 1
- 229940046307 sodium thioglycolate Drugs 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- UENNEPPWFZYINW-UHFFFAOYSA-M sodium;2-amino-4,6-dinitrophenolate Chemical compound [Na+].NC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1[O-] UENNEPPWFZYINW-UHFFFAOYSA-M 0.000 description 1
- KJCLYACXIWMFCC-UHFFFAOYSA-M sodium;5-benzoyl-4-hydroxy-2-methoxybenzenesulfonate Chemical compound [Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 KJCLYACXIWMFCC-UHFFFAOYSA-M 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- JEUDXCQTVURKDL-UHFFFAOYSA-L strontium;2-sulfanylacetate Chemical compound [Sr+2].[O-]C(=O)CS.[O-]C(=O)CS JEUDXCQTVURKDL-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
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- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 229960000368 sulisobenzone Drugs 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
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- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- IFYFNVDTVZKNBZ-UHFFFAOYSA-N tetradecyl 2-hydroxybenzoate Chemical compound CCCCCCCCCCCCCCOC(=O)C1=CC=CC=C1O IFYFNVDTVZKNBZ-UHFFFAOYSA-N 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
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- 229940116362 tragacanth Drugs 0.000 description 1
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- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- 235000001019 trigonella foenum-graecum Nutrition 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000012079 tsuwabuki Nutrition 0.000 description 1
- 244000215641 tsuwabuki Species 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 150000003669 ubiquinones Chemical group 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- GAAKLDANOSASAM-UHFFFAOYSA-N undec-10-enoic acid;zinc Chemical compound [Zn].OC(=O)CCCCCCCCC=C GAAKLDANOSASAM-UHFFFAOYSA-N 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 150000003697 vitamin B6 derivatives Chemical class 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical group 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Chemical group 0.000 description 1
- 150000003721 vitamin K derivatives Chemical group 0.000 description 1
- 235000019143 vitamin K2 Nutrition 0.000 description 1
- 239000011728 vitamin K2 Substances 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 229940010250 vitamin k 2 Drugs 0.000 description 1
- 229940041603 vitamin k 3 Drugs 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 235000001459 whitebark Nutrition 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
- HLDCSYXMVXILQC-UHFFFAOYSA-N xenysalate Chemical compound CCN(CC)CCOC(=O)C1=CC=CC(C=2C=CC=CC=2)=C1O HLDCSYXMVXILQC-UHFFFAOYSA-N 0.000 description 1
- 229960003434 xenysalate Drugs 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000009538 yokuinin Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
- 229940098697 zinc laurate Drugs 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 229940012185 zinc palmitate Drugs 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229940057977 zinc stearate Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229940118257 zinc undecylenate Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- ZNVKGUVDRSSWHV-UHFFFAOYSA-L zinc;4-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=C(S([O-])(=O)=O)C=C1.OC1=CC=C(S([O-])(=O)=O)C=C1 ZNVKGUVDRSSWHV-UHFFFAOYSA-L 0.000 description 1
- LTBBHPKPFHCPTL-UHFFFAOYSA-L zinc;carbonotrithioate Chemical compound [Zn+2].[S-]C([S-])=S LTBBHPKPFHCPTL-UHFFFAOYSA-L 0.000 description 1
- GPYYEEJOMCKTPR-UHFFFAOYSA-L zinc;dodecanoate Chemical compound [Zn+2].CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O GPYYEEJOMCKTPR-UHFFFAOYSA-L 0.000 description 1
- GJAPSKMAVXDBIU-UHFFFAOYSA-L zinc;hexadecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O GJAPSKMAVXDBIU-UHFFFAOYSA-L 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、アルテア、アルニ
カ、ボダイジュ、ボタンピからの4種植物の混合抽出物
を含有する抗アレルギー剤、ヒスタミン遊離抑制剤又は
化粧料組成物への応用に関するものである。TECHNICAL FIELD The present invention relates to an application to an antiallergic agent, a histamine release inhibitor or a cosmetic composition containing a mixed extract of four kinds of plants from Altea, Arnica, Bodaiju and Botanpi. .
【0002】その利用分野は、例えば、各種の外用製剤
類(動物用に使用する製剤も含む)全般において利用で
き、具体的には、アンプル、カプセル、丸剤、錠剤、粉
末、顆粒、固形、液体、ゲル又は気泡の1)医薬品類、2)
医薬部外品類、3)局所用又は全身用の皮膚用化粧品類
(例えば、化粧水、乳液、クリーム、軟膏、ローショ
ン、オイル、パックなどの基礎化粧料、洗顔料や皮膚洗
浄料、マッサージ用剤、クレンジング用剤、除毛剤、脱
毛剤、髭剃り処理料、アフターシェーブローション、プ
レショーブローション、シェービングクリーム、ファン
デーション、口紅、頬紅、アイシャドウ、アイライナ
ー、マスカラなどのメークアップ化粧料、香水類、パッ
プ剤、プラスター剤、テープ剤、シート剤、貼付剤、エ
アゾール剤など)、4)頭皮・頭髪に適用する薬用又は/
及び化粧用の製剤類(例えば、シャンプー剤、リンス
剤、トリートメント剤、パーマネント液、染毛料、整髪
料、ヘアートニック剤、育毛・養毛料、パップ剤、プラ
スター剤、テープ剤、シート剤、貼付剤、エアゾール剤
など)、5)浴湯に投じて使用する浴用剤、6)その他、腋
臭防止剤や消臭剤、防臭剤、衛生用品、衛生綿、ウエッ
トティシュ、口中清涼剤(例えば、歯磨き、マウスウオ
ッシュなど)などが挙げられる。[0002] The field of application is, for example, applicable to all kinds of external preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) of liquid, gel or air bubbles
Quasi-drugs, 3) topical or systemic skin cosmetics (e.g., basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents) , Cleansing agents, depilatory, depilatory, shaving treatment, aftershave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eyeshadow, eyeliner, makeup cosmetics such as mascara, perfumes, Cataplasms, plasters, tapes, sheets, patches, aerosols, etc.), 4) Medicinal or /
And cosmetic preparations (eg, shampoos, rinses, treatments, permanent liquids, hair dyes, hair dressings, hair tonics, hair growth / hair restoration, cataplasms, plasters, tapes, sheets, patches) , Aerosols, etc.), 5) bath agents for use in bath water, 6) other, axillary deodorants and deodorants, deodorants, hygiene products, sanitary cotton, wet tissues, mouth fresheners (eg toothpaste, Mouse wash, etc.).
【0003】[0003]
【従来の技術】今日、最近の環境条件の悪化や生活様式
の変化、社会生活の複雑化に伴うストレスの増加などに
より、花粉症・アレルギー性鼻炎・気管支喘息・アトピ
ー性皮膚炎・薬物による蕁麻疹などのアレルギー性疾患
や、肌荒れ、乾燥肌などに悩み苦しむ人が増加してい
る。特に、アトピー性皮膚炎は子供のみならず、成人に
及ぶまでの広い年代層でその増加が叫ばれ、現代病のひ
とつとして注目されている。2. Description of the Related Art In recent years, owing to recent deterioration of environmental conditions, changes in lifestyles, and increased stress due to the complication of social life, hay fever, allergic rhinitis, bronchial asthma, atopic dermatitis, drug urticity have occurred. The number of people suffering from allergic diseases such as measles, rough skin, and dry skin is increasing. In particular, atopic dermatitis has been attracting attention as one of the modern illnesses, as its increase is screaming not only in children but also in a wide range of ages up to adults.
【0004】本来、生体には、体内に侵入した異物(細
菌、花粉、ダニなど:抗原)を排除するために、それに
対抗する生体成分(抗体、リンパ球など)を産生して体
を守るように働く免疫機能を備えている。ところが、時
としてその反応が過敏になるために身体に有害となり、
種々の病気の原因となってしまうことがある。この免疫
機能による障害反応をアレルギーと呼んでおり、4つの
型に分類されている。[0004] Originally, in order to eliminate foreign substances (antigens such as bacteria, pollen, mites, etc.) which have entered the body, it is necessary to produce biological components (antibodies, lymphocytes, etc.) to protect the body. It has an immune function that works. However, sometimes the reaction becomes too sensitive and harmful to the body,
It can cause various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into four types.
【0005】免疫系を構成する中心的細胞は、主に骨
髄、胸腺、脾臓、リンパ節、血液などに存在するB細
胞、T細胞と呼ばれる2種類のリンパ球の集団である。
B細胞は体液性免疫(I〜III型アレルギー)に関与し、
抗原に反応して形質細胞(抗体産生細胞)に分化、増殖
し、抗体を細胞外に分泌するようになる。又、T細胞は
主に細胞性免疫(IV型アレルギー)に関与し、抗原と反
応すると、分化、増殖し、抗原を破壊する活性化T細胞
になる。[0005] The central cells constituting the immune system are a group of two types of lymphocytes called B cells and T cells mainly present in bone marrow, thymus, spleen, lymph nodes, blood and the like.
B cells are involved in humoral immunity (type I-III allergy)
In response to the antigen, the cells differentiate and proliferate into plasma cells (antibody-producing cells), and secrete the antibody outside the cells. In addition, T cells are mainly involved in cell-mediated immunity (type IV allergy). When they react with an antigen, they become differentiated, proliferate, and become activated T cells that destroy the antigen.
【0006】I型アレルギー反応は、最も発症頻度が多
い型であり、主に免疫グロブリンE(IgE)抗体が関与
している。その発症過程は、外来性の抗原に対してB細
胞からIgE抗体が産生され、肥満細胞や好塩基球にIgE抗
体が固着し感作が成立する第1段階、抗原が再び接触し
た感作細胞からヒスタミン、セロトニン、SRS−Aな
どの化学伝達物質が遊離する第2段階、遊離した化学伝
達物質が平滑筋の収縮、血管透過性の亢進、浮腫、神経
刺激などを引き起こしたりして、各種のアレルギー症状
を発現する第3段階に大別される。[0006] Type I allergic reactions are the most frequent type, and mainly involve immunoglobulin E (IgE) antibodies. The onset process is the first step in which IgE antibodies are produced from B cells against exogenous antigens, the IgE antibodies adhere to mast cells and basophils, and sensitization is established. Histamine, serotonin, SRS-A and other chemical mediators are released from the second stage, the released chemical mediators cause smooth muscle contraction, increased vascular permeability, edema, nerve stimulation, etc. It is roughly divided into the third stage of developing allergic symptoms.
【0007】II型アレルギー反応はIgGやIgM抗体によっ
て組織の細胞が破壊されて起こる障害反応である。抗体
が抗原細胞に結合すると、補体系(抗体のエフェクター
作用によって活性化して、抗原の細胞を殺したり、貪食
細胞による抗原の分解を著しく促進したりする血清タン
パク質の系)が連鎖的に活性化され、細胞膜を破壊する
複合体が形成されるために、細胞が破壊される。又、活
性化された補体系の成分が細胞に結合すると、多形核白
血球やマクロファージなどの貪食細胞によって抗原細胞
は捕捉されて分解し、除去される。一方、補体系の活性
化の過程で、貪食細胞による抗原の分解を著しく促進す
る作用を有するアナフィラトキシンと呼ばれる物質が生
じる。これは毛細血管の透過性を増大させる作用、平滑
筋を収縮させる作用、肥満細胞からヒスタミンを遊離さ
せる作用も持っているため、過剰に生成されると各種の
アレルギー症状が発現することとなる。A type II allergic reaction is a disorder reaction that occurs when cells in a tissue are destroyed by IgG or IgM antibodies. When an antibody binds to an antigen cell, the complement system (a serum protein system that is activated by the effector action of the antibody to kill the antigen cell or significantly accelerate the degradation of the antigen by phagocytic cells) is chain-activated. The cells are destroyed because a complex is formed that destroys the cell membrane. When the activated components of the complement system bind to cells, antigen cells are captured by phagocytic cells such as polymorphonuclear leukocytes and macrophages, decomposed, and removed. On the other hand, during the activation of the complement system, a substance called anaphylatoxin, which has an action of significantly promoting the degradation of antigens by phagocytes, is generated. It also has the effect of increasing the permeability of capillaries, the effect of contracting smooth muscle, and the effect of releasing histamine from mast cells, so that when it is excessively produced, various allergic symptoms will be manifested.
【0008】III型アレルギー反応は主にIgG抗体によっ
て起こるが、その発症は補体系や多形核白血球などの多
くの因子が関与する複雑な機構で起こる。抗原に抗体が
結合して生成した抗原抗体結合物は血管、腎臓、関節、
皮膚などの組織に沈着して補体系を活性化する。結合物
の量が多いときには、補体系が過度に活性化してアナフ
ィラトキシンが生じ、そのために血管透過性が増大した
りして炎症が起こる。又、アナフィラトキシンの作用で
貪食細胞が抗原抗体結合物を除去しようと働く際に、リ
ソソームの脱顆粒反応が起こり、リソソーム内のプロテ
アーゼなど多種類の加水分解酵素が細胞外に放出される
ため、組織や細胞の障害が進み、III型アレルギーが発
症する。[0008] Type III allergic reactions are mainly caused by IgG antibodies, but their onset is caused by a complex mechanism involving many factors such as the complement system and polymorphonuclear leukocytes. Antigen-antibody conjugates produced by binding antibodies to antigens are used in blood vessels, kidneys, joints,
It deposits on tissues such as the skin and activates the complement system. When the amount of conjugate is high, the complement system is over-activated to produce anaphylatoxins, which may increase vascular permeability or cause inflammation. Also, when phagocytic cells try to remove antigen-antibody conjugates by the action of anaphylatoxin, lysosomal degranulation reaction occurs, and various types of hydrolases such as proteases in lysosomes are released outside the cells, Tissue and cell damage progresses and type III allergy develops.
【0009】I〜III型アレルギー反応がいずれも体液性
免疫による反応で、抗原と接触後2〜3分で反応が現
れ、十数分で反応が最高となるため、即時型と呼ばれる
のに対し、IV型アレルギー反応は数時間後に現れ、最高
に達するには48〜72時間かかることから、遅延型アレル
ギーと呼ばれる。このアレルギー反応は細胞性免疫によ
る反応で、T細胞の一部が抗原と反応して活性化T細胞
となり、これが再び抗原と反応すると、リンホカインと
呼ばれる種々の炎症性因子(マクロファージ走化性因
子、リンパ球遊走因子、マクロファージ活性化因子、血
管透過性因子など)を放出する。これらにより抗原を排
除するように働くが、この反応が過度に進行すると障害
反応としてアレルギーが発症する。[0009] Type I-III allergic reactions are all reactions by humoral immunity, a reaction appears 2-3 minutes after contact with the antigen, and the response is highest in more than 10 minutes. Type IV allergic reactions appear after a few hours and are called delayed allergies because they take 48-72 hours to reach a maximum. This allergic reaction is a reaction by cell-mediated immunity. A part of T cells reacts with an antigen to become activated T cells, and when this reacts with the antigen again, various inflammatory factors called lymphokines (macrophage chemotactic factor, Release lymphocyte chemotactic factors, macrophage activating factors, vascular permeability factors, etc.). These act to eliminate the antigen, but if this reaction progresses excessively, allergy develops as a disorder reaction.
【0010】[0010]
【発明が解決しようとする課題】従来より使用されてい
る抗アレルギー剤の多くは、作用点が比較的明らかなI
型アレルギー反応によって引き起こされる疾患に対する
薬剤である。例えば、平滑筋を弛緩させる鎮痙薬や毛細
血管の透過性の亢進を抑制する交感神経興奮薬、さらに
は抗ヒスタミン薬などが挙げられるが、これらはいずれ
も第3段階に作用する対照的治療薬であり、しかも、そ
のほとんどが合成医薬品であり、副作用の点で問題があ
った。Many of the conventionally used anti-allergic agents have an action point relatively clear.
It is a drug for diseases caused by type allergic reactions. Examples include antispasmodics that relax smooth muscle, sympathomimetics that suppress the increase in capillary permeability, and antihistamines, all of which are contrasting therapeutic agents that act in the third stage. Most of them are synthetic pharmaceuticals, and have a problem in side effects.
【0011】一方、現在最も活発に行われているI型ア
レルギー疾患に関与する抗アレルギー剤の研究は、化学
伝達物質の遊離を抑制する薬剤、遊離された化学伝達物
質に対して拮抗作用を示す薬剤など、第2段階を抑制す
る薬剤の開発であるが、充分な効力を有するものは見つ
かっておらず、又、II、III型及びIV型アレルギー反応
に対する特異的な抗アレルギー剤も見い出されていない
のが現状である。On the other hand, the most active research on antiallergic drugs involved in type I allergic diseases at present is a drug which inhibits release of chemical mediators, and exhibits an antagonistic effect on the released chemical mediators. Although the development of drugs that suppress the second stage, such as drugs, has not been found to have sufficient efficacy, and specific antiallergic drugs against type II, III and IV allergic reactions have also been found. There is no present.
【0012】[0012]
【課題を解決するための手段】このような事情に鑑み、
本発明者らは、抗アレルギー作用に優れ、かつ副作用が
なく、皮膚に緩和である物質について、天然物である植
物からのスクリーニングを試みた。その結果、アルテ
ア、アルニカ、ボダイジュ、ボタンピからの4種植物混
合抽出物に、強いヒスタミン遊離抑制作用を有すること
を見い出し、又、これらをを含有してなるアレルギー性
の皮膚炎症疾患(例えば、発赤、浮腫、湿疹、腫脹な
ど)や、アトピー性皮膚炎、あるいは肌荒れといった皮
膚・頭皮のトラブルの予防や改善に優れ、安全性の高い
化粧料組成物を提供することをもって、本発明を完成す
るに至った。[Means for Solving the Problems] In view of such circumstances,
The present inventors have tried to screen substances that are excellent in antiallergic action, have no side effects, and are gentle on the skin from plants that are natural products. As a result, it was found that a mixed extract of four species from Althea, Arnica, Bodaiju and Pontopia has a strong histamine release inhibitory action, and that allergic skin inflammatory diseases containing these (for example, redness) Edema, eczema, swelling, etc.), atopic dermatitis, and skin and scalp troubles such as rough skin, which are excellent in prevention and improvement, and by providing a highly safe cosmetic composition. Reached.
【0013】[0013]
【発明の実施の形態】尚、本発明で使用する「アルテア
(ビロードアオイ、ウスベニタチアオイ、マロウ)」と
は、アオイ科(Malvaceae)、タチアオイ属(Althaea.L)の
植物:ビロードアオイ(Althaea officinalis)の根
茎、葉、幹、枝を用いる。DETAILED DESCRIPTION OF THE INVENTION The term "Altea (velvet mallow)" used in the present invention refers to a plant of the family Malvaceae (Malvaceae) or the genus Talaoi (Althaea.L): velvet mallow (Althaea). officinalis) using rhizomes, leaves, trunks and branches.
【0014】「アルニカ」とは、キク科(Composita
e)、ウサギギク属(Arnica.L)の植物:アルニカ(Arn
ica montama.L)の根、花を用いるが、その他、同属植
物のアメリカアルニカ(A.fulgens Pursh)、A.sororia
Greene、A.cordifolia Hooker、ウサギギク(A.unalasc
hensis.L)の根や花などを用いることもできる。"Arnica" means asteraceae (Composita
e), a plant of the genus Agaricus (Arnica.L): Arnica (Arnica
ica montama.L) roots and flowers, but other congeners such as American Arnica (A.fulgens Pursh) and A.sororia
Greene, A. cordifolia Hooker, Rabbit (A. unalasc)
hensis.L) can also be used.
【0015】「ボダイジュ:菩提樹」とは、シナノキ科
(Tiliaceae)、シナノキ属(Tilia)の植物:フユボダイジ
ュ(T.cordata Mill,;T.ulmifolia Scop.;T.parvifolia
Ehrh.)の花、果実、樹皮などを用いるが、その他近縁植
物:ナツボダイジュ(T.platyphyllos)、セイヨウシナ
ノキ(T.×europaea L.)などの花、果実、樹皮を用い
ることができる。"Bodyju: Bodhi tree" means linden family
(Tiliaceae), a plant of the genus Tilia: T.cordata Mill ,; T.ulmifolia Scop.; T.parvifolia
Ehrh.) Flowers, fruits, bark and the like, but other closely related plants: flowers, fruits and bark such as T. platyphyllos and T. xeuropaea L. can also be used.
【0016】「ボタンピ:牡丹皮」とは、ボタン科(Pae
oniaccae)、ボタン属(Paeonia)の植物:ボタン(=ハツ
カグサ、フカミグサ、ナトリグサ)「Paeonia moutan S
ims(=Paeonia suffruticosa Andrews)」の根皮、根
茎、根を用いる。"Bonpi: Peony" is a family of Pae (Pae)
oniaccae), Plants of the genus Paeonia: Buttons (= Chagusa, Fucamigusa, Natrigusa) "Paeonia moutan S
Use the root bark, rhizome and root of "ims (= Paeonia suffruticosa Andrews)".
【0017】本発明で使用するアルテア、アルニカ、ボ
ダイジュ、ボタンピの抽出物とは、各々の植物体の各種
部位(花、果実、葉、枝、幹、茎、樹皮、根茎、根皮、
根など)をそのまま或い粉砕後搾取したもの。又は、そ
のまま或いは粉砕後、溶媒で抽出したものを用いる。The extracts of Altea, Arnica, Bodaiju and Pontopi used in the present invention include various parts of each plant (flower, fruit, leaf, branch, stem, stem, bark, rhizome, root bark,
Roots, etc.) are crushed and then squeezed. Alternatively, those extracted with a solvent as it is or after pulverization are used.
【0018】植物抽出物の抽出溶媒としては、水、アル
コール類(例えば、メタノール、無水エタノール、エタ
ノールなどの低級アルコール、或いはプロピレングリコ
ール、1,3-ブチレングリコールなどの多価アルコー
ル)、アセトンなどのケトン類、エチルエーテル、ジオ
キサン、アセトニトリル、酢酸エチルエステルなどのエ
ステル類、キシレン、ベンゼン、クロロホルムなどの有
機溶媒を、単独或いは2種類以上を任意に組み合わせて
使用することができる。更に、各々の植物を上記抽出溶
媒で抽出した後、4種の植物抽出物を組み合わせたも
の。又、植物4種を最初から混合し、上記の抽出溶媒で
抽出したものも使用できる。Examples of the extraction solvent for the plant extract include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), acetone and the like. Ketones, esters such as ethyl ether, dioxane, acetonitrile, and ethyl acetate, and organic solvents such as xylene, benzene, and chloroform can be used alone or in any combination of two or more. Further, after extracting each plant with the above-mentioned extraction solvent, four kinds of plant extracts are combined. Moreover, what mixed four kinds of plants from the beginning and extracted with the above-mentioned extraction solvent can also be used.
