JP2001095563A5 - - Google Patents

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Publication number
JP2001095563A5
JP2001095563A5 JP2000236804A JP2000236804A JP2001095563A5 JP 2001095563 A5 JP2001095563 A5 JP 2001095563A5 JP 2000236804 A JP2000236804 A JP 2000236804A JP 2000236804 A JP2000236804 A JP 2000236804A JP 2001095563 A5 JP2001095563 A5 JP 2001095563A5
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JP
Japan
Prior art keywords
protein
proenzyme
protease
blood coagulation
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000236804A
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English (en)
Japanese (ja)
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JP2001095563A (ja
Filing date
Publication date
Priority claimed from DE19937219A external-priority patent/DE19937219A1/de
Application filed filed Critical
Publication of JP2001095563A publication Critical patent/JP2001095563A/ja
Publication of JP2001095563A5 publication Critical patent/JP2001095563A5/ja
Pending legal-status Critical Current

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JP2000236804A 1999-08-06 2000-08-04 イオン交換クロマトグラフィーによって血液凝固第ｖｉｉ因子を活性化するプロテアーゼ、そのプロ酵素または両タンパク質の混合物を純粋形態で調製する方法 Pending JP2001095563A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19937219A DE19937219A1 (de) 1999-08-06 1999-08-06 Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Ionenaustauscherchromatographie
DE19937219:5 1999-08-06

Publications (2)

Publication Number Publication Date
JP2001095563A JP2001095563A (ja) 2001-04-10
JP2001095563A5 true JP2001095563A5 (https=) 2007-06-07

Family

ID=7917489

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000236804A Pending JP2001095563A (ja) 1999-08-06 2000-08-04 イオン交換クロマトグラフィーによって血液凝固第ｖｉｉ因子を活性化するプロテアーゼ、そのプロ酵素または両タンパク質の混合物を純粋形態で調製する方法

Country Status (8)

Country Link
US (2) US6677440B1 (https=)
EP (1) EP1074616B1 (https=)
JP (1) JP2001095563A (https=)
KR (1) KR20010049988A (https=)
AT (1) ATE386798T1 (https=)
CA (1) CA2315306A1 (https=)
DE (2) DE19937219A1 (https=)
ES (1) ES2298110T3 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19903693A1 (de) * 1998-04-24 1999-10-28 Centeon Pharma Gmbh Protease zur Aktivierung des Gerinnungsfaktors VII
DE10023923A1 (de) * 1999-06-10 2000-12-14 Aventis Behring Gmbh Verfahren zur Bestimmung der Aktivität der Faktor VII-aktivierenden Protease aus Proteinlösungen
US7153679B2 (en) 2000-07-26 2006-12-26 Aventis Behring Gmbh Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis
ES2257361T3 (es) 2000-07-26 2006-08-01 Zlb Behring Gmbh Mutantes de la proteasa activadora del factor vii y procedimiento de deteccion con anticuerpos especificos.
JP4005338B2 (ja) * 2000-11-29 2007-11-07 ペンタックス株式会社 抗体固相化担体、および、その製造方法
US20020114800A1 (en) 2000-11-29 2002-08-22 Asahi Kogaku Kogyo Kabushiki Kaisha Carrier having immobilized antigens or antibodies and method of manufacturing thereof
DE10148037A1 (de) * 2001-09-28 2003-04-17 Aventis Behring Gmbh Verwendung der den Blutgerinnungsfaktor VII aktivierenden Protease zur Prophylaxe und Therapie von vaso-proliferativen Erkrankungen
DE10205520A1 (de) 2002-02-08 2003-08-14 Aventis Behring Gmbh Inhibitorischer, monoklonaler Antikörper gegen die den Blutgerinnungsfaktor VII aktivierende Protease
AU2003232315A1 (en) * 2002-05-07 2003-11-11 Medical Research Council Sarcosyl buffer and its use for the purification of prion protein
KR100508606B1 (ko) * 2002-11-15 2005-08-17 주식회사 바이오세움 효소 안정화 조성물 및 상기 조성물을 이용한 효소 보관방법
RU2364626C2 (ru) * 2003-03-18 2009-08-20 Ново Нордиск Хелт Кэр Аг Способ получения, способ очистки и способ стабилизации полипептидов фактора vii, ix и x
WO2008031020A2 (en) * 2006-09-08 2008-03-13 Wyeth Arginine wash in protein purification using affinity chromatography
US7705132B2 (en) * 2006-10-20 2010-04-27 Amgen Inc. Stable polypeptide formulations
BRPI0810172A2 (pt) 2007-04-13 2014-10-14 Catalyst Biosciences Inc Polipeptídeos de fator vii modificado e seus usos
JP5119545B2 (ja) * 2007-06-19 2013-01-16 国立大学法人 筑波大学 蛋白質を含む液状組成物中における蛋白質の安定化方法
TWI465247B (zh) 2008-04-11 2014-12-21 Catalyst Biosciences Inc 經修飾的因子ｖｉｉ多肽和其用途
CA2821711C (en) 2010-12-15 2017-10-10 Baxter International Inc. Eluate collection using conductivity gradient
EP2729570B1 (en) 2011-07-04 2017-11-22 Qiagen GmbH Reagent usable for the isolation and/or purification of nucleic acids
GB2504499A (en) * 2012-07-31 2014-02-05 Baxter Healthcare Sa Selective measurement of active human protease coagulation factors
KR102382402B1 (ko) 2014-02-04 2022-04-01 바이오젠 엠에이 인코포레이티드 번역 후 변형을 강화시키기 위한 통류 방식 양이온 교환 크로마토그래피의 용도
WO2021030787A1 (en) 2019-08-15 2021-02-18 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration and on-demand treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
DE19903693A1 (de) * 1998-04-24 1999-10-28 Centeon Pharma Gmbh Protease zur Aktivierung des Gerinnungsfaktors VII
DE19937218A1 (de) * 1999-08-06 2001-02-08 Aventis Behring Gmbh Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie

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