JP2001039824A - Cosmetic composition containing low-irritation aloe mesophyll - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject mesophyll capable of providing a cosmetic having reduced irritation to the skin, excellent humectance, excellently improving action on rough skin, etc., by cleaning an aloe mesophyll with an organic solvent. SOLUTION: This aloe mesophyll is obtained by cleaning an aloe mesophyll with an organic solvent, preferably ethanol. Only a mesophyll part from which leaves and skin are removed from an aloe such as Aloe barbadensis is used as the aloe and the thinly cut mesophyll is preferably used. For example, an aloe mesophyll is cleaned with ethanol in an amount of 2/3 weight of the aloe mesophyll and further cleaned once to three times. After the cleaning, the aloe mesophyll is, if required, subjected to a treatment such as drying, grinding, pasting, etc. In the case of the mesophyll as a cosmetic, the amount of the aloe mesophyll added is about 0.01-20 wt.% based on the total composition. The composition is preferably mixed with various kinds of oils and fats, waxes, etc., if necessary.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing aloe gel with reduced irritating feeling. More specifically, the present invention relates to an aloe leaf for cosmetics in which the leaf portion excluding the aloe leaf skin is washed with an organic solvent to reduce the irritability of the aloe leaf.

[0002]

2. Description of the Related Art Investigations on cosmetics containing aloe, which have been known so far, include those containing an extract or extract powder of water, alcohol, polyhydric alcohol, oils and fats, or a leaf skin. A typical one is to mix a powder obtained by drying the whole plant containing it.

[0003] The aloe mesophyll is gel-like, has a good feel, and is a material that can be applied to cosmetics. However, irritation to the skin was observed, and it could not be applied to cosmetics as it was.

[0004]

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide an aloe gel having reduced skin irritation and to obtain a cosmetic composition containing the aloe leaf obtained therefrom.

[0005]

Means for Solving the Problems As a result of washing aloe leaf with various solvents to solve the above-mentioned problems, aloe leaf obtained by washing with an organic solvent has no irritation and a cosmetic containing the same. Is the moisturizing property, the effect of improving rough skin,
It has been found that the present invention has excellent massage effect and appearance, and has completed the present invention.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The aloe used in the present invention is a plant of the genus Aloe of the family Liliaceae (Aloe) (Aloe barbadensis Mill.), (Aloe Vera L.)
And its variants (Aloe Vera L.var.chinensis (Haw.) Berg
er), (Aloe saponaria Haw.) and other congeners of Aloe arborescens Mill., Socotra aloe (Aloeperryi Baker), Natal aloe (Aloe bainesii)
Th.Dyer), Aloe dichotohoma
L.), Aloe marlothii Berger,
Aloe rupestris Baker, Aloe spinosis sima (Aloe spinosis sima Hort.), Aloe plicatilis Mill., Aloe asperifolia A.Berger, Aloe capitata polypolicola (Aloe captata Bak) .var.cipolinicol
a H.Perr.), Aloe splendens L
avranos), Aloe humilis Mill., Aloe mitriformis Mill., Aloe variegata L., Cape Aloe (Aloe ferox Mill.), Aloe africana.
ricanaMill.), Aloe spicata Bake
r), (Aloe haworthiodes Baker), (Aloe succotrina
Lam.,) Or the like, aloe vera leaves or stems can be used, and among them, aloe vera can be suitably used.

As the aloe used in the present invention, only the mesophyll excluding the leaf bark is used. The leaf portion may be used as it is, but in order to obtain the effect of the present invention, it is preferable to perform a shredding treatment.

The organic solvent used in the present invention includes alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol) and ketones such as acetone. , Ethyl ether, dioxane, acetonitrile, esters such as ethyl acetate, and organic solvents such as xylene, benzene and chloroform can be used alone or as a mixture of two or more kinds. Further, a mixed solution of these and water may be used, but ethanol can be suitably used.

[0009] The ratio of aloe to the solvent in the washing treatment is not particularly limited, but in order to enhance the effect,
Preferably, ethanol is used at two-thirds the weight of the aloe leaf, and more preferably one to three washes.

After the cleaning treatment, if necessary, drying,
Processing such as pulverization and pasting can be performed. Further, in many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected.

The aloe mesophyll for cosmetics of the present invention slightly varies depending on the type of cosmetic composition and the degree of expected action, but in order to obtain effects such as moisturizing properties, skin roughness improving effects, massage effects, and appearance, The total amount is usually 0.01 to 20% by weight or more (hereinafter, expressed as%), preferably 0.05 to 5%, and the effect cannot be sufficiently expected if the amount is less than 0.001%.

The cosmetic composition containing the aloe mesophyll for cosmetics of the present invention may contain, in addition to the aforementioned essential components,
The components and additives exemplified below can be arbitrarily selected and used in combination within a range that does not impair the effects of the present invention.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )Such.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oils Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene such as ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide or polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decoloration, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later. However, usually, water or a water-soluble organic solvent (for example, ethanol) is used. ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from among 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