【0019】尚、製造方法は特に制限されるものはない
が、通常、常温、常圧下での溶媒の沸点の範囲であれば
良く、抽出後は濾過又はイオン交換樹脂を用い、吸着・
脱色・精製して溶液状、ペースト状、ゲル状、粉末状と
すれば良い。更に多くの場合は、そのままの状態で利用
できるが、必要ならば、その効果に影響のない範囲で更
に脱臭、脱色などの精製処理を加えても良く、脱臭・脱
色などの精製処理手段としては、活性炭カラムなどを用
いれば良く、抽出物質により一般的に適用される通常の
手段を任意に選択して行えば良い。The production method is not particularly limited, but may be usually within the range of the boiling point of the solvent at normal temperature and normal pressure.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.
【0020】又、アルテア、アルニカ、ボダイジュ、ボ
タンピの4種植物混合抽出物は応用する抗アレルギー
剤、ヒスタミン遊離抑制剤又は化粧料組成物の剤型・形
態により乾燥、濃縮、或いは希釈などを任意に行い調整
すれば良い。The mixed extract of the four kinds of plants, Althea, Arnica, Bodaiju and Pontopia, may be dried, concentrated or diluted depending on the type and form of the antiallergic agent, histamine release inhibitor or cosmetic composition to be applied. And adjust it.
【0021】本発明のアルテア、アルニカ、ボダイジ
ュ、ボタンピの4種植物混合抽出物は、そのまま抗アレ
ルギー剤、ヒスタミン遊離抑制剤として利用できる他、
化粧料組成物へ含有できるが、その含有量は特に規定さ
れるものではなく、抗アレルギー剤、ヒスタミン遊離抑
制剤、化粧料組成物の剤型の種類、品質、期待される作
用の程度によって若干異なり、通常、0.001重量%以上
(以下、%で表わす)好ましくは0.1〜10%が良い。
尚、含有量が0.001%より少ないと効果が充分期待でき
ない。The extract of four species of plant mixture of Artea, Arnica, Bodaiju and Pontopi of the present invention can be used as it is as an antiallergic agent and a histamine release inhibitor.
Although it can be contained in the cosmetic composition, its content is not particularly limited, and may vary depending on the antiallergic agent, histamine release inhibitor, type of cosmetic composition, quality, expected degree of action. On the contrary, the content is usually 0.001% by weight or more (hereinafter, expressed by%), preferably 0.1 to 10%.
If the content is less than 0.001%, the effect cannot be expected sufficiently.
【0022】尚、本発明の抗アレルギー剤、ヒスタミン
遊離抑制剤又は化粧料組成物は、前記の必須物質に加え
必要に応じ、本発明の効果を損なわない範囲内で、下記
に例示する成分や添加剤を任意に選択・併用して製造す
ることができる。The antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention may further comprise, if necessary, the components listed below as long as the effects of the present invention are not impaired. The additives can be arbitrarily selected and used in combination.
【0023】(1)各種油脂類 アボガド油、アーモンド油、ウイキョウ油、エゴマ油、
オリーブ油、オレンジ油、オレンジラファー油、ゴマ
油、カカオ脂、カミツレ油、カロット油、キューカンバ
ー油、牛脂脂肪酸、ククイナッツ油、サフラワー油、シ
ア脂、液状シア脂、大豆油、ツバキ油、トウモロコシ
油、ナタネ油、パーシック油、ヒマシ油、綿実油、落花
生油、タートル油、ミンク油、卵黄油、パーム油、パー
ム核油、モクロウ、ヤシ油、牛脂、豚脂又はこれら油脂
類の水素添加物(硬化油等)など。(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )Such.
【0024】(2)ロウ類 ミツロウ、カルナバロウ、鯨ロウ、ラノリン、液状ラノ
リン、還元ラノリン、硬質ラノリン、カンデリラロウ、
モンタンロウ、セラックロウ、ライスワックス、スクワ
レン、スクワラン、プリスタンなど。(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.
【0025】(3)鉱物油 流動パラフィン、ワセリン、パラフィン、オゾケライ
ド、セレシン、マイクロクリスタンワックスなど。(3) Mineral oils Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.
【0026】(4)脂肪酸類 ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン
酸、ベヘン酸、オレイン酸、12-ヒドロキシステアリン
酸、ウンデシレン酸、トール油、ラノリン脂肪酸などの
天然脂肪酸、イソノナン酸、カプロン酸、2-エチルブタ
ン酸、イソペンタン酸、2-メチルペンタン酸、2-エチル
ヘキサン酸、イソペンタン酸などの合成脂肪酸。(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil and lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.
【0027】(5)アルコール類 エタノール、イソピロパノール、ラウリルアルコール、
セタノール、ステアリルアルコール、オレイルアルコー
ル、ラノリンアルコール、コレステロール、フィトステ
ロールなどの天然アルコール、2-ヘキシルデカノール、
イソステアリルアルコール、2-オクチルドデカノールな
どの合成アルコール。(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.
【0028】(6)多価アルコール類 酸化エチレン、エチレングリコール、ジエチレングリコ
ール、トリエチレングリコール、エチレングリコールモ
ノエチルエーテル、エチレングリコールモノブチルエー
テル、ジエチレングリコールモノメチルエーテル、ジエ
チレングリコールモノエチルエーテル、ポリエチレング
リコール、酸化プロピレン、プロピレングリコール、ポ
リプロピレングリコール、1,3-ブチレングリコール、グ
リセリン、ペンタエリトリトール、ソルビトール、マン
ニトールなど。(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.
【0029】(7)エステル類 ミリスチン酸イソプロピル、パルミチン酸イソプロピ
ル、ステアリン酸ブチル、ラウリン酸ヘキシル、ミリス
チン酸ミリスチル、オレイン酸オレイル、オレイン酸デ
シル、ミリスチン酸オクチルドデシル、ジメチルオクタ
ン酸ヘキシルデシル、乳酸セチル、乳酸ミリスチル、フ
タル酸ジエチル、フタル酸ジブチル、酢酸ラノリン、モ
ノステアリン酸エチレングリコール、モノステアリン酸
プロピレングリコール、ジオレイン酸プロピレングリコ
ールなど。(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.
【0030】(8)金属セッケン類 ステアリン酸アルミニウム、ステアリン酸マグネシウ
ム、ステアリン酸亜鉛、ステアリン酸カルシウム、パル
ミチン酸亜鉛、ミリスチン酸マグネシウム、ラウリン酸
亜鉛、ウンデシレン酸亜鉛など。(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.
【0031】(9)ガム質、糖類又は水溶性高分子化合物 アラビアゴム、ベンゾインゴム、ダンマルゴム、グアヤ
ク脂、アイルランド苔、カラヤゴム、トラガントゴム、
キャロブゴム、クインシード、寒天、カゼイン、乳糖、
果糖、ショ糖又はそのエステル、トレハロース又はその
誘導体、デキストリン、ゼラチン、ペクチン、デンプ
ン、カラギーナン、カルボキシメチルキチン又はキトサ
ン、エチレンオキサイドなどのアルキレン(C2〜C4)
オキサイドが付加されたヒドロキシアルキル(C2〜C
4)キチン又はキトサン、低分子キチン又はキトサン、
キトサン塩、硫酸化キチン又はキトサン、リン酸化キチ
ン又はキトサン、アルギン酸又はその塩、ヒアルロン酸
又はその塩、コンドロイチン硫酸又はその塩、ヘパリ
ン、エチルセルロース、メチルセルロース、カルボキシ
メチルセルロース、カルボキシエチルセルロース、カル
ボキシエチルセルロースナトリウム、ヒドロキシエチル
セルロース、ヒドロキシプロピルセルロース、ニトロセ
ルロース、結晶セルロース、ポリビニルアルコール、ポ
リビニルメチルエーテル、ポリビニルピロリドン、ポリ
ビニルメタアクリレート、ポリアクリル酸塩、ポリエチ
レンオキサイドやポリプロピレンオキサイドなどのポリ
アルキレンオキサイド又はその架橋重合物、カルボキシ
ビニルポリマー、ポリエチレンイミンなど。(9) Gum, saccharide or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene such as ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide or polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.
【0032】(10)界面活性剤 アニオン界面活性剤(アルキルカルボン酸塩、アルキル
スルホン酸塩、アルキル硫酸エステル塩、アルキルリン
酸エステル塩)、カチオン界面活性剤(アルキルアミン
塩、アルキル四級アンモニウム塩)、両性界面活性剤:
カルボン酸型両性界面活性剤(アミノ型、ベタイン
型)、硫酸エステル型両性界面活性剤、スルホン酸型両
性界面活性剤、リン酸エステル型両性界面活性剤、非イ
オン界面活性剤(エーテル型非イオン界面活性剤、エー
テルエステル型非イオン界面活性剤、エステル型非イオ
ン界面活性剤、ブロックポリマー型非イオン界面活性
剤、含窒素型非イオン界面活性剤)、その他の界面活性
剤(天然界面活性剤、タンパク質加水分解物の誘導体、
高分子界面活性剤、チタン・ケイ素を含む界面活性剤、
フッ化炭素系界面活性剤)など。(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).
【0033】(11)各種ビタミン類 ビタミンA群:レチノール、レチナール(ビタミンA
1)、デヒドロレチナール(ビタミンA2)、カロチ
ン、リコピン(プロビタミンA)、ビタミンB群:チア
ミン塩酸塩、チアミン硫酸塩(ビタミンB1)、リボフ
ラビン(ビタミンB2)、ピリドキシン(ビタミンB
6)、シアノコバラミン(ビタミンB12)、葉酸類、
ニコチン酸類、パントテン酸類、ビオチン類、コリン、
イノシトール類、ビタミンC群:ビタミンC酸又はその
誘導体、ビタミンD群:エルゴカルシフェロール(ビタ
ミンD2)、コレカルシフェロール(ビタミンD3)、
ジヒドロタキステロール、ビタミンE群:ビタミンE又
はその誘導体、ユビキノン類、ビタミンK群:フィトナ
ジオン(ビタミンK1)、メナキノン(ビタミンK
2)、メナジオン(ビタミンK3)、メナジオール(ビ
タミンK4)、その他、必須脂肪酸(ビタミンF)、カ
ルニチン、フェルラ酸、γ−オリザノール、オロット
酸、ビタミンP類(ルチン、エリオシトリン、ヘスペリ
ジン)、ビタミンUなど。(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.
【0034】(12)各種アミノ酸類 バリン、ロイシン、イソロイシン、トレオニン、メチオ
ニン、フェニルアラニン、トリプトファン、リジン、グ
リシン、アラニン、アスパラギン、グルタミン、セリ
ン、システイン、シスチン、チロシン、プロリン、ヒド
ロキシプロリン、アスパラギン酸、グルタミン酸、ヒド
ロキシリジン、アルギニン、オルニチン、ヒスチジンな
どや、それらの硫酸塩、リン酸塩、硝酸塩、クエン酸
塩、或いはピロリドンカルボン酸のごときアミノ酸誘導
体など。(12) Various amino acids: valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.
【0035】(13)植物又は動物系原料由来の種々の添加
物 これらは、添加しようとする製品種別、形態に応じて常
法的に行われる加工(例えば、粉砕、製粉、洗浄、加水
分解、醗酵、精製、圧搾、抽出、分画、ろ過、乾燥、粉
末化、造粒、溶解、滅菌、pH調整、脱臭、脱色などを
任意に選択、組合わせた処理)を行い、各種の素材から
任意に選択して供すれば良い。(13) Various additives derived from plant or animal raw materials These are processed in a usual manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.
【0036】尚、抽出に用いる溶媒については、供する
製品の使用目的、種類、或いは後に行う加工処理等を考
慮した上で選択すれば良いが、通常では、水、水溶性有
機溶媒(例えば、エタノール、プロピレングリコール、
1,3-ブチレングリコールなど)の中から選ばれる1種も
しくは2種以上の混液を用いるのが望ましい。但し、用
途により有機溶媒の含有が好ましくない場合において
は、水のみを使用したり、あるいは抽出後に除去しやす
いエタノールを採用し、単独又は水との任意の混液で用
いたりすれば良く、又、搾取抽出したものでも良い。The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later. Usually, water and a water-soluble organic solvent (eg, ethanol) are used. ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from among 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.
【0037】尚、植物又は動物系原料由来の添加物を、
全身用又は局所用の外用剤、化粧品類に供する場合、皮
膚や頭髪の保護をはじめ、保湿、感触・風合いの改善、
柔軟性の付与、刺激の緩和、芳香によるストレスの緩
和、細胞賦活(細胞老化防止)、炎症の抑制、肌質・髪
質の改善、肌荒れ防止及びその改善、発毛、育毛、脱毛
防止、光沢の付与、清浄効果、疲労の緩和、血流促進、
温浴効果などの美容的効果のほか、香付け、消臭、増
粘、防腐、緩衝などの効果も期待できる。In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.
【0038】原料とする具体的な植物(生薬)としては、
例えば、アーモンド(へん桃)、アイ(藍葉)、アオカズラ
(清風藤)、アオキ(青木)、アオギリ又はケナシアオギリ
(梧桐)、アオツヅラフジ(木防巳)、アカシア、アカショ
ウマ(赤升麻)、アカスグリ「果実」、アカツメクサ、ア
カブドウ、アカミノキ(ログウッド)、アカメガシワ(赤
芽柏)、アカネ(茜草根)、アカヤジオウ又はジオウ(地
黄)、アギ(阿魏)、アキカラマツ、アキニレ(榔楡皮)、
アグアイー・グァスー、アグアヘ(オオミテングヤシ)、
アケビ(木通)、アサ(麻子仁)、マルバアサガオ又はアサ
ガオ(牽牛子)、アジサイ(紫陽花)、アシタバ(明日葉)、
アズキ(赤小豆)、アセロラ、アセンヤク(阿仙薬)、アチ
ラ(ショクヨウカンナ)、アニス、アビウ、アビウラー
ナ、アブラナ、アベマキ「果実」、アボカド、アマ、ア
マチャ(甘茶)、アマチャヅル、アマドコロ(玉竹)、アマ
ナ(光慈姑)、アマランサス(ヒユ、ハゲイトウ、ヒモゲ
イトウ、センニンコク、スギモリゲイトウ、ホソアオゲ
イトウ、アオゲイトウ、ハリビユ、アマラントウス・ヒ
ポコンドリアクス)、アミガサユリ又はバイモ(貝母)、
アリストロメリア(ユリズイセン)、アルカナ(アルカン
ナ)、アルガローボ(キャベ)、アルピニア又はカツマダ
イ(ソウズク)、アロエ(蘆薈)、アロエベラ、アンジェリ
カ、アンズ又はホンアンズ(杏仁)、アンソッコウ(安息
香)、イエローサポテ、イガコウゾリナ(地胆頭)、イカ
リソウ又はヤチマタイカリソウ(インヨウカク)、イグサ
(灯心草)、イタドリ(虎杖根)、イチイ(一位)、イチゴ、
イチジク(無花果「果実、葉」)、イチハツ(一初)、イチ
ビ(冬葵子)、イチヤクソウ(一薬草)、イチョウ(銀杏
「種子、葉」)、イトヒメハギ(遠志)、イナゴマメ、イ
ヌナズナ(テイレキシ)、イヌビユ(ホナガイヌビユ)、イ
ネ「種子、種皮」、イノンド「種子」、イブキジャコウ
ソウ、イラクサ、イランイラン、イワタバコ(岩萵苣)、
イワヒバ又はイワマツ(巻柏)、ウーロン茶、ウイキョウ
(茴香)、ウィート(チブサノキ)、ウキヤガラ(三稜)、ウ
グイスカグラ「果実」、ヒメウイキョウ、ウコン(鬱
金)、ウキクサ(浮萍)、ウスバサイシン又はケイリンサ
イシン又はオウシュウサイシン(細辛)、ウスベニアオ
イ、ウツボグサ(夏枯草)、ウド又はシシウド(羌活、独
活、唐独活)、ウニャデガト(ウンカリア、キャッツクロ
ー)、ウバ茶、ウメ(烏梅「種子、果肉」)、ウラジロガ
シ、ウワウルシ(クサコケモモ)、ウンシュウミカン(陳
皮)、エストラゴン、エゾウコギ(蝦夷五加)、エチナシ
(ホソバムラサキバレンギク)、エニシダ、エノキタケ
(榎茸)、エビスグサ又はカッシア・トーラ(決明子)、エ
ルカンプレ、エルダーベリー「果実」、エレミ、エリン
ギィ又はプレロータスエリンジ、エンジュ(槐花、槐花
米)、オウギ又はキバナオウギ(黄耆)、オウセイ(ナルコ
ユリ、カギクルマバナルコユリ)、オウヒササノユキ又
はササノユキ、オウレン(黄連)、オオガタホウケン、オ
オカラスウリ(カロコン)、オオグルマ(土木香)、オオツ
ヅラフジ(防己)、オオバコ(車前子、車前草)、オオハシ
バミ(榛子)、オオハシラサボテン、オオバナオケラ又は
オケラ(白朮)、オオバナサルスベリ(バナバ)、オオバ
ヤシャブシ「果実」、オオホシグサ(穀精草)、オオミア
カテツ、オオミサンザシ又はサンザシ(山査子)、オオム
ギ(大麦)、オカ、オカゼリ(蛇床子)、オクラ「果実」、
オグルマ(旋覆)、オタネニンジン又はトチバニンジン
(人参)、オトギリソウ又はコゴメバオトギリソウ又はセ
イヨウオトギリソウ(弟切草)、オドリコソウ(続断)、オ
ナモミ(蒼耳子)、オニグルミ、オニドコロ又はトコロ又
はナガドコロ(ヒカイ)、オニノヤガラ(天麻)、オニユリ
又はササユリ又はハカタユリ(百合)、オノニス、オヒョ
ウ(裂葉楡)、オミナエシ(敗醤)、オユーコ、オランダカ
ラシ(クレソン)、オランダゼリ、オランダミツバ、オリ
ーブ「果実、種子、葉」、オレガノ、オレンジ「果実、
果皮」、カイケイジオウ(熟地黄)、カカオ「果実、果
皮、種子」、カキ(柿蒂「葉」)、カギカズラ(釣藤鈎)、
カキドオシ又はカントリソウ(蓮銭草)、ガクアジサイ、
カシア、カジノキ(楮実「果実」)、ガジュツ(莪朮)、カ
シワ(槲樹、槲葉)、カスカリラ、カスカラサグラダ、カ
スミソウ、カニクサ(金沙藤)、カニーワ、カーネーショ
ン、カノコソウ(吉草根)、カバノキ又はシダレカンバ
(白樺)、ガーベラ、カボチャ、カポックノキ「種子」、
カホクサンショウ(蜀椒)、ガマ(蒲黄)、カミツレ又はロ
ーマカミツレ、カミヤツデ(通草)、カムカム(カモカ
モ)、カラー、カラクサケマン、カラスウリ又はシナカ
ラスウリ(王瓜)、カラスビシャク(半夏)、カラスムギ、
ガラナ「種子」、カラホオ(厚朴)、カラヤ、ガリュウ、
カリン(木瓜)、ガルシニア、カワミドリ、カワラサイコ
(委陵菜、翻白草)、カワヂシャ、カワラタケ、カワラナ
デシコ(石竹)又はエゾカワラナデシコ(瞿麦、瞿麦子)、
カワラニンジン(青蒿)、カワラヨモギ(茵チン蒿)、カン
スイ(甘遂)、カンゾウ(甘草)、カンタラアサ、カンデリ
ラ、カントウ、カンナ、キイチゴ(エゾイチゴ、オラン
ダイチゴ、エビガライチゴ、ナワシロイチゴ、モミジイ
チゴ、ヨーロッパキイチゴ)、キウイ「果実、葉」、キ
カラスウリ(瓜呂根)、キキョウ(桔梗、桔梗根)、キク
(菊花、シマカンギク、チョウセンノギク)、キクタニギ
ク、キササゲ(梓実)、ギシギシ(羊蹄根)、キジツ(枳
実)、キズタ、キダチアロエ、キダチハッカ、キナ、キ
ナノキ(シンコーナ、アカキナノキ)、キヌア(キノア)、
キハダ(黄柏)、ギムネマ・シルベスタ、キメンカク、キ
ャベツ、キャベブ「未熟果」、キュウリ、ギョリュウ
(西河柳、てい柳)、キラジャ・サポナリア、キラヤ、キ
ランソウ(金瘡小草)、キンカン「果実」、ギンセカイ、
キンブセン、キンマ、キンミズヒキ(仙鶴草)、グァペー
バ・ヴェルメーリャ、グアバ「果実」、グアユーレ、ク
ェルクス・インフェクトリア(没食子)、ククイナッツ、
クコ(枸杞、枸杞子、枸杞葉、地骨皮)、クサスギカズラ
(天門冬)、クズ(葛根)、クスノキ、グースベリー「果
実」、クソニンジン(黄花蒿)、クティティリバー、クチ
ナシ(山梔子)、クヌギ(樸ソウ)、クプアス、クマザサ、
クマツヅラ(馬鞭草)、クララ(苦参)、クランベリー「果
実」、クリ「種子、果実、渋皮」、クルクリゴ・ラチフ
ォリア「果実」、グレープフルーツ「果実・葉」、クロ
ウメモドキ、クロガネモチ(救必応)、クロバナヒキオコ
シ又はヒキオコシ(延命草)、クローブ(丁子、丁香)、グ
ンバイナズナ(セキメイ、セキメイシ)、ケイガイ(荊
芥、荊芥穂)、ケイトウ(鶏冠花、鶏冠子)、ゲッカビジ
ン、ゲッケイジュ(月桂樹)、ケナシサルトリイバラ(土
茯苓、山帰来)、ゲンチアナ、ゲンノショウコ(老鸛
草)、ケンポナシ(キグシ)、コウキセッコク、キシュウ
ミカン(コウジ、タチバナ、オオベニミカン、フクレミ
カン、サガミコウジ、ポンカン、サンタラ(橘皮))、コ
ウシンバラ(月季花)、コウスイハッカ、コウゾ「果
実」、コウチャ(紅茶)、コウホネ(川骨)、コウホン(藁
本、唐藁本)、コウリャン、コウリョウキョウ(高良
姜)、コエンドロ「果実」、コオウレン(胡黄連)、コガ
ネバナ(黄ゴン)、コケモモ(越橘)、ココヤシ「果実」、
ゴシュユ(呉茱萸)、ゴショイチゴ(覆盆子)、コショウ
(胡椒)、コスモス、コパイババルサム、コーヒー「種
子、葉」、コブシ又はモクレン(辛夷)、ゴボウ(牛蒡、
牛蒡子)、コボタンヅル、ゴマ(胡麻)、ゴマノハグサ(玄
参)、ゴミシ(五味子)、サネカズラ又はビナンカズラ又
はマツブサ、コムギ(小麦)、米又は米糠「赤糠、白
糠」、コメ油、コーラ・アクミナタ「種子」、コーラ・
ベラ「種子」、コロニーリャ、コロハ「果実」、コロン
ボ、コンズランゴ、コンブ、コンニャク、コンフリー
(鰭張草)、サイザル(サイザルアサ)、サキシマボタンヅ
ル又はシナボタンヅル又はシナセンニンソウ(威霊仙)、
サクラ(オオシマザクラ、ヤマザクラ、オオヤマザク
ラ、エドヒガシ、マメザクラ、ミヤマザクラ、ソメイヨ
シノ、タカネザクラ、カスミザクラ、チョウジザクラ、
コヒガン、サトザクラ、カンザクラ「葉、花、果実、樹
皮(桜皮)」)、サクランボ、ザクロ、ササ、サザンカ、
サジオモダカ(沢瀉)、サツマイモ、サトウキビ、サトウ
ダイコン、サネブトナツメ(酸棗仁)、サフラン(番紅
花、西紅花)、サポジラ、サポテアマリヨ、ザボン「果
実」、サボンソウ、サーモンベリー「果実」、サラシナ
ショウマ(升麻)、サルビア(セージ)、サワギキョウ(山
梗菜)、サワグルミ(山胡桃)、サンカクサボテン、サン
グレデグラード(クロトン)、サンシクヨウソウ、サンシ
チニンジン(三七人参)、サンシュユ(山茱萸)、サンショ
ウ(山椒)、サンズコン(山豆根)、シア(カリテ)、シアノ
キ「果実」、シイタケ(椎茸)、シオン(紫苑)、ジキタリ
ス、シクンシ(使君子)、シソ又はアオジソ又はチリメン
ジソ又はカタメンジソ(紫蘇葉、紫蘇子)、シタン、シナ
ホオノキ、シナレンギョウ(連翹)、シメジ(ヒンシメ
ジ、シャカシメジ、ハタケシメジ、オシロイシメジ、ブ
ナシメジ、ホンジメシ、シロタモギタケ)、シモクレン
(辛夷)、シモツケソウ、ジャガイモ、シャクヤク(芍
薬)、シャジン(沙参)、ジャスミン(マツリカ)、ジャ
ノヒゲ(麦門冬)、シュクコンカスミソウ、シュクシャミ
ツ(砂仁、縮砂)、ジュズダマ、シュロ「果実」、ショウ
ガ(生姜)、ジョウザンアジサイ(常山)、ショウブ(菖
蒲、菖蒲根)、ショズク「果実」、シラカシ「種子」、
シロゴチョウ「種子」、シロツメクサ(クローバー)、シ
ロトウアズキ(鶏骨草)、シロバナイリス(ニオイイリ
ス)、シロバナツタ「花」、シロミナンテン(南天実)、
シンコナサクシルブラ、ジンチョウゲ(瑞香、瑞香花、
沈丁花)、シンナモン、シンナモムム・カッシア(桂
皮)、スイカ(西瓜)、スイカズラ(金銀花、忍冬)、スイ
バ(酸模)、スイムベリー「果実」、スターアップル、ス
テビア、ストロベリー「果実」、スズサイコ(徐長卿)、
スギナ(問荊)、スベリヒユ(馬歯けん、馬歯けん子)、ス
モモ「果実」、セイヨウアカマツ「球果」、セイヨウカ
ラマツ、セイヨウキズタ、セイヨウグルミ、セイヨウサ
ンザシ、セイヨウタンポポ、セイヨウトチノキ(マロニ
エ)、セイヨウナシ「果実」、セイヨウナツユキソウ、
セイヨウニワトコ(エルダー)、セイヨウネズ(ジュニパ
ー、杜松)、セイヨウノコギリソウ(ミルフォイル)、セ
イヨウバラ、セイヨウフウチョウボク、セイヨウヤドリ
ギ、セイヨウハッカ又はセイヨウヤマハッカ、セイヨウ
ワサビ、セキショウ(石菖根)、セッコク(石斛)、セドロ
ン(ボウシュウボク)、ゼニアオイ、ヒロハセネガ、セネ
ガ、セリ、セロリ、センキュウ(川キュウ)、センシンレ
ン(穿心連)、センダン、センニンサボテン、センナ「果
実、葉」、センニンソウ(大蓼)、センブリ(当薬)、ソウ
カ(草果)、ゾウゲチュウ、ソバ「種実」、ソメモノイ
モ、ダイオウ(大黄)、大根、大豆、ダイダイ(橙皮、枳
実)、タカサブロウ(旱蓮草)、タカトウダイ(大戟)、タ
カワラビ(狗脊)、ダークスィートチェリー「果実」、タ
チアオイ、タチジャコウソウ(タイム、百里香)、タチド
コロ(ヒカイ)、タチヤナギ、タマリンド「種子」、タマ
ネギ、タムシバ(辛夷)、タラノキ「果実、葉、根皮」、
ダリア(テンジクボタン)、タルウィ、タンシウチワ、タ
ンジン(丹参)、タンポポ(蒲公英)又はシロバナタンポポ
又はモウコタンポポ、ダンマル、チェリー「果実」、チ
