JP2001139489A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new and safe cosmetic composition. SOLUTION: An antiallergic agent, a histamine release inhibitor or this cosmetic composition comprising mixed extracts of four kinds of plants of Althaea officinalis, Arnica montama.L, Tilia miqueliana Maxim and Paeonia moutan Sims is provided. The cosmetic composition has antiallergic action and histamine release-inhibiting action and is effective to skin inflammation diseases (e.g. flare, eczema, edema or swelling), atopic dermatitis, chapped skin, etc. Furthermore, the cosmetic composition enables utilization to general beverages and foods.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an application to an antiallergic agent, a histamine release inhibitor or a cosmetic composition containing a mixed extract of four kinds of plants from Altea, Arnica, Bodaiju and Botanpi. .

[0002] The field of application is, for example, applicable to all kinds of external preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) of liquid, gel or air bubbles
Quasi-drugs, 3) topical or systemic skin cosmetics (e.g., basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents) , Cleansing agents, depilatory, depilatory, shaving treatment, aftershave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eyeshadow, eyeliner, makeup cosmetics such as mascara, perfumes, Cataplasms, plasters, tapes, sheets, patches, aerosols, etc.), 4) Medicinal or /
And cosmetic preparations (eg, shampoos, rinses, treatments, permanent liquids, hair dyes, hair dressings, hair tonics, hair growth / hair restoration, cataplasms, plasters, tapes, sheets, patches) , Aerosols, etc.), 5) bath agents for use in bath water, 6) other, axillary deodorants and deodorants, deodorants, hygiene products, sanitary cotton, wet tissues, mouth fresheners (eg toothpaste, Mouse wash, etc.).

[0003]

2. Description of the Related Art In recent years, owing to recent deterioration of environmental conditions, changes in lifestyles, and increased stress due to the complication of social life, hay fever, allergic rhinitis, bronchial asthma, atopic dermatitis, drug urticity have occurred. The number of people suffering from allergic diseases such as measles, rough skin, and dry skin is increasing. In particular, atopic dermatitis has been attracting attention as one of the modern illnesses, as its increase is screaming not only in children but also in a wide range of ages up to adults.

[0004] Originally, in order to eliminate foreign substances (antigens such as bacteria, pollen, mites, etc.) which have entered the body, it is necessary to produce biological components (antibodies, lymphocytes, etc.) to protect the body. It has an immune function that works. However, sometimes the reaction becomes too sensitive and harmful to the body,
It can cause various diseases. The disorder reaction caused by this immune function is called allergy, and is classified into four types.

[0005] The central cells constituting the immune system are a group of two types of lymphocytes called B cells and T cells mainly present in bone marrow, thymus, spleen, lymph nodes, blood and the like.
B cells are involved in humoral immunity (type I-III allergy)
In response to the antigen, the cells differentiate and proliferate into plasma cells (antibody-producing cells), and secrete the antibody outside the cells. In addition, T cells are mainly involved in cell-mediated immunity (type IV allergy). When they react with an antigen, they become differentiated, proliferate, and become activated T cells that destroy the antigen.

[0006] Type I allergic reactions are the most frequent type, and mainly involve immunoglobulin E (IgE) antibodies. The onset process is the first step in which IgE antibodies are produced from B cells against exogenous antigens, the IgE antibodies adhere to mast cells and basophils, and sensitization is established. Histamine, serotonin, SRS-A and other chemical mediators are released from the second stage, the released chemical mediators cause smooth muscle contraction, increased vascular permeability, edema, nerve stimulation, etc. It is roughly divided into the third stage of developing allergic symptoms.

A type II allergic reaction is a disorder reaction that occurs when cells in a tissue are destroyed by IgG or IgM antibodies. When an antibody binds to an antigen cell, the complement system (a serum protein system that is activated by the effector action of the antibody to kill the antigen cell or significantly accelerate the degradation of the antigen by phagocytic cells) is chain-activated. The cells are destroyed because a complex is formed that destroys the cell membrane. When the activated components of the complement system bind to cells, antigen cells are captured by phagocytic cells such as polymorphonuclear leukocytes and macrophages, decomposed, and removed. On the other hand, during the activation of the complement system, a substance called anaphylatoxin, which has an action of significantly promoting the degradation of antigens by phagocytes, is generated. It also has the effect of increasing the permeability of capillaries, the effect of contracting smooth muscle, and the effect of releasing histamine from mast cells, so that when it is excessively produced, various allergic symptoms will be manifested.

[0008] Type III allergic reactions are mainly caused by IgG antibodies, but their onset is caused by a complex mechanism involving many factors such as the complement system and polymorphonuclear leukocytes. Antigen-antibody conjugates produced by binding antibodies to antigens are used in blood vessels, kidneys, joints,
It deposits on tissues such as the skin and activates the complement system. When the amount of conjugate is high, the complement system is over-activated to produce anaphylatoxins, which may increase vascular permeability or cause inflammation. Also, when phagocytic cells try to remove antigen-antibody conjugates by the action of anaphylatoxin, lysosomal degranulation reaction occurs, and various types of hydrolases such as proteases in lysosomes are released outside the cells, Tissue and cell damage progresses and type III allergy develops.

[0009] Type I-III allergic reactions are all reactions by humoral immunity, a reaction appears 2-3 minutes after contact with the antigen, and the response is highest in more than 10 minutes. Type IV allergic reactions appear after a few hours and are called delayed allergies because they take 48-72 hours to reach a maximum. This allergic reaction is a reaction by cell-mediated immunity. A part of T cells reacts with an antigen to become activated T cells, and when this reacts with the antigen again, various inflammatory factors called lymphokines (macrophage chemotactic factor, Release lymphocyte chemotactic factors, macrophage activating factors, vascular permeability factors, etc.). These act to eliminate the antigen, but if this reaction progresses excessively, allergy develops as a disorder reaction.

[0010]

Many of the conventionally used anti-allergic agents have an action point relatively clear.
It is a drug for diseases caused by type allergic reactions. Examples include antispasmodics that relax smooth muscle, sympathomimetics that suppress the increase in capillary permeability, and antihistamines, all of which are contrasting therapeutic agents that act in the third stage. Most of them are synthetic pharmaceuticals, and have a problem in side effects.

On the other hand, the most active research on antiallergic drugs involved in type I allergic diseases at present is a drug which inhibits release of chemical mediators, and exhibits an antagonistic effect on the released chemical mediators. Although the development of drugs that suppress the second stage, such as drugs, has not been found to have sufficient efficacy, and specific antiallergic drugs against type II, III and IV allergic reactions have also been found. There is no present.

[0012]

[Means for Solving the Problems] In view of such circumstances,
The present inventors have tried to screen substances that are excellent in antiallergic action, have no side effects, and are gentle on the skin from plants that are natural products. As a result, it was found that a mixed extract of four species from Althea, Arnica, Bodaiju and Pontopia has a strong histamine release inhibitory action, and that allergic skin inflammatory diseases containing these (for example, redness) Edema, eczema, swelling, etc.), atopic dermatitis, and skin and scalp troubles such as rough skin, which are excellent in prevention and improvement, and by providing a highly safe cosmetic composition. Reached.

[0013]

DETAILED DESCRIPTION OF THE INVENTION The term "Altea (velvet mallow)" used in the present invention refers to a plant of the family Malvaceae (Malvaceae) or the genus Talaoi (Althaea.L): velvet mallow (Althaea). officinalis) using rhizomes, leaves, trunks and branches.