Specific plants (crude drugs) as raw materials include:
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsumuraji (Kibo), Acacia, Akashoma (Akashoma), Akasuguri "fruit", Akagrape, Akaminoki (Logwood), Akamegawiwa (Akabu Kashiwa), Akane
(Akane grass root), Acacia elegans or Jiou (Jihuang), Agi (Awei), Aki larch, Akinire (Royu skin), Aguahe (Omiten palm), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Towushi) ), Hydrangea (hydrangea), ashitaba (morning leaf), adzuki (red azuki bean), acerola, asenyaku (asenyaku), acira (shokuyoukanna), anise, abemaki `` fruit '', avocado, ama, amacha (sweet tea), Amachaworu, Amadokoro (Jade bamboo), Amana (Hikarigi), Amaranthus (Amaranthus), Amaranthus (Hymoptera), Senninkoku, Sugimorigeitou, Hosoaoigaito, Aogetoudo, Haribiyu, Amaranthus hippochondriacus, Amigasayuri or Birnamo Alcanna), Argarrobo (cabbage), Altea, Arnica,
Alpinia or Katsudai (Sou-zuku), Angelica,
Apricot or Hong apricot (Anjin), Ansokkou (benzo),
Ikakozolina (biliary head), Epimedium or Epimedium (Inyokaku), Igusa (light heart grass), Knotweed (Tiger root), Yew (1st), Strawberries, Figs (Figurine and leaves), Ichihatsu (First time) ), Ichibai (Aoiko Fuyu), Ichiyakusou (Ichiyaku herb), Ginkgo (Ginkgo `` seed, leaf ''), Itohimehagi (Enshi), Carob, Cornus bean (Telelexi),
Inubeille (Sonagainubiru), rice “seed, seed coat”, inondo “seed”, Ibuki-kusou, nettle, ylang-ylang, iwa-tobacco (Iwatochi chi), iwahiba or iwamatsu
(Makikashiwa), Oolong tea, Fennel (Fenka), Wheat (Chibusanoki), Ukiyagara (Mitsuryo), Uguisukagura `` fruit '', Himeukikyo, Turmeric (Utsukin), Duckweed (floating), Usubasaishin or Keirinsaishin or Ou Shusaishin (spicy), Usbania oyster, Usbeni tallow mallow, Moray blight (summer hay), Udo or Shishiudo (Qang activity,
Unya de Gato (Unkaria, Cat's claw), Uba tea, Ume (Ume `` seed, pulp ''), Urajirogashi, Uwaurushi (Kusaco peach), Unshu mandarin orange
(Chen skin), Estragon, Eleuthero (Ezo Goka), Echinashi (Hoshibamurasakibarengiku), Enishida, Enokitake
(Enoki mushroom), Ebisugusa or Cassia tora (Kyoko), Elcampre, Elderberry `` fruit '', Elemi, Eryngii or Pre-Lotus Eringe, Endu (Gossip, Sophora rice), Ougi or Kibana-ohgi (Ogi), Ouren (Yoren), Giant crow (Kurokon), Giant squirrel (Public incense), Giant squirrel (self-defense), Giant psyllium (car front child, car front grass), Toucan hazel (Haruko), Obanana okera or Okera
(White jujutsu), giant sedge beetle (banaba), giant beetle "fruit", hawthorn or hawthorn (yamako),
Ousei (Naruko Yuri, Kagi Kuruma Banaru Yuri), Ohisasanoyuki or Sasanoyuki, Barley (barley), Ooishigusa (cereal grass), Oka, Okazeri (Snakebed), Oguruma
(Turning over), Okra `` fruit '', Panax ginseng or Caribbean ginseng (carrot), Hypericum perforatum or Scutellaria perforatum or St. John's wort (brother's cut grass), Odorikosou (intermittent), Onamimimi (blue ears), Onigurimi, Onidokoro or Tokoroko or Nagakokoroko ), Oninoyagara (Tianma),
Oyuri or Sasasayuri or Hakatayuri (Yuri), Ononis, Halibut (Hihayu), Ominaeshi (Loyal sauce), Oyuco,
Dutch mustard (Watercress), Dutch jelly, Dutch honeybee, olives "fruits, seeds, leaves", oregano, orange "fruits, pericarp", caycaio (ripened yellow), cacao "fruits, pericarp, seeds", oysters (persimmons) `` Leaves ''),
(Hooks of Choto), Persimmon or Kantriso (Rensenso), Cassia, Cinnamon (Kozomi `` fruits ''), Gajutsu (Shadojutsu), Kashiwa
(Kazuki, Sakura), Kascarilla, Kascara sagrada, Gypsophila, Kanixa (Kinosato), Kaniwa, Kanokosou (Vineflower root), Birch or Weeping birch (White birch), Pumpkin, Capoknoki `` seed '', Kahokokusansho (shopper) , Gama
(Kabou), Chamomile or Roman chamomile, Camellia deer (weed), Kamkamu (Duck), Karakakeman, Rasuri or Sinakarauri (Our melon), Rasubisaku (midsummer),
Oats, guarana `` seed '', karahoo (thick), karaya, karin (gourd), garcinia, kawamidori, kawara psycho (geirinsai, translucent grass), kawajisha, kawaratake, kawaranadeshiko (stone bamboo) or ezokawaranadeshiko (black bean, mulberry) Baby carrot (carrot), blue croaker (blue croaker), red mulberry (inchinko), kansui (sweet), licorice (licorice), kantarasa, candelilla, kantou, canna, raspberry (ezo strawberry, holland strawberry, shrimp strawberry, pear strawberry, maple strawberry, europe (Rawberry), Kiwi (fruit, leaf), Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum, Chrysanthemum, Drosophila), Catalpa (Azumino), Rabbit (Sheephoof), Pheasant ( Kikomi), Kizuta, Kidachiminka, Kina, Kinoki (Shincona, Akinoki), Quinoa (Quinoa), Kihada (Huangbashi)
Gymnema Sylvesta, Cabbage, Cabbage "Immature Fruit", Cucumber, Gyoryu (Nishikawayanagi, Ichiyanagi), Kiraja Saponaria, Kiraya, Kiranso (Gold Acne Herb), Kumquat "Fruit", Kinma, Kinmizuki (Sengakuriku), Guava Fruits, Guayule, Quercus Infectria
(Gallery), Kukui Nuts, Kukui (Gugi, Kikougi, Kikou Leaves, Skeletal Bark), Kusagi Kazura (Tenmen Winter), Kuzu (Kuzukane),
Camphor tree, gooseberry `` fruit '', ginseng, yellow gardenia, gardenia, kunugi, kupuasu,
Kumazasa, Kumamatsuura (horse whip grass), Clara (bitter butter), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit /
`` Leaves '', buckthorn, black squirrel (needs rescue), black blossoms or scented sprouts (extended life grass), cloves (cloves, cloves), gumbinazu (sekimei, sekimeishi),
Kaigai (Thorndust, Ikutakeho), Celosia (Rooster, Chicken),
Bay laurel, kenashi sartorii rose (Tobukuryo, Yamakiko), gentian, gennoshoko (Old treasured),
Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan
(Koji, Tachibana, Olivenimikan, Fukuromikan,
Sagami Koji, Ponkan, Santara (Tachibana skin)), Koshinbara (Monthly flower), Kouzi mint, Kozo `` fruit '', Kocha (tea), Kouhone (river bone), Kouhon (straw, Kara straw), Koryan, Koryokyo ( Kojiro), cilantro (fruit), coconut (kohuangren), koganebana (yellow gon), lingonberry (koshibachi), coconut palm (fruit), goshyu (goshuyu), goshoichigo (covered bonsai), pepper (pepper), kopaiba balsam , Coffee `` seed, leaves '', kobushi or magnolia (spicy), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame seeds (ginseng), goji (sesame), scallop or binankazura or Matsubusa, wheat (wheat) ),
Rice or rice bran “red bran, white bran”, rice oil, cola acuminata “seed”, cola vera “seed”, fenugreek “fruit”,
Colombo, Konzulango, Kombu, Konjac, Comfrey (Shinbari grass), Sisal (Sisal Asa), Sakisima button or Sinata button or Sinensensou (Eisensen), Sakura (Oshimashima cherry, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyayamazakura, Someiyoshino, Takanezakura, Kasumizakura, Chojizakura, Kohigan, Satozakura, Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''), cherries, pomegranate, sasa, sasanqua, sagemodaka (sawashari), sweet potato, sugarcane,
Sugar beet, Sun jujube (acid jujube), saffron
(Bamboo safflower, West safflower), Pomelo `` fruit '', Soapwort, Salmonberry `` fruit '', Sarashina-sho (Masahima), Salvia (Sage), Sawagikyo (Yamakona), Sawagurumi (Yamagomo), Sangre degrad (Croton ), Panax ginseng, Panax ginseng (Sax carrot), Sanshuyu (sanshuyu), Sansho (Sansho), Sandscon (Yamazone), Shea (Karite), Cyano (fruit), Shiitake (Shiitake mushroom), Zion ( (Shien), Dictalis, Shikunshi (Kimiko), Perilla or Aodiso or Chirimenzo or Katamamenjiso (Shiyo-leaf, Shiso), Rosewood, Shinanoki, Shinanohonoki, Chinese Forsythia (Forsythia), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshureshimaji) , Honjimeshi, Shimotamogitake), Spiraea, Potato, Peony (Shakuyaku), Shajin (Shasan), Jasmine (Ma Rika),
Jano-beard (Bakumon winter), Gypsophila paniculata, Sku-shamitsu (sand sand, sand compaction), Juzudama, Palm `` fruit '', ginger (ginger), jadean hydrangea (Joyama), shobu
(Irises, iris roots), shojiku `` fruits '', shirakashi `` seed '', white walnuts `` seed '', white adzuki bean (chicken bone), white iris (small iris), white napatsuta `` flower '', white nanten (minamitenmi), shinkonasakushi Rubra, Jinkoge (Mizuka, Mizuka, Shencho), Cinnamon, Watermelon (watermelon), Honeysuckle (gold and silver flowers, Shinobi), Suiba
(Acid model), swim berry `` fruit '', stevia, strawberry `` fruit '', suzu psycho (Xu Chang Lord), horsetail (infestation), purslane (horse ken, horse dent), plum berry, pine cone pine cone '', Larch, edible walnuts, walnuts, walnuts, hawthorn, dandelion, horse chestnuts (malonie), pears `` fruits '', plum blossoms, walnuts
(Elder), Atlantic shrew (Juniper, Juniper), Achillea millefolium (Mirfoil), Atlantic rose, Atlantic anemone butterfly, Atlantic mistletoe, Atlantic mint or Atlantic mint, Horseradish, Sekisho
(Iris), Sekoku (Ishimasu), Cedron (Bowshokuboku), Zeniaoi, Hirohasenega, Senega, Seri, Celery, Sengoku (Kawakyu), Sengshinren (Shinshinren), Sengdan, Sembri (Drug), Senna `` Fruit, Leaf '', Senninsou (great tate), Soka (grass), buckwheat "seed", Somei potato, Rhubarb (daioh), radish, soybean, daidai (orange peel,
Kikomi), Takasaburo (Dried lotus grass), Takatodai (Daikyo),
Takawarabi (Dog), Dark Sweet Cherry "Fruit",
Tachioi, Tachijakoso (thyme, Hyoka), Tachidokoro (Hikari), Tachiyanagi, Tamarind `` seed '', onion, tamshiba (spicy), taro tree `` fruit, leaf, root bark '', talwi, tanjin (dansan), dandelion (gakko) Or white dandelion or moko dandelion, dammar, cherry `` fruit '', twigs `` fruit, roots, buds '', ginseng carrots (bamboo ginseng), chicory, chancapiedra (kichichikomikansou), kosendaidai (daihuang), kosensen Ii), Artemisia (Aiba), Choreimaitake (Irei), Chorogi, Tsukimiso, Tsukutake (Mushroom), Camellia, Camellia, Tsumekusa (lacquer primrose),
Twigweed (duckling grass), vine adzuki (red azuki bean), tsuldokudami
(Hanshu crow), Tsuruna (Ban apricot), Ginseng (four-leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tengusa, Tencha (Tencha), Tendaiyaku (Wakayaku), Touga (Fruit gourd), Toukagizura, Capsicum (Pan pepper), Touki (Toki), Tokinsenka (Marigold), Tounabena (River cut), Corn or corn hair (Nanban hair),
Ligustrum (Female Sadako), Eucalyptus or Korean Rosemary (Ryubin), Tokusa (Pirates), Dokudami (Jyuku), Tokon (root), Toshishi or Mamedaoshi or Porpoise, Eucommia (Tonaka `` bark, leaves, roots '') , Ash (qin peel), tomato, tragacanth, triacanthus `` seed '', tormentilla, dronoki, trolo-mallow, Niseria berry `` fruit '', potato or yam (herbal medicine), nagikadada (butcher bloom), naginata kouji, nazuna, rapeseed, natto bean Or vertical shrimp (swords), jujube, jujube
(Dajutsu), Naniwaibara (Kanekurako), Navena (Continuous), Nameko, Narco lily (Yoshisei), Peanut (peanut), Nanten (Minami Tenmi), Nambangarashi (ramie), Nigaki (Makiki),
Artemisia (bitter mite), nutmeg, cay or nikkei or ceylon nikkei or yabnikkei (cinnamon bark) or Keishi (keiseki), leek (niriko), elderberry (grafted tree `` fruit, flower, stem,
Leaf)), garlic (garlic), nulde (fivefold), leek, nemuki or neb or nebi or nemuriki or digokubana