ガヤ「果実、根、芽」、チクセツニンジン(竹節人参)、
チコリ、チャンカピエドラ(キダチコミカンソウ)、チョ
ウセンダイオウ(大黄)、チョウセンニレ(蕪夷)、チョウ
センヨモギ(艾葉)、チョレイマイタケ(猪苓)、チョロ
ギ、ツキミソウ、ツクリタケ(マッシュルーム)、ツバ
キ、ツボクサ、ツメクサ(漆姑草)、ツユクサ(鴨跖草)、
ツルアズキ(赤小豆)、ツルドクダミ(何首烏)、ツルナ
(蕃杏)、ツルニンジン(四葉参)、ツワブキ、デイコ、テ
ウチグルミ、デュベリー「果実」、チューリップ、チョ
コノステイ、テングサ、テンチャ(甜茶)、テンダイウヤ
ク(烏薬)、トウガ(冬瓜子)、トウカギカズラ、トウガラ
シ(番椒)、トウキ(当帰)、トウキンセンカ(マリーゴー
ルド)、トウナベナ(川断)、トウモロコシ又はトウモロ
コシ毛(南蛮毛)、トウネズミモチ(女貞子)、トウリンド
ウ又はチョウセンリンドウ(竜胆)、トクサ(木賊)、ドク
ダミ(十薬)、トコン(吐根)、トシシ又はマメダオシ又は
ネナシカズラ、トチュウ(杜仲「樹皮、葉、根」)、トネ
リコ(秦皮)、トマト、トラガント、トリアカンソス「種
子」、トルコキキョウ、トルメンチラ、ドロノキ、トロ
ロアオイ、ナイゼリアベリー「果実」、ナガイモ又はヤ
マノイモ(山薬)、ナギイカダ(ブッチャーブルーム)、ナ
ギナタコウジュ、ナズナ、ナタネ、ナタマメ又はタテハ
キ(刀豆)、ナツミカン、ナツメ(大棗)、ナニワイバラ
(金桜子)、ナベナ(続断)、ナメコ、ナルコユリ(黄精)、
ナンキンマメ(落花生)、ナンテン(南天実)、ナンバンカ
ラムシ(苧麻)、ニオイスミレ、ニガキ(苦木)、ニガヨモ
ギ(苦艾)、ニクズク、ケイ又はニッケイ又はセイロンニ
ッケイ又はヤブニッケイ(桂皮)又はケイシ(桂枝)、ニラ
(韮子)、ニワトコ(接骨木「果実、花、茎、葉」)、ニン
ニク(大蒜)、ヌルデ(五倍子)、ネギ、ネムノキ又はネブ
又はネビ又はネムリノキ又はジゴクバナ(合歓)、ノアザ
ミ(大薊)、ノイバラ(営実)、ノコギリソウ、ノダケ(前
胡)、ノバラ、ノモモ、パイナップル「果実」、ハイビ
スカス(ブッソウゲ、フウリンブッソウゲ、ローゼル)、
ハイリンドウ、ハウチワ、パウ・ドーセ、ハカマウラボ
シ(骨砕補)、ハクセン(白癬皮)、ハクルベリー「果
実」、ハコベ(繁縷)、ハシバミ(榛子)、ハシリドコロ
(ロート根)、バジル、ハス(蓮、蓮肉、蓮子)、パセリ
(オランダゼリ)、ハダカムギ、バタタ、ハチク又はマダ
ケ(竹茹)、パチョリー、ハッカ(薄荷、薄荷葉)、ハトム
ギ(ヨクイニン)、ハナスゲ(知母)、バナナ、ハナハッ
カ、ハナビシ(シツリシ、シシツリ)、バニラビンズ、パ
パイヤ、ハハコグサ(鼠麹草)、パハロボボ、ハブ「全
草、茎、葉」、パプリカ、ハマゴウ又はミツバハマゴウ
(蔓荊子)、ハマスゲ(香附子)、ハマビシ(シツ莉子)、ハ
マナス(マイカイ花)、ハマボウフウ(浜防風)、ハマメリ
ス、パーム、バラ(薔薇)、バラータ、バラタゴムノキ、
ハラタケ(ハラタケ、シロオオハラタケ、ウスキモリノ
カサ)、ハラン、パリウルス(セイヨウハマナツメ)、パ
リエタリア、バルサミーナ(ツルレイシ、ニガウリ)、ハ
ルニレ(楡皮、楡白皮、楡葉)、バルバスコ、ハルリンド
ウ、ハンダイカイ(胖大海)、パンノキ、ヒオウギ(射
干)、ヒカゲツルニンジン(党参)、ピーカンナッツ、ヒ
ガンバナ(石蒜、蔓珠沙華)、ヒグルマダリア、ヒシ(菱
実)、ピスタチオ、ビート、ヒトツバ(石葦)、ヒトツバ
エニシダ、ヒナギク(デージー)、ヒナタイノコズチ(牛
膝)、ヒノキ、ヒバ、ヒマシ、ヒマワリ、ピーマン、ヒ
メウズ(天葵)、ヒメガマ(香蒲)、ヒメマツタケ(カワリ
ハラタケ、ヒロマツタケ)、ピメンタ「果実」、ビャク
シ、ビャッキュウ、ヒユ「果実」、ヒロハオキナグサ
(白頭翁)、ビワ「果実、葉、茎」、ビンロウ(大服皮、
檳榔子)、プーアル茶(普?茶)、フウトウカズラ(南
籐)、フキ、フキタンポポ(款冬花、款冬葉)、フジバカ
マ(蘭草)、フジマメ(扁豆)、ブドウ「果実、果皮、種
子、葉」、ブナ、フユムシナツクサタケ(冬虫夏草)、ブ
ラジルカンゾウ、ブラジルニンジン、ブラックカーラン
ト「果実」、ブラックベリー、ブラーニェン、プラム
「果実」、フルセラリア、ブルーベリー(セイヨウヒメ
スノキ)、プルーン、フローラルブランカ、ブロンドサ
イリウム、ブンドウ(緑豆)、ヘーゼルナッツ、ヘチマ、
ベニバナ(紅花)、ヘネケン、ベラドンナ、ベリー「果
実」、ペルセア、ペルビアンバーグ、ペレスキア・グラ
ンディフォリア、ベンケイソウ又はイキクサ(景天)、ボ
イセンベリー「果実」、ホウキギ又はニワクサ又はネン
ドウ又はハハキギ・コキア(地膚子)、ホウセンカ(鳳
仙、急性子、透骨草)、ポウテリア・サポタ、ポウテリ
ア・ルクマ、ホウノキ、ボウフウ(防風)、ホウレンソ
ウ、ホオズキ(登呂根)、ホオノキ(和厚朴、朴)、ボケ
(木瓜)、ホソバナオケラ(蒼朮)、ホソバノキリンソウ
(景天三七)、ホソババレンギク、ホップ、ホホバ、ボリ
ジ(ルリチシャ)、ボルドー、ホワートルベリー「果
実」、ホンオニク(肉じゅ蓉、大芸)、ホンセッコク(鉄
皮石斛、雀山石斛)、マイズルテンナンショウ(天南
星)、マイタケ(舞茸)、マオウ(麻黄)、マカ、マカデミ
アナッツ、マーガレット(モクシュンギク)、マクリ(海
人草)、マグワ(桑白皮「樹皮、葉」)、マグノリア・ス
プレンゲリ、マサランヅーバ、マサランズーバ・ド・セ
アラー、マシェイラ・デ・ボイ、マシュア(タマノウゼ
ンハレン、キュウコンキンレンカ)、マタタビ(木天
蓼)、マツカサ、松「葉、樹皮、根」、マッタ・オーリ
ョ、マツホド(茯苓)、マティコ(コルドンシージョ)、マ
ヨラム(ハナハッカ)、マルバノジャジン(苦参)、マルベ
リー「果実」、マルメロ、マレイン(ビロウドモウズイ
カ)、マンゴー、マンゴスチン、マンサーニャ(アンデス
カミツレ)、マンシュウグルミ、マンダリン「果実」、
マンネンタケ(霊芝)、キジツ(枳実「果実」)、ミシマサ
イコ(柴胡)、ミズオオバコ又はミズアサガオ(竜舌草)、
ミゾカクシ(半辺蓮)、ミソハギ(千屈菜)、ミチヤナギ又
はニワヤナギ(篇蓄)、ミツガシワ、ミツバ、ミドリサポ
テ、ミドリハッカ、ミモザ、ミョウガ、ミラクルフルー
ツ「果実」、ミルラ、ミロバラン、ムギワラギク、ムク
ゲ(木槿)、ムクノキ、ムクロジ(延命皮)、ムニャ、ムラ
サキ(紫根)、ムラサキシキブ又はオオムラサキシキブ
(紫珠)、ムラサキトウモロコシ、ムラサキナツフジ(昆
明鶏血藤)、メガカンサ・オプンティカ、メハジキ(益母
草)、メボウギ、メラロイカ、メリッサ、メリロート、
メロン「果実」、モウコヨモギ、モウソウチク、モクキ
リン、モジェ(コショウボク)、モッコウ(木香)、モミジ
バダイオウ、モモ(桃「葉、種子、花、果実」)、モヤ
シ、モレロチェリー「果実」、モロヘイヤ(黄麻)、ヤカ
ワムラサキイモ、ヤクチ(益智)、ヤグルマソウ(ヤグル
マギク)、ヤグルマハッカ、ヤーコン、ヤシャブシ(矢
車)又はヒメヤシャブシ又はオオバヤシャブシ「果実、
果皮、果穂」、ヤチヤナギ、ヤツデ(八角金盤)、ヤドリ
ギ(柳寄生)、ヤナギ(カワヤナギ、タチヤナギ、シダレ
ヤナギ、アカメヤナギ、ネコヤナギ、イヌコリヤナギ、
キヌヤナギ、コリヤナギ、ウンリュウヤナギ、ミヤマヤ
ナギ、ヤシ、ヤマヤナギ、オオバヤナギ、タイリクキヌ
ヤナギ、キツネヤナギ、ドロノキ)、ヤナギタデ「葉、
茎」、ヤブガラシ、ヤブコウジ(紫金牛)、ヤブタバコ
(鶴虱、天名精)、ヤマゴボウ(商陸)、ヤマハンノキ(山
榛)、ヤマモモ(楊梅皮)、ヤマヨモギ、ユーカリ、ユキ
ノシタ(虎耳草)、ユッカ又はフレビフォリア、ユズ「果
実」、ユリ、ヨロイグサ、ヨモギ(艾葉)、ライガン(雷
丸)、ライム「果実」、ライムギ、ラカンカ「果実」、
ラズベリー「葉、果実」、ラタニア(クラメリア)、ラッ
キョウ又はエシャロット(薤白)、ラベンダー、リュウガ
ン(竜眼肉)、リュウゼツラン(アオノリュウゼツラン、
フクリンリュウゼツラン)、リョクチャ(緑茶)、リンゴ
「果実、種子、葉、根」、リンドウ、ルバス又はスアビ
シムス(甜涼)、レイシ(茘枝、茘枝核)、レタス(チシ
ャ)、レッドカーラント「果実」、レッドピタヤ、レモ
ン「果実」、レモングラス、レンギョウ又はシナレンギ
ョウ(連翹)、レンゲソウ、ロウヤシ、ロコン(ヨシ、蘆
根)、ローガンベリー「果実」、ローズマリー(マンネン
ロウ)、ローズヒップ(ノバラ)、ワサビ、ワレモコウ(地
楡)などが挙げられる。Specific plants (crude drugs) as raw materials include:
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsujirafuji (Kibo), Acacia, Akasho (Akasho), Akasuri `` Fruit '', Red clover, Red grape, Akaminoki (Logwood), Red acacia (Red bud), Akane (Akane grass root), Red acacia or Jio ( Ground yellow), Agi (Awei), Aki Larch, Akinire (Latinaceae),
Aguay Guacu, Aguahe (Omitengu palm),
Akebi (Kidori), Asa (John Asako), Malva Asagao or Asagao (Toshibushi), Hydrangea (hydrangea), Ashitaba (Ashitaba),
Azuki (red azuki), acerola, asenyaku (Asenyaku), acira (shokuyoukanna), anise, abiu, abiurana, rape, avemaki `` fruit '', avocado, ama, amacha (sweet tea), amachaworu, amadocoro (tamatake), Amana (Kikomiko), Amaranthus (Amaranthus), Amaranthus hippochondriacus, Haribiyu, Amaranthus hippochondriax, Amigasa lily or Bimo (shellfish),
Aristolomelia (Yurizisen), Arcana (Alcanna), Argarrobo (Cabbage), Alpinia or Katsumadai (Soudu-ku), Aloe (Length), Aloe vera, Angelica, Apricot or Hong apricot (Apricot kernel), Ansokkou (benzoin), Yellow sapote, Igakouzolina ( Bile head), Epimedium or Epimedium (Inyokaku), rush
(Wicked grass), Knotweed (Tiger root), Yew (1st), Strawberry,
Figs (fructose `` fruits and leaves ''), Ichihatsu (primary), ichibi (winter aoiko), Ichiyakusou (one medicinal herb), ginkgo (ginko `` seed and leaves ''), Itohimehagi (enshi), carob, and locust bean (Telexa) , Inubeil (Honagainubeil), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou, nettle, ylang-ylang, iwa-tobacco
Iwahiba or iwamatsu (makikashiwa), oolong tea, fennel
(Fenka), Wheat (Chibusanoki), Ukiyagara (Sanryong), Uguisukagura `` fruit '', Himeukikyo, turmeric (Utsukin), Duckweed (buoying), Usubasaishin or Keirinsaishin or Oushusaishin (spicy), Usveniaoi , Utsubogusa (summer hay), Udo or Shishiudo (Qang, Independent, Tang Independent), Unyadegato (Unkaria, Cat's claw), Uba tea, Ume (Ume `` seed, pulp ''), Vladinki, Uwaurushi (Kusaco peach), Unshumikan ( Chen), estragon, elephant, echinashi
(Hoshibamurasakibarengiku), Enishida, Enokitake
(Enoki mushroom), Ebisugusa or Cassia tora (Kyoko), El Campre, Elderberry `` fruit '', Elemi, Eryngii or Pre-Lotus Eringe, Endu (Gossip, Sophora rice), Ougi or Kibana-ohgi (Ohioki), Ousei (Naruko Yuri, Kagikurumabanarukoyuri), Ohhisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Hawken, Ookarasuri (Karokon), Ooguruma (engineering incense), Ooturafuji (self-protection), Oobako (car front child, car front grass), Oohashi Haruko), Toucan cactus, Obanana okera or Okera (white jujube), Obanassarsbergi (Banaba), Obanayashabushi "fruit", Ooishigusa (grain sperm), Oumia catechu, Oohashi hawthorn or Hawthorn (barley), barley (barley), barley (barley), barley (barley), barley (barley), barley (barley), barley (barley), barley (barley) , Okazeri (snake bed), okra "fruit",
Oguruma (turning over), Panax ginseng or Panax ginseng
(Ginseng), Hypericum perforatum or St. John's wort or St. John's wort (brother cutting), Odorikosou (interrupted), Onamimomi (blue ears), Onigurimi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma) or Oyuriha or Yuyari Yuri), Ononis, Halibut (Hihayu), Ominaeshi (Defeated), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch honeysuckle, Olive "fruit, seed, leaf", Oregano, Orange "fruit,
Pericarp, caycaio (ripe yellow), cacao, fruit, pericarp, seed, persimmon, persimmon, leaf
Persimmon or licorice, lotus hydrangea, gaku hydrangea,
Cassia, casino (Kozomi `` fruit ''), gajutsu (shajujutsu), kasiwa (shaki, kayoha), cascallilla, cascara sagrada, gypsophila, kanikusa (kinsato), kaniwa, carnation, kanokosou (yoshikone), birch Or weeping birch
(Birch), gerbera, pumpkin, capokoki `` seed '',
Kahoku Sansho (shopper), Gama (bamboo), Chamomile or Roman chamomile, Camellia japonica (weed), Kamkamu (Kamokamo), Color, Karaku Sakeman, Ragwort or Chinese Ragwort (Gourd), Ragwishak (midsummer), Ragwort,
Guarana `` seed '', Karahoo (thick), Karaya, Galyu,
Karin (Gourd), Garcinia, Kawamidori, Kawara Psycho
(Seiryona, vermilion grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko),
Red carrot (Aoko), Red wormwood (Inchinko), Kansui (Sweet), Licorice (Kanzo), Kantara Asa, Candelilla, Kantou, Canna, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Sawberry strawberry, Maple strawberry, European strawberry) Kiwi "fruits and leaves", Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku
(Chrysanthemum flower, oak daisies, artichokes), cypress daisies, catalpa (Azumitsu), sagebrush (sheep hoof root), pheasant (kokomi), kizuta, kidachi aloe, lucky mint, quina, chinoki (shincona, red linden), quinoa (quinoa),
Yellowfin (Hypashi), Gymnema Sylvesta, Kimmenkaku, Cabbage, Cabbage "Immature Fruit", Cucumber, Gyoryu
(Nishikawayanagi, Ichiyanagi), Kiraja Saponaria, Kiraya, Kiranso (Gold Acne Herb), Kumquat `` Fruits '', Ginseki,
Kimbusen, betel, golden hibiscus (Sesame crass), guapeba vermelha, guava `` fruit '', guayule, quelux infectria (gallicate), cucumber nuts,
Wolfberry (Gugi, gugi, gugi leaf, skeletal bark)
(Tenmen winter), Kudzu (Kakkon), camphor tree, gooseberry `` fruit '', Ginseng (yellow flower), Kutiti River, Gardenia (Gardenia), Kunugi (Bokuso), Kupuas, Kumazasa,
Black pine (horse whip grass), Clara (bitter butter), cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curculigo latifolia `` fruit '', grapefruit `` fruit / leaf '', buckthorn, black squirrel (rescue), Kurobana Hikiokoshi Or Hikiokoshi (extended lifegrass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi), kaigai (infestation, infestation), celosia (corolla, rooster), gekkavidin, bayberry (laurel), kenashisarutoribara (soil) (Bukuryo, mountain return), gentian, genoshoko (old treasured grass), kenponashi (kigushi), koukisekoku, kishumikan (kouji, tachibana, ovenimikan, fukuremican, sagamikouji, ponkan, santara (tachibana)), koshinbara (monthly flower) , Kosui mint, Kozo "fruit", Kocha (tea), Kouhone (river bone), Koho (Straw and Kara straw), Koryang, Kouryokyo (Korakyo), Cilantro `` fruit '', Kourouen (Kohren), Koganebana (yellow gon), bilberry (Koshibachi), coconut `` fruit '',
Goshuyu (goshuyu), Goshoichigo (covered bonko), pepper
(Pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot spring), burdock (burdock,
Burdock), kobotdur, sesame (sesame), sesame seeds (gensin), garnish (gomiko), sanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata " Seeds ", Cola
Vera “seed”, colony lya, fenugreek “fruit”, colombo, kondurango, kelp, konjac, comfrey
(Final barn grass), sisal (sisal asa), saxima button or syna button or cinnamon
Sakura (Ooshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Yoshino cherry tree, Takanezakura, Kasumizakura, Chojizakura,
Kohigan, Satozakura, Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''), cherries, pomegranates, sasa, sasanqua,
Sage Modaka (Sawaka), Sweet Potato, Sugarcane, Sugar Beet, Sunabet Jujube (Satsumitsu Jin), Saffron (Safflower, West Safflower), Sapodilla, Sapotea Marillo, Pomelo "Fruit", Sabonsou, Salmon Berry "Fruit", Sarasinoshima (Masuma) , Salvia (sage), Sawagyoukyo (Sancho-na), Sawagumi (Sanguo), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin carrot (San carrot), Sanshuyu (sanshuyu), Sanshoyu (sanshoyu) ), Sandscon (Yamazone), Shea (Carite), Cyano (fruit), Shiitake (Shitake), Shion (Shion), Dikitaris, Shikunshi (Kimiko), Perilla or Aodiso or Chirimendiso or Katamenziso (Perilla leaves, Perilla) ), Rosewood, Japanese pine, Chinese Forsythia (Forsythia), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiro) Ishimeji, Bunashimeji, Honjimeshi, Shirotamogitake), Shimokren
(Shinyi), Spiraea, Potato, Peony (Shakuyaku), Shajin (Shasan), Jasmine (Matsurika), Janohige (Motomon winter), Scutellaria paniculata, Skushamamitsu (sand sand, sand compaction), Juzudama, Palm fruit , Ginger (ginger), ginseng hydrangea (Tsuneyama), shobu (irises, iris roots), shojiku "fruits", shirakashi "seed",
White butterfly (seed), white clover (clover), white adzuki (chicken bone grass), white iris (small iris), white natto (flower), white nanten (minamitenmi),
Cinchona Sacrifura, Jinjuge (Mizuka, Mizuka,
Cinnamon), cinnamon, cinnamomum cassia (cinnamon bark), watermelon (watermelon), honeysuckle (gold and silver flowers, shinto winter), sorrel (acid model), swimberry "fruit", star apple, stevia, strawberry "fruit", tin shiko ,
Horsetail (Thorn), Purslane (Horse Tongue, Horse Tongue), Plum (Fruit), Pinus sylvestris (Cones), Larix sylvestris, European Lentils, European Walnut, European Hawthorn, European Dandelion, European Chestnut (Marronnier), Pear "fruit", snow pear,