"Arnica" means asteraceae (Composita
e), a plant of the genus Agaricus (Arnica.L): Arnica (Arnica
ica montama.L) roots and flowers, but other congeners such as American Arnica (A.fulgens Pursh) and A.sororia
Greene, A. cordifolia Hooker, Rabbit (A. unalasc)
hensis.L) can also be used.

"Bodyju: Bodhi tree" means linden family
(Tiliaceae), a plant of the genus Tilia: T.cordata Mill ,; T.ulmifolia Scop.; T.parvifolia
Ehrh.) Flowers, fruits, bark and the like, but other closely related plants: flowers, fruits and bark such as T. platyphyllos and T. xeuropaea L. can also be used.

"Bonpi: Peony" is a family of Pae (Pae)
oniaccae), Plants of the genus Paeonia: Buttons (= Chagusa, Fucamigusa, Natrigusa) "Paeonia moutan S
Use the root bark, rhizome and root of "ims (= Paeonia suffruticosa Andrews)".

The extracts of Altea, Arnica, Bodaiju and Pontopi used in the present invention include various parts of each plant (flower, fruit, leaf, branch, stem, stem, bark, rhizome, root bark,
Roots, etc.) are crushed and then squeezed. Alternatively, those extracted with a solvent as it is or after pulverization are used.

Examples of the extraction solvent for the plant extract include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), acetone and the like. Ketones, esters such as ethyl ether, dioxane, acetonitrile, and ethyl acetate, and organic solvents such as xylene, benzene, and chloroform can be used alone or in any combination of two or more. Further, after extracting each plant with the above-mentioned extraction solvent, four kinds of plant extracts are combined. Moreover, what mixed four kinds of plants from the beginning and extracted with the above-mentioned extraction solvent can also be used.

The production method is not particularly limited, but may be usually within the range of the boiling point of the solvent at normal temperature and normal pressure.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The mixed extract of the four kinds of plants, Althea, Arnica, Bodaiju and Pontopia, may be dried, concentrated or diluted depending on the type and form of the antiallergic agent, histamine release inhibitor or cosmetic composition to be applied. And adjust it.

The extract of four species of plant mixture of Artea, Arnica, Bodaiju and Pontopi of the present invention can be used as it is as an antiallergic agent and a histamine release inhibitor.
Although it can be contained in the cosmetic composition, its content is not particularly limited, and may vary depending on the antiallergic agent, histamine release inhibitor, type of cosmetic composition, quality, expected degree of action. On the contrary, the content is usually 0.001% by weight or more (hereinafter, expressed by%), preferably 0.1 to 10%.
If the content is less than 0.001%, the effect cannot be expected sufficiently.

The antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention may further comprise, if necessary, the components listed below as long as the effects of the present invention are not impaired. The additives can be arbitrarily selected and used in combination.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )Such.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oils Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil and lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharide or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene such as ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide or polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.

(12) Various amino acids: valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a usual manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later. Usually, water and a water-soluble organic solvent (eg, ethanol) are used. ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from among 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