(Healing), Nori Thistle (Ohi), Noibara (Fruit), Yarrow, Nodake (Maehu), Nobara, Nomomo, Palm, Pineapple `` Fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hilindou, Hakamauraboshi
(Bone crush), Hachsen (ringworm skin), Huckleberry `` fruit '',
Chickweed (Horiko), Hazel (Haruko), Hashidokoro (Roth Root), Basil, Lotus (Lotus, Lotus, Lotus), Parsley (Netherland Jelly), Naked Wheat, Batata, Hachiku or Madake (Bamboo Boiled), Patchouli, Mint ( Light load, light load leaf), Adlay (Yokuinin), Hanasuge (Omochimo), Banana, Hana mint, Hanabishi (Siturishi, Shititsuri), Vanillabins, Papaya, Scotch grass (rat), Pahalobobo, Hub `` Whole grass,
Stalks and leaves '', paprika, hamago or honeysuckle (vine thorns), hamasuge (katsuki), hamabishi (ritsuko), hamanas (maikai flower), hamaba fu (beach windbreak), hamamelis, rose (rose), agaric (haratake) , White-faced Agaricus, Usukimori nokasa), Haran, Paliurus (Pleurotus japonicus), Parietaria, Balsamina (Tsurureishi, Nigaruri), Harunire (Yellow, Yu-white skin, Yu-leaf), Harindou, Handaikai (Bear large sea), Pannoki, Hiougi
(Shadow), lizard carrot (party), Puer tea (usually?)
Tea), pecan nuts, amaryllidaceae (stone and garlic)
Hishi (Hishimi), Pistachio, Beet, Amber (Stone reed), Aedes terrestris, Hinata no Kozuchi (cow knee), Hinoki, Hiba, Castor, Sunflower, Bell pepper, Himeuzu (Tamaoi), Himegama (Kawagama), Himematsutake (Kawariharatake) , Hiromatsu mushroom), Pimenta "fruit", juniper, juniper, hiyu "fruit", below mallow, hiroha okinagusa
(Shiratoo), loquat `` fruits, leaves, stems '', betel nut (large clothing skin,
Betel palm), spruce buds (southern rattan), butterbur, dandelion
(Winter winter flowers, winter leaves), fujibakama (orchid grass), wisteria bean (tomato), grape `` fruit, pericarp, seeds, leaves '', beech, Fuyumushinatsukutaketake (corbicula), Brazilian licorice, Brazilian carrot, blackcurrant `` fruit '' ”, Blackberry, plum“ fruit ”, flucellaria, blueberry
(Prunus americana), prune, blonde psyllium, bundo (green bean), hazelnut, loofah, safflower (safflower), henneken, belladonna, berry `` fruit '', Peruvian berg, benceisou or duckweed (Keiten), Boysenberry `` fruit '' , Broomstick or Elderflower or Nendowe or Hawakigi Kokia (Dermatology), Baldwink (Fengshen, acute child, osteophyte), Spinach, Bowlew (Windbreak), Spinach, Physalis (Torone), Hoonoki (Wakoboku,
Park), Bokeh (Gourd), Hosovanaokera (Soujutsu), Hosobanokirinsou (Kageten Sanshichi), Hosobabarengiku, Bodaiju
(Bodai tree), button (peony `` flower, leaf, stem, bark ''), buttonpi (peony bark), hop, jojoba, bordeaux, white berry `` fruit '', hon-oniku (meat ゅ ゅ, large art), hon-sekkok ( Iron skin stone, Sparrow mountain stone)
(Tennan star), Maitake (Maitake), Ephedra (Mahuang), Maca, Macadamia nuts, Macri (Martian grass), Magwa (Mulberry white bark `` bark, leaves ''), Magnolia splengeri, Mashua (Tamanouzenhallen, Kyukon) Nasturtium), Matatabi (Kinten Tate), Matsukasa, Pine `` leaves, bark, roots '', Matsuhod (Bukuryo), Matico (Cordon Sillo), Mayorum (Hanahakka), Malvanojazine (Difficult), Mulberry `` Fruits '',
Quince, mango, mangosteen, mansagna (andesukamitsure), manshu walnut, mandarin `` fruit '', mannentake (reishi), pheasant (kinkumi `` fruit ''), mishimasaiko (saiko), mizuobaba or mizuasagao (dragon tongue grass), Mizokukushi (half-edge lotus), Misohagi (Chishunna), Mizunagi or Shiroyanagi (hen), Mitsugashiwa, Mitsuba, Midorihakka, Mimosa, Myoga, Miracle fruit `` Fruit '', Myrrh, Myrobaran, Mugiwaragiku, Mukugeki (Mokunoki), Mukunoki , Mukuroji (extended skin), Munya, Murasaki
(Purple root), murasakisikibu or omurasakisikibu (purple pearl), murasaki maize, murasakinut wisteria (Kunming chicken blood wisteria), mehajiki (mass mother grass), mebokugi, melaroika, melissa, melilot, melon `` fruit '', sagebrush,
Moso bamboo, moje (koreboku), mokko (mochi), maple blossom, peach (peach "leaves, seeds, flowers, fruits"), sprouts, morello cherry "fruits", Moroheiya
(Burlap), yakawamurasakiimo, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yacon, yashabushi (arrow car) or himeyashabushi or giant yashabushi `` fruit, peel, kaho '', yachiyanagi, yatsude (octagonal metal) , Mistletoe (willow parasitism), willow (river willow, twill willow, weeping willow, red willow, pussy willow, dog puppy willow, kinuyanagi, kolyanagi, unryuyanagi, yamayanagi, palm, yamayanagi, obanyanagi,
(European willow, fox, willow tree), willow leaf `` leaves and stems '', yabugarashi, yabukouji (purple gold beef),
Japanese tobacco (Tsurusui, Tenmei), Japanese pokeweed (land), Japanese alder (Yamaharu), Japanese peach (Yumemei), Japanese sagebrush, Eucalyptus, Yukinoshita (Tiger ear grass), Yucca or flevifolia, Yuzu `` fruit '', lily, Artemisia, mugwort (Aiba),
Rigan (Raimaru), lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaves, berries '', ratania (clameria), rakkyo or shallots (scallop), lavender, longan (longan meat), agave (Aonour agave, fukurin) Agave), Ryokucha (green tea), Apple `` fruits, seeds, leaves, roots '', gentian, rubus or suavisimus (sweeten), litchi (lichi, lichi nucleus), lettuce (chisha), red currant `` fruit '', lemon "Fruit", lemongrass, forsythia or Chinese forsythia
(Forsythia), astragalus, wax palm, lokon (reed, azun),
Loganberry "fruit", rosemary (mannen wax), rose hips (nobara), wasabi, waremokou (chiyu) and the like.

