JP2000517292A5 - - Google Patents
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- Publication number
- JP2000517292A5 JP2000517292A5 JP1997537492A JP53749297A JP2000517292A5 JP 2000517292 A5 JP2000517292 A5 JP 2000517292A5 JP 1997537492 A JP1997537492 A JP 1997537492A JP 53749297 A JP53749297 A JP 53749297A JP 2000517292 A5 JP2000517292 A5 JP 2000517292A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9619082.2 | 1996-09-12 | ||
| GBGB9619082.2A GB9619082D0 (en) | 1996-09-12 | 1996-09-12 | Further cyclopropylindoles and their seco precursors,and their use as prodrugs |
| GB9707394.4 | 1997-04-10 | ||
| GBGB9707394.4A GB9707394D0 (en) | 1997-04-10 | 1997-04-10 | Further cyclopropylindoles and their seco precursors, and their use as prodrugs |
| PCT/NZ1997/000117 WO1998011101A2 (en) | 1996-09-12 | 1997-09-12 | Condensed n-aclyindoles as antitumor agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000517292A JP2000517292A (ja) | 2000-12-26 |
| JP2000517292A5 true JP2000517292A5 (cg-RX-API-DMAC10.html) | 2005-01-13 |
| JP4155598B2 JP4155598B2 (ja) | 2008-09-24 |
Family
ID=26310030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53749297A Expired - Fee Related JP4155598B2 (ja) | 1996-09-12 | 1997-09-12 | 抗癌剤としての縮合ｎ−アシルインドール |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0938474B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4155598B2 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE310725T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU721037B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2265874C (cg-RX-API-DMAC10.html) |
| DE (1) | DE69734722T2 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2253786T3 (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ334344A (cg-RX-API-DMAC10.html) |
| WO (1) | WO1998011101A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE240334T1 (de) | 1998-08-27 | 2003-05-15 | Spirogen Ltd | Pyrrolobenzodiazepine |
| GB9818730D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
| GB9909612D0 (en) * | 1999-04-26 | 1999-06-23 | Cancer Res Campaign Tech | N-protected amines and their use as prodrugs |
| US6909006B1 (en) * | 1999-08-27 | 2005-06-21 | Spirogen Limited | Cyclopropylindole derivatives |
| BR0110414A (pt) * | 2000-04-28 | 2003-02-11 | Baxter Healthcare Sa | Derivados de 2-acil indol e seu uso como agentes antitumores |
| DE50104114D1 (de) * | 2000-05-02 | 2004-11-18 | Tietze Lutz F | Neue prodrugs von 6-hydroxy-2,3-dihydro-1h-indolen, 5-hydroxy-1,2-dihydro-3h-pyrrolo 3,2-e]indolen und 5-hydroxy-1,2-dihydro-3h-benzo e]indolen sowie von 6-hydroxy-1,2,3,4-tetrahydro-benzo f]chinolin-derivaten für eine selektive krebstherapie |
| DE60211905T2 (de) * | 2001-02-22 | 2007-01-18 | School Of Pharmacy, University Of London | Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung |
| AU2003228173A1 (en) * | 2002-05-17 | 2003-12-02 | Auckland Uniservices Limited | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3h-(ring fused indol-5-yl(amine-derived)) compounds and analogues thereof, and to products obtained therefrom |
| GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
| ATE435649T1 (de) * | 2003-05-02 | 2009-07-15 | Elan Pharm Inc | 4-brom-5-(2-chlor-benzoylamino)-1h-pyrazol-3- carbonsäure(phenyl)amid-derivate und verwandte verbindungen als bradykinin b1 receptor antagonisten zur behandlung von entzündlichen erkrankungen |