Specific plants (crude drugs) as raw materials include:
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsujirafuji (Kibo), Acacia, Akasho (Akasho), Akasuri `` Fruit '', Red clover, Red grape, Akaminoki (Logwood), Red acacia (Red bud), Akane (Akane grass root), Red acacia or Jio ( Ground yellow), Agi (Awei), Aki Larch, Akinire (Latinaceae),
Aguay Guacu, Aguahe (Omitengu palm),
Akebi (Kidori), Asa (John Asako), Malva Asagao or Asagao (Toshibushi), Hydrangea (hydrangea), Ashitaba (Ashitaba),
Azuki (red azuki), acerola, asenyaku (Asenyaku), acira (shokuyoukanna), anise, abiu, abiurana, rape, avemaki `` fruit '', avocado, ama, amacha (sweet tea), amachaworu, amadocoro (tamatake), Amana (Kikomiko), Amaranthus (Amaranthus), Amaranthus hippochondriacus, Haribiyu, Amaranthus hippochondriax, Amigasa lily or Bimo (shellfish),
Aristolomelia (Yurizisen), Arcana (Alcanna), Argarrobo (Cabbage), Alpinia or Katsumadai (Soudu-ku), Aloe (Length), Aloe vera, Angelica, Apricot or Hong apricot (Apricot kernel), Ansokkou (benzoin), Yellow sapote, Igakouzolina ( Bile head), Epimedium or Epimedium (Inyokaku), rush
(Wicked grass), Knotweed (Tiger root), Yew (1st), Strawberry,
Figs (fructose `` fruits and leaves ''), Ichihatsu (primary), ichibi (winter aoiko), Ichiyakusou (one medicinal herb), ginkgo (ginko `` seed and leaves ''), Itohimehagi (enshi), carob, and locust bean (Telexa) , Inubeil (Honagainubeil), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou, nettle, ylang-ylang, iwa-tobacco
Iwahiba or iwamatsu (makikashiwa), oolong tea, fennel
(Fenka), Wheat (Chibusanoki), Ukiyagara (Sanryong), Uguisukagura `` fruit '', Himeukikyo, turmeric (Utsukin), Duckweed (buoying), Usubasaishin or Keirinsaishin or Oushusaishin (spicy), Usveniaoi , Utsubogusa (summer hay), Udo or Shishiudo (Qang, Independent, Tang Independent), Unyadegato (Unkaria, Cat's claw), Uba tea, Ume (Ume `` seed, pulp ''), Vladinki, Uwaurushi (Kusaco peach), Unshumikan ( Chen), estragon, elephant, echinashi
(Hoshibamurasakibarengiku), Enishida, Enokitake
(Enoki mushroom), Ebisugusa or Cassia tora (Kyoko), El Campre, Elderberry `` fruit '', Elemi, Eryngii or Pre-Lotus Eringe, Endu (Gossip, Sophora rice), Ougi or Kibana-ohgi (Ohioki), Ousei (Naruko Yuri, Kagikurumabanarukoyuri), Ohhisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Hawken, Ookarasuri (Karokon), Ooguruma (engineering incense), Ooturafuji (self-protection), Oobako (car front child, car front grass), Oohashi Haruko), Toucan cactus, Obanana okera or Okera (white jujube), Obanassarsbergi (Banaba), Obanayashabushi "fruit", Ooishigusa (grain sperm), Oumia catechu, Oohashi hawthorn or Hawthorn (barley), barley (barley), barley (barley), barley (barley), barley (barley), barley (barley), barley (barley), barley (barley) , Okazeri (snake bed), okra "fruit",
Oguruma (turning over), Panax ginseng or Panax ginseng
(Ginseng), Hypericum perforatum or St. John's wort or St. John's wort (brother cutting), Odorikosou (interrupted), Onamimomi (blue ears), Onigurimi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma) or Oyuriha or Yuyari Yuri), Ononis, Halibut (Hihayu), Ominaeshi (Defeated), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch honeysuckle, Olive "fruit, seed, leaf", Oregano, Orange "fruit,
Pericarp, caycaio (ripe yellow), cacao, fruit, pericarp, seed, persimmon, persimmon, leaf
Persimmon or licorice, lotus hydrangea, gaku hydrangea,
Cassia, casino (Kozomi `` fruit ''), gajutsu (shajujutsu), kasiwa (shaki, kayoha), cascallilla, cascara sagrada, gypsophila, kanikusa (kinsato), kaniwa, carnation, kanokosou (yoshikone), birch Or weeping birch
(Birch), gerbera, pumpkin, capokoki `` seed '',
Kahoku Sansho (shopper), Gama (bamboo), Chamomile or Roman chamomile, Camellia japonica (weed), Kamkamu (Kamokamo), Color, Karaku Sakeman, Ragwort or Chinese Ragwort (Gourd), Ragwishak (midsummer), Ragwort,
Guarana `` seed '', Karahoo (thick), Karaya, Galyu,
Karin (Gourd), Garcinia, Kawamidori, Kawara Psycho
(Seiryona, vermilion grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko),
Red carrot (Aoko), Red wormwood (Inchinko), Kansui (Sweet), Licorice (Kanzo), Kantara Asa, Candelilla, Kantou, Canna, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Sawberry strawberry, Maple strawberry, European strawberry) Kiwi "fruits and leaves", Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku
(Chrysanthemum flower, oak daisies, artichokes), cypress daisies, catalpa (Azumitsu), sagebrush (sheep hoof root), pheasant (kokomi), kizuta, kidachi aloe, lucky mint, quina, chinoki (shincona, red linden), quinoa (quinoa),
Yellowfin (Hypashi), Gymnema Sylvesta, Kimmenkaku, Cabbage, Cabbage "Immature Fruit", Cucumber, Gyoryu
(Nishikawayanagi, Ichiyanagi), Kiraja Saponaria, Kiraya, Kiranso (Gold Acne Herb), Kumquat `` Fruits '', Ginseki,
Kimbusen, betel, golden hibiscus (Sesame crass), guapeba vermelha, guava `` fruit '', guayule, quelux infectria (gallicate), cucumber nuts,
Wolfberry (Gugi, gugi, gugi leaf, skeletal bark)
(Tenmen winter), Kudzu (Kakkon), camphor tree, gooseberry `` fruit '', Ginseng (yellow flower), Kutiti River, Gardenia (Gardenia), Kunugi (Bokuso), Kupuas, Kumazasa,
Black pine (horse whip grass), Clara (bitter butter), cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curculigo latifolia `` fruit '', grapefruit `` fruit / leaf '', buckthorn, black squirrel (rescue), Kurobana Hikiokoshi Or Hikiokoshi (extended lifegrass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi), kaigai (infestation, infestation), celosia (corolla, rooster), gekkavidin, bayberry (laurel), kenashisarutoribara (soil) (Bukuryo, mountain return), gentian, genoshoko (old treasured grass), kenponashi (kigushi), koukisekoku, kishumikan (kouji, tachibana, ovenimikan, fukuremican, sagamikouji, ponkan, santara (tachibana)), koshinbara (monthly flower) , Kosui mint, Kozo "fruit", Kocha (tea), Kouhone (river bone), Koho (Straw and Kara straw), Koryang, Kouryokyo (Korakyo), Cilantro `` fruit '', Kourouen (Kohren), Koganebana (yellow gon), bilberry (Koshibachi), coconut `` fruit '',
Goshuyu (goshuyu), Goshoichigo (covered bonko), pepper
(Pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot spring), burdock (burdock,
Burdock), kobotdur, sesame (sesame), sesame seeds (gensin), garnish (gomiko), sanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata " Seeds ", Cola
Vera “seed”, colony lya, fenugreek “fruit”, colombo, kondurango, kelp, konjac, comfrey
(Final barn grass), sisal (sisal asa), saxima button or syna button or cinnamon
Sakura (Ooshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Yoshino cherry tree, Takanezakura, Kasumizakura, Chojizakura,
Kohigan, Satozakura, Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''), cherries, pomegranates, sasa, sasanqua,
Sage Modaka (Sawaka), Sweet Potato, Sugarcane, Sugar Beet, Sunabet Jujube (Satsumitsu Jin), Saffron (Safflower, West Safflower), Sapodilla, Sapotea Marillo, Pomelo "Fruit", Sabonsou, Salmon Berry "Fruit", Sarasinoshima (Masuma) , Salvia (sage), Sawagyoukyo (Sancho-na), Sawagumi (Sanguo), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin carrot (San carrot), Sanshuyu (sanshuyu), Sanshoyu (sanshoyu) ), Sandscon (Yamazone), Shea (Carite), Cyano (fruit), Shiitake (Shitake), Shion (Shion), Dikitaris, Shikunshi (Kimiko), Perilla or Aodiso or Chirimendiso or Katamenziso (Perilla leaves, Perilla) ), Rosewood, Japanese pine, Chinese Forsythia (Forsythia), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiro) Ishimeji, Bunashimeji, Honjimeshi, Shirotamogitake), Shimokren
(Shinyi), Spiraea, Potato, Peony (Shakuyaku), Shajin (Shasan), Jasmine (Matsurika), Janohige (Motomon winter), Scutellaria paniculata, Skushamamitsu (sand sand, sand compaction), Juzudama, Palm fruit , Ginger (ginger), ginseng hydrangea (Tsuneyama), shobu (irises, iris roots), shojiku "fruits", shirakashi "seed",
White butterfly (seed), white clover (clover), white adzuki (chicken bone grass), white iris (small iris), white natto (flower), white nanten (minamitenmi),
Cinchona Sacrifura, Jinjuge (Mizuka, Mizuka,
Cinnamon), cinnamon, cinnamomum cassia (cinnamon bark), watermelon (watermelon), honeysuckle (gold and silver flowers, shinto winter), sorrel (acid model), swimberry "fruit", star apple, stevia, strawberry "fruit", tin shiko ,