In addition, other seawaters such as seawater salt, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango) Species, for example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients:
Silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese,
Arsenic, water), Shotoku stone.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown alga: Kombu algae: , Resilicon b, hosomekobu, mishitoshibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red alga: hijirimen, maxa ( Tengsa),
Hirakusa, Omikusa, Obakusa, Katao Bakusa, Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Zyakushinkirinsai, Tsunomata, Obatsunomata, Tochaka , Ibotsunomata, Yaleus Banori, Kagius Banori,
Sujiusbanori, haiusbanori, akaminominori] and the like.

Other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaet, Genus Genus genus, Species of the genus Cyperaceae: Species of the genus Cyperaceae, the genus of the spider genus;

Blue-green algae (Genus L .: L., L., L., L .: L., mushrooms,
(Hassay, Yuremo genus, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio) genus, etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp.
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cyno (Kayamonoli etc.).

Red algae (Russia genus: Ushikenori, Funorinoushike, Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakraitus: Genus Odonata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Hounoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge and genus: ssp.
Genus: crocodile, crocodile, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullconi, Shikokonori, Hananoeda: Hanaeda, Hiratagoat: Hiratagoat, Darusu: Dars, Masagoshibari, Anadars, Weedbugsa: Uebaguni, Benifukunori
Species of sarcophagi: sarcophagia, scorpion, scorpion, scorpion genus: syllabus, smelt, ssp. Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagusubanori, Jauresubanoli, Jaureusubanoli, Jaureusubanori, Jaureusubanoli
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dassia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Makuri, Yanagina, Hana, Rana Salix var. Genus Isomegusa: Isomegusa, Suginashigusa: Suginashigusa, Isobashi Genus: Isobashi, Fujimatsumo: Fujimatsumo, Sawweed: Mushroom Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).

The axle algae (Charus spider, Shiratamago,
Hossiturimo: Hossiturimo, Lychnotanus genus, Hessian moss: Himejirasamo, Chaboshiramo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Materials derived from animal raw materials include a cockscomb extract, a cow or human placenta extract, an extract of a stomach, duodenum, or intestine of a pig or cow or a decomposition product thereof, and an extract of a spleen of a pig or cow. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Cow milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolites Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran ferment extract, euglena extract, lactic acid fermentation product of raw milk or skim milk powder and trehalose Or a derivative thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, monodiparamethoxycinnamate
Glyceryl-2-ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, diamine Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and so on.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (eg, magnesium phosphate of vitamin C, vitamin C glucoside), hydroquinone or a derivative thereof (eg, hydroquinone benzyl ether), kojic acid or a derivative thereof, vitamin E or a derivative thereof Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extracts (chamomile, mulberry, mulberry, waremokou, clara, mugwort, Honeysuckle, yellowfin, yellowtail, matsuhodo, pearl barley, scotch, hops, hawthorn, eucalyptus, achillea millefolium, althea, keihi, mankeishi, hamamelis, yamaguwa, enmeisou, bellflower, toshishi, seizome, sun dried, mao, senkyu Dokkatsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.

(21) Action of promoting turnover / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odrich, Assemble, Touki, Calendula officinalis, Amacha, Hypericum perforatum, Cucumber, Periwinkle,
Rosemary, parsley).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compounds) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Amami,
Ages, ginkgo, green tea) etc.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde , Hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Natto extract, etc.

