JP2001031551A - Preparation for preventing and improving chapped skin for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject preparation which is used by external use, has an excellent preventing and improving effects on chapped skin, and can remarkably increase a preventing effect on the flabbiness of skin, the disappearance of gloss, and so on, thereby preventing the aging of the skin, by compounding a specific 1-acyllysophospholipid and a specified sugar alcohol. SOLUTION: This preparation for preventing and improving chapped skins for external use contains (A) a 1-acyllysophospholipied of formula I (R1 is a 11 to 18C saturated fatty acid residue or a 18C fatty acid residue having one to three unsaturated double bonds; M is H or an alkali metal) or formula II (R2 is a 13 to 18C saturated fatty acid residue or a 18C fatty acid residue having one to three unsaturated double bonds) and (B) at least one compound selected from 4 to 6C sugar alcohols. The components A and B are preferably contained in amounts of 0.0001 to 1.0 wt.% and 0.001 to 20.0 wt.%, respectively. The component A is preferably lysolecithin, and the component B is preferably xylitol or erythritol.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for preventing and improving skin roughness, and more particularly to a skin external preparation having a high effect of preventing skin aging, preventing sagging of the skin, loss of gloss, and the like, in addition to prevention of skin roughness and improvement of skin roughness. -It relates to a skin external preparation for improvement.

[0002]

2. Description of the Related Art Conventionally, amino acids, polyhydric alcohols, saccharides, and the like have been blended in skin external preparations for the purpose of imparting a moisturizing effect. Although these components are effective in terms of moisturizing effect, they cannot be said to be sufficient in view of the anti-aging effect and did not meet the expected effects. Further, the effect of preventing rough skin was not always satisfactory.

[0003]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to find out how to improve the effect of preventing skin aging by preventing the skin from sagging and losing its luster, etc. It has been found that this object can be achieved by blending a specific 1-acyl lysophospholipid with at least one compound selected from sugar alcohols having 4 to 6 carbon atoms, and completed the present invention.

That is, in the present invention, a 1-acyl lysophospholipid represented by the following general formula (A) or (B) is blended with at least one compound selected from sugar alcohols having 4 to 6 carbon atoms. An external preparation for preventing and improving rough skin characterized by the following.

[0005]

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[0006]

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[0007] (wherein, R ¹ is a saturated fatty acid residue or a C 18 11-18 carbon atoms, it represents a fatty acid residue having 1 to 3 unsaturated double bonds, R ² is 13 carbon atoms ~ 18
Represents a saturated fatty acid residue or a fatty acid residue having 1 to 3 unsaturated double bonds having 18 carbon atoms, and M represents H or an alkali metal atom. )

According to the present invention, a 1-acyl lysophospholipid represented by the general formula (A) or (B) is blended with at least one compound selected from sugar alcohols having 4 to 6 carbon atoms. A skin external preparation for aging is provided.

Hereinafter, the configuration of the present invention will be described in detail. The 1-acyl lysophospholipid used in the present invention may be a commercially available product, or may be obtained by treating a commercially available phospholipid with phospholipase A2. Alternatively, it is also possible to obtain a 1-acyl lysophospholipid having a constant carbon number by treating the synthesized 1,2-diacyl phospholipid with phospholipase A2. Also, in the case of lysophosphatidylcholine obtained by reacting 1 mol or less of a fatty acid anhydride or a fatty acid halide with respect to 1 mol of glycerophosphocholine in the presence of a catalyst, a lysophosphatidylcholine having a constant carbon chain can be obtained (Japanese Unexamined Patent Publication No. 63-225388). Further, phospholipids such as those derived from soybeans may be treated with phospholipase A2.

In the 1-acyl lysophospholipid used in the present invention, when R ¹ is a single acyl group, it is preferably an acyl group derived from oleic acid, and R ² is a single acyl group. Is preferably an acyl group derived from linolenic acid, and R ² is 2
When it contains more than one type of acyl group, it is preferably a soybean-derived fatty acid residue. These are one kind alone,
Alternatively, two or more kinds can be used in combination. Particularly preferred among these 1-acyl lysophospholipids are those having a fatty acid residue having two carbon atoms and two unsaturated double bonds in the general formula (B), wherein R ² has 18 carbon atoms (lysolecithin);
And R ^{2 in the} general formula (B) is a saturated fatty acid residue having 16 carbon atoms, and lysolecithin is particularly preferred.