Horsetail (Thorn), Purslane (Horse Tongue, Horse Tongue), Plum (Fruit), Pinus sylvestris (Cones), Larix sylvestris, European Lentils, European Walnut, European Hawthorn, European Dandelion, European Chestnut (Marronnier), Pear "fruit", snow pear,
Sambucus elder (Elder), Atlantic shrew (Juniper, Juniper), Achillea millefolium (Mirfoil), Atlantic rose, Aurora magnolia, Atlantic mistletoe, Western mackerel or Western mackerel, Western horseradish, Sekisho (stone irises) Cedron (Bowshukuboku), Zeniaoi, Hirohasenega, Senega, Seri, Celery, Senkyu (River Kyu), Senshinren (Shingenren), Sendan, Sennin Cactus, Senna `` Fruits, Leaves '', Senninsou (Otatate), Senbri ), Souka (grass), elephant, buckwheat `` seed '', soybean potato, rhubarb (daisuki), radish, soybean, daidai (orange skin, kikomi), takasaburo (dry lotus grass), takatodai (daigeki), takawarabi (dog) Spine), dark sweet cherry "fruit", hollyhock, hollyhock (thyme) HyakuRika), Tachidokoro (explicit solution), Tachiyanagi, tamarind "seed", onions, Magnolia salicifolia (fist), Aralia elata "fruit, leaf, root bark",
Dahlia (Tengiku button), Tarui, Tanshiniwa, Tanjin (Dan ginseng), Dandelion (Bamboo British) or Shirobana dandelion or Moko dandelion, Dammar, Cherry `` fruit '', Tigaya `` fruit, root, bud '', Chikusetsu carrot (Bamboo ginseng),
Chicory, chancapiedra (Kidachikomikansou), Chinese radish (Ohio), Korean lance (Wuyi), Korean sagebrush (Aiba), Choreimaitake (Irei), Chorogi, Tsukimisou, Tsukuritake (mushroom), camellia, camellia, clover (Lacquer mother grass), twigweed (duckling grass),
Tsuruazuki (red azuki bean), tsuldokudami (how many crows), tsuruna
(Kankyo), Carrot (four-leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tulip, Chocolate stay, Tengusa, Tencha (Tencha), Tendaiyaku (Wakayaku), Touga (Winter melancholy), Toukagi Kazura, Capsicum (Pepper), Touki (Toki), Calendula (Marigold), Tonabena (River cut), Maize or Maize hair (Nanban hair), Toad Mochi (Female Sadako), Toudodou or Korean gentian (Ryubile), Tokusa (wood pirates), dokudami (jujutsu), konkon (sore root), sashimi or mamedaoshi or scutellaria, eucommia (mushroom `` bark, leaves, roots ''), ash (qin bark), tomato, tragacanth, triacanthos `` seed '', Turkey Kikyo, Tormentilla, Dronoki, Trolo-mallow, Niseria berry `` fruit '', Chinese yam or Yamanoimo (herbal medicine), (Chur Bloom), Naginata Kouju, Nazuna, Rape, Rape Bean or Harbinger (Sword Bean), Natsumikan, Jujube (Dajutsu), Naniwaibara
(Kanekurako), Navena (intermittent), Nameko, Narco lily (Yoshimi),
Peanut (peanut), Nanten (Minami Tenmi), Namban Karamushi (ramie), Niois violet, Nigaki (Makiki), Nigamogi (Grasshopper), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabnikkei (Chicago) or Keishi (Katsushige) ), Chinese chive
(Niriko), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nurde (five times), leek, nemoki or neb or nebi or nemuriki or digokbana (health), thistle (Oji) , Noibara (fruit), Yarrow, Japanese radish (Maeko), Nobara, Nomomo, Pineapple `` fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle),
Hyakudo, Hauchiwa, Pau Dosse, Hakayamauraboshi (bone crushing), Hakusen (ringworm skin), Huckleberry `` fruit '', Hakobe (growth), Hashibami (Haruko), Hashiridekoro
(Roth root), basil, lotus (lotus, lotus, lotus), parsley
(Netherland jelly), naked mussel, batata, bee or medake (bamboo boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuinin), hanasuge (chimbo), banana, hana mint, hanabishi (situri, shisuturi), vanilla bins , Papaya, japonicus (rat koji), pahalobobo, hub "whole plant, stem, leaf", paprika, hamago or honeysuckle
(Vine vine), hamasuge (katsuki), hamabishi (shikoriko), hamanas (maikai flower), hamabafu (beach storm), hamamelis, palm, rose (rose), balata, balata rubber tree,
Agaric (Agaric, Agaricus agaricus, Uskimorinosa), Haran, Pariurus (Pleurotus japonicus), Parietaria, Balsamina (Tsurureishi, Nigari), Harunire (Yellow, Yule bark, Yuba), Barbasco, Harindou, Handaikai ), Breadfruit, giant gourd (sun dried), lizard ginseng (party), pecan nuts, gangamana (stones and garlic), higuru madaria, Japanese cypress (hishomi), pistachio, beet, hitotsuba (stone reed), tsutsubayashida , Daisies (daisy), hinotainokozuchi (cow knees), hinoki, cypress, castor, sunflower, peppers, himezu (tenoi), himema (scent), himematsutake (kawariharatake, hiromatsutake), pimenta `` fruit '', juniper, beakyuu , Hiyu (fruit), Hiroha okinagusa
(Shiratoo), loquat `` fruits, leaves, stems '', betel nut (large clothing skin,
Areca roe), Pu'er tea (Pu-cha), Sperm kazura (Southern rattan), Butterflies, Butterbur dandelion (Apricot winter flower, Azalea winter leaf), Fuji bacama (Orchid grass), Fuji bean (Tan beans), Grapes "fruit, peel, seeds, leaves", Beech, Fuyusinatsutake mushroom (Cordyceps), Brazilian liquorice, Brazilian carrot, Black currant `` fruit '', Blackberry, Bragnen, Plum `` fruit '', Flucellaria, Blueberry (Prunus avium), Prune, Floral blanka, Blonde psyllium, Bundou (mung bean), hazelnut, loofah,
Safflower (safflower), henneken, belladonna, berry `` fruit '', persea, perbianberg, pereschia grandifolia, benceisou or duckweed (scenic), boysenberry `` fruit '', broom beetle or elder or nendou or haeukigi kokia (skin skin) (Children), Balsam (Hosen, acute offspring, osteophyte), Potteria sapota, Potteria lukuma, Spinach, Bohu (windbreak), Spinach, Physalis (Torone), Physalis (Wakoboku, Park), Bokeh
(Gourd), Hosovanaokera (Sojutsu), Hosobanokirinsou
(Kageten Sanshichi), Hosobabarengiku, Hop, Jojoba, Boriji (Ruritisha), Bordeaux, Whiteberry Berry `` Fruit '', Hongoniku (Meat Jilong, Daigei), Hongsekok (Iron bark, Sparrow mountain stone), Meisulten Nansho (Tiannan star), Maitake (Maitake), Ephedra (mao), Maca, Macadamia nut, Margaret (Mokshungiku), Macri (Martian grass), Magwa (Mulberry white bark `` bark, leaves ''), Magnolia splengeri, Masaranpouba, Masaranzuba de Ceara, Masaira De Boi, Masahua (Tamanouzenhallen, Kyukonkinrenka), Matabi (Kiten Tate), Matsukasa, Pine `` leaves, bark, roots '', Matta Olho, Matsuhodo (Bukuryo) ), Matico (Cordoncillo), Mayorum (Hanamint), Malvanozadin (Difficult), Mulberry "Fruit", Quince, Malein (Beloyd Mou) Squid), mango, mangosteen, Mansanya (Andes chamomile), Manshuugurumi, Mandarin "fruit",
Mannentake (Lingzhi), Pheasant (Kikomi `` fruits ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokukushi (Hanbe Lotus), Misohagi (Chisatsuna), Mizunyanagi or Shiroyanagi (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle Fruit `` Fruit '', Myrrh, Milobalan, Wheatwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (prolonged skin), Munya, Purple (purple root), Purple or purple
(Purple pearl), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, mehajiki (mother grass), mebougi, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), mock berry (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), sprouts, morello cherry `` fruits '', Moroheiya (Burlap), yakawamurasaki potato, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yacon, yashabushi (arrow wheel) or himeyashabushi or giant yashabushi `` fruit,
`` Peel, ears '', willows, yatsude (octagonal gilded), mistletoe (parasitic willow), willows (kawayanagi, tachiyanagi, weeping willow, red willow, pussy willow, dogwood willow,
(Sweet willow, koreanagi, unryuyanagi, yamayamayanagi, palm, yamayanagi, giant psyllium, tyrichkinuyanagi, foxwillow, bonsai), willow `` leaf,
Stalk '', scabbard, savannah koji (purple beef), savory tobacco
(Tsurusui, Tenmei), pokeweed (commercial land), yamanoki (yamaharu), yamamomo (yangmei), yamamugi, eucalyptus, yukinoshita (tiger ear grass), yucca or flevifolia, yuzu `` fruit '', lily, yorigusa , Mugwort (Aiba), reigan (Rainuma), lime "fruit", rye, lakanka "fruit",
Raspberry `` leaves, fruits '', latania (Clameria), Rakkyo or shallots (Shiroi), lavender, longan (longan meat), agave (Aono agave,
Fukurin agave), Ryokucha (green tea), apple `` fruit, seeds, leaves, roots '', gentian, rubus or suavisimus (sweeten), litchi (lichi, lichi nucleus), lettuce (chisha), red currant `` fruit '', Red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (forsythia), astragalus, coconut palm, locust (reed, azuki), loganberry `` fruit '', rosemary (mannen wax), rosehip (nobara), wasabi, Waremokou (chiyu) and the like.