Sambucus elder (Elder), Atlantic shrew (Juniper, Juniper), Achillea millefolium (Mirfoil), Atlantic rose, Aurora magnolia, Atlantic mistletoe, Western mackerel or Western mackerel, Western horseradish, Sekisho (stone irises) Cedron (Bowshukuboku), Zeniaoi, Hirohasenega, Senega, Seri, Celery, Senkyu (River Kyu), Senshinren (Shingenren), Sendan, Sennin Cactus, Senna `` Fruits, Leaves '', Senninsou (Otatate), Senbri ), Souka (grass), elephant, buckwheat `` seed '', soybean potato, rhubarb (daisuki), radish, soybean, daidai (orange skin, kikomi), takasaburo (dry lotus grass), takatodai (daigeki), takawarabi (dog) Spine), dark sweet cherry "fruit", hollyhock, hollyhock (thyme) HyakuRika), Tachidokoro (explicit solution), Tachiyanagi, tamarind "seed", onions, Magnolia salicifolia (fist), Aralia elata "fruit, leaf, root bark",
Dahlia (Tengiku button), Tarui, Tanshiniwa, Tanjin (Dan ginseng), Dandelion (Bamboo British) or Shirobana dandelion or Moko dandelion, Dammar, Cherry `` fruit '', Tigaya `` fruit, root, bud '', Chikusetsu carrot (Bamboo ginseng),
Chicory, chancapiedra (Kidachikomikansou), Chinese radish (Ohio), Korean lance (Wuyi), Korean sagebrush (Aiba), Choreimaitake (Irei), Chorogi, Tsukimisou, Tsukuritake (mushroom), camellia, camellia, clover (Lacquer mother grass), twigweed (duckling grass),
Tsuruazuki (red azuki bean), tsuldokudami (how many crows), tsuruna
(Kankyo), Carrot (four-leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tulip, Chocolate stay, Tengusa, Tencha (Tencha), Tendaiyaku (Wakayaku), Touga (Winter melancholy), Toukagi Kazura, Capsicum (Pepper), Touki (Toki), Calendula (Marigold), Tonabena (River cut), Maize or Maize hair (Nanban hair), Toad Mochi (Female Sadako), Toudodou or Korean gentian (Ryubile), Tokusa (wood pirates), dokudami (jujutsu), konkon (sore root), sashimi or mamedaoshi or scutellaria, eucommia (mushroom `` bark, leaves, roots ''), ash (qin bark), tomato, tragacanth, triacanthos `` seed '', Turkey Kikyo, Tormentilla, Dronoki, Trolo-mallow, Niseria berry `` fruit '', Chinese yam or Yamanoimo (herbal medicine), (Chur Bloom), Naginata Kouju, Nazuna, Rape, Rape Bean or Harbinger (Sword Bean), Natsumikan, Jujube (Dajutsu), Naniwaibara
(Kanekurako), Navena (intermittent), Nameko, Narco lily (Yoshimi),
Peanut (peanut), Nanten (Minami Tenmi), Namban Karamushi (ramie), Niois violet, Nigaki (Makiki), Nigamogi (Grasshopper), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabnikkei (Chicago) or Keishi (Katsushige) ), Chinese chive
(Niriko), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nurde (five times), leek, nemoki or neb or nebi or nemuriki or digokbana (health), thistle (Oji) , Noibara (fruit), Yarrow, Japanese radish (Maeko), Nobara, Nomomo, Pineapple `` fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle),
Hyakudo, Hauchiwa, Pau Dosse, Hakayamauraboshi (bone crushing), Hakusen (ringworm skin), Huckleberry `` fruit '', Hakobe (growth), Hashibami (Haruko), Hashiridekoro
(Roth root), basil, lotus (lotus, lotus, lotus), parsley
(Netherland jelly), naked mussel, batata, bee or medake (bamboo boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuinin), hanasuge (chimbo), banana, hana mint, hanabishi (situri, shisuturi), vanilla bins , Papaya, japonicus (rat koji), pahalobobo, hub "whole plant, stem, leaf", paprika, hamago or honeysuckle
(Vine vine), hamasuge (katsuki), hamabishi (shikoriko), hamanas (maikai flower), hamabafu (beach storm), hamamelis, palm, rose (rose), balata, balata rubber tree,
Agaric (Agaric, Agaricus agaricus, Uskimorinosa), Haran, Pariurus (Pleurotus japonicus), Parietaria, Balsamina (Tsurureishi, Nigari), Harunire (Yellow, Yule bark, Yuba), Barbasco, Harindou, Handaikai ), Breadfruit, giant gourd (sun dried), lizard ginseng (party), pecan nuts, gangamana (stones and garlic), higuru madaria, Japanese cypress (hishomi), pistachio, beet, hitotsuba (stone reed), tsutsubayashida , Daisies (daisy), hinotainokozuchi (cow knees), hinoki, cypress, castor, sunflower, peppers, himezu (tenoi), himema (scent), himematsutake (kawariharatake, hiromatsutake), pimenta `` fruit '', juniper, beakyuu , Hiyu (fruit), Hiroha okinagusa
(Shiratoo), loquat `` fruits, leaves, stems '', betel nut (large clothing skin,
Areca roe), Pu'er tea (Pu-cha), Sperm kazura (Southern rattan), Butterflies, Butterbur dandelion (Apricot winter flower, Azalea winter leaf), Fuji bacama (Orchid grass), Fuji bean (Tan beans), Grapes "fruit, peel, seeds, leaves", Beech, Fuyusinatsutake mushroom (Cordyceps), Brazilian liquorice, Brazilian carrot, Black currant `` fruit '', Blackberry, Bragnen, Plum `` fruit '', Flucellaria, Blueberry (Prunus avium), Prune, Floral blanka, Blonde psyllium, Bundou (mung bean), hazelnut, loofah,
Safflower (safflower), henneken, belladonna, berry `` fruit '', persea, perbianberg, pereschia grandifolia, benceisou or duckweed (scenic), boysenberry `` fruit '', broom beetle or elder or nendou or haeukigi kokia (skin skin) (Children), Balsam (Hosen, acute offspring, osteophyte), Potteria sapota, Potteria lukuma, Spinach, Bohu (windbreak), Spinach, Physalis (Torone), Physalis (Wakoboku, Park), Bokeh
(Gourd), Hosovanaokera (Sojutsu), Hosobanokirinsou
(Kageten Sanshichi), Hosobabarengiku, Hop, Jojoba, Boriji (Ruritisha), Bordeaux, Whiteberry Berry `` Fruit '', Hongoniku (Meat Jilong, Daigei), Hongsekok (Iron bark, Sparrow mountain stone), Meisulten Nansho (Tiannan star), Maitake (Maitake), Ephedra (mao), Maca, Macadamia nut, Margaret (Mokshungiku), Macri (Martian grass), Magwa (Mulberry white bark `` bark, leaves ''), Magnolia splengeri, Masaranpouba, Masaranzuba de Ceara, Masaira De Boi, Masahua (Tamanouzenhallen, Kyukonkinrenka), Matabi (Kiten Tate), Matsukasa, Pine `` leaves, bark, roots '', Matta Olho, Matsuhodo (Bukuryo) ), Matico (Cordoncillo), Mayorum (Hanamint), Malvanozadin (Difficult), Mulberry "Fruit", Quince, Malein (Beloyd Mou) Squid), mango, mangosteen, Mansanya (Andes chamomile), Manshuugurumi, Mandarin "fruit",
Mannentake (Lingzhi), Pheasant (Kikomi `` fruits ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokukushi (Hanbe Lotus), Misohagi (Chisatsuna), Mizunyanagi or Shiroyanagi (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle Fruit `` Fruit '', Myrrh, Milobalan, Wheatwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (prolonged skin), Munya, Purple (purple root), Purple or purple
(Purple pearl), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, mehajiki (mother grass), mebougi, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), mock berry (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), sprouts, morello cherry `` fruits '', Moroheiya (Burlap), yakawamurasaki potato, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yacon, yashabushi (arrow wheel) or himeyashabushi or giant yashabushi `` fruit,
`` Peel, ears '', willows, yatsude (octagonal gilded), mistletoe (parasitic willow), willows (kawayanagi, tachiyanagi, weeping willow, red willow, pussy willow, dogwood willow,
(Sweet willow, koreanagi, unryuyanagi, yamayamayanagi, palm, yamayanagi, giant psyllium, tyrichkinuyanagi, foxwillow, bonsai), willow `` leaf,
Stalk '', scabbard, savannah koji (purple beef), savory tobacco
(Tsurusui, Tenmei), pokeweed (commercial land), yamanoki (yamaharu), yamamomo (yangmei), yamamugi, eucalyptus, yukinoshita (tiger ear grass), yucca or flevifolia, yuzu `` fruit '', lily, yorigusa , Mugwort (Aiba), reigan (Rainuma), lime "fruit", rye, lakanka "fruit",
Raspberry `` leaves, fruits '', latania (Clameria), Rakkyo or shallots (Shiroi), lavender, longan (longan meat), agave (Aono agave,
Fukurin agave), Ryokucha (green tea), apple `` fruit, seeds, leaves, roots '', gentian, rubus or suavisimus (sweeten), litchi (lichi, lichi nucleus), lettuce (chisha), red currant `` fruit '', Red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (forsythia), astragalus, coconut palm, locust (reed, azuki), loganberry `` fruit '', rosemary (mannen wax), rosehip (nobara), wasabi, Waremokou (chiyu) and the like.
【0039】又、その他の海水類、例えば、海水塩、海
水乾燥物、死海又は大西洋又は太平洋の海より得た無機
塩(塩化ナトリウム、塩化マグネシウム、塩化カリウム
など)、海泥又は泥(ファンゴ)類、例えば、イタリア
ファンゴ、ドイツファンゴ、アイフェルファンゴ、フラ
イブルグファンゴなどの各地の海泥又は泥(含有成分:
二酸化珪素、二酸化チタン、酸化アルミニウム、酸化
鉄、酸化マンガン、酸化ナトリウム、酸化カリウム、酸
化マグネシウム、酸化カルシウム、酸化ストロンチウ
ム、ナトリウム、カリウム、マグネシウム、カルシウ
ム、クロム、鉄、銅、ニッケル、亜鉛、鉛、マンガン、
ヒ素、水)、聖徳石など。In addition, other seawaters, for example, seawater salt, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango) Species, for example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients:
Silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese,
Arsenic, water), Shotoku stone.
【0040】海藻類としては、海藻[緑藻類:クロレラ
・ブルガリス、クロレラ・ピレノイドサ、クロレラ・エ
リプソイデイア、アオノリ(ウスバアオノリ、スジアオ
ノリ、ヒラアオノリ、ボウアオノリ、ホソエダアオノ
リ)、アナアオサ(アオサ)]、海藻[褐藻類:コンブ
(マコンブ、リシリコンブ、ホソメコンブ、ミツイシコ
ンブ)、ワカメ、ヒロメ、アオワカメ、ジャイアントケ
ルプ(マクロシスティス・ピリフェラ、マクロシスティ
ス・インテグリフォリア、ネオシティス・ルエトケアー
ナ)、ヒジキ、ヒバマタ、ウミウチワ、ウスバウミウチ
ワ、キレバノウミウチワ、アカバウミウチワ、コナウミ
ウチワ、オキナウチワ、ウスユキウチワ、エツキウミウ
チワ]、海藻[紅藻類:ヒジリメン、マクサ(テング
サ)、ヒラクサ、オニクサ、オバクサ、カタオバクサ、
ヤタベグサ、ユイキリ、シマテングサ、トサカノリ、ト
ゲキリンサイ、アマクサキリンサイ、キリンサイ、ビャ
クシンキリンサイ、ツノマタ、オオバツノマタ、トチャ
カ(ヤハズツノマタ)、エゾツノマタ、トゲツノマタ、ヒ
ラコトジ、コトジツノマタ、スギノリ、シキンノリ、カ
イノリ、イボツノマタ、ヤレウスバノリ、カギウスバノ
リ、スジウスバノリ、ハイウスバノリ、アカモミジノ
リ]などが代表的なものとして挙げられる。Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaonori, Hosoedaoonori), Anaaousa (Aousa) and the seaweed [Aosa] Kinds: Kombu (Macambu, Rishikonbu, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Ao-Wakame, Giant kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuyuki prickly pear, Echinoki prickly pear], seaweed [Red algae: Hijirimen, Maxa (Tengusa), Hiracusa, Oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonoji, Kotobino, Kotobino , Hyus banori, Akamomininori] and the like.
【0041】又、その他の藻類、例えば、緑藻類(クラ
ミドモナス属:クラミドモナス、アカユキモ、ドゥナリ
エラ属:ドゥナリエラ、クロロコッカス属:クロロコッ
カス、クワノミモ属:クワノミモ、ボルボックス属:オ
オヒゲマワリ、ボルボックス、パルメラ属、ヨツメモ
属、アオミドロ属:ヒザオリ、アオミドロ、ツルギミド
ロ属、ヒビミドロ属:ヒビミドロ、アオサ属:アナアオ
サ、アミアオサ、ナガアオサ、カワノリ属:カワノリ、
フリッチエラ属、シオグサ属:オオシオグサ、アサミド
リシオグサ、カワシオグサ、マリモ、バロニア属:タマ
ゴバロニア、タマバロニア、マガタマモ属:マガタマ
モ、イワヅタ属:フサイワヅタ、スリコギヅタ、ヘライ
ワヅタ、クロキヅタ、ハネモ属、ミル属:ミル、クロミ
ル、サキブチミル、ナガミル、ヒラミル、カサノリ属:
カサノリ、ジュズモ属:フトジュズモ、タマジュズモ、
ミゾジュズモ、ミカヅキモ属、コレカエテ属、ツヅミモ
属、キッコウグサ属:キッコウグサ、ヒトエグサ属:ヒ
トエグサ、ヒロハノヒトエグサ、ウスヒトエグサ、モツ
キヒトエ、サヤミドロ属、クンショウモ属、スミレモ
属:スミレモ、ホシミドロ属、フシナシミドロ属な
ど)。Other algae such as green algae (Chlamydomonas spp .: Chlamydomonas, Akayukimo, Dunaliella spp .: Dunaliella, Chlorococcus spp. Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaet, Genus Genus genus, Species of the genus Cyperaceae: Species of the genus Cyperaceae, the genus of the spider genus;
【0042】藍藻類(スイゼンジノリ属:スイゼンジノ
リ、アオコ属、ネンジュモ属:カワタケ、イシクラゲ、
ハッサイ、ユレモ属、ラセンモ(スピルリナ)属:スピル
リナ、トリコデスミウム(アイアカシオ)属など)。Cyanobacteria (Genus L .: L., L., L .; L., L .;
(Hassay, Yuremo genus, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio) genus, etc.).
【0043】褐藻類(ピラエラ属:ピラエラ、シオミド
ロ属:ナガミシオミドロ、イソブドウ属:イソブドウ、
イソガワラ属:イソガワラ、クロガシラ属:グンセンク
ロガシラ、カシラザキ属:カシラザキ、ムチモ属:ムチ
モ、ヒラムチモ、ケベリグサ、アミジグサ属:アミジグ
サ、サキビロアミジ、サナダグサ属:サナダグサ、フク
リンアミジ、コモングサ属:コモングサ、ヤハズグサ
属:エゾヤハズ、ヤハズグサ、ウラボシヤハズ、ジガミ
グサ属:ジガミグサ、ウミウチワ属:ウミウチワ、コナ
ウミウチワ、アカバウミウチワ、ナミマクラ属:ヒルナ
ミマクラ、ソメワケグサ属:ソメワケグサ、ナバリモ
属:ナバリモ、チャソウメン属:モツキチャソウメン、
マツモ属:マツモ、ナガマツモ属:ナガマツモ、オキナ
ワモズク属:オキナワモズク、ニセフトモズク属:ニセ
フトモズク、フトモズク属:フトモズク、イシモズク
属:イシモズク、クロモ属:クロモ、ニセモズク属:ニ
セモズク、モズク属:モズク、イシゲ属:イシゲ、イロ
ロ、イチメガサ属:イチメガサ、ケヤリ属:ケヤリ、ウ
ミボッス属:ウミボッス、ウルシグサ属:ウルシグサ、
ケウルシグサ、タバコグサ、コンブモドキ属:コンブモ
ドキ、ハバモドキ属:ハバモドキ、ハバノリ属:ハバノ
リ、セイヨウハバノリ属:セイヨウハバノリ、コモンブ
クロ属:コモンブクロ、エゾブクロ属:エゾブクロ、フ
クロノリ属:フクロノリ、ワタモ、チシマフクロノリ
属:チシマフクロノリ、カゴメノリ属:カゴメノリ、ム
ラリドリ属:ムラチドリ、サメズグサ属:サメズグサ、
イワヒゲ属:イワヒゲ、ヨコジマノリ属:ヨコジマノ
リ、カヤモノリ属:カヤモノリ、ウイキョウモ属:ウイ
キョウモ、ツルモ属:ツルモ、アナメ属:アナメ、スジ
メ属:スジメ、ミスジコンブ属:ミスジコンブ、アツバ
ミスジコンブ、コンブ属:ガツガラコンブ、カキジマコ
ンブ、オニコンブ、ゴヘイコンブ、ナガコンブ、エンド
ウコンブ、オオチヂミコンブ、トロロコンブ属:トロロ
コンブ、アントクメ属:アントクメ、カジメ属:カジ
メ、ツルアラメ、クロメ、キクイシコンブ属:キクイシ
コンブ、ネジレコンブ属:ネジレコンブ、クロシオメ
属:クロシオメ、ネコアシコンブ属:ネコアシコンブ、
アラメ属:アラメ、アイヌワカメ属:アイヌワカメ、チ
ガイソ、オニワカメエゾイシゲ属:エゾイシゲ、ヤバネ
モク属:ヤバネモク、ラッパモク属:ラッパモク、ジョ
ロモク属:ウガノモク、ジョロモク、ヒエモク、ホンダ
ワラ属:タマナシモク、イソモク、ナガシマモク、アカ
モク、シダモク、ホンダワラ、ネジモク、ナラサモ、マ
メタワラ、タツクリ、ヤツマタモク、ウミトラノオ、オ
オバモク、フシズシモク、ハハキモク、トゲモク、ヨレ
モク、ノコギリモク、オオバノコギリモク、スギモク
属:スギモク、ウキモ属:オオウキモ、ブルウキモ属:
ブルウキモ、カヤモノリ属:カヤモノリなど)。Brown algae (Piraella spp .: Piraella spp., Shiomid spp .: Naganami spp., Isogrape spp .: Isogrape,
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cyno (Kayamonoli etc.).