The 1-acyl lysophospholipid of the present invention is commercially available as, for example, sanlyzolecithin (manufactured by Taiyo Kagaku Co., Ltd., having a general formula (B), wherein R ² has 18 carbon atoms and two unsaturated double bonds. Having a fatty acid residue as a main component), lysolecithin Kyowa (Iwase Cospha Corporation:
In the general formula (B), the main component is a fatty acid residue in which R ² has 18 carbon atoms and has two unsaturated double bonds. ) And the like.

In the present invention, the amount of the 1-acyl lysophospholipid incorporated into the external preparation for skin is 0.0001 to 1.0% by weight, preferably 0.001 to 0.5% by weight. 0.
If it is less than 0001% by weight, a sufficient effect cannot be obtained.
If it is added in excess of% by weight, discoloration occurs over time, which is not preferable in terms of stability.

As the sugar alcohol having 4 to 6 carbon atoms used in the present invention, xylitol and erythritol are preferable. One of these sugar alcohols having 4 to 6 carbon atoms can be used alone or in combination of two or more. The compounding amount is 0.001 to 20.0% by weight, more preferably 0.01 to 10.0% by weight, based on the total amount of the external preparation for preventing and improving skin roughness.

The external preparation for skin of the present invention includes, in addition to the above essential components, other components usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, avocado oil, palm oil, peanut oil, tallow, rice bran oil, Oils such as jojoba oil, carnauba wax, lanolin, liquid paraffin, oxystearic acid, isostearyl palmitate, isostearyl alcohol; glycerin, sorbitol, polyethylene glycol, pyrrolidone carboxylic acid and salts thereof, collagen,
Moisturizing agents such as hyaluronic acid and its salts, chondroitin sulfate and its salts; UV absorbers such as amyl paradimethylaminobenzoate, urocanic acid and ethyl diisopropylcinnamate; antioxidants such as sodium erythorbate, sage extract and parahydroxyanisole Agents: sodium stearyl sulfate, diethanolamine cetyl sulfate,
Surfactants such as cetyltrimethylammonium saccharin, polyethylene glycol isostearate, and glyceryl arachiate; preservatives such as ethylparaben and butylparaben; , Grape, yokuinin, loofah, lily, saffron, senkyu, ginger, hypericum, ononis, rosemary, garlic, etc .; A whitening agent such as placenta extract, glutathione, saxifrage extract, or ascorbic acid derivative; an activator such as royal jelly, a photosensitizer, a cholesterol derivative, or various amino acids; γ-oryzano Blood circulation promoters such as sodium and dextran sulfate; antiseborrheic agents such as sulfur and thiantole; fragrance; water; alcohol; thickeners such as carboxyvinyl polymers; coloring agents such as titanium yellow, carsamine, and safflower red are required. Can be appropriately compounded according to the conditions.

The dosage form of the external preparation for skin of the present invention is arbitrary,
Any dosage form, such as a solution system, a solubilizing system, an emulsifying system, a powder dispersion system, a water-oil two-layer system, a water-oil-powder three-layer system, may be used. The use of the external preparation for skin of the present invention is also optional, and it can be used for facial cosmetics such as lotions, emulsions, creams, packs, etc., foundations, body cosmetics, ointments and the like.

[0016]

EXAMPLES Next, the present invention will be specifically described with reference to examples. The present invention is not limited by this. The compounding amount is% by weight.

Examples 1 and 2, Comparative Examples 1 to 4 Creams having the formulations shown in Table 1 below were prepared by the methods described below.

[0018]

[Table 1] ───────────────────────────────── Example Comparative example ───── ──── {1 2 1 2 3 4} A. Oil phase Cetanol 0.5 0.5 0.5 0.5 0.5 0.5 Vaseline 2.0 2.0 2.0 2.0 2.0 2.0 Squalane 7.0 7.0 7.0 7.0 7.0 7.0 Self-emulsifying monoglyceryl stearate 2.5 2.5 2.5 2.5 2.5 2.5 Polyoxyethylene sorbitan monostearate (20EO) 1.5 1.5 1.5 1.5 1.5 1.5 Pantothenyl ethyl ether 0.5 0.5 0.5 0.5 0.5 0.5 Jojoba oil 5.0 5.0 5.0 5.0 5.0 5.0 Water phase Propylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 Glycerin 5.0 5.0 5.0 5.0 5.0 5.0 1-Acyl lysophospholipid 0.01 0.01 − − 0.01 − Vegum (montmorillonite) 5.0 5.0 5.0 5.0 5.0 5.0 Xylitol 5.0 − 5.0 − − − Erythritol − 5.0 − 5.0 − − Potassium hydroxide 0.3 0.3 0.3 0.3 0.3 0.3 Water Residue Residue Residue Residue Residue ─────────────────────────────────

(Preparation method) A (oil phase) and B (aqueous phase) are each heated to 70 ° C. and completely dissolved. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream. As the 1-acyl lysophospholipid, san lysolecithin (manufactured by Taiyo Kagaku Co., Ltd .: a fatty acid residue having two carbon atoms and having two unsaturated double bonds in the general formula (B) where R ² is 18) is a main component. ) Was used.