In addition, other seawaters, for example, seawater salt, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango) Species, for example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients:
Silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese,
Arsenic, water), Shotoku stone.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaonori, Hosoedaoonori), Anaaousa (Aousa) and the seaweed [Aosa] Kinds: Kombu (Macambu, Rishikonbu, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Ao-Wakame, Giant kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuyuki prickly pear, Echinoki prickly pear], seaweed [Red algae: Hijirimen, Maxa (Tengusa), Hiracusa, Oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonoji, Kotobino, Kotobino , Hyus banori, Akamomininori] and the like.

Other algae such as green algae (Chlamydomonas spp .: Chlamydomonas, Akayukimo, Dunaliella spp .: Dunaliella, Chlorococcus spp. Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaet, Genus Genus genus, Species of the genus Cyperaceae: Species of the genus Cyperaceae, the genus of the spider genus;

Cyanobacteria (Genus L .: L., L., L .; L., L .;
(Hassay, Yuremo genus, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio) genus, etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomid spp .: Naganami spp., Isogrape spp .: Isogrape,
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cyno (Kayamonoli etc.).

Red algae (Russula genus: Rush genus, Funorinoshiki, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakraitus: Genus Odonata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Hounoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge and genus: ssp.
Genus: crocodile, crocodile, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullconi, Shikokonori, Hananoeda: Hanaeda, Hiratagoat: Hiratagoat, Darusu: Dars, Masagoshibari, Anadars, Weedbugsa: Uebaguni, Benifukunori
Species of sarcophagi: sarcophagia, scorpion, scorpion, scorpion genus: syllabus, smelt, ssp. Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagusubanori, Jauresubanoli, Jaureusubanoli, Jaureusubanori, Jaureusubanoli
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dassia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Makuri, Yanagina, Hana, Rana Salix var. Genus Isomegusa: Isomegusa, Suginashigusa: Suginashigusa, Isobashi Genus: Isobashi, Fujimatsumo: Fujimatsumo, Sawweed: Mushroom Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).

Axles of the axle (Charium spp.
Hossiturimo: Hossiturimo, Lychnotanus genus, Hessian moss: Himejirasamo, Chaboshiramo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Materials derived from animal raw materials include a cockscomb extract, a cow or human placenta extract, a pig or cow stomach, a duodenum or an intestinal extract or a decomposition product thereof, and a pig or cow spleen extract. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Cow milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran (red bran, white bran) ferment extract, euglena extract, raw milk or skim milk powder Lactic acid fermentation products and trehalose or derivatives thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, monodiparamethoxycinnamate
Glyceryl-2-ethylhexanoate), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, diamine Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and so on.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (eg, magnesium phosphate of vitamin C, vitamin C glucoside), hydroquinone or a derivative thereof (eg, hydroquinone benzyl ether), kojic acid or a derivative thereof, vitamin E or a derivative thereof Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, corn, waremokou, clara, mugwort, Honeysuckle, yellowfin, amberjack, matsuhodo, adlay, dragonflies, hops, hawthorn, eucalyptus, achillea millefolium, althea, keihi, mankeishi, hamamelis, yamaguwa, enmeisou, bellflower, toshishi, seizome, sun dried, mao, senkyu Dokkatsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odrich, Assemble, Touki, Calendula officinalis, Amacha, Hypericum perforatum, Cucumber, Periwinkle,
Rosemary, parsley).

(22) Astringent Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Amami,
Ages, ginkgo, green tea) etc.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde , Hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Natto extract, Loofah water, Birch (birch) or Sap of Akamatsu

(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, Gennoshoko, comfrey, sage, seaweed, bollige, botanpi), seaweed extract and the like.

(30) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placenta extract, biotin, glyceride pentadecanoate and the like.

(35) Antiseborrheic agents pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(38) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shape essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemon grass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives and anti-binders, fresheners, stabilizers, emulsifiers, animal and plant proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and antiallergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral preparations, deodorants / deodorants, bittering agents, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

The dosage form of the antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention is arbitrary, and may be capsules, powders, granules, solids, liquids, gels, air bubbles, emulsions, creams, ointments, sheets. And the like.

Specifically, for example, external preparations, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, and packs, facial cleansers and skin cleansers, depilatory agents, depilatory agents, aftershave lotions , Pre-show lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, makeup cosmetics such as mascara, perfume, shampoo, rinse,
Hair treatments, hair styling agents, perming agents, hair tonics, hair dyes, hair cosmetics such as hair growth and hair restoration, bath agents, deodorants, deodorants, cataplasms, plasters, tapes, sheets, patches, It can be applied to various products such as aerosols, toothpastes, mouth fresheners / gargles, sanitary cotton, wet tissues, and can be used for general foods and drinks.

The method of addition to the antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention may be added in advance or during the production.
What is necessary is just to select suitably in consideration of workability.

[0080]

The present invention will be described below with reference to Test Examples and Formulation Examples, but the present invention is not limited to these.

(Production Example 1) 100 g of each dried plant (equal amount mixture) of Althea, Arnica, Bodaiju, and Botanpi was 50%
After being immersed in 1 L of an ethanol solution and extracted at room temperature for 3 days and nights, the extract was filtered and dried (dry solid content: Artea 0.5 to 2.5).
%, Arnica 0.8-2.4%, Bodaige 1.5-3.2%, Buttonpig 0.5-2.5%).

(Production Example 2) 100 g of each dried plant (mixed in equal amounts) of each of Altea, Arnica, Bodaiju and Buttonpig is 30%
A 1 L mixed solution of an equal volume of a propylene glycol solution and a 30% 1,3-butylene glycol solution is gently heated and extracted at 50 ° C. for 6 hours, filtered by suction, and extracted (dry solid content: Althea 0.1%).
5-2.6%, Arnica 0.8-2.5%, Bodaige 1.5-3.3
%, Buttonpi 0.5-2.6%) about 1.0-3.0kg.

(Production Example 3) 100 g of each dried plant (mixed in an equal amount) of Altea, Arnica, Bodaiju, and Pontopia was immersed in 1 L of purified water (about 80 ° C.), heated and extracted for about 5 hours, and filtered. Extract (Dry solid content: Althea 0.6-2.5%, Arnica 0.9-2.4%, Bodaige 1.6-3.2%, Bompi 0.6-
2.5%) from about 1.0 to 3.0 kg.

(Production Example 4) 100 g of each dried plant (equal amount mixture) of Althea, Arnica, Bodaiju, and Bompei was heated and extracted with purified water (normal temperature) for about 5 hours, and filtered to obtain an extract (dry solid). Minutes: Althea 0.4-2.5%, Arnica 0.6-2.4
%, Bodaige 1.3-3.2%, button pig 0.7-2.5%)
Get 1.0-3.0kg.