【0044】紅藻類(ウシケノリ属:ウシケノリ、フノ
リノウシケ、アマノリ属:アサクサノリ、スサビノリ、
ウップルイノリ、オニアマノリ、タサ、フイリタサ、ベ
ニタサ、ロドコルトン属:ミルノベニ、アケボノモズク
属:アケボノモズク、コナハダ属:ハイコナハダ、ヨゴ
レコナハダ、アオコナハダ、ウミゾウメン属:ウミゾウ
メン、ツクモノリ、カモガシラノリ、ベニモズク属:ベ
ニモズク、ホソベニモズク、カサマツ属:カサマツ、フ
サノリ属:フサノリ、ニセフサノリ属:ニセフサノリ、
ソデガラミ属:ソデガラミ、ガラガラ属:ガラガラ、ヒ
ラガラガラ、ヒロハタマイタダキ属:ヒロハタマイタダ
キ、タマイタダキ属:タマイタダキ、カギケノリ属:カ
ギノリ、カギケノリ、テングサ属:ヒメテングサ、ハイ
テングサ、オオブサ、ナンブグサ、コヒラ、ヨヒラ、キ
ヌクサ、ヒビロウド属:ヒビロウド、ヒメヒビロウド、
イソムメモドキ属:イソムメモドキ、 ミチガエソウ
属:ミチガエソウ、リュウモンソウ属:リュウモンソ
ウ、ヘラリュウモン、ニセカレキグサ属:ニセカレキグ
サ、オキツバラ属:オオバオキツバラ、アカバ属:アカ
バ、マルバアカバ、ナミノハナ属:ホソバナミノハナ、
ナミノハナ、サンゴモドキ属:ガラガラモドキ、シオグ
サゴロモ属:シオグサゴロモ、イワノカワ属:エツキイ
ワノカワ、カイノカワ属:カイノカワ、カニノテ属:カ
ニノテ、サンゴモ属:サンゴモ、ムカデノリ属:ムカデ
ノリ、スジムカデ、カタノリ、ヒラムカデ、キョウノヒ
モ、サクラノリ、ニクムカデ、タンバノリ、ツルツル、
イソノハナ属:ヌラクサ、クロヌラクサ、オオムカデノ
リ、ヒラキントキ属:ヒラキントキ、マタボウ属:マタ
ボウ、キントキ属:チャボキントキ、キントキ、マツノ
リ、コメノリ、トサカマツ、ヒトツマツ、カクレイト
属:オオバキントキ、イトフノリ属:イトフノリ、ナガ
オバネ属:ナガオバネ、フノリ属:ハナフノリ、フクロ
フノリ、マフノリ、カレキグサ属:カレキグサ、トサカ
モドキ属:ホソバノトサカモドキ、ヒロハノトサカモド
キ、ヤツデガタトサカモドキ、クロトサカモドキ、ネザ
シノトサカモドキ、キヌハダ属:キヌハダ、エゾトサカ
属:エゾトサカ、ツカサノリ属:エナシカリメニア、オ
オツカサノリ、ハナガタカリメニア、ホウノオ属:ホウ
ノオ、ヒカゲノイト属:ヒカゲノイト、ウスギヌ、ニク
ホウノオ属:ニクホウノオ、ベニスナゴ属:ベニスナ
ゴ、ススカケベニ属:ススカケベニ、オカムラグサ属:
ヤマダグサ、ミリン属:ミリン、ホソバミリン、トサカ
ノリ属:キクトサカ、エゾナメシ属:エゾナメシ、イソ
モッカ属:イソモッカ、ユカリ属:ユカリ、ホソユカ
リ、イバラノリ属:イバラノリ、サイダイバラ、タチイ
バラ、カギイバラノリ、キジノオ属:キジノオ、イソダ
ンツウ属:イソダンツウ、アツバノリ属:アツバノリ、
オゴノリ属:オゴノリ、ツルシラモ、シラモ、オオオゴ
ノリ、ミゾオコノリ、カバノリ、テングサモドキ属:ハ
チジョウテングサモドキ、フシクレノリ属:フシクレノ
リ、ナミイワタケ属:ナミイワタケ、カイメンソウ属:
カイメンソウ、オキツノリ属:オキツノリ、サイミ属:
イタニグサ、サイミ、ハリガネ、ハスジグサ属:ハスジ
グサ、スギノリ属:イカノアシ、ホソイボノリ、ノボノ
リ、クロハギンナンソウ属:クロハギンナンソウ、アカ
バギンナンソウ属:アカバギンナンソウ、ヒシブクロ
属:ヒシブクロ、マダラグサ属:トゲマダラ、エツキマ
ダラ、タオヤギソウ属:タオヤギソウ、ハナサクラ、フ
クロツナギ属:フクロツナギ、スジコノリ、ハナノエダ
属:ハナノエダ、ヒラタオヤギ属:ヒラタオヤギ、ダル
ス属:ダルス、マサゴシバリ、アナダルス、ウエバグサ
属:ウエバグサ、ベニフクロノリ属:ベニフクロノリ、
フシツナギ属:フシツナギ、ヒメフシツナギ、ヒロハフ
シツナギ、ワツナギソウ属:ヒラワツナギソウ、ウスバ
ワツナギソウ、イギス属:イギス、ケイギス、ハリイギ
ス、ハネイギス、アミクサ、エゴノリ属:エゴノリ、フ
トイギス、サエダ属:サエダ、チリモミジ属:チリモミ
ジ、コノハノリ科:ハブタエノリ、コノハノリ、スズシ
ロノリ、ウスベニ属:ウスベニ、ハスジギヌ属:ハスジ
ギヌ、ナガコノハノリ属:ナガコノハノリ、スジギヌ
属:スジギヌ、アツバスジギヌ、ハイウスバノリ属:カ
ギウスバノリ、ヤレウスバノリ、スジウスバノリ、ハイ
ウスバノリ、ウスバノリモドキ属:ウスバノリモドキ、
アヤニシキ属:アヤニシキ、アヤギヌ属:アヤギヌ、ダ
ジア属:エナシダジア、シマダジア属:イソハギ、シマ
ダジア、ダジモドキ属:ダジモモドキ、イトグサ属:モ
ロイトグサ、フトイグサ、マクリ属:マクリ、ヤナギノ
リ属:ハナヤナギ、ユナ、ヤナギノリ、モツレユナ、ベ
ニヤナギコリ、モサヤナギ、ササバヤナギノリ、ソゾ
属:クロソゾ、コブソゾ、ハネソゾ、ソゾノハナ、ハネ
グサ属:ハネグサ、ケハネグサ、コザネモ属:コザネ
モ、イソムラサキ、ホソコザネモ、ヒメゴケ属:ヒメゴ
ケ、クロヒメゴケ、ヒオドシグ属:キクヒオドシ、ヒオ
ドシグサ、ウスバヒオドシ、アイソメグサ属:アイソメ
グサ、スジナシグサ属:スジナシグサ、イソバショウ
属:イソバショウ、フジマツモ属:フジマツモ、ノコギ
リヒバ属:ハケサキノコギリヒバ、カワモズク属:カワ
モズク、アオカワモズク、ヒメカワモズク、イデユコゴ
メ属:イデユコゴメ、オキチモズク属:オキチモズク、
イトグサ属、チノリモ属:チノリモ、チスジノリ属:チ
スジノリなど)。Red algae (Russula genus: Rush genus, Funorinoshiki, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakraitus: Genus Odonata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Hounoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge and genus: ssp.
Genus: crocodile, crocodile, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullconi, Shikokonori, Hananoeda: Hanaeda, Hiratagoat: Hiratagoat, Darusu: Dars, Masagoshibari, Anadars, Weedbugsa: Uebaguni, Benifukunori
Species of sarcophagi: sarcophagia, scorpion, scorpion, scorpion genus: syllabus, smelt, ssp. Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagusubanori, Jauresubanoli, Jaureusubanoli, Jaureusubanori, Jaureusubanoli
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dassia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Makuri, Yanagina, Hana, Rana Salix var. Genus Isomegusa: Isomegusa, Suginashigusa: Suginashigusa, Isobashi Genus: Isobashi, Fujimatsumo: Fujimatsumo, Sawweed: Mushroom Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).
【0045】車軸藻類(シャジクモ属、シラタマモ属、
ホシツリモ属:ホシツリモ、リクノタムヌス属、フラス
コモ属:ヒメフラスコモ、チャボフラスコモ、トリペラ
属など)、黄色藻類(ヒカリモ属:ヒカリモなど)な
ど。Axles of the axle (Charium spp.
Hossiturimo: Hossiturimo, Lychnotanus genus, Hessian moss: Himejirasamo, Chaboshiramo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).
【0046】又、動物系原料由来の素材としては、鶏冠
抽出物、牛又は人の胎盤抽出物、豚又は牛の胃や十二指
腸或いは腸の抽出物若しくはその分解物、豚又は牛の脾
臓の抽出物若しくはその分解物、豚又は牛の脳組織の抽
出物、水溶性コラーゲン、アシル化コラーゲン等のコラ
ーゲン誘導体、コラーゲン加水分解物、エラスチン、エ
ラスチン加水分解物、水溶性エラスチン誘導体、ケラチ
ン及びその分解物又はそれらの誘導体、シルク蛋白及び
その分解物又はそれらの誘導体、豚又は牛血球蛋白分解
物(グロビンペプチド)、豚又は牛ヘモグロビン分解物
(ヘミン、ヘマチン、ヘム、プロトヘム、ヘム鉄等)、
牛乳、カゼイン及びその分解物又はそれらの誘導体、脱
脂粉乳及びその分解物又はそれらの誘導体、ラクトフェ
リン又はその分解物、鶏卵成分、魚肉分解物など。Materials derived from animal raw materials include a cockscomb extract, a cow or human placenta extract, a pig or cow stomach, a duodenum or an intestinal extract or a decomposition product thereof, and a pig or cow spleen extract. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Cow milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.
【0047】(14)微生物培養代謝物 酵母代謝物、酵母菌抽出エキス、納豆菌代謝物、納豆抽
出エキス、米発酵エキス、米糠(赤糠、白糠)発酵エキ
ス、ユーグレナ抽出物、生乳又は脱脂粉乳の乳酸発酵物
やトレハロース又はその誘導体など。(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran (red bran, white bran) ferment extract, euglena extract, raw milk or skim milk powder Lactic acid fermentation products and trehalose or derivatives thereof.
【0048】(15)α-ヒドロキシ酸類 グリコール酸、クエン酸、リンゴ酸、酒石酸、乳酸な
ど。(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.
【0049】(16)無機顔料 無水ケイ酸、ケイ酸マグネシウム、タルク、カオリン、
ベントナイト、マイカ、雲母チタン、オキシ塩化ビスマ
ス、酸化ジルコニウム、酸化マグネシウム、酸化亜鉛、
酸化チタン、炭酸カルシウム、炭酸マグネシウム、黄酸
化鉄、ベンガラ、黒酸化鉄、グンジョウ、酸化クロム、
水酸化クロム、カーボンブラック、カラミンなど。(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.
【0050】(17)紫外線吸収/遮断剤 ベンゾフェノン誘導体(2-ヒドロキシ-4-メトキシベン
ゾフェノン、2-ヒドロキシ-4-メトキシベンゾフェノン-
5-スルホン酸、2-ヒドロキシ-4-メトキシベンゾフェノ
ン-5-スルホン酸ナトリウム、ジヒドロキシジメトキシ
ベンゾフェノン、ジヒドロキシジメトキシベンゾフェノ
ン−スルホン酸ナトリウム、2,4-ジヒドロキシベンゾフ
ェノン、テトラヒドロキシベンゾフェノンなど)、p-
アミノ安息香酸誘導体(パラアミノ安息香酸、パラアミ
ノ安息香酸エチル、パラアミノ安息香酸グリセリル、パ
ラジメチルアミノ安息香酸アミル、パラジメチルアミノ
安息香酸オクチルなど)、メトキシ桂皮酸誘導体(パラ
メトキシ桂皮酸エチル、パラメトキシ桂皮酸イソプロピ
ル、パラメトキシ桂皮酸オクチル、パラメトキシ桂皮酸
2-エトキシエチル、パラメトキシ桂皮酸ナトリウム、パ
ラメトキシ桂皮酸カリウム、ジパラメトキシ桂皮酸モノ
-2-エチルヘキサン酸グリセリルなど)、サリチル酸誘
導体(サリチル酸オクチル、サリチルフェニル、サリチ
ル酸ホモメンチル、サリチル酸ジプロピレングリコー
ル、サリチル酸エチレングリコール、サリチル酸ミリス
チル、サリチル酸メチルなど)、アントラニル酸誘導体
(アントラニル酸メチルなど)、ウロカニン酸誘導体
(ウロカニン酸、ウロカニン酸エチルなど)、クマリン
誘導体、アミノ酸系化合物、ベンゾトリアゾール誘導
体、テトラゾール誘導体、イミダゾリン誘導体、ピリミ
ジン誘導体、ジオキサン誘導体、カンファー誘導体、フ
ラン誘導体、ピロン誘導体、核酸誘導体、アラントイン
誘導体、ニコチン酸誘導体、ビタミンB6誘導体、ウン
ベリフェロン、エスクリン、桂皮酸ベンジル、シノキサ
ート、オキシベンゾン、ジオキシベンゾン、オクタベン
ゾン、スリソベンゾン、ベンゾレソルシノール、アルブ
チン、グアイアズレン、シコニン、バイカリン、バイカ
レイン、ベルベリン、ネオヘリオパン、エスカロール、
酸化亜鉛、タルク、カオリンなど。(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, monodiparamethoxycinnamate
Glyceryl-2-ethylhexanoate), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, diamine Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.
【0051】(18)美白剤 p−アミノ安息香酸誘導体、サルチル酸誘導体、アント
ラニル酸誘導体、クマリン誘導体、アミノ酸系化合物、
ベンゾトリアゾール誘導体、テトラゾール誘導体、イミ
ダゾリン誘導体、ピリミジン誘導体、ジオキサン誘導
体、カンファー誘導体、フラン誘導体、ピロン誘導体、
核酸誘導体、アラントイン誘導体、ニコチン酸誘導体、
ビタミンC又はその誘導体(ビタミンCリン酸エステル
マグネシウム塩、ビタミンCグルコシドなど)、ビタミ
ンE又はその誘導体、コウジ酸又はその誘導体、オキシ
ベンゾン、ベンゾフェノン、アルブチン、グアイアズレ
ン、シコニン、バイカリン、バイカレイン、ベルベリ
ン、胎盤エキス、エラグ酸、ルシノールなど。(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and so on.
【0052】(19)チロシナーゼ活性阻害剤 ビタミンC又はその誘導体(ビタミンCリン酸エステル
マグネシウム塩、ビタミンCグルコシドなど)、ハイド
ロキノン又はその誘導体(ハイドロキノンベンジルエー
テルなど)、コウジ酸又はその誘導体、ビタミンE又は
その誘導体、N−アセチルチロシン又はその誘導体、グ
ルタチオン、過酸化水素、過酸化亜鉛、胎盤エキス、エ
ラグ酸、アルブチン、ルシノール、シルク抽出物、植物
エキス(カミツレ、クワ、トウキ、ワレモコウ、クラ
ラ、ヨモギ、スイカズラ、キハダ、ドクダミ、マツホ
ド、ハトムギ、オドリコソウ、ホップ、サンザシ、ユー
カリ、セイヨウノコギリソウ、アルテア、ケイヒ、マン
ケイシ、ハマメリス、ヤマグワ、延命草、桔梗、トシ
シ、続随子、射干、麻黄、センキュウ、ドッカツ、サイ
コ、ボウフウ、ハマボウフウ、オウゴン、牡丹皮、シャ
クヤク、ゲンノショウコ、葛根、甘草、五倍子、アロ
エ、ショウマ、紅花、緑茶、紅茶、阿仙薬)など。(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (eg, magnesium phosphate of vitamin C, vitamin C glucoside), hydroquinone or a derivative thereof (eg, hydroquinone benzyl ether), kojic acid or a derivative thereof, vitamin E or a derivative thereof Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, corn, waremokou, clara, mugwort, Honeysuckle, yellowfin, amberjack, matsuhodo, adlay, dragonflies, hops, hawthorn, eucalyptus, achillea millefolium, althea, keihi, mankeishi, hamamelis, yamaguwa, enmeisou, bellflower, toshishi, seizome, sun dried, mao, senkyu Dokkatsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.
【0053】(20)メラニン色素還元/分解物質 フェニル水銀ヘキサクロロフェン、酸化第二水銀、塩化
第一水銀、過酸化水素水、過酸化亜鉛、ハイドロキノン
又はその誘導体(ハイドロキノンベンジルエーテル)な
ど。(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.
【0054】(21)ターンオーバーの促進作用/細胞賦活
物質 ハイドロキノン、乳酸菌エキス、胎盤エキス、霊芝エキ
ス、ビタミンA、ビタミンE、アラントイン、脾臓エキ
ス、胸腺エキス、酵母エキス、発酵乳エキス、植物エキ
ス(アロエ、オウゴン、スギナ、ゲンチアナ、ゴボウ、
シコン、ニンジン、ハマメリス、ホップ、ヨクイニン、
オドリコソウ、センブリ、トウキ、トウキンセンカ、ア
マチャ、オトギリソウ、キュウリ、タチジャコウソウ、
ローズマリー、パセリ)など。(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odrich, Assemble, Touki, Calendula officinalis, Amacha, Hypericum perforatum, Cucumber, Periwinkle,
Rosemary, parsley).
【0055】(22)収斂剤 コハク酸、アラントイン、塩化亜鉛、硫酸亜鉛、酸化亜
鉛、カラミン、p-フェノールスルホン酸亜鉛、硫酸ア
ルミニウムカリウム、レゾルシン、塩化第二鉄、タンニ
ン酸(カテキン化合物を含む)など。(22) Astringent Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.
【0056】(23)活性酸素消去剤 SOD、カタラーゼ、グルタチオンパーオキシダーゼな
ど。(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.
【0057】(24)抗酸化剤 ビタミンC又はその塩、ステアリン酸エステル、ビタミ
ンE又はその誘導体、ノルジヒドログアセレテン酸、ブ
チルヒドロキシトルエン(BHT)、ブチルヒドロキシ
アニソール(BHA)、ヒドロキシチロソール、パラヒ
ドロキシアニソール、没食子酸プロピル、セサモール、
セサモリン、ゴシポールなど。(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, etc.
【0058】(25)過酸化脂質生成抑制剤 β-カロチン、植物エキス(ゴマ培養細胞、アマチャ、
オトギリソウ、ハマメリス、チョウジ、メリッサ、エン
メイソウ、シラカバ、セージ、ローズマリー、南天実、
エイジツ、イチョウ、緑茶)など。(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Amami,
Ages, ginkgo, green tea) etc.
【0059】(26)抗炎症剤 イクタモール、インドメタシン、カオリン、サリチル
酸、サリチル酸ナトリウム、サリチル酸メチル、アセチ
ルサリチル酸、塩酸ジフェンヒドラミン、d-カンフル、
dl-カンフル、ヒドロコルチゾン、グアイアズレン、カ
マズレン、マレイン酸クロルフェニラミン、グリチルリ
チン酸又はその塩、グリチルレチン酸又はその塩、甘草
エキス、シコンエキス、エイジツエキスなど。(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.
【0060】(27)抗菌・殺菌・消毒薬 アクリノール、イオウ、グルコン酸カルシウム、グルコ
ン酸クロルヘキシジン、スルファミン、マーキュロクロ
ム、ラクトフェリン又はその加水分解物、塩化アルキル
ジアミノエチルグリシン液、トリクロサン、次亜塩素酸
ナトリウム、クロラミンT、サラシ粉、ヨウ素化合物、
ヨードホルム、ソルビン酸又はその塩、サルチル酸、デ
ヒドロ酢酸、パラヒドロキシ安息香酸エステル類、ウン
デシレン酸、チアミンラウリル硫酸塩、チアミンラウリ
ル硝酸塩、フェノール、クレゾール、p-クロロフェノー
ル、p-クロロ-m-キシレノール、p-クロロ-m-クレゾー
ル、チモール、フェネチルアルコール、o-フェニルフ
ェノール、イルガサンCH3565、ハロカルバン、ヘキサク
ロロフェン、クロロヘキシジン、エタノール、メタノー
ル、イソプロピルアルコール、ベンジルアルコール、エ
チレングリコール、プロピレングリコール、フェノキシ
エタノール、クロロブタノール、イソプロピルメチルフ
ェノール、非イオン界面活性剤(ポリオキシエチレンラ
ウリルエーテル、ポリオキシエチレンノニルフェニルエ
ーテル、ポリオキシエチレンオクチルフェニルエーテル
など)、両性界面活性剤、アニオン界面活性剤(ラウリ
ル硫酸ナトリウム、ラウロイルサルコシンカリウムな
ど)、カチオン界面活性剤(臭化セチルトリメチルアン
モニウム、塩化ベンザルコニウム、塩化ベンゼトニウ
ム、塩化メチルロザニリン)、ホルムアルデヒド、ヘキ
サミン、ブリリアントグリーン、マラカイトグリーン、
クリスタルバイオレット、ジャーマル、感光素101
号、感光素201号、感光素401号、N-長鎖アシル塩
基性アミノ酸誘導体及びその酸附加塩、酸化亜鉛、ヒノ
キチオール、クジンなど。(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde , Hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.
【0061】(28)保湿剤 グリセリン、プロピレングリコール、1,3-ブチレングリ
コール、ヒアルロン酸又はその塩、ポリエチレングリコ
ール、コンドロイチン硫酸又はその塩、水溶性キチン或
いはキトサン誘導体、ピロリドンカルボン酸又はその
塩、乳酸ナトリウム、ミニササニシキエキス、納豆菌代
謝物、納豆抽出エキス、ヘチマ水、シラカバ(白樺)又
は赤松の樹液(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Natto extract, Loofah water, Birch (birch) or Sap of Akamatsu
【0062】(29)エラスターゼ活性阻害剤 フロオロリン酸ジイソプロピル、植物エキス(オウゴ
ン、オトギリソウ、クララ、桑の葉、ケイヒ、ゲンノシ
ョウコ、コンフリー、セージ、セイヨウニワトコ、ボダ
イジュ、ボタンピ)、海藻エキスなど。(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, Gennoshoko, comfrey, sage, seaweed, bollige, botanpi), seaweed extract and the like.