The creams obtained in Examples 1 and 2 and Comparative Examples 1 to 4 were used to evaluate the effect of preventing and improving the roughness of the skin on the human body panel, and to evaluate the sagging and gloss of the skin.

That is, with respect to the effect of preventing rough skin and improving the rough skin, a replica of the skin of a healthy woman (face) is taken by a replica method using a silicone resin and observed with a microscope (17 times). Using 60 people (rough skin panels) determined to have skin roughness evaluations 1 and 2 based on the criteria shown in Table 2 based on the criteria shown in Table 2 from the state of the skin pattern and the peeling state of the stratum corneum, the left and right half of the face were compared with Examples 1-2. Examples 1-4
The six types of creams obtained in the above were allocated so that each of them was applied to 20 persons, and applied twice a day. Two weeks later, replicas on the right and left sides of the face were taken again, and the condition of the skin was observed. Table 3 shows the results.

Regarding the sagging and gloss of the skin, five specialized panels each applied the six types of creams obtained in Examples 1-2 and Comparative Examples 1-4 twice a day. The skin condition after two weeks was visually evaluated before and after use according to the following criteria. Table 3 also shows the results. (Visual evaluation) 視: The skin is very sticky and there is no sagging. ：: There is still skin and no sagging. Δ: The skin does not have much swelling and feels sagging. ×: There is no skin on the skin and it is sagging.

[0023]

[Table 2] ────────────────────────────── Rating Evaluation Remarks ───────────── ───────────────── 1 Elimination of skin ridges and skin hills; turning over a wide area of the stratum corneum Rough skin 2 Skin sulcus and skin hills are unclear; , Skin hills are recognized but flat. ───────────

[0024]

[Table 3] 例 Example Comparative example ───── ──────── １ 1 2 1 2 3 4 ───────────────────────────── Replica evaluation 10 0 0 7 8 6 people 10 people 2 0 people 0 people 6 people 5 people 6 people 8 people 3 2 people 2 people 6 people 4 people 6 people 2 people 4 6 people 8 people 1 person 3 people 2 people 0 people 5 12 people 10 people 0 Name 0 people 0 people 0 people ───────────────────────────── Visual evaluation Before use ◎ 0 people 0 people 0 people 0 people 0 people 0 people ○ 1 person 1 person 1 person 1 person 0 people 1 person △ 3 people 4 people 2 people 3 people 3 people 3 people × 1 person 0 people 2 people 1 person 2 people 1 person After use ◎ 2 people 2 people 0 people 0 people 1 person 0 people ○ 3 people 3 people 3 people 2 people 1 person 0 people △ 0 people 0 people 1 people 2 people 2 people 3 people × 0 people 0 people 1 person 1 person 1 person 2 people ─────────────────────────────

From the results shown in Table 3, the facial part using a cosmetic containing 1-acyl lysophospholipid and at least one compound selected from sugar alcohols having 4 to 6 carbon atoms used other cosmetics. It can be seen that a remarkable effect of preventing rough skin and improving rough skin is recognized as compared with the facial part.

Example 3 Cream A. Oil phase Stearic acid 10.0% by weight Stearyl alcohol 4.0 Butyl stearate 8.0 Monoglycerin stearate 2.0 Vitamin E acetate 0.5 Vitamin A palmitate 0.1 Macadamia nut oil 1.0 Fragrance 0.4 Preservative Agent appropriate amount B. Aqueous phase glycerin 4.0 1,2 pentanediol 3.0 potassium hydroxide 0.4 magnesium ascorbate 0.1 L-arginine hydrochloride 0.01 trisodium edetate 0.05 1-acyl lysophospholipid 0.5 (San lysolecithin) Xylitol 1.0 Purified water residue (Preparation method) The oil phase of A and the water phase of B are each heated to 70 ° C. and completely dissolved. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream.

Example 4 Cream A. Oil phase Cetanol 4.0% by weight Vaseline 7.0 Isopropyl myristate 8.0 Squalane 15.0 Monoglycerin stearate 2.2 POE (20) Sorbitan monostearate 2.8 Vitamin E nicotinate 2.0 Fragrance 0.0 3 Appropriate amount of antioxidant Preservative appropriate amount B. Aqueous phase glycerin 10.0 dipropylene glycol 4.0 sodium pyrrolidone carboxylate 1.0 1-acyl lysophospholipid 0.05 (lysolecithin Kyowa) lysine 3.0 xylitol 10.0 tranexamic acid 3.0 disodium edetate 0.01 Purified water residue (Production method) A cream was obtained according to Example 3.