(Comparative Example 1) 100 g of each dried plant of Altea, Arnica, Bodaiju and Bompei was immersed in 1 L of a 50% ethanol solution, extracted at room temperature for three days and nights, and then filtered to obtain an extract (dry solid content). : Althea 0.5-2.5%, Arnica 0.8-2.4%, Bodaige 1.5-3.2%, Buttonpi 0.5-
2.5%) from about 1.0 to 3.0 kg.

(Test 1) Histamine Release Inhibition Test In a type I allergic reaction, histamine and other chemical mediators are released from mast cells or basophils sensitized in the second stage. Therefore, a substance that suppresses histamine release can be expected to have an antiallergic effect. In this test, comp, a histamine release reagent from rat mast cells, was used.
Test method to release histamine at ound48 / 80 (J. Soc. Cos
met.Japan, Vol.25, No.4, P.246 (1992)), and the extracts obtained in Production Example 1 and Comparative Example 1 were examined.

"Test Method and Evaluation Method" a. Sample The sample for the histamine release inhibition test is Production Example 1 of the present invention.
Using the extract obtained in the above (adjusted to a solid content of 0.5%), it was subjected to a test. As comparative samples, cromolyn (manufactured by Sigma) and each plant extract of Comparative Example 1 were prepared under the same conditions and used for the test. b. Measurement of the amount of free histamine A 0.2 mL sample was added to 1.2 mL of a mast cell suspension collected from the intraperitoneal cavity of a rat (Slc: Wister male rat, about 4 to 9 weeks old).
And compound48 / 80 were added to a final concentration of 1 μg / mL, and incubated at 37 ° C. for 15 minutes. After stopping the reaction by cooling on ice, the reaction solution was centrifuged, the histamine released from the supernatant was extracted and purified, and the color was developed with o-phthaldialdehyde. The histamine release inhibition rate was determined by the following equation (Equation 1), and the results are shown in FIG.

<Equation 1> Histamine release inhibition rate (%) = ｛1− (A−C / B−)
C)｝ × 100 A: Fluorescence intensity of histamine released when a histamine releasing agent was added to a sample coexisting with mast cells B: Fluorescence intensity of histamine released when a histamine releasing agent was added to mast cells C: Fluorescence intensity of histamine naturally released from mast cells (A, B and C are measured values minus blind values)

(Test Results) As shown in FIG. 1, it was confirmed that the mixed extract of the four kinds of plants of the present invention had a very strong histamine release inhibitory action as compared with cromolyn.
In addition, it has been confirmed that it has a stronger histamine release inhibitory action than the single plant extracts of Althea, Arnica, Bodaiju and Botanpi, and thus can be effectively used as an antiallergic agent.

(Test 2) Safety test (1) Skin primary irritation test The extract obtained in Production Examples 1 to 4 was prepared so that the solid concentration was about 2.0%.
This was applied to the skin of a Hartley-type guinea pig (female, 3 per group, weight: 300 to 350 g) having a shaved back at a rate of 0.03 mL per 2 × 2 cm ² square. Judgment was carried out 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indices. As a result, in all the animals, no erythema and edema were observed, and the animals were determined to be negative.

(Test 3) Safety Test (2) Skin Cumulative Irritation Test The extract obtained in Production Examples 1 to 4 has a solid content of about 2.0%.
It is prepared so that the flank is shaved (2 × 4 cm ² )
Hartley guinea pigs (female, 3 per group, weight 32
0.5 g / animal) was applied to the skin (about 0 g) once a day, 5 times a week. Application was over two weeks and shaving was performed on the last application day of each week. The determination was made on the day following each application day and on the day after the last application day, using primary irritancy scoring as an index of erythema and edema. As a result, in all animals, no erythema and edema were observed for 2 weeks after application, and the animals were judged to be negative.

(Test 4) Safety Test (3) Single Dose Toxicity Test Each of the plant extract powders obtained in Production Examples 1 to 4 was adjusted with purified water to a concentration of 12.5%. The dose of kg was orally administered to ddy mice (male and female, 5 mice per group, 5 weeks old), which had been fasted for 16 hours before the test, and observed over time with the appearance and degree of toxic symptoms. did. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, LD50 is 2,00
It was 0 mg / kg or more, so it was judged as a safe substance.

(Prescription examples) Preparation of antiallergic agent, histamine release inhibitor or cosmetic composition In accordance with the above evaluation results, the following formulation examples are shown. And only the compounding amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Soorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. Four kinds of mixed plant extracts of Production Example 5.0 10. Preservative (paraoxybenzoate) qs 11. Purified water 100

(Formulation Example 2) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Four kinds of mixed plant extract of Production Example 3 1.0 6. Gennoshoko hot water Extract 1.0 1.0 Rice bran hot water extract 1.0 8. Butylhydroxyanisole 0.1 9. Preservative (benzalkonium chloride) qs 10. Fragrance (flavour) qs 11. Purified water 100

(Formulation Example 3) Flexible lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Production Example 1-4 Seed plant mixture extract 2.0 6. Yamakoko 50% ethanol extract 1.0 7. Comfrey 50% ethanol extract 1.0 8. Antibacterial and preservative (thiamine lauryl sulfate) qs 9. Flavor (chamomile water) qs 10. Purified water 100 and the rest

(Formulation Example 4) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Skin 50% 1,3-butylene glycol extract 2.0 5. Preparation Example 1 Mixed extract of four kinds of plants 2.0 6. Green tea 50% ethanol extract 1.0 7. Tormentilla 50% ethanol extract 1.0 8. Hamamelis 50% ethanol extract 1.0 9. Allantoin 0.2 10. Astringent (zinc sulfocarbonate) 0.2 11. Antibacterial and preservative (thiamine lauryl sulfate) qs 12. perfume (lavender water) qs 13. purified water 100

(Formulation Example 5) Two-layer lotion (liquid to liquid type) weight% 1. squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. sorbit 1.0 4. ethanol 15.0 5. 4 kinds of plant mixture 30 % Ethanol extract 10.0 6. Spicy 30% ethanol extract 1.0 7. Genoko ginger 30% ethanol extract 1.0 8. Ascorbic acid 0.2 9. Astringent (sodium sulfocarbonate) 0.2 10. Preservative (phenoxyethanol) qs 11. (Bodhi tree water) Appropriate amount 12. Residual water with 100 purified water

(Formulation Example 6) Carmine lotion (liquid to solid) wt% 1. Glycerin 3.0 2.1, 3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7. 50% propylene glycol extract of a mixture of four plants 5.0 8. 50% propylene glycol extract 2.0 9. Peach seed 50% propylene glycol extract 2.0 10. Placenta extract 1.0 11. Camphor 0.2 12. Phenol 0.03 13. Preservative Agent (photosensitizer No. 201) appropriate amount 14. fragrance (Tokimizu) appropriate amount 15. purified water 100 residue

(Formulation Example 7) Pack weight% 1. Polyvinyl alcohol 15.0 2. Sodium carboxymethyl cellulose 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Four kinds of plant mixed extract of Production Example 1 2.0 6. Calendula 50% Ethanol extract 1.0 7. Saxifrage 50% ethanol extract 1.0 8. Soapwort 50% ethanol extract 1.0 9. Preservative (paraoxybenzoate) qs 10. qsperfume (sage water) qs 11. Purified water 100