(29) Inhibitors of elastase activity diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, sage, seaweed, bollige, buttonpi), seaweed extracts and the like.

(30) Hair Agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Topical stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activator Photosensitizer 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placental extract, biotin, pentadecanoic acid glyceride and the like.

(35) Antiseborrheic agents pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(38) Hair remover strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, Coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Greater Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemon grass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bitters, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

The cosmetic composition containing the aloe mesophyll for cosmetics of the present invention can be prepared in the form of capsules, powders, granules, creams, sheets, liquids, solids, pastes, or the like, using conventional methods. It can be in the form of a cosmetic composition such as a gel, an O / W emulsion, a W / O emulsion, an aqueous cosmetic composition, an emulsified cosmetic composition, a liquid crystal cosmetic composition, and the like. It is preferable to use a W-emulsion state and an aqueous state. It can also be used in dosage forms such as a type that is only applied, a type that is washed away after massaging, and a type that is wiped off.

Further, the cosmetic composition containing the aloe mesophyll for cosmetics of the present invention can be used for the face, neck, hands,
It can be used by applying it to the wrist, ankle, belly, calf, crotch, hair, scalp, etc., but if it is massaged or applied manually, a higher effect can be obtained. When used by massaging or applying, for example, take a required amount of 2 to 3 g in your hand, apply it to the face, neck, hands, feet, hair, scalp, etc., and gently massage with your palm or fingertips (about 10 to 20).
Seconds) and wipe off with tissue or cotton, or rinse off with water or hot water.

Specifically, for example, basic preparations such as medicinal preparations for external use, lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, shampoos , Rinse, hair treatment, hair styling, perm, hair tonic,
Hair / scalp cosmetics such as hair dyes, hair restoration / hair nourishing, makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, bath agents, other toothpastes, mouthwash, It can be applied to various products such as gargle, deodorant / deodorant, sanitary cotton, wet tissue, etc.

The method of adding the aloe mesophyll for cosmetics of the present invention to a cosmetic composition containing the aloe medicament may be added in advance or during the course of production. Just choose.

[0071]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) Ethanol (200 g) was added to minced aloe leaf meat (300 g), and the mixture was immersed overnight and filtered. Ethanol (200 g) is further added to the filtration residue, soaked overnight, and then filtered. This is repeated once more, and the obtained residue is dried in vacuo.

(Production Example 2) Purified water (200 g) was added to minced aloe leaf meat (300 g), and the mixture was immersed overnight and filtered. Purified water (200 g) is further added to the filtration residue, soaked overnight, and then filtered. This is repeated once more, and the obtained residue is dried in vacuo.

(Production Example 3) Ethanol (200 g) was added to minced aloe leaf meat (300 g), and the mixture was immersed overnight and filtered. The residue obtained is dried under vacuum.

(Production Example 4) Ethanol (100 g) was added to aloe leaf meat (300 g), and the mixture was immersed overnight and filtered. Ethanol (100 g) is further added to the filtration residue, soaked overnight, and then filtered. This is repeated once more, and the obtained residue is dried in vacuo.

[0076]

[Examples] Safety test (1) Cumulative skin irritation test The dried aloe mesophyll obtained in Production Examples 1 to 4 was swollen with purified water (solid concentration: 2.0%), and the flanks were depilated. Hartley guinea pigs (female, 5 per group, weight 320
g) on the skin once a day, 5 times a week, 0.5 mL /
Per animal was applied. Application was performed over 4 weeks and hair removal was performed on the last application day of each week. Judgment was made on the day following the last day of each week by primary irritation scoring, using erythema and edema as indices. As a result, erythema was observed after application, and it was determined to be positive only in the animal to which the aloe mesophyll of Production Example 2 was applied.

[0077]

EXAMPLES Evaluation of skin irritation In order to evaluate the skin irritation of the aloe mesophyll for cosmetics of the present invention, a patch test was carried out on five male and female monitors. (Sample) The dried aloe mesophylls obtained in Production Examples 1 to 4 were swollen with purified water. (Method) For each sample, a patch tester "Tori" was used to apply an obstruction to the upper arm flexion side of the subject for 24 hours. Judged. That is, the sample was removed 24 hours after the application, and 24 hours and 48 hours later, the state of the skin was observed and judged, and the average value was shown in Table 1. (Judgment criteria) Judgment was made based on the following criteria. No reaction 0 point Minor erythema 1 point Obvious erythema 2 points Erythema and swelling, erythema and papules 3 points Other small water bubbles above 4 points Desquamation with marked erythema 5 points

[0078]

From Table 1, it was found that the aloe mesophyll for cosmetics according to the present invention had improved skin irritation.

[0080]

Example: Moisturizing property of aloe leaf for cosmetics To evaluate the moisturizing property of aloe leaf for cosmetics of the present invention,
The changes over time in the transepidermal water loss were measured by monitors of five men and women. (Sample) A product obtained by swelling the dried aloe leaf meat obtained in Production Examples 1 to 4 with purified water (Measurement device) TEWAMETER TM210; COURAGE + KHAZAKA Electro
nic Gmbh (Method) Put each sample (1g) on the left and right forearm flexing side of the monitor.
Apply three times a day and wipe off for one minute after application. After the third application, after stabilizing for 1 hour in a thermo-hygrostat (24 ° C., 50% RH), measurement of transepidermal water loss is started. The measurement was performed at 2 second intervals for 3 minutes, and the average value of all the values was used for TEWL of the test site.
Value. Each blank was measured under the same conditions before sample application.

Table 2 shows the results of the average water change of the five monitors. It has been found that the aloe leaf for cosmetics according to the present invention suppresses transepidermal water evaporation and exhibits a good moisturizing action.