【0063】(30)頭髪用剤 二硫化セレン、臭化アルキルイソキノリニウム液、ジン
クピリチオン、ビフェナミン、チアントール、カスタリ
チンキ、ショウキョウチンキ、トウガラシチンキ、塩酸
キニーネ、強アンモニア水、臭素酸カリウム、臭素酸ナ
トリウム、チオグリコール酸など。(30) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.
【0064】(31)抗アンドロゲン剤 卵胞ホルモン(エストロン、エストラジオール、エチニ
ルエストラジオールなど)、イソフラボン、オキセンド
ロンなど。(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.
【0065】(32)末梢血管血流促進剤 ビタミンE又はその誘導体、センブリエキス、ニンニク
エキス、人参エキス、アロエエキス、ゲンチアナエキ
ス、トウキエキス、セファランチン、塩化カルプロニウ
ム、ミノキシジルなど。(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.
【0066】(33)刺激剤 トウガラシチンキ、ノニル酸バニルアミド、カンタリス
チンキ、ショウキョウチンキ、ハッカ油、l-メントー
ル、カンフル、ニコチン酸ベンジルなど。(33) Stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.
【0067】(34)代謝活性剤 感光素301号、ヒノキチオール、パントテン酸又はそ
の誘導体、アラントイン、胎盤エキス、ビオチン、ペン
タデカン酸グリセリドなど。(34) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placenta extract, biotin, glyceride pentadecanoate and the like.
【0068】(35)抗脂漏剤 ピリドキシン又はその誘導体、イオウ、ビタミンB6な
ど。(35) Antiseborrheic agents pyridoxine or its derivatives, sulfur, vitamin B6 and the like.
【0069】(36)角質溶解剤 レゾルシン、サリチル酸、乳酸など。(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.
【0070】(37)酸化剤 過酸化水素水、過硫酸ナトリウム、過硫酸アンモニウ
ム、過ホウ酸ナトリウム、過酸化尿素、過炭酸ナトリウ
ム、過酸化トリポリリン酸ナトリウム、臭素酸ナトリウ
ム、臭素酸カリウム、過酸化ピロリン酸ナトリウム、過
酸化オルソリン酸ナトリウム、ケイ酸ナトリウム過酸化
水素付加体、硫酸ナトリウム塩化ナトリウム過酸化水素
付加体、β-チロシナーゼ酵素液、マッシュルーム抽出
液など。(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.
【0071】(38)除毛剤 硫酸ストロンチウム、硫化ナトリウム、硫化バリウム、
硫化カルシウムなどの無機系還元剤、チオグリコール酸
又はその塩類(チオグリコール酸カルシウム、チオグリ
コール酸ナトリウム、チオグリコール酸リチウム、チオ
グリコール酸マグネシウム、チオグリコール酸ストロン
チウム)など。(38) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.
【0072】(39)毛髪膨潤剤 エタノールアミン、尿素、グアニジンなど。(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.
【0073】(40)染料剤 5-アミノオルトクレゾール、2-アミノ-4-ニトロフェノ
ール、2-アミノ-5-ニトロフェノール、1-アミノ-4-メチ
ルアミノアントラキノン、3,3′-イミノジフェノール、
塩酸2,4-ジアミノフェノキシエタノール、塩酸2,4-ジア
ミノフェノール、塩酸トルエン-2,5-ジアミン、塩酸ニ
トロパラフェニレンジアミン、塩酸パラフェニレンジア
ミン、塩酸N-フェニルパラフェニレンジアミン、塩酸メ
タフェニレンジアミン、オルトアミノフェノール、酢酸
N−フェニルパラフェニレンジアミン、1,4-ジアミノア
ントラキノン、2,6-ジアミノピリジン、1,5-ジヒドロキ
シナフタレン、トルエン-2,5-ジアミン、トルエン-3,4-
ジアミン、ニトロパラフェニレンジアミン、パラアミノ
フェノール、パラニトロオルトフェニレンジアミン、パ
ラフェニレンジアミン、パラメチルアミノフェノール、
ピクラミン酸、ピクラミン酸ナトリウム、N,N′-ビス
(4-アミノフェニル)-2,5-ジアミノ-1,4-キノンジイミ
ン、5-(2-ヒドロキシエチルアミノ)-2-メチルフェノ
ール、N-フェニルパラフェニレンジアミン、メタアミノ
フェノール、メタフェニレンジアミン、硫酸5-アミノオ
ルトクレゾール、硫酸2-アミノ-5-ニトロフェノール、
硫酸オルトアミノフェノール、硫酸オルトクロルパラフ
ェニレンジアミン、硫酸4,4′-ジアミノジフェニルアミ
ン、硫酸2,4-ジアミノフェノール、硫酸トルエン-2,5-
ジアミン、硫酸ニトロパラフェニレンジアミン、硫酸パ
ラアミノフェノール、硫酸パラニトロオルトフェニレン
ジアミン、硫酸パラニトロメタフェニレンジアミン、硫
酸パラフェニレンジアミン、硫酸パラメチルアミノフェ
ノール、硫酸メタアミノフェノール、硫酸メタフェニレ
ンジアミン、カテコール、ジフェニルアミン、α−ナフ
トール、ヒドロキノン、ピロガロール、フロログルシ
ン、没食子酸、レゾルシン、タンニン酸、2-ヒドロキシ
-5-ニトロ-2′,4′-ジアミノアゾベンゼン-5′-スルホ
ン酸ナトリウム、ヘマテインなど。(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.
【0074】(41)香料 ジャコウ、シベット、カストリウム、アンバーグリスな
どの天然動物性香料、アニス精油、アンゲリカ精油、イ
ランイラン精油、イリス精油、ウイキョウ精油、オレン
ジ精油、カナンガ精油、カラウェー精油、カルダモン精
油、グアヤクウッド精油、クミン精油、黒文字精油、ケ
イ皮精油、シンナモン精油、ゲラニウム精油、コパイバ
バルサム精油、コリアンデル精油、シソ精油、シダーウ
ッド精油、シトロネラ精油、ジャスミン精油、ジンジャ
ーグラス精油、杉精油、スペアミント精油、西洋ハッカ
精油、大茴香精油、チュベローズ精油、丁字精油、橙花
精油、冬緑精油、トルーバルサム精油、バチュリー精
油、バラ精油、パルマローザ精油、桧精油、ヒバ精油、
白檀精油、プチグレン精油、ベイ精油、ベチバ精油、ベ
ルガモット精油、ペルーバルサム精油、ボアドローズ精
油、芳樟精油、マンダリン精油、ユーカリ精油、ライム
精油、ラベンダー精油、リナロエ精油、レモングラス精
油、レモン精油、ローズマリー精油、和種ハッカ精油な
どの植物性香料、その他合成香料など。(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shape essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemon grass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.
【0075】(42)色素・着色剤 赤キャベツ色素、赤米色素、アカネ色素、アナトー色
素、イカスミ色素、ウコン色素、エンジュ色素、オキア
ミ色素、柿色素、カラメル、金、銀、クチナシ色素、コ
ーン色素、タマネギ色素、タマリンド色素、スピルリナ
色素、ソバ全草色素、チェリー色素、海苔色素、ハイビ
スカス色素、ブドウ果汁色素、マリーゴールド色素、紫
イモ色素、紫ヤマイモ色素、ラック色素、ルチンなど。(42) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.
【0076】その他、保湿剤、ホルモン類、金属イオン
封鎖剤、pH調整剤、キレート剤、防腐・防バイ剤、清
涼剤、安定化剤、乳化剤、動・植物性蛋白質及びその分
解物、動・植物性多糖類及びその分解物、動・植物性糖
蛋白質及びその分解物、血流促進剤、消炎剤・抗アレル
ギー剤、細胞賦活剤、角質溶解剤、創傷治療剤、増泡
剤、増粘剤、口腔用剤、消臭・脱臭剤、苦味料、調味
料、酵素などが上げられ、これらとの併用によって、相
加的及び相乗的な各種の効果が期待できる。In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives and anti-binders, fresheners, stabilizers, emulsifiers, animal and plant proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and antiallergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral preparations, deodorants / deodorants, bittering agents, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.
【0077】又、本発明の抗アレルギー剤、ヒスタミン
遊離抑制剤又は化粧料組成物の剤型は任意であり、カプ
セル、粉末、顆粒、固形、液体、ゲル、気泡、乳液、ク
リーム、軟膏、シートなどの形態で配合して用いること
ができる。The dosage form of the antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention is arbitrary, and may be capsules, powders, granules, solids, liquids, gels, air bubbles, emulsions, creams, ointments, sheets. And the like.
【0078】具体的には、例えば、外用薬用製剤、化粧
水、乳液、クリーム、軟膏、ローション、オイル、パッ
クなどの基礎化粧料、洗顔料や皮膚洗浄料、除毛剤、脱
毛剤、アフターシェーブローション、プレショーブロー
ション、シェービングクリーム、ファンデーション、口
紅、頬紅、アイシャドウ、アイライナー、マスカラなど
のメークアップ化粧料、香水類、シャンプー、リンス、
ヘアートリートメント、整髪料、パーマ剤、ヘアートニ
ック、染毛料、育毛・養毛料などの頭髪化粧料、浴用
剤、消臭剤、防臭剤、パップ剤、プラスター剤、テープ
剤、シート剤、貼付剤、エアゾール剤、その他、歯磨き
類、口中清涼剤・含嗽剤、衛生綿類、ウエットティシュ
など様々な製品に応用でき、又、一般的な飲食品への使
用もできる。Specifically, for example, external preparations, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, and packs, facial cleansers and skin cleansers, depilatory agents, depilatory agents, aftershave lotions , Pre-show lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, makeup cosmetics such as mascara, perfume, shampoo, rinse,
Hair treatments, hair styling agents, perming agents, hair tonics, hair dyes, hair cosmetics such as hair growth and hair restoration, bath agents, deodorants, deodorants, cataplasms, plasters, tapes, sheets, patches, It can be applied to various products such as aerosols, toothpastes, mouth fresheners / gargles, sanitary cotton, wet tissues, and can be used for general foods and drinks.
【0079】尚、本発明の抗アレルギー剤、ヒスタミン
遊離抑制剤又は化粧料組成物への添加の方法について
は、予め加えておいても、製造途中で添加しても良く、
作業性を考えて適宜選択すれば良い。The method of addition to the antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention may be added in advance or during the production.
What is necessary is just to select suitably in consideration of workability.
【0080】[0080]
【実施例】以下に、試験例、処方例を挙げて説明する
が、本発明はこれらに制約されるものではない。The present invention will be described below with reference to Test Examples and Formulation Examples, but the present invention is not limited to these.
【0081】(製造例1)アルテア、アルニカ、ボダイ
ジュ、ボタンピの各植物乾燥物(等量混合)100gを50%
エタノール溶液1Lに浸漬し、室温にて3昼夜抽出した
後、濾過して抽出液(乾燥固形分:アルテア0.5〜2.5
%、アルニカ0.8〜2.4%、ボダイジュ1.5〜3.2%、ボタ
ンピ0.5〜2.5%)を約1.0〜3.0kg得る。(Production Example 1) 100 g of each dried plant (equal amount mixture) of Althea, Arnica, Bodaiju, and Botanpi was 50%
After being immersed in 1 L of an ethanol solution and extracted at room temperature for 3 days and nights, the extract was filtered and dried (dry solid content: Artea 0.5 to 2.5).
%, Arnica 0.8-2.4%, Bodaige 1.5-3.2%, Buttonpig 0.5-2.5%).
【0082】(製造例2)アルテア、アルニカ、ボダイ
ジュ、ボタンピの各植物乾燥物(等量混合)100gを30%
プロピレングリコール溶液及び30%1,3-ブチレングリコ
ール溶液の等量混液1Lにて50℃で6時間緩やかに加温
抽出し、吸引ろ過して抽出液(乾燥固形分:アルテア0.
5〜2.6%、アルニカ0.8〜2.5%、ボダイジュ1.5〜3.3
%、ボタンピ0.5〜2.6%)を約1.0〜3.0kg得る。(Production Example 2) 100 g of each dried plant (mixed in equal amounts) of each of Altea, Arnica, Bodaiju and Buttonpig is 30%
A 1 L mixed solution of an equal volume of a propylene glycol solution and a 30% 1,3-butylene glycol solution is gently heated and extracted at 50 ° C. for 6 hours, filtered by suction, and extracted (dry solid content: Althea 0.1%).
5-2.6%, Arnica 0.8-2.5%, Bodaige 1.5-3.3
%, Buttonpi 0.5-2.6%) about 1.0-3.0kg.
【0083】(製造例3)アルテア、アルニカ、ボダイ
ジュ、ボタンピの各植物乾燥物(等量混合)100gを精製
水(約80℃)1Lに浸漬し、約5時間加温抽出し、濾過
して抽出液(乾燥固形分:アルテア0.6〜2.5%、アルニ
カ0.9〜2.4%、ボダイジュ1.6〜3.2%、ボタンピ0.6〜
2.5%)を約1.0〜3.0kg得る。(Production Example 3) 100 g of each dried plant (mixed in an equal amount) of Altea, Arnica, Bodaiju, and Pontopia was immersed in 1 L of purified water (about 80 ° C.), heated and extracted for about 5 hours, and filtered. Extract (Dry solid content: Althea 0.6-2.5%, Arnica 0.9-2.4%, Bodaige 1.6-3.2%, Bompi 0.6-
2.5%) from about 1.0 to 3.0 kg.
【0084】(製造例4)アルテア、アルニカ、ボダイ
ジュ、ボタンピの各植物乾燥物(等量混合)100gを精製
水(常温)にて約5時間加温抽出し、濾過して抽出液
(乾燥固形分:アルテア0.4〜2.5%、アルニカ0.6〜2.4
%、ボダイジュ1.3〜3.2%、ボタンピ0.7〜2.5%)を約
1.0〜3.0kg得る。(Production Example 4) 100 g of each dried plant (equal amount mixture) of Althea, Arnica, Bodaiju, and Bompei was heated and extracted with purified water (normal temperature) for about 5 hours, and filtered to obtain an extract (dry solid). Minutes: Althea 0.4-2.5%, Arnica 0.6-2.4
%, Bodaige 1.3-3.2%, button pig 0.7-2.5%)
Get 1.0-3.0kg.
【0085】(比較例1)アルテア、アルニカ、ボダイ
ジュ、ボタンピの各植物乾燥物100gを各々50%エタノー
ル溶液1Lに浸漬し、室温にて3昼夜抽出した後、濾過
して抽出液(乾燥固形分:アルテア0.5〜2.5%、アルニ
カ0.8〜2.4%、ボダイジュ1.5〜3.2%、ボタンピ0.5〜
2.5%)を約1.0〜3.0kg得る。(Comparative Example 1) 100 g of each dried plant of Altea, Arnica, Bodaiju and Bompei was immersed in 1 L of a 50% ethanol solution, extracted at room temperature for three days and nights, and then filtered to obtain an extract (dry solid content). : Althea 0.5-2.5%, Arnica 0.8-2.4%, Bodaige 1.5-3.2%, Buttonpi 0.5-
2.5%) from about 1.0 to 3.0 kg.
【0086】(試験1)ヒスタミン遊離抑制試験 I型アレルギー反応では、第2段階において感作された
肥満細胞あるいは好塩基球からヒスタミンなどの化学伝
達物質が遊離する。従って、ヒスタミン遊離を抑制する
ような物質は抗アレルギー作用が期待できる。本試験で
はラットの肥満細胞からヒスタミン遊離試薬であるcomp
ound48/80でヒスタミンを遊離させる試験法(J.Soc.Cos
met.Japan,Vol.25,No.4,P.246(1992))を用い、製
造例1及び比較例1で得られた抽出液について検討し
た。(Test 1) Histamine Release Inhibition Test In a type I allergic reaction, histamine and other chemical mediators are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this test, comp, a histamine release reagent from rat mast cells, was used.
Test method to release histamine at ound48 / 80 (J. Soc. Cos
met.Japan, Vol.25, No.4, P.246 (1992)), and the extracts obtained in Production Example 1 and Comparative Example 1 were examined.
【0087】「試験方法及び評価方法」 a.試料 尚、ヒスタミン遊離抑制試験の試料は本発明の製造例1
で得られた抽出液(固形分濃度:0.5%に調整)を用
い、試験に供した。尚、比較用試料として、クロモリン
(シグマ製)及び比較例1の各植物抽出液を同様の条件
で調製し、試験に用いた。 b.遊離ヒスタミン量の測定 ラット(Slc:Wister系雄性ラット,約4〜9週齢)の
腹腔内から採取した肥満細胞浮遊液1.2mLに、試料0.2mL
とcompound48/80を最終濃度1μg/mLとなるように加
え、37℃で15分間インキュベートした。氷冷して反応停
止後、反応液を遠心分離し、上澄から遊離したヒスタミ
ンを抽出、精製し、o-フタルジアルデヒドにて発色さ
せ、励起波長360nm、蛍光波長450nmにおける蛍光吸光度
を測定し、次式(数1)によりヒスタミン遊離抑制率を
求め、結果は図1に示した。"Test Method and Evaluation Method" a. Sample The sample for the histamine release inhibition test is Production Example 1 of the present invention.
Using the extract obtained in the above (adjusted to a solid content of 0.5%), it was subjected to a test. As comparative samples, cromolyn (manufactured by Sigma) and each plant extract of Comparative Example 1 were prepared under the same conditions and used for the test. b. Measurement of the amount of free histamine A 0.2 mL sample was added to 1.2 mL of a mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: Wister male rat, about 4 to 9 weeks old).
And compound48 / 80 were added to a final concentration of 1 μg / mL, and incubated at 37 ° C. for 15 minutes. After stopping the reaction by cooling on ice, the reaction solution was centrifuged, the histamine released from the supernatant was extracted and purified, and the color was developed with o-phthaldialdehyde. The histamine release inhibition rate was determined by the following equation (Equation 1), and the results are shown in FIG.
【0088】〈数1〉 ヒスタミン遊離抑制率(%)={1−(A−C/B−
C)}×100 A:肥満細胞に試料を共存させてヒスタミン遊離剤を加
えたときに遊離したヒスタミンの蛍光強度 B:肥満細胞にヒスタミン遊離剤を加えたときに遊離し
たヒスタミンの蛍光強度 C:肥満細胞から自然に遊離されるヒスタミンの蛍光強
度(A,B,Cは測定値から盲検値を引いたものであ
る。)<Equation 1> Histamine release inhibition rate (%) = {1− (A−C / B−)
C)} × 100 A: Fluorescence intensity of histamine released when a histamine releasing agent was added to a sample coexisting with mast cells B: Fluorescence intensity of histamine released when a histamine releasing agent was added to mast cells C: Fluorescence intensity of histamine naturally released from mast cells (A, B and C are measured values minus blind values)
【0089】(試験結果)図1の通り、本発明の4種植
物混合抽出液は、クロモリンと比較すると、非常に強い
ヒスタミン遊離抑制作用を有することが確認できた。
又、アルテア、アルニカ、ボダイジュ、ボタンピの単独
の植物抽出物よりも強いヒスタミン遊離抑制作用を有す
ることが確認され、従って、有効に抗アレルギー剤とし
て利用できる。(Test Results) As shown in FIG. 1, it was confirmed that the mixed extract of the four kinds of plants of the present invention had a very strong histamine release inhibitory action as compared with cromolyn.
In addition, it has been confirmed that it has a stronger histamine release inhibitory action than the single plant extracts of Althea, Arnica, Bodaiju and Botanpi, and thus can be effectively used as an antiallergic agent.
【0090】(試験2)安全性試験 (1)皮膚一次刺激性試験 製造例1〜4で得られた抽出液を固形分濃度が約2.0%
になるように調製し、これを背部を剪毛したハートレー
系モルモット(雌性,1群3匹,体重300〜350g)の皮
膚の2×2cm2の四角当たり0.03mLずつ塗布した。判定
は、適用後24,48,72時間に一次刺激性の評点法により
紅斑及び浮腫を指標として行った。その結果、全ての動
物において、何等、紅斑及び浮腫を認めず陰性と判定さ
れた。(Test 2) Safety test (1) Skin primary irritation test The extract obtained in Production Examples 1 to 4 was prepared so that the solid concentration was about 2.0%.
This was applied to the skin of a Hartley-type guinea pig (female, 3 per group, weight: 300 to 350 g) having a shaved back at a rate of 0.03 mL per 2 × 2 cm 2 square. Judgment was carried out 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indices. As a result, in all the animals, no erythema and edema were observed, and the animals were determined to be negative.
【0091】(試験3)安全性試験 (2)皮膚累積刺激性試験 製造例1〜4で得られた抽出液を固形分濃度が約2.0%
となるように調製し、これを側腹部を剪毛(2×4cm2)
したハートレー系モルモット(雌性,1群3匹,体重32
0g前後)の皮膚に1日1回、週5回、0.5mL/動物当り
を塗布した。塗布は2週にわたって、又、剪毛は各週の
最終塗布日に行った。判定は、各塗布日及び最終塗布日
の翌日に一次刺激性の評点法により紅斑及び浮腫を指標
として行った。その結果、全ての動物において、塗布後
2週間にわたって、何等、紅斑及び浮腫を認めず陰性と
判断された。(Test 3) Safety Test (2) Skin Cumulative Irritation Test The extract obtained in Production Examples 1 to 4 has a solid content of about 2.0%.
It is prepared so that the flank is shaved (2 × 4 cm 2 )
Hartley guinea pigs (female, 3 per group, weight 32
0.5 g / animal) was applied to the skin (about 0 g) once a day, 5 times a week. Application was over two weeks and shaving was performed on the last application day of each week. The determination was made on the day following each application day and on the day after the last application day, using primary irritancy scoring as an index of erythema and edema. As a result, in all animals, no erythema and edema were observed for 2 weeks after application, and the animals were judged to be negative.