(Formulation Example 8) Peel-off pack wt% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Jasmine essential oil 3.0 8 .Extract of four kinds of mixed plants of Production Example 1 2.0 9. Seaweed (wakame) 50% ethanol extract 1.0 10. Preservative (paraoxybenzoate) qs 11. Fragrance (rose water) qs 12. Purified water 100 Residue

(Formulation Example 9) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 15.0 5. Borax 0.5 6. Liquid shea fat 1.0 7. 50% of a mixture of four kinds of plants 1,3-butylene glycol extract 5.0 8. Western sheer 50% 1,3-butylene glycol extract 2.0 9. Lactoferrin solution 2.0 10. Western plum 50% 1,3-butylene glycol extract 2.0 11. Yeast metabolic extract 2.0 12. Preservative (acrinol) 0.1 13. Appropriate amount of fragrance (Tangerine water) 14. Residual to make purified water 100

(Formulation Example 10) Emollient cream% by weight 1. Stearic acid 2.0 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalane 5.0 5. Octyldodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Four kinds of mixed plant extract of Production Example 4.0 4.0 Ginkgo biloba 50% 1,3-butylene glycol extract 2.0 11. Kuma bamboo leaf 50% 1 2,3-butylene glycol extract 2.0 12. Melissa 50% 1,3-butylene glycol extract 2.0 13. Trehalose solution 2.0 14. Preservative (paraben) qs 15. Flavor (apple water) qs 16. Purified water 100 Residue

(Formulation Example 11) Face wash cream% by weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Production example 1. A mixture of four kinds of plant extracts 4.0 8. Agarisk 70% 1,3-butylene glycol extract 2.0 9. Akamatsu bark 70% 1,3-butylene glycol extract 2.0 10. Dipotassium glycyrrhetinate 1.0 11. Royal jelly extract 0.1 12 Preservative (salicylic acid) 0.1 13.Perfume (sage water) appropriate amount 14.Purified water 100 residue

(Formulation Example 12) Face Wash Cream% by Weight 1. Stearic acid 10.0 2. Palmitic acid 10.0 3. Myristic acid 12.0 4. Lauric acid 4.0 5. Oleyl alcohol 1.5 6. Lanolin derivative (EO adduct) 1.0 7. Glycerin 18.0 8. Potassium hydroxide 6.0 9. Mixed extract of four kinds of plants of Production Example 3 7.0 10. Glycyrrhetinic acid 1.0 11. Honey 1.0 12. Preservative (salicylic acid) 0.1 13. Appropriate amount of fragrance (iris water) 14. Purified water 100 and the rest

(Formulation Example 13) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. 30% 1,3-butylene glycol extract of a mixture of four plants 5.0 5. Safflower 30% 1,3-butylene glycol extract 0.5 6. Orange peel 30% 1,3-butylene glycol extract 0.5 7. Loofah 30% 1,3-butylene glycol extract 0.5 8. Odrichou 30% 1,3-butylene Glycol extract 0.5 9. Polyethylene powder 0.5 10. Bacillus natto metabolite 0.5 11. Amino acid (glycine, glutamine, etc.) 0.5 12. Preservative (undecylenic acid, phenol) qs 13. pH adjuster qs 14. Fragrance (grape water) Appropriate amount 15.Purified water 100 residue

(Formulation Example 14) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Polyethyl acrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 99% 1.0 12. Titanium dioxide 5.0 13. Four plants of Production Example 3 Mixed extract 2.0 14. Birch hot water extract 0.5 15. Loquat leaf hot water extract 0.5 16. Preservative (paraben) qs 17. Fragrance (apple water) qs 18. Purified water 100

(Formulation Example 15) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Four types of Production Example 1 Plant mixed extract 2.0 6. Lotus flower 30% 1,3-butylene glycol extract 0.5 7. Cornflower 30% 1,3-butylene glycol extract 0.5 8. Lotus flower 30% ethanol extract 0.5 9. Antioxidant (butylhydroxyl Toluene) Appropriate amount 10.Fragrance (Tokisui) Appropriate amount

(Formulation Example 16) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11. Kaolin 3.0 12. Talc 3.0 13. Color pigment 1.0 14. Dry powder of the four plant mixed extract of Production Example 1 0.1 15. Huangbai hot water extract powder 0.2 16. Preservative (paraben) suitable amount 17. Fragrance (lavender water) proper amount 18. Purified water 100 residue

(Formulation Example 17) Shampoo weight% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. 50% propylene glycol extract of a mixture of four plants 10.0 7. Seaweed (Hibamata) 50% propylene glycol extract 2.0 8. Rosemary 50% propylene glycol extract 1.0 9. Collagen hydrolyzate 1.0 10. Antibacterial and antiseptic Agent (thiamine lauryl sulfate) qs 11. pH adjuster qs 12. perfume (hamamelis water) qs 13. Purified water 100 balance

(Formulation Example 18) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Four kinds of mixed plant extract of Production Example 1 5.0 6. Carrageenan 1.0 7. Half summer 50% ethanol extract 1.0 8. Artemisia 50% ethanol extract 1.0 9. Trehalose solution 1.0 10. Hydrolyzed silk solution 1.0 11. Equivalent 50% ethanol extract 0.5 12. Antibacterial・ Preservative (benzalkonium chloride) appropriate amount 13.Fragrance (bodhi tree) appropriate amount 14.Purified water 100 residue

(Formulation Example 19) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Mixed extract of four kinds of plants of Production Example 1 5.0 6.Ethanol extract 50% for crow drug 1.0 7.Sodium alginate 1.0 8.Ethanol extract 50% for shakuyaku 1.0 9.Hydrolyzed silk solution 1.0 10.Seawater dried product 1.0 11.Antibacterial and preservative (benzalkonium chloride) 12. Appropriate amount of fragrance (chamois water) 13. Residual water with 100 purified water

(Formulation Example 20) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Mixed extraction of four kinds of plants of Production Example 4 Liquid 3.0 6. Cultivated water extract 1.0 7. Eucalyptus leaf water extract 1.0 8. Rosemary water extract 1.0 9. Carpronium chloride 0.3 10. Hinokitiol 0.5 11. Keratin decomposition solution 1.0 12. Antibacterial and preservative (paraben, Benzalkonium chloride) Appropriate amount 13. Fragrance (apple water) Appropriate amount 14. Purified water 100 residue

(Formulation Example 21) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Mixed extraction of four kinds of plants of Production Example 1 Solution 5.0 6. 50% Ethanol extract 1.05 Grape leaf 50% ethanol extract 1.0 8. 50% ethanol extract of seaweed (Hijirimen, Kombu) 1.0 9. Keratin decomposition solution 1.0 10. Antibacterial and preservative (paraben, Benzalkonium chloride) Appropriate amount 11. Fragrance (lemon water) Appropriate amount 12. Purified water 100 residue

(Formulation Example 22) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Mixed extract of four kinds of plants of Production Example 1 15.0 5. Preservation Reagent (paraben) qs 6. Residual water to 100

(Formulation Example 23) Hair tonic% by weight 1. L-menthol 0.2 2. Ethanol 32.5 3. Polyoxyethylene hydrogenated castor oil 0.5 4. Propylene glycol 5.0 5. Diphenhydramine hydrochloride 0.3 6. Four kinds of plant mixture of Production Example 1 Extract 5.0 7. Sodium hyaluronate solution 1.0 8. Carboxymethyl chitin solution 1.0 9. Whey solution 1.0 10. Antibacterial and preservative (paraben) 0.1 11. Flavor (rose water) qs 12. Purified water 100