[0082]

Example Effect of Improving Skin Roughness In order to evaluate the effect of improving the skin roughness of aloe leaf for cosmetics obtained in the present invention, an application test was carried out using a guinea pig having a rough skin model. In addition, the sample was adjusted to the same solid content concentration, and only the solvent was used as a comparison. (Sample) The dried aloe mesophylls obtained in Production Examples 1 to 4 were swollen with purified water. (Method) White petrolatum was added to a Hartley-type guinea pig (female, 5 weeks old, 3 animals per group) whose back was shaved. 3% by weight
The sodium lauryl sulfate (0.2 g) adjusted to the above was continuously applied for three days to form rough skin. 4 rough skin creation sites
Then, each sample (1 g) was applied three times / day, and three days later, the degree of skin roughness was evaluated according to a criterion (score) determined by observation.

The results are as shown in Table 3. The aloe leaf for cosmetics of the present invention was found to be effective in improving rough skin.

[0084]

EXAMPLES Production of Cosmetics Containing Aloe Leaf Meal Various external preparation compositions according to the present invention were produced. The formulation examples are shown below, but the invention is not limited thereto.

(Formulation Example 1) Massage cream (O / W type)% by weight 1. Vaseline 15.0 2. Liquid paraffin 50.0 3.1,3-butylene glycol 5.0 4. Glycerin monostearate 3.0 5. Polyoxyethylene (20) sodium Oralutin monolaurate 2.0 6. Aloe leaf meat according to Preparation Example 5.0 5. Appropriate amount of fragrance, preservative, antioxidant 8. Purified water 100 residue

(Formulation Example 2) Massage cream (W / O type)% by weight 1. Microcrystalline wax 9.0 2. Solid paraffin 2.0 3. Beeswax 3.0 4. Vaseline 5.0 5. Reduced lanolin 5.0 6. Squalane 34.0 7. Hexadecyl Adipic acid ester 10.0 8. Propylene glycol 5.0 9. Glycerin monooleate 3.5 10. Polyoxyethylene (20) sodium oryl monooleate 1.0 11. Aloe leaf meat according to Production Example 3.0 12. Fragrance, preservative, antioxidant Agent qs 13.residual water to 100

(Formulation Example 3) Cleansing cream (W / O type) wt% 1. Liquid paraffin 50.0 2. Beeswax 10.0 3. Sorbitan sesquioleate 1.0 4. Lanolin 3.0 5. Glycerin 4.0 6. Sulfur powder 3.0 7. Production Aloe leaf meat according to Example 1 3.0 8. Perfume, preservative, antioxidant appropriate amount 9. Purified water 100 residue

(Formulation Example 4) Cleansing cream (O / W type) wt% 1. Squalane 85.0 2. Sorbitan monooleate 4.0 3. Aloe leaf meat according to Production Example 5.0 4. Appropriate amount of fragrance, preservative, antioxidant 5. Residue with 100 purified water

(Prescription Example 5) Face Wash Cream% by weight 1. Myristic acid 20.0 2. Stearic acid 5.0 3. Tallow fatty acid 3.0 4. Propylene glycol 9.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Production example Aloe leaf meat by 1 5.0 9. Flavors, preservatives, antioxidants appropriate amount 10. Purified water 100 residue

(Formulation Example 6) Paste peel off pack weight% 1. Titanium oxide 3.0 2. Kaolin 5.0 3. Aloe leaf meat according to Production Example 2.0 4. Sodium alginate 1.0 5. Ethanol 8.0 6.1,3-butylene glycol 8.0 7. Perfume, preservative, antioxidant appropriate amount 8. Purified water 100 residue

(Formulation Example 7) Rinse-off clay pack weight% 1. Zinc oxide 3.0 2. Bentonite 5.0 3. Aloe leaf meat according to Production Example 5.0 4. Glycerin 5.0 5. Propylene glycol 5.0 6. Ethanol 8.0 7. Fragrance, preservative , Antioxidant appropriate amount 8. Purified water 100 residue

(Formulation Example 8) Cold cream weight% 1. Beetroot wax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Almond oil 15.0 5. Borax 0.5 6. Aloe leaf meat according to Production Example 3.0 7. Perfume, preservative Agent, antioxidant suitable amount 8. Purified water 100 residue

(Formulation Example 9) Powdered powder weight% 1. Talc 81.0 2. Titanium oxide 5.0 3. Zinc laurate 5.0 4. Aloe leaf meat according to Production Example 6.0 5. Appropriate amount of flavor, preservative, coloring pigment

(Formulation Example 10) O / W type cream foundation weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. beeswax 3.0 7. tri Ethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.5 10. Titanium oxide 8.0 11. Talc 4.0 12. Aloe leaf meat according to Production Example 6.0 13. Appropriate perfume, preservative, antioxidant 14. Purified water 100

(Formulation Example 11) Eye shadow weight% 1. Mica titanium 70.0 2. Zinc laurate 3.0 3. Aloe leaf meat according to Production Example 6.0 4. Shea butter 2.0 5. Color pigment 1.5 6. Liquid paraffin 10.0 7. Palmitin Octyl acid 5.0 8. Appropriate amount of fragrance, preservative, antioxidant 9. Purified water 100 residue

(Formulation Example 12) Solid blusher weight% 1. Talc 70.0 2. Kaolin 10.0 3. Zinc laurate 3.0 4. Precipitable calcium carbonate 6.0 5. Aloe leaf meat according to Production Example 6.0 6. Liquid paraffin 1.5 7. Octyl palmitate 1.5 8. Color pigment appropriate amount 9. Perfume, preservative, antioxidant appropriate amount 10. Purified water 100 residue