【0092】(試験4)安全性試験 (3)単回投与毒性試験 製造例1〜4で得られた各種植物抽出粉末を12.5%濃度
になるよう精製水にて調整し、一匹につき16mL/kg量
を、試験前、16時間絶食させたddy系マウス(雄性及び
雌性、1群5匹、5週齢)に経口にてゾンデを以て投与
し、毒性症状の発現、程度などを経時的に観察した。そ
の結果、全てのマウスにおいて14日間、何等異常を認め
ず、解剖の結果も異常がなかった。よって、LD50は2,00
0mg/kg以上であり、安全な物質と判断した。(Test 4) Safety Test (3) Single Dose Toxicity Test Each of the plant extract powders obtained in Production Examples 1 to 4 was adjusted with purified water to a concentration of 12.5%. The dose of kg was orally administered to ddy mice (male and female, 5 mice per group, 5 weeks old), which had been fasted for 16 hours before the test, and observed over time with the appearance and degree of toxic symptoms. did. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, LD50 is 2,00
It was 0 mg / kg or more, so it was judged as a safe substance.
【0093】(処方例)抗アレルギー剤、ヒスタミン遊
離抑制剤又は化粧料組成物の製造上記の評価結果に従
い、以下にその処方例を示すが、各処方例は各製品の製
造における常法により製造したもので良く、配合量のみ
を示した。又、本発明はこれらに限定されるわけではな
い。(Prescription examples) Preparation of antiallergic agent, histamine release inhibitor or cosmetic composition In accordance with the above evaluation results, the following formulation examples are shown. And only the compounding amount is shown. Further, the present invention is not limited to these.
【0094】 (処方例1)乳液 重量% 1.スクワラン 8.0 2.ホホバ油 7.0 3.セチルアルコール 1.5 4.グリセリンモノステアレート 2.0 5.ポリオキシエチレン(20)セチルエーテル 3.0 6.ポリオキシエチレン(20)ソオルビタンモノオレート 2.0 7.1,3-ブチレングリコール 1.0 8.グリセリン 2.0 9.製造例1の4種植物混合抽出液 5.0 10.防腐剤(パラオキシ安息香酸エステル) 適量 11.精製水 100とする残余(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Soorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. Four kinds of mixed plant extracts of Production Example 5.0 10. Preservative (paraoxybenzoate) qs 11. Purified water 100
【0095】 (処方例2)化粧用オイル 重量% 1.流動パラフィン 30.0 2.スクワラン 20.0 3.オリーブ油 20.0 4.パルミチン酸イソプロピル 10.0 5.製造例3の4種植物混合抽出液 1.0 6.ゲンノショウコ熱水抽出エキス 1.0 7.米糠熱水抽出エキス 1.0 8.ブチルヒドロキシアニソール 0.1 9.防腐剤(塩化ベンザルコニウム) 適量 10.香料(茴香水) 適量 11.精製水 100とする残余(Formulation Example 2) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Four kinds of mixed plant extract of Production Example 3 1.0 6. Gennoshoko hot water Extract 1.0 1.0 Rice bran hot water extract 1.0 8. Butylhydroxyanisole 0.1 9. Preservative (benzalkonium chloride) qs 10. Fragrance (flavour) qs 11. Purified water 100
【0096】 (処方例3)柔軟性化粧水 重量% 1.グリセリン 5.0 2.1,3-ブチレングリコール 5.0 3.モノラウリン酸ホ゜リオキシエチレンソルヒ゛タン(20E.O) 1.0 4.エタノール 15.0 5.製造例1の4種植物混合抽出液 2.0 6.山査子50%エタノール抽出液 1.0 7.コンフリー50%エタノール抽出液 1.0 8.抗菌・防腐剤(チアミンラウリル硫酸塩) 適量 9.香料(カミツレ水) 適量 10.精製水 100とする残余(Formulation Example 3) Flexible lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Production Example 1-4 Seed plant mixture extract 2.0 6. Yamakoko 50% ethanol extract 1.0 7. Comfrey 50% ethanol extract 1.0 8. Antibacterial and preservative (thiamine lauryl sulfate) qs 9. Flavor (chamomile water) qs 10. Purified water 100 and the rest
【0097】 (処方例4)収れん化粧水 重量% 1.ソルビット 2.0 2.POE(20)オレイルアルコール 1.0 3.エタノール 15.0 4.陳皮50%1,3-ブチレングリコール抽出液 2.0 5.製造例1の4種植物混合抽出液 2.0 6.緑茶50%エタノール抽出液 1.0 7.トルメンチラ50%エタノール抽出液 1.0 8.ハマメリス50%エタノール抽出液 1.0 9.アラントイン 0.2 10.収れん剤(スルホ石炭酸亜鉛) 0.2 11.抗菌・防腐剤(チアミンラウリル硫酸塩) 適量 12.香料(ラベンダー水) 適量 13.精製水 100とする残余(Formulation Example 4) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Skin 50% 1,3-butylene glycol extract 2.0 5. Preparation Example 1 Mixed extract of four kinds of plants 2.0 6. Green tea 50% ethanol extract 1.0 7. Tormentilla 50% ethanol extract 1.0 8. Hamamelis 50% ethanol extract 1.0 9. Allantoin 0.2 10. Astringent (zinc sulfocarbonate) 0.2 11. Antibacterial and preservative (thiamine lauryl sulfate) qs 12. perfume (lavender water) qs 13. purified water 100
【0098】 (処方例5)2層式化粧水(液〜液型) 重量% 1.スクワラン 8.0 2.POEソルヒ゛タンテトラオレイン酸エステル 0.3 3.ソルビット 1.0 4.エタノール 15.0 5.4種植物混合の30%エタノール抽出液 10.0 6.細辛30%エタノール抽出液 1.0 7.ゲンノショウコ30%エタノール抽出液 1.0 8.アスコルビン酸 0.2 9.収れん剤(スルホ石炭酸ソーダ) 0.2 10.防腐剤(フェノキシエタノール) 適量 11.香料(菩提樹水) 適量 12.精製水 100とする残余(Formulation Example 5) Two-layer lotion (liquid to liquid type) weight% 1. squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. sorbit 1.0 4. ethanol 15.0 5. 4 kinds of plant mixture 30 % Ethanol extract 10.0 6. Spicy 30% ethanol extract 1.0 7. Genoko ginger 30% ethanol extract 1.0 8. Ascorbic acid 0.2 9. Astringent (sodium sulfocarbonate) 0.2 10. Preservative (phenoxyethanol) qs 11. (Bodhi tree water) Appropriate amount 12. Residual water with 100 purified water
【0099】 (処方例6)カーマインローション(液〜固型) 重量% 1.グリセリン 3.0 2.1,3-ブチレングリコール 5.0 3.エタノール 15.0 4.酸化鉄(ベンガラ) 0.2 5.酸化亜鉛 0.5 6.カオリン 2.0 7.4種植物混合の50%プロピレングリコール抽出液 5.0 8.オウゴン50%プロピレングリコール抽出液 2.0 9.桃仁50%プロピレングリコール抽出液 2.0 10.プラセンタエキス 1.0 11.カンファー 0.2 12.フェノール 0.03 13.防腐剤(感光素201号) 適量 14.香料(当帰水) 適量 15.精製水 100とする残余(Formulation Example 6) Carmine lotion (liquid to solid) wt% 1. Glycerin 3.0 2.1, 3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. 50% propylene glycol extract of a mixture of four plants 5.0 8. 50% propylene glycol extract 2.0 9. Peach seed 50% propylene glycol extract 2.0 10. Placenta extract 1.0 11. Camphor 0.2 12. Phenol 0.03 13. Preservative Agent (photosensitizer No. 201) appropriate amount 14. fragrance (Tokimizu) appropriate amount 15. purified water 100 residue
【0100】 (処方例7)パック 重量% 1.ポリビニルアルコール 15.0 2.カルボキシメチルセルロースナトリウム 5.0 3.プロピレングリコール 3.0 4.エタノール 10.0 5.製造例1の4種植物混合抽出液 2.0 6.トウキンセンカ50%エタノール抽出液 1.0 7.ユキノシタ50%エタノール抽出液 1.0 8.サボンソウ50%エタノール抽出液 1.0 9.防腐剤(パラオキシ安息香酸エステル) 適量 10.香料(セージ水) 適量 11.精製水 100とする残余(Formulation Example 7) Pack weight% 1. Polyvinyl alcohol 15.0 2. Sodium carboxymethyl cellulose 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Four kinds of plant mixed extract of Production Example 1 2.0 6. Calendula 50% Ethanol extract 1.0 7. Saxifrage 50% ethanol extract 1.0 8. Soapwort 50% ethanol extract 1.0 9. Preservative (paraoxybenzoate) qs 10. qsperfume (sage water) qs 11. Purified water 100
【0101】 (処方例8)ピールオフパック 重量% 1.グリセリン 5.0 2.プロピレングリコール 4.0 3.ポリビニルアルコール 15.0 4.エタノール 8.0 5.ポリオキシエチレングリコール 1.0 6.パントテニルエチルエーテル 1.0 7.ジャスミン精油 3.0 8.製造例1の4種植物混合抽出液 2.0 9.海藻(ワカメ)50%エタノール抽出液 1.0 10.防腐剤(パラオキシ安息香酸エステル) 適量 11.香料(ローズ水) 適量 12.精製水 100とする残余(Formulation Example 8) Peel-off pack wt% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Jasmine essential oil 3.0 8 .Extract of four kinds of mixed plants of Production Example 1 2.0 9. Seaweed (wakame) 50% ethanol extract 1.0 10. Preservative (paraoxybenzoate) qs 11. Fragrance (rose water) qs 12. Purified water 100 Residue
【0102】 (処方例9)コールドクリーム 重量% 1.サラシミツロウ 11.0 2.流動パラフィン 22.0 3.ラノリン 10.0 4.オリーブ油 15.0 5.ホウ砂 0.5 6.液状シア脂 1.0 7.4種植物混合の50%1,3-ブチレングリコール抽出液 5.0 8.西洋薄荷50%1,3-ブチレングリコール抽出液 2.0 9.ラクトフェリン溶液 2.0 10.西洋スモモ50%1,3-ブチレングリコール抽出液 2.0 11.酵母代謝エキス 2.0 12.防腐剤(アクリノール) 0.1 13.香料(ミカン水) 適量 14.精製水 100とする残余(Formulation Example 9) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 15.0 5. Borax 0.5 6. Liquid shea fat 1.0 7. 50% of a mixture of four kinds of plants 1,3-butylene glycol extract 5.0 8. Western sheer 50% 1,3-butylene glycol extract 2.0 9. Lactoferrin solution 2.0 10. Western plum 50% 1,3-butylene glycol extract 2.0 11. Yeast metabolic extract 2.0 12. Preservative (acrinol) 0.1 13. Appropriate amount of fragrance (Tangerine water) 14. Residual to make purified water 100
【0103】 (処方例10)エモリエントクリーム 重量% 1.ステアリン酸 2.0 2.ステアリルアルコール 7.0 3.還元ラノリン 2.0 4.スクワラン 5.0 5.オクチルドデカノール 6.0 6.ポリオキシエチレンセチルエーテル(25E.O.) 3.0 7.親油性モノステアリン酸グリセリン 2.0 8.プロピレングリコール 5.0 9.製造例1の4種植物混合抽出液 4.0 10.銀杏葉50%1,3-ブチレングリコール抽出液 2.0 11.熊笹葉50%1,3-ブチレングリコール抽出液 2.0 12.メリッサ50%1,3-ブチレングリコール抽出液 2.0 13.トレハロース溶液 2.0 14.防腐剤(パラベン) 適量 15.香料(リンゴ水) 適量 16.精製水 100とする残余(Formulation Example 10) Emollient cream% by weight 1. Stearic acid 2.0 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalane 5.0 5. Octyldodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Four kinds of mixed plant extract of Production Example 4.0 4.0 Ginkgo biloba 50% 1,3-butylene glycol extract 2.0 11. Kuma bamboo leaf 50% 1 2,3-butylene glycol extract 2.0 12. Melissa 50% 1,3-butylene glycol extract 2.0 13. Trehalose solution 2.0 14. Preservative (paraben) qs 15. Flavor (apple water) qs 16. Purified water 100 Residue
【0104】 (処方例11)洗顔クリーム 重量% 1.ミリスチン酸 25.0 2.ステアリン酸 5.0 3.牛脂脂肪酸 5.0 4.プロピレングリコール 10.0 5.水酸化カリウム 6.0 6.ヤシ油脂肪酸ジエタノールアミド 6.0 7.製造例1の4種植物混合抽出液 4.0 8.アガリスク70%1,3-ブチレングリコール抽出液 2.0 9.赤松樹皮70%1,3-ブチレングリコール抽出液 2.0 10.グリチルレチン酸ジカリウム 1.0 11.ローヤルゼリーエキス 0.1 12.防腐剤(サルチル酸) 0.1 13.香料(セージ水) 適量 14.精製水 100とする残余(Formulation Example 11) Face wash cream% by weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Production example 1. A mixture of four kinds of plant extracts 4.0 8. Agarisk 70% 1,3-butylene glycol extract 2.0 9. Akamatsu bark 70% 1,3-butylene glycol extract 2.0 10. Dipotassium glycyrrhetinate 1.0 11. Royal jelly extract 0.1 12 Preservative (salicylic acid) 0.1 13.Perfume (sage water) appropriate amount 14.Purified water 100 residue
【0105】 (処方例12)洗顔クリーム 重量% 1.ステアリン酸 10.0 2.パルミチン酸 10.0 3.ミリスチン酸 12.0 4.ラウリン酸 4.0 5.オレイルアルコール 1.5 6.ラノリン誘導体(E.O.付加物) 1.0 7.グリセリン 18.0 8.水酸化カリウム 6.0 9.製造例3の4種植物混合抽出液 7.0 10.グリチルリレチン酸 1.0 11.蜂蜜 1.0 12.防腐剤(サルチル酸) 0.1 13.香料(菖蒲水) 適量 14.精製水 100とする残余(Formulation Example 12) Face Wash Cream% by Weight 1. Stearic acid 10.0 2. Palmitic acid 10.0 3. Myristic acid 12.0 4. Lauric acid 4.0 5. Oleyl alcohol 1.5 6. Lanolin derivative (EO adduct) 1.0 7. Glycerin 18.0 8. Potassium hydroxide 6.0 9. Mixed extract of four kinds of plants of Production Example 3 7.0 10. Glycyrrhetinic acid 1.0 11. Honey 1.0 12. Preservative (salicylic acid) 0.1 13. Appropriate amount of fragrance (iris water) 14. Purified water 100 and the rest
【0106】 (処方例13)ボディーソープ 重量% 1.ラウリン酸カリウム 15.0 2.ミリスチン酸カリウム 5.0 3.プロピレングリコール 5.0 4.4種植物混合の30%1,3-ブチレングリコール抽出液 5.0 5.紅花30%1,3-ブチレングリコール抽出液 0.5 6.橙皮30%1,3-ブチレングリコール抽出液 0.5 7.ヘチマ30%1,3-ブチレングリコール抽出液 0.5 8.オドリコソウ30%1,3-ブチレングリコール抽出液 0.5 9.ポリエチレン末 0.5 10.納豆菌代謝物 0.5 11.アミノ酸(グリシン、グルタミンなど) 0.5 12.防腐剤(ウンデシレン酸、フェノール) 適量 13.pH調整剤 適量 14.香料(ブドウ水) 適量 15.精製水 100とする残余(Formulation Example 13) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. 30% 1,3-butylene glycol extract of a mixture of four plants 5.0 5. Safflower 30% 1,3-butylene glycol extract 0.5 6. Orange peel 30% 1,3-butylene glycol extract 0.5 7. Loofah 30% 1,3-butylene glycol extract 0.5 8. Odrichou 30% 1,3-butylene Glycol extract 0.5 9. Polyethylene powder 0.5 10. Bacillus natto metabolite 0.5 11. Amino acid (glycine, glutamine, etc.) 0.5 12. Preservative (undecylenic acid, phenol) qs 13. pH adjuster qs 14. Fragrance (grape water) Appropriate amount 15.Purified water 100 residue
【0107】 (処方例14)サンスクリーン化粧品(O/W型) 重量% 1.オキシベンゾン 2.0 2.パラメトキシケイ皮酸オクチル 5.0 3.スクワラン 10.0 4.ワセリン 5.0 5.ステアリルアルコール 3.0 6.ステアリン酸 3.0 7.グリセリルモノステアレート 2.0 8.ポリアクリル酸エチル 1.0 9.1,3-ブチレングリコール 6.0 10.エデト酸二ナトリウム 0.1 11.トリエタノールアミン99% 1.0 12.二酸化チタン 5.0 13.製造例3の4種植物混合抽出液 2.0 14.白樺熱水抽出液 0.5 15.枇杷葉熱水抽出液 0.5 16.防腐剤(パラベン) 適量 17.香料(リンゴ水) 適量 18.精製水 100とする残余(Formulation Example 14) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 99% 1.0 12. Titanium dioxide 5.0 13. Four plants of Production Example 3 Mixed extract 2.0 14. Birch hot water extract 0.5 15. Loquat leaf hot water extract 0.5 16. Preservative (paraben) qs 17. Fragrance (apple water) qs 18. Purified water 100
【0108】 (処方例15)サンスクリーン化粧品(オイルタイプ) 重量% 1.流動パラフィン 70.0 2.パラアミノ安息香酸エチル 1.0 3.テトラヒドロキシベンゾフェノン 1.0 4.セチルオクタノエート 25.0 5.製造例1の4種植物混合抽出液 2.0 6.蓮華草30%1,3-ブチレングリコール抽出液 0.5 7.ヤグルマギク30%1,3-ブチレングリコール抽出液 0.5 8.蓮華草30%エタノール抽出液 0.5 9.酸化防止剤(ブチルヒドロキシトルエン) 適量 10.香料(当帰水) 適量(Formulation Example 15) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Four types of Production Example 1 Plant mixed extract 2.0 6. Lotus flower 30% 1,3-butylene glycol extract 0.5 7. Cornflower 30% 1,3-butylene glycol extract 0.5 8. Lotus flower 30% ethanol extract 0.5 9. Antioxidant (butylhydroxyl Toluene) Appropriate amount 10.Fragrance (Tokisui) Appropriate amount
【0109】 (処方例16)クリームファンデーション(O/W型) 重量% 1.ステアリン酸 4.0 2.モノステアリン酸グリセリン 3.0 3.セタノール 1.5 4.ミリスチン酸イソプロピル 7.0 5.流動パラフィン 10.0 6.サラシミツロウ 3.0 7.トリエタノールアミン 1.5 8.グリセリン 3.0 9.ベントナイト 1.0 10.酸化チタン 8.0 11.カオリン 3.0 12.タルク 3.0 13.着色顔料 1.0 14.製造例1の4種植物混合抽出液の乾燥粉末 0.1 15.黄柏熱水抽出粉末 0.2 16.防腐剤(パラベン) 適量 17.香料(ラベンダー水) 適量 18.精製水 100とする残余(Formulation Example 16) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11. Kaolin 3.0 12. Talc 3.0 13. Color pigment 1.0 14. Dry powder of the four plant mixed extract of Production Example 1 0.1 15. Huangbai hot water extract powder 0.2 16. Preservative (paraben) suitable amount 17. Fragrance (lavender water) proper amount 18. Purified water 100 residue
【0110】 (処方例17)シャンプー 重量% 1.ラウリル硫酸トリエタノールアミン 5.0 2.ポリオキシエチレンラウリルエーテル硫酸ナトリウム 12.0 3.1,3-ブチレングリコール 4.0 4.ラウリン酸ジエタノールアミド 2.0 5.エデト酸二ナトリウム 0.1 6.4種植物混合の50%プロピレングリコール抽出液 10.0 7.海藻(ヒバマタ)50%プロピレングリコール抽出液 2.0 8.ローズマリー50%プロピレングリコール抽出液 1.0 9.コラーゲン加水分解物 1.0 10.抗菌・防腐剤(チアミンラウリル硫酸塩) 適量 11.pH調整剤 適量 12.香料(ハマメリス水) 適量 13.精製水 100とする残余(Formulation Example 17) Shampoo weight% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. 50% propylene glycol extract of a mixture of four plants 10.0 7. Seaweed (Hibamata) 50% propylene glycol extract 2.0 8. Rosemary 50% propylene glycol extract 1.0 9. Collagen hydrolyzate 1.0 10. Antibacterial and antiseptic Agent (thiamine lauryl sulfate) qs 11. pH adjuster qs 12. perfume (hamamelis water) qs 13. Purified water 100 balance
【0111】 (処方例18)リンス 重量% 1.塩化ステアリルトリメチルアンモニウム 2.0 2.セトステアリルアルコール 2.0 3.ポリオキシエチレンラノリンエーテル 3.0 4.プロピレングリコール 5.0 5.製造例1の4種植物混合抽出液 5.0 6.カラギーナン 1.0 7.半夏50%エタノール抽出液 1.0 8.ヨモギ50%エタノール抽出液 1.0 9.トレハロ−ス溶液 1.0 10.加水分解シルク溶液 1.0 11.当帰50%エタノール抽出液 0.5 12.抗菌・防腐剤(塩化ベンザルコニウム) 適量 13.香料(菩提樹) 適量 14.精製水 100とする残余(Formulation Example 18) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Four kinds of mixed plant extract of Production Example 1 5.0 6. Carrageenan 1.0 7. Half summer 50% ethanol extract 1.0 8. Artemisia 50% ethanol extract 1.0 9. Trehalose solution 1.0 10. Hydrolyzed silk solution 1.0 11. Equivalent 50% ethanol extract 0.5 12. Antibacterial・ Preservative (benzalkonium chloride) appropriate amount 13.Fragrance (bodhi tree) appropriate amount 14.Purified water 100 residue
【0112】 (処方例19)リンス 重量% 1.塩化ステアリルトリメチルアンモニウム 2.0 2.セトステアリルアルコール 2.0 3.ポリオキシエチレンラノリンエーテル 3.0 4.プロピレングリコール 5.0 5.製造例1の4種植物混合抽出液 5.0 6.烏薬50%エタノール抽出液 1.0 7.アルギン酸ナトリウム 1.0 8.芍薬50%エタノール抽出液 1.0 9.加水分解シルク溶液 1.0 10.海水乾燥物 1.0 11.抗菌・防腐剤(塩化ベンザルコニウム) 適量 12.香料(カミツレ水) 適量 13.精製水 100とする残余(Formulation Example 19) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Mixed extract of four kinds of plants of Production Example 1 5.0 6.Ethanol extract 50% for crow drug 1.0 7.Sodium alginate 1.0 8.Ethanol extract 50% for shakuyaku 1.0 9.Hydrolyzed silk solution 1.0 10.Seawater dried product 1.0 11.Antibacterial and preservative (benzalkonium chloride) 12. Appropriate amount of fragrance (chamois water) 13. Residual water with 100 purified water
【0113】 (処方例20)ヘアーリキッド 重量% 1.エタノール 29.0 2.ポリオキシプロピレンブチルエーテルリン酸 10.0 3.ポリオキシプロピレンモノブチルエーテル 5.0 4.トリエタノールアミン 1.0 5.製造例4の4種植物混合抽出液 3.0 6.烏薬水抽出液 1.0 7.ユーカリ葉水抽出液 1.0 8.ローズマリー水抽出液 1.0 9.塩化カルプロニウム 0.3 10.ヒノキチオール 0.5 11.ケラチン分解溶液 1.0 12.抗菌・防腐剤(パラベン、塩化ベンザルコニウム) 適量 13.香料(リンゴ水) 適量 14.精製水 100とする残余(Formulation Example 20) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Mixed extraction of four kinds of plants of Production Example 4 Liquid 3.0 6. Cultivated water extract 1.0 7. Eucalyptus leaf water extract 1.0 8. Rosemary water extract 1.0 9. Carpronium chloride 0.3 10. Hinokitiol 0.5 11. Keratin decomposition solution 1.0 12. Antibacterial and preservative (paraben, Benzalkonium chloride) Appropriate amount 13. Fragrance (apple water) Appropriate amount 14. Purified water 100 residue