| ES2314418T3 (es) * | 2003-05-02 | 2009-03-16 | Elan Pharmaceuticals, Inc. | Derivados de amidas del acido 4-bromo-5-(2-clorobenzoilamino)-1h-pirazol-3-carboxicilico y compuestos relacionados como antagonistas del receptor b1 de bradiquinina para el tratamiento de enfermedades inflamatorias. |
| GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
| NZ536107A (en) | 2004-10-22 | 2007-06-29 | Auckland Uniservices Ltd | Nitrobenzindoles and their use in cancer therapy |
| WO2007059404A2 (en) * | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
| CN101415679A (zh) * | 2006-02-02 | 2009-04-22 | 辛塔佳有限公司 | 水溶性cc-1065类似物及其缀合物 |
| WO2008039087A2 (en) * | 2006-09-29 | 2008-04-03 | Auckland Uniservices Limited | Indoline derivatives and uses thereof |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
| WO2008103693A2 (en) | 2007-02-21 | 2008-08-28 | Medarex, Inc. | Chemical linkers with single amino acids and conjugates thereof |
| US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
| AU2009320481C1 (en) | 2008-11-03 | 2016-12-08 | Syntarga B.V. | Novel CC-1065 analogs and their conjugates |
| DE102009051438A1 (de) | 2009-10-30 | 2011-05-05 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts | Fluoreszenzfarbstoffe |
| WO2011133039A2 (en) * | 2010-04-21 | 2011-10-27 | Syntarga B.V. | Novel conjugates of cc-1065 analogs and bifunctional linkers |
| MY177390A (en) | 2014-01-10 | 2020-09-14 | Byondis Bv | Method for purifying cys-linked antibody-drug conjugates |
| CN105899237B (zh) | 2014-01-10 | 2019-09-03 | 斯索恩生物制药有限公司 | 用于治疗子宫内膜癌的倍癌霉素adc |
| SG10201911860VA (en) | 2014-01-10 | 2020-02-27 | Synthon Biopharmaceuticals Bv | Duocarmycin adcs showing improved in vivo antitumor activity |
| CN108653288B (zh) * | 2018-05-29 | 2020-05-05 | 福建医科大学孟超肝胆医院(福州市传染病医院) | 一种乏氧响应聚合物纳米粒及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU617304B2 (en) * | 1986-12-19 | 1991-11-28 | Pharmacia & Upjohn Company | Novel cc-1065 analogs |
| JP2642165B2 (ja) * | 1988-07-22 | 1997-08-20 | 協和醗酵工業株式会社 | 新規ｄｃ−８９化合物およびその製造法 |
| AU648313B2 (en) * | 1990-04-25 | 1994-04-21 | Pharmacia & Upjohn Company | Novel CC-1065 analogs |
| GB9516943D0 (en) * | 1995-08-18 | 1995-10-18 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs |
| JPH11513391A (ja) * | 1995-10-03 | 1999-11-16 | ザ スクリップス リサーチ インスティテュート | Ｃｃ−１０６５ 及びズオカーマイシンのｃｂｉ 類縁体 |
| US5985908A (en) * | 1996-03-08 | 1999-11-16 | The Scripps Research Institute | MCBI analogs of CC-1065 and the duocarmycins |
-
1997
- 1997-09-12 WO PCT/NZ1997/000117 patent/WO1998011101A2/en not_active Ceased
- 1997-09-12 EP EP97942316A patent/EP0938474B1/en not_active Expired - Lifetime
- 1997-09-12 DE DE69734722T patent/DE69734722T2/de not_active Expired - Fee Related
- 1997-09-12 ES ES97942316T patent/ES2253786T3/es not_active Expired - Lifetime
- 1997-09-12 AT AT97942316T patent/ATE310725T1/de not_active IP Right Cessation
- 1997-09-12 CA CA002265874A patent/CA2265874C/en not_active Expired - Fee Related
- 1997-09-12 NZ NZ334344A patent/NZ334344A/xx unknown
- 1997-09-12 AU AU44039/97A patent/AU721037B2/en not_active Ceased
- 1997-09-12 JP JP53749297A patent/JP4155598B2/ja not_active Expired - Fee Related