(Formulation Example 13) Lipstick weight% 1. Candelilla wax 10.0 2. Carnauba wax 3.0 3. Microcrystalline wax 3.0 4. Lanolin 11.0 5. Liquid paraffin 10.0 6. Glycerin tri-2-ethylhexanoate 40.0 7. Castor Oil 18.0 8. Aloe leaf meat according to Production Example 5.0 5.0 Red 202, Red 226, Yellow 4 Aluminum lake qs 10. Flavor, preservative, antioxidant qs

(Formulation Example 14) Aqueous suspension type eyeliner weight% 1. Acrylic resin alkanolamine amine salt (40%) 4.0 2. Bentonite 5% dispersion 40.0 3.1,3-butylene glycol 8.0 4. Polyvinyl alcohol 3.0 5. Titanium oxide 2.0 6. Iron oxide yellow 20.0 7. Aloe leaf meat according to Production Example 5.0 8. Appropriate amount of fragrance, preservative, antioxidant 9. Residue with purified water 100

(Formulation Example 15) O / W sunscreen emulsion weight% 1. stearic acid 2.0 2. self-emulsifying glyceryl monostearate 1.0 3. cetanol 1.0 4. dimethylpolysiloxane 3.0 5. liquid paraffin 10.0 6. Triethanolamine 1.5 7. Bentonite 0.5 8. Propylene glycol 3.0 9. Titanium oxide 5.0 10. Iron oxide yellow 20.0 11. Aloe leaf meat according to Production Example 3.0 12. Appropriate perfume, preservative, antioxidant 13. Purified water 100 Residue to do

(Formulation Example 16) Deodorant powder weight% 1. Zinc oxide 4.9 2. Triclosan 0.1 3. Talc 82.0 4. Liquid paraffin 5.0 5. Aloe leaf meat according to Production Example 3.0 7. Perfume, preservative, antioxidant Appropriate amount

(Formulation Example 17) Nail enamel weight% 1. Nitrocellulose (1/4 second) 15.0 2. Alkyd resin 13.0 3. Ethyl acetate 14.0 4. Butyl acetate 20.0 5. Triethyl acetylcitrate 6.0 6. Butanol 5.0 7. Toluene 23.0 8. Aloe leaf meat according to Production Example 4.0 4.0 9. Guanine proper amount 10. Color pigment proper amount 11. Pigment settling inhibitor proper amount

(Formulation Example 18) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Aloe leaf meat according to Production Example 5.0 5.0 7. Appropriate amount of fragrance and preservative 8. Residue to 100 purified water

(Formulation Example 19) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Aloe leaf meat according to Production Example 2.0 6. pH adjuster qs 7. Preservative qs 8 .Remaining amount of purified water 100

(Formulation Example 20) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Shea fat 3.0 6. Aloe leaf meat according to Production Example 1 3.0 7.Appropriate amount of pH adjuster 8.Appropriate amount of preservative 9.Purified water 100 residue

(Formulation Example 21) Coating protective agent Aloe mesophyll according to Production Example 1 on gauze or liniment cloth
It is impregnated with a prescription solution containing an appropriate amount of antibiotics, anti-inflammatory, etc., and attached to the wound. Alternatively, the aloe leaf may be directly sprayed locally and covered with gauze or the like.

[0106]

[Examples] Use test of various external preparation compositions (1) Implementation procedure The massage cream (O / W type), cleansing cream (O / W type), shampoo and rinse prepared in the examples are used as test items (a). A usage test was conducted by male and female panelists (10 persons in total). As a comparative product (b), a preparation excluding the aloe mesophyll of the present invention in the formulation of each external preparation composition was prepared, and the test product (a) was used for one month after the start of the test, and then the following 1
During the month, the comparison product (b) was used under the following conditions, and a response was asked from a questionnaire.

(2) Usage conditions Massage cream: applied to face immediately after bathing at night. Massage (O / W type) for 1 minute after application and wipe off. 2g each, 1 time / day Cleansing Cream: Apply to face before washing face at night. Massage (O / W type) for 1 minute after application and wipe off. 2g each, 1 time / day Shampoo: Used for washing hair, 10mL, 1 time / day Rinse: Used immediately after shampoo, 10mL, 1 time / day

(3) Questionnaire Result Table 4 shows the result of the questionnaire.

[0109]

The aloe mesophyll for cosmetics of the present invention does not irritate the conventional skin, and if it is added to the cosmetics, further effects such as moisturizing properties, skin roughness improving effects, massage effects and appearance are expected. it can.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification code FI Theme coat ゛ (Reference) A61K 7/031 A61K 7/031 7/032 7/032 7/043 7/043 7/075 7/075 7 / 08 7/08 7/42 7/42 7/50 7/50 F term (reference) 4C083 AA082 AA111 AA112 AA122 AB032 AB112 AB152 AB212 AB232 AB242 AB322 AB432 AB442 AC012 AC022 AC072 AC102 AC122 AC172 AC182 AC242 AC352 AC372 AC422 AC442 AC532 AC542 AC642 AC692 AC742 AC782 AC792 AC812 AC852 AC862 AD092 AD112 AD152 AD262 AD302 AD512 CC02 CC05 CC07 CC12 CC13 CC14 CC17 CC19 CC23 CC28 CC38 CC39 DD17 DD22 DD32 DD33 DD39 EE10 EE17 FF01

Claims (4)

[Claims] 1. A method for producing aloe leaf for cosmetics, which is obtained by washing aloe leaf with an organic solvent. 2. The method for producing aloe leaf for cosmetics according to claim 1, wherein the leaf of aloe is shredded. 3. The method for producing aloe leaf for cosmetics according to claim 1, wherein the organic solvent is ethanol. 4. A cosmetic composition comprising the aloe leaf for cosmetics according to claim 1.