Example 5 Emulsion A. Oil phase Squalane 5.0% by weight Oleyl oleate 3.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether (20EO) 1.2 Evening primrose oil 0.5 Perfume 0.3 Preservative Suitable amount B. Aqueous phase 1,3 butylene glycol 4.5 Melissa extract 1.5 ethanol 3.0 carboxyvinyl polymer 0.2 potassium hydroxide 0.1 L-arginine L-aspartate 0.01 1-acyl lysophospholipid 0.001 (San lysolecithin) Erythritol 0.5 Sodium hexametaphosphate 0.05 Purified water residue (Preparation method) An emulsion was obtained according to Example 3.

Example 6 Foundation A. Oil phase Cetanol 3.5% by weight Deodorized lanolin 4.0 Jojoba oil 5.0 Vaseline 2.0 Squalane 6.0 Monoglycerin stearate 2.5 POE (60) Hardened castor oil 1.5 POE (20) Cetyl ether 1.0 Pyridoxine tripalmitate 0.1 Preservative appropriate amount Fragrance 0.3 B. Aqueous phase Propylene glycol 10.0 Compound powder 12.0 L-arginine 5.0 Xylitol 3.0 1-acyl lysophospholipid 0.05 (San lysolecithin) Trisodium edetate 0.2 Purified water Residue (Preparation method) A foundation was obtained according to the criteria.

Example 7 Toner A. Alcohol phase ethanol 5.0% by weight POE oleyl alcohol ether 2.0 oleyl alcohol 0.1 2-ethylhexyl-P-dimethylaminobenzoate 0.18 fragrance 0.05 B. Aqueous phase 1,3 butylene glycol 9.5 glycerin 2.0 sodium pyrrolidone carboxylate 0.5 nicotinamide 0.3 1-acyl lysophospholipid 0.0005 (lysolecithin Kyowa) β-cyclodextrin 1.0 erythritol 0.05 purified water Residue (Preparation method) The alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion.

[0031]

As described above, the external preparation for preventing and improving skin roughness according to the present invention comprises a 1-acyl lysophospholipid,
By blending with at least one compound selected from sugar alcohols having 4 to 6 carbon atoms, it has an excellent effect of preventing rough skin and improving rough skin, and sags the skin.
This has the advantage that the effect of preventing aging by preventing loss of gloss can be significantly increased.

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C083 AA112 AA122 AB032 AB282 AB442 AC012 AC022 AC072 AC102 AC112 AC122 AC131 AC132 AC182 AC242 AC352 AC402 AC422 AC432 AC442 AC532 AC552 AC582 AC612 AC622 AC642 AD042 AD092 AD252 AD512 AD571 AD572 AD622 AD632 AD642AD CC05 CC12 DD23 DD31 EE12 FF05

Claims (4)

[Claims] 1. A composition comprising a 1-acyl lysophospholipid represented by the following general formula (A) or (B) and at least one compound selected from sugar alcohols having 4 to 6 carbon atoms. An external preparation for preventing and improving rough skin. Embedded image Embedded image (Wherein, R ¹ represents a saturated fatty acid residue having 11 to 18 carbon atoms or a fatty acid residue having 1 to 3 unsaturated double bonds having 18 carbon atoms, and R ² represents a fatty acid residue having 13 to 18 carbon atoms. Represents a saturated fatty acid residue or a fatty acid residue having 1 to 3 unsaturated double bonds having 18 carbon atoms, and M represents H or an alkali metal atom.) 2. The external preparation for preventing or improving rough skin according to claim 1, wherein the 1-acyl lysophospholipid is lysolecithin. 3. The external preparation for preventing or improving rough skin according to claim 1, wherein the sugar alcohol having 4 to 6 carbon atoms is xylitol or erythritol. 4. A method comprising blending a 1-acyl lysophospholipid represented by the following general formula (A) or (B) and at least one compound selected from sugar alcohols having 4 to 6 carbon atoms. Anti-aging skin external preparation. Embedded image Embedded image (Wherein, R ¹ represents a saturated fatty acid residue having 11 to 18 carbon atoms or a fatty acid residue having 1 to 3 unsaturated double bonds having 18 carbon atoms, and R ² represents a fatty acid residue having 13 to 18 carbon atoms. Represents a saturated fatty acid residue or a fatty acid residue having 1 to 3 unsaturated double bonds having 18 carbon atoms, and M represents H or an alkali metal atom.)