【0114】 (処方例21)ヘアーリキッド 重量% 1.エタノール 29.0 2.ポリオキシプロピレンブチルエーテルリン酸 10.0 3.ポリオキシプロピレンモノブチルエーテル 5.0 4.トリエタノールアミン 1.0 5.製造例1の4種植物混合抽出液 5.0 6.オドリコソウ50%エタノール抽出液 1.0 7.葡萄葉50%エタノール抽出液 1.0 8.海藻(ヒジリメン、コンブ)50%エタノール抽出液 1.0 9.ケラチン分解溶液 1.0 10.抗菌・防腐剤(パラベン、塩化ベンザルコニウム) 適量 11.香料(レモン水) 適量 12.精製水 100とする残余(Formulation Example 21) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Mixed extraction of four kinds of plants of Production Example 1 Solution 5.0 6. 50% Ethanol extract 1.05 Grape leaf 50% ethanol extract 1.0 8. 50% ethanol extract of seaweed (Hijirimen, Kombu) 1.0 9. Keratin decomposition solution 1.0 10. Antibacterial and preservative (paraben, Benzalkonium chloride) Appropriate amount 11. Fragrance (lemon water) Appropriate amount 12. Purified water 100 residue
【0115】 (処方例22)ヘアートニック 重量% 1.エタノール 40.0 2.オレイン酸エチル 1.0 3.ポリオキシエチレン(40)硬化ヒマシ油 2.0 4.製造例1の4種植物混合抽出液 15.0 5.防腐剤(パラベン) 適量 6.精製水 100とする残余(Formulation Example 22) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Mixed extract of four kinds of plants of Production Example 1 15.0 5. Preservation Reagent (paraben) qs 6. Residual water to 100
【0116】 (処方例23)ヘアートニック 重量% 1.lーメントール 0.2 2.エタノール 32.5 3.ポリオキシエチレン硬化ヒマシ油 0.5 4.プロピレングリコール 5.0 5.塩酸ジフェンヒドラミン 0.3 6.製造例1の4種植物混合抽出液 5.0 7.ヒアルロン酸ナトリウム溶液 1.0 8.カルボキシメチルキチン溶液 1.0 9.ホエイ溶液 1.0 10.抗菌・防腐剤(パラベン) 0.1 11.香料(ローズ水) 適量 12.精製水 100とする残余(Formulation Example 23) Hair tonic% by weight 1. L-menthol 0.2 2. Ethanol 32.5 3. Polyoxyethylene hydrogenated castor oil 0.5 4. Propylene glycol 5.0 5. Diphenhydramine hydrochloride 0.3 6. Four kinds of plant mixture of Production Example 1 Extract 5.0 7. Sodium hyaluronate solution 1.0 8. Carboxymethyl chitin solution 1.0 9. Whey solution 1.0 10. Antibacterial and preservative (paraben) 0.1 11. Flavor (rose water) qs 12. Purified water 100
【0117】 (処方例24)育毛・養毛剤 重量% 1.エタノール 60.0 2.製造例3の4種植物混合抽出液 5.0 3.マロニエ50%プロピレングリコール抽出液 2.0 4.ゴボウ70%プロピレングリコール抽出液 2.0 5.ビタミンE誘導体 1.0 6.トウガラシチンキ 1.0 7.レゾルシン 0.5 8.グリチルリチン酸 0.5 9.ヒドロキシプロピルキトサン溶液 0.5 10.牛ヘマチン液 0.5 11.チンピ50%プロピレングリコール抽出液 2.0 12.白樺50%プロピレングリコール抽出液 2.0 13.アミノ酸(グリシン、グルタミンなど) 0.5 14.抗菌・防腐剤(パラベン) 0.1 15.香料(ローズマリー) 適量 16.精製水 100とする残余(Formulation Example 24) Hair restorer / hair restorer (% by weight) 1. Ethanol 60.0 2. Mixed extract of four kinds of plants in Production Example 5.0 3. Maronier 50% propylene glycol extract 2.0 4. Burdock 70% propylene glycol extract 2.0 5. Vitamin E derivative 1.0 6. Pepper tincture 1.0 7. Resorcinol 0.5 8. Glycyrrhizic acid 0.5 9. Hydroxypropyl chitosan solution 0.5 10. Beef hematin solution 0.5 11. Thympi 50% propylene glycol extract 2.0 12. Birch 50% propylene glycol Extract 2.0 2.0 13. Amino acids (glycine, glutamine, etc.) 0.5 14. Antibacterial and preservative (paraben) 0.1 15. Perfume (rosemary) qs 16. Purified water 100
【0118】 (処方例25)育毛・養毛剤 重量% 1.エタノール 60.0 2.製造例1の4種植物混合抽出液 5.0 3.ホップ50%エタノール抽出液 5.0 4.桜葉50%エタノール抽出液 5.0 5.カンタリスチンキ 0.5 6.パントテン酸誘導体 0.5 7.レゾルシン 0.5 8.グリチルリチン酸 0.5 9.サリチル酸 0.5 10.ヒドロキシエチルキトサン溶液 0.5 11.エラスチン加水分解液 0.5 12.蘭(シンビジユーム)50%1,3-ブチレングリコール抽出液 2.0 13.紫蘇葉50%1,3-ブチレングリコール抽出液 2.0 14.エラスチン加水分解液 0.5 15.抗菌・防腐剤(パラベン) 0.1 16.香料(ラベンダー) 適量 17.精製水 100とする残余(Formulation Example 25) Hair restorer / hair restorer (% by weight) 1. Ethanol 60.0 2. Mixed extract of four plants of Production Example 5.0 3. Ethanol extract 50% of hops 5.0 4. Ethanol extract 50% of cherry blossoms 5.0 5. Cantaris tincture 0.5 6. Pantothenic acid derivative 0.5 7. Resorcin 0.5 0.5 Glycyrrhizic acid 0.5 9. Salicylic acid 0.5 10. Hydroxyethyl chitosan solution 0.5 11. Elastin hydrolyzate 0.5 12. Orchid (Symbidium) 50% 1,3-butylene Glycol extract 2.0 13. Shiso leaf 50% 1,3-butylene glycol extract 2.0 14. Elastin hydrolyzate 0.5 15. Antibacterial and preservative (paraben) 0.1 16. Perfume (lavender) proper amount 17. Make purified water 100 Residue
【0119】 (処方例26)顆粒浴用剤 重量% 1.炭酸水素ナトリウム 58.0 2.無水硫酸ナトリウム 30.0 3.ホウ砂 3.0 4.製造例1の4種植物混合抽出粉末 10.0 5.色素(グンジョウ黄) 適量(Formulation Example 26) Granule bath agent weight% 1. Sodium hydrogen carbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Four kinds of mixed plant extracted powder of Production Example 1 10.0 5. Pigment (Gunjo yellow) Appropriate amount
【0120】 (処方例27)顆粒浴用剤 重量% 1.炭酸水素ナトリウム 58.0 2.無水硫酸ナトリウム 30.0 3.ホウ砂 3.0 4.製造例3の4種植物混合抽出粉末 5.0 5.オドリコソウ70%エタノール抽出粉末 1.0 6.カミツレ70%エタノール抽出粉末 1.0 7.桑白皮70%エタノール抽出粉末 1.0 8.白檀70%エタノール抽出粉末 1.0 9.色素(黄酸化鉄) 適量 10.香料(ハマメリス水) 適量(Formulation Example 27) Granule bath preparation weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Four kinds of mixed plant extracted powder of Production Example 3 5.0 5. 70% ethanolic extract Powder 1.0 6. Chamomile 70% ethanol extracted powder 1.0 7. Mulberry bark 70% ethanol extracted powder 1.0 8. Sandalwood 70% ethanol extracted powder 1.0 9. Pigment (yellow iron oxide) qs 10. Fragrance (hamamerisu water) qs
【0121】(処方例28)被覆保護剤 ガーゼ又はリニメント布に製造例1の4種植物混合抽出
液、抗生物質・抗炎症など適量を混合した処方液を含浸
させ、外傷部に添付する。又、製造例1の4種植物混合
抽出液を直接、局所に散布し、ガーゼなどで被覆しても
良い。(Prescription Example 28) Coating protective agent A gauze or liniment cloth is impregnated with a prescription liquid obtained by mixing the four plant mixture extract of Preparation Example 1 and an appropriate amount of an antibiotic, anti-inflammatory, etc., and attached to the wound. Alternatively, the four plant mixture extract of Production Example 1 may be directly applied locally and covered with gauze or the like.
【0122】(試験5)使用効果試験 本発明の化粧料組成物を実際に使用した場合の効果につ
いて検討を行った。使用テストは湿疹,肌のカユミ,肌
荒れやアトピー性皮膚炎などの皮膚疾患で悩む2〜30
歳の10名をパネラーとし、毎日、朝と夜の2回、洗顔
後に処方例1の乳液の適量を顔面に3ヶ月に渡って塗布
することにより行った。 又、頭皮や髪の生え際に同様
の皮膚疾患が見られる10名(2〜40歳)について
も、毎日の洗髪後、処方例22のヘアートニックの適量
を頭皮に3ヶ月に渡って塗布することにより使用テスト
を実施した。(Test 5) Use Effect Test The effect of the cosmetic composition of the present invention actually used was examined. Use test is 2-30 which is troubled by skin diseases such as eczema, skin kayumi, rough skin and atopic dermatitis
The test was performed by applying an appropriate amount of the emulsion of Formulation Example 1 to the face for three months, twice daily in the morning and evening, after washing the face twice a year. Also, for 10 people (2 to 40 years old) who have the same skin disease on the scalp and hairline, apply the appropriate amount of the hair tonic of Formulation Example 22 to the scalp for 3 months after daily hair washing. The use test was carried out by.
【0123】更に、処方例26の浴用剤についても、湿
疹,肌のカユミ,肌荒れやアトピー性皮膚炎などの皮膚
疾患で悩む0〜45歳の10名を対象に、3ヶ月間、必
ず1日1回適量の浴用剤を溶解させた浴湯に入浴しても
らい、使用テストを実施した。対照には、乳液,ヘアー
トニックから本発明のアルテア、アルニカ、ボダイジ
ュ、ボタンピの4種植物混合抽出液を除き、精製水に変
えたものを同様な方法にて処方したものを用いた。又、
浴用剤については本発明のアルテア、アルニカ、ボダイ
ジュ、ボタンピの4種植物混合抽出液の乾燥粉末の代わ
りに無水硫酸ナトリウムで補正し、同様の方法にて処方
したものを用いた。又、評価方法は下記の基準にて行
い、結果は表1の通りで表中の数値は人数を表す。尚、
使用期間中に皮膚又は頭皮の異常を訴えた者はなかっ
た。Further, the bath preparation of Prescription Example 26 was also used for 10 months aged 0 to 45 years old who suffered from skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis for one month for three months. One time, the subject was bathed in a bath water in which an appropriate amount of bath agent was dissolved, and a use test was performed. As a control, a mixture prepared by the same method except that the extract of the four kinds of plants of the present invention, Altea, Arnica, Bodaiju and Botanpi, was used instead of the emulsion and the hair tonic and replaced with purified water was used. or,
The bath preparation was prepared by the same method as that of the Altea, Arnica, Bodaiju, and Botanpi of the present invention. The evaluation was performed according to the following criteria. The results are as shown in Table 1 and the numbers in the table represent the number of persons. still,
No one complained of skin or scalp abnormalities during the period of use.
【0124】「皮膚(頭皮)疾患改善効果」 有 効:湿疹,肌のカユミ,肌荒れやアトピー性皮膚
炎などの皮膚疾患が改善された。 やや有効:湿疹,肌のカユミ,肌荒れやアトピー性皮膚
炎などの皮膚疾患がやや改善された。 無 効:使用前と変化なし。[Effect of improving skin (scalp) disease] Effective: Skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis were improved. Slightly effective: Skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis were slightly improved. Ineffective: No change from before use.
【0125】 [0125]
【0126】(試験結果)表1の通り、本発明のアルテ
ア、アルニカ、ボダイジュ、ボタンピの4種植物混合抽
出液を含有した化粧料組成物(乳液、ヘアートニック、
浴用剤)の使用は、湿疹、かゆみ、肌荒れやアトピー性
皮膚炎などの皮膚・頭皮疾患に対して、良好な効果が確
認された。(Test Results) As shown in Table 1, a cosmetic composition (emulsion, hair tonic,
The use of bath agent) was confirmed to have a good effect on skin and scalp diseases such as eczema, itching, rough skin and atopic dermatitis.
【0127】[0127]
【発明の効果】本発明のアルテア、アルニカ、ボダイジ
ュ、ボタンピの4種植物混合抽出液は、強いヒスタミン
遊離抑制作用を有し、人又は動物に対して外用しても安
全なものである。従って、抗アレルギー剤、ヒスタミン
遊離抑制剤として使用でき、あらゆる形態の製剤(医薬
品類、医薬部外品類、化粧品類)への応用も可能であ
る。又、本発明の化粧料組成物は、アレルギー性・接触
性の皮膚炎症疾患(例えば、発赤、湿疹、浮腫、腫脹な
ど)や、アトピー性皮膚炎、肌荒れといったトラブルを
有する皮膚・頭皮に対して、その予防及び改善を目的と
して使用することができ、その他、口腔用組成物や食品
への利用展開も可能である。EFFECT OF THE INVENTION The mixed extract of four kinds of plants, Altea, Arnica, Bodaiju and Pontopia, of the present invention has a strong histamine release inhibitory action and is safe even when applied externally to humans or animals. Therefore, it can be used as an antiallergic agent and a histamine release inhibitor, and can be applied to all forms of preparations (medicines, quasi-drugs, cosmetics). Further, the cosmetic composition of the present invention can be used for skin and scalp having troubles such as allergic / contact skin inflammatory diseases (for example, redness, eczema, edema, swelling, etc.), atopic dermatitis, and rough skin. Can be used for the purpose of prevention and improvement thereof, and can also be used for oral compositions and foods.
【図1】本発明のアルテア、アルニカ、ボダイジュ、ボ
タンピの4種植物混合抽出液及びアルテア、アルニカ、
ボダイジュ、ボタンピの各植物抽出液、クロモリンのヒ
スタミン遊離抑制作用を示す図である。FIG. 1 is a mixed extract of four species of Altea, Arnica, Bodaiju and Botanpi of the present invention, and Altea, Arnica,
It is a figure which shows the histamine release inhibitory effect of each plant extract of bodaiju and buttonpi, and cromolyn.
─────────────────────────────────────────────────────
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【手続補正書】[Procedure amendment]
【提出日】平成13年2月22日(2001.2.2
2)[Submission date] February 22, 2001 (2001.2.2)
2)
【手続補正1】[Procedure amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】0022[Correction target item name] 0022
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【0022】尚、本発明の抗アレルギー剤、ヒスタミン
遊離抑制剤又は化粧料組成物は、前記の必須物質に加え
必要に応じ、本発明の効果を損なわない範囲内で、下記
に例示する成分や添加剤を任意に選択・併用して製造す
ることができ、製剤中への含有量は、特に規定しない
が、通常、0.0001〜50%が好ましい。The antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention may further comprise, if necessary, the components listed below as long as the effects of the present invention are not impaired. The additives can be arbitrarily selected and used in combination, and the content in the preparation is not particularly limited, but usually 0.0001 to 50% is preferable.
フロントページの続き Fターム(参考) 4C083 AA032 AA072 AA082 AA111 AA112 AA122 AA162 AB032 AB212 AB232 AB242 AB272 AB312 AB352 AB432 AB442 AC012 AC022 AC072 AC092 AC102 AC122 AC132 AC182 AC242 AC342 AC352 AC402 AC422 AC432 AC472 AC482 AC532 AC542 AC552 AC582 AC642 AC682 AC692 AC782 AC792 AC852 AC862 AC902 AD022 AD042 AD092 AD112 AD192 AD272 AD302 AD322 AD332 AD352 AD412 AD432 AD442 AD452 AD512 AD532 AD552 AD642 AD662 BB51 BB53 CC04 CC05 CC06 CC07 CC12 CC19 CC23 CC25 CC32 CC37 CC38 CC39 DD16 DD23 DD27 DD31 DD33 EE11 EE12 EE13 EE17 EE21 EE22 EE28 EE29 EE42 4C088 AB12 AB13 AB26 AB58 AC03 AC04 AC05 AC06 AC11 AC13 BA08 BA09 BA10 MA07 MA63 NA14 ZA89 ZB13 ZC13 Continued on the front page F-term (reference) 4C083 AA032 AA072 AA082 AA111 AA112 AA122 AA162 AB032 AB212 AB232 AB242 AB272 AB312 AB352 AB432 AB442 AC012 AC022 AC072 AC092 AC102 AC122 AC132 AC182 AC242 AC342 AC352 AC402 AC422 AC432 AC472 AC482 AC542 AC542 AC792 AC852 AC862 AC902 AD022 AD042 AD092 AD112 AD192 AD272 AD302 AD322 AD332 AD352 AD412 AD432 AD442 AD452 AD512 AD532 AD552 AD642 AD662 BB51 BB53 CC04 CC05 CC06 CC07 CC12 CC19 CC23 CC25 CC32 CC37 CC38 CC39 DD16 DD23 DD27 DD31 DD29 EE42 4C088 AB12 AB13 AB26 AB58 AC03 AC04 AC05 AC06 AC11 AC13 BA08 BA09 BA10 MA07 MA63 NA14 ZA89 ZB13 ZC13
Claims (3)
ピの4種植物混合抽出物を含有することを特徴とする抗
アレルギー剤。(1) An antiallergic agent comprising an extract of a plant mixture of four species of Altea, Arnica, Bodaiju, and Pontopia.
ピの4種植物混合抽出物を含有することを特徴とするヒ
スタミン遊離抑制剤。2. A histamine release inhibitor comprising an extract of a plant mixture of four species of Altea, Arnica, Bodaiju and Pontopia.
ー剤、ヒスタミン遊離抑制剤の何れか1種以上を含有す
ることを特徴とする化粧料組成物。3. A cosmetic composition comprising at least one of the antiallergic agent and the histamine release inhibitor according to claim 1 or 2.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP32624999A JP2001139489A (en) | 1999-11-17 | 1999-11-17 | Cosmetic composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP32624999A JP2001139489A (en) | 1999-11-17 | 1999-11-17 | Cosmetic composition |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001139489A true JP2001139489A (en) | 2001-05-22 |
Family
ID=18185670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP32624999A Pending JP2001139489A (en) | 1999-11-17 | 1999-11-17 | Cosmetic composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2001139489A (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003095967A (en) * | 2001-09-27 | 2003-04-03 | Ichimaru Pharcos Co Ltd | Anti-allergic medicine |
WO2004016236A1 (en) * | 2002-08-14 | 2004-02-26 | Fancl Corporation | Cosmetics |
JP2006290802A (en) * | 2005-04-11 | 2006-10-26 | Kanebo Cosmetics Inc | New diagnostic method for constitution and counseling method using the diagnosis |
JP2007217479A (en) * | 2006-02-15 | 2007-08-30 | Toyo Shinyaku:Kk | Barley young leaf soap |
JP2010241762A (en) * | 2009-04-09 | 2010-10-28 | Korin Pharma Co Ltd | Cosmetic |
JP2011184300A (en) * | 2010-03-04 | 2011-09-22 | Lotte Co Ltd | Immunoglobulin a secretion-promoter |
EP2712899A1 (en) | 2012-09-28 | 2014-04-02 | Ricoh Company, Ltd. | Ink composition, recording method, printed matter, ink cartridge, and inkjet recording device |
JP2015110658A (en) * | 2015-03-05 | 2015-06-18 | 株式会社ロッテ | Immunoglobulin a secretion-promoter |
CN105168066A (en) * | 2015-10-14 | 2015-12-23 | 湖州凯润生物科技有限公司 | Process for preparing antiallergic essence by means of Chinese herbal medicine |
-
1999
- 1999-11-17 JP JP32624999A patent/JP2001139489A/en active Pending
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003095967A (en) * | 2001-09-27 | 2003-04-03 | Ichimaru Pharcos Co Ltd | Anti-allergic medicine |
WO2004016236A1 (en) * | 2002-08-14 | 2004-02-26 | Fancl Corporation | Cosmetics |
JP2006290802A (en) * | 2005-04-11 | 2006-10-26 | Kanebo Cosmetics Inc | New diagnostic method for constitution and counseling method using the diagnosis |
JP2007217479A (en) * | 2006-02-15 | 2007-08-30 | Toyo Shinyaku:Kk | Barley young leaf soap |
JP2010241762A (en) * | 2009-04-09 | 2010-10-28 | Korin Pharma Co Ltd | Cosmetic |
JP2011184300A (en) * | 2010-03-04 | 2011-09-22 | Lotte Co Ltd | Immunoglobulin a secretion-promoter |
EP2712899A1 (en) | 2012-09-28 | 2014-04-02 | Ricoh Company, Ltd. | Ink composition, recording method, printed matter, ink cartridge, and inkjet recording device |
JP2015110658A (en) * | 2015-03-05 | 2015-06-18 | 株式会社ロッテ | Immunoglobulin a secretion-promoter |
CN105168066A (en) * | 2015-10-14 | 2015-12-23 | 湖州凯润生物科技有限公司 | Process for preparing antiallergic essence by means of Chinese herbal medicine |
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