(Formulation Example 24) Hair restorer / hair restorer (% by weight) 1. Ethanol 60.0 2. Mixed extract of four kinds of plants in Production Example 5.0 3. Maronier 50% propylene glycol extract 2.0 4. Burdock 70% propylene glycol extract 2.0 5. Vitamin E derivative 1.0 6. Pepper tincture 1.0 7. Resorcinol 0.5 8. Glycyrrhizic acid 0.5 9. Hydroxypropyl chitosan solution 0.5 10. Beef hematin solution 0.5 11. Thympi 50% propylene glycol extract 2.0 12. Birch 50% propylene glycol Extract 2.0 2.0 13. Amino acids (glycine, glutamine, etc.) 0.5 14. Antibacterial and preservative (paraben) 0.1 15. Perfume (rosemary) qs 16. Purified water 100

(Formulation Example 25) Hair restorer / hair restorer (% by weight) 1. Ethanol 60.0 2. Mixed extract of four plants of Production Example 5.0 3. Ethanol extract 50% of hops 5.0 4. Ethanol extract 50% of cherry blossoms 5.0 5. Cantaris tincture 0.5 6. Pantothenic acid derivative 0.5 7. Resorcin 0.5 0.5 Glycyrrhizic acid 0.5 9. Salicylic acid 0.5 10. Hydroxyethyl chitosan solution 0.5 11. Elastin hydrolyzate 0.5 12. Orchid (Symbidium) 50% 1,3-butylene Glycol extract 2.0 13. Shiso leaf 50% 1,3-butylene glycol extract 2.0 14. Elastin hydrolyzate 0.5 15. Antibacterial and preservative (paraben) 0.1 16. Perfume (lavender) proper amount 17. Make purified water 100 Residue

(Formulation Example 26) Granule bath agent weight% 1. Sodium hydrogen carbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Four kinds of mixed plant extracted powder of Production Example 1 10.0 5. Pigment (Gunjo yellow) Appropriate amount

(Formulation Example 27) Granule bath preparation weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. Four kinds of mixed plant extracted powder of Production Example 3 5.0 5. 70% ethanolic extract Powder 1.0 6. Chamomile 70% ethanol extracted powder 1.0 7. Mulberry bark 70% ethanol extracted powder 1.0 8. Sandalwood 70% ethanol extracted powder 1.0 9. Pigment (yellow iron oxide) qs 10. Fragrance (hamamerisu water) qs

(Prescription Example 28) Coating protective agent A gauze or liniment cloth is impregnated with a prescription liquid obtained by mixing the four plant mixture extract of Preparation Example 1 and an appropriate amount of an antibiotic, anti-inflammatory, etc., and attached to the wound. Alternatively, the four plant mixture extract of Production Example 1 may be directly applied locally and covered with gauze or the like.

(Test 5) Use Effect Test The effect of the cosmetic composition of the present invention actually used was examined. Use test is 2-30 which is troubled by skin diseases such as eczema, skin kayumi, rough skin and atopic dermatitis
The test was performed by applying an appropriate amount of the emulsion of Formulation Example 1 to the face for three months, twice daily in the morning and evening, after washing the face twice a year. Also, for 10 people (2 to 40 years old) who have the same skin disease on the scalp and hairline, apply the appropriate amount of the hair tonic of Formulation Example 22 to the scalp for 3 months after daily hair washing. The use test was carried out by.

Further, the bath preparation of Prescription Example 26 was also used for 10 months aged 0 to 45 years old who suffered from skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis for one month for three months. One time, the subject was bathed in a bath water in which an appropriate amount of bath agent was dissolved, and a use test was performed. As a control, a mixture prepared by the same method except that the extract of the four kinds of plants of the present invention, Altea, Arnica, Bodaiju and Botanpi, was used instead of the emulsion and the hair tonic and replaced with purified water was used. or,
The bath preparation was prepared by the same method as that of the Altea, Arnica, Bodaiju, and Botanpi of the present invention. The evaluation was performed according to the following criteria. The results are as shown in Table 1 and the numbers in the table represent the number of persons. still,
No one complained of skin or scalp abnormalities during the period of use.

[Effect of improving skin (scalp) disease] Effective: Skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis were improved. Slightly effective: Skin diseases such as eczema, skin swelling, rough skin and atopic dermatitis were slightly improved. Ineffective: No change from before use.

[0125]

(Test Results) As shown in Table 1, a cosmetic composition (emulsion, hair tonic,
The use of bath agent) was confirmed to have a good effect on skin and scalp diseases such as eczema, itching, rough skin and atopic dermatitis.

[0127]

EFFECT OF THE INVENTION The mixed extract of four kinds of plants, Altea, Arnica, Bodaiju and Pontopia, of the present invention has a strong histamine release inhibitory action and is safe even when applied externally to humans or animals. Therefore, it can be used as an antiallergic agent and a histamine release inhibitor, and can be applied to all forms of preparations (medicines, quasi-drugs, cosmetics). Further, the cosmetic composition of the present invention can be used for skin and scalp having troubles such as allergic / contact skin inflammatory diseases (for example, redness, eczema, edema, swelling, etc.), atopic dermatitis, and rough skin. Can be used for the purpose of prevention and improvement thereof, and can also be used for oral compositions and foods.

[Brief description of the drawings]

FIG. 1 is a mixed extract of four species of Altea, Arnica, Bodaiju and Botanpi of the present invention, and Altea, Arnica,
It is a figure which shows the histamine release inhibitory effect of each plant extract of bodaiju and buttonpi, and cromolyn.

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[Procedure amendment]

[Submission date] February 22, 2001 (2001.2.2)
2)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0022

[Correction method] Change

[Correction contents]

The antiallergic agent, histamine release inhibitor or cosmetic composition of the present invention may further comprise, if necessary, the components listed below as long as the effects of the present invention are not impaired. The additives can be arbitrarily selected and used in combination, and the content in the preparation is not particularly limited, but usually 0.0001 to 50% is preferable.

Continued on the front page F-term (reference) 4C083 AA032 AA072 AA082 AA111 AA112 AA122 AA162 AB032 AB212 AB232 AB242 AB272 AB312 AB352 AB432 AB442 AC012 AC022 AC072 AC092 AC102 AC122 AC132 AC182 AC242 AC342 AC352 AC402 AC422 AC432 AC472 AC482 AC542 AC542 AC792 AC852 AC862 AC902 AD022 AD042 AD092 AD112 AD192 AD272 AD302 AD322 AD332 AD352 AD412 AD432 AD442 AD452 AD512 AD532 AD552 AD642 AD662 BB51 BB53 CC04 CC05 CC06 CC07 CC12 CC19 CC23 CC25 CC32 CC37 CC38 CC39 DD16 DD23 DD27 DD31 DD29 EE42 4C088 AB12 AB13 AB26 AB58 AC03 AC04 AC05 AC06 AC11 AC13 BA08 BA09 BA10 MA07 MA63 NA14 ZA89 ZB13 ZC13

Claims (3)

[Claims] (1) An antiallergic agent comprising an extract of a plant mixture of four species of Altea, Arnica, Bodaiju, and Pontopia. 2. A histamine release inhibitor comprising an extract of a plant mixture of four species of Altea, Arnica, Bodaiju and Pontopia. 3. A cosmetic composition comprising at least one of the antiallergic agent and the histamine release inhibitor according to claim 1 or 2.