IL123164A
(en)
*
|
1995-08-30 |
2001-03-19 |
Searle & Co |
Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them
|
US6245809B1
(en)
|
1996-12-09 |
2001-06-12 |
Cor Therapeutics Inc. |
Integrin antagonists
|
AU5596298A
(en)
*
|
1996-12-09 |
1998-07-03 |
Cor Therapeutics, Inc. |
Integrin antagonists
|
AU8063098A
(en)
*
|
1997-06-10 |
1998-12-30 |
Eli Lilly And Company |
Combinatorial process for preparing substituted phenylalanine libraries
|
SI1005445T1
(en)
*
|
1997-08-22 |
2004-12-31 |
F. Hoffmann-La Roche Ag |
N-alkanoylphenylalanine derivatives
|
US6229011B1
(en)
|
1997-08-22 |
2001-05-08 |
Hoffman-La Roche Inc. |
N-aroylphenylalanine derivative VCAM-1 inhibitors
|
WO1999010312A1
(en)
*
|
1997-08-22 |
1999-03-04 |
F. Hoffmann-La Roche Ag |
N-alkanoylphenylalanine derivatives
|
US6455550B1
(en)
|
1997-08-22 |
2002-09-24 |
Hoffmann-La Roche Inc. |
N-alkanoylphenylalanine derivatives
|
US6262069B1
(en)
*
|
1997-08-29 |
2001-07-17 |
Protherics Molecular Design Limited |
1-amino-7-isoquinoline derivatives as serine protease inhibitors
|
US6740682B2
(en)
|
1997-08-29 |
2004-05-25 |
Tularik Limited |
Meta-benzamidine derivatives as serine protease inhibitors
|
AU748041B2
(en)
|
1997-10-31 |
2002-05-30 |
Aventis Pharma Limited |
Substituted anilides
|
AU747907B2
(en)
*
|
1997-12-23 |
2002-05-30 |
Aventis Pharma Limited |
Substituted beta-alanines
|
US6329372B1
(en)
|
1998-01-27 |
2001-12-11 |
Celltech Therapeutics Limited |
Phenylalanine derivatives
|
US6555562B1
(en)
*
|
1998-02-26 |
2003-04-29 |
Celltech R&D Limited |
Phenylalanine derivatives
|
GB9805655D0
(en)
|
1998-03-16 |
1998-05-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
US6521626B1
(en)
*
|
1998-03-24 |
2003-02-18 |
Celltech R&D Limited |
Thiocarboxamide derivatives
|
AU759449C
(en)
|
1998-04-09 |
2003-10-30 |
Meiji Seika Pharma Co.,Ltd. |
Aminopiperidine derivatives as integrin alpha v beta 3 antagonists
|
GB9811159D0
(en)
|
1998-05-22 |
1998-07-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9811969D0
(en)
*
|
1998-06-03 |
1998-07-29 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9812088D0
(en)
|
1998-06-05 |
1998-08-05 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9814414D0
(en)
|
1998-07-03 |
1998-09-02 |
Celltech Therapeutics Ltd |
Chemical compounds
|
US6352977B1
(en)
|
1998-07-13 |
2002-03-05 |
Aventis Pharma Limited |
Substituted β-alanines
|
GB9821061D0
(en)
*
|
1998-09-28 |
1998-11-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9821222D0
(en)
|
1998-09-30 |
1998-11-25 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9825652D0
(en)
|
1998-11-23 |
1999-01-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
GB9826174D0
(en)
*
|
1998-11-30 |
1999-01-20 |
Celltech Therapeutics Ltd |
Chemical compounds
|
US6677360B2
(en)
|
1998-12-16 |
2004-01-13 |
Bayer Aktiengesellschaft |
Biphenyl and biphenyl-analogous compounds as integrin antagonists
|
ATE303359T1
(de)
*
|
1998-12-16 |
2005-09-15 |
|
Biphenylverbindungen und biphenyl-analoge als intergrin-antagonisten
|
AU2210400A
(en)
|
1998-12-23 |
2000-07-31 |
G.D. Searle & Co. |
Method of using a cyclooxygenase-2 inhibitor and an integrin antagonist as a combination therapy in the treatment of neoplasia
|
US6858598B1
(en)
|
1998-12-23 |
2005-02-22 |
G. D. Searle & Co. |
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
US6833373B1
(en)
|
1998-12-23 |
2004-12-21 |
G.D. Searle & Co. |
Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
US6291503B1
(en)
|
1999-01-15 |
2001-09-18 |
Bayer Aktiengesellschaft |
β-phenylalanine derivatives as integrin antagonists
|
US6344484B1
(en)
*
|
1999-02-12 |
2002-02-05 |
3-Dimensional Pharmaceuticals, Inc. |
Tyrosine alkoxyguanidines as integrin inhibitors
|
TR200102399T2
(tr)
*
|
1999-02-18 |
2002-01-21 |
F. Hoffmann-La Roch Ag |
Tiyoamid türevleri
|
PL349463A1
(en)
*
|
1999-02-18 |
2002-07-29 |
Hoffmann La Roche |
Phenylalaninol derivatives
|
FR2792314B1
(fr)
*
|
1999-04-15 |
2001-06-01 |
Adir |
Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
US6518283B1
(en)
|
1999-05-28 |
2003-02-11 |
Celltech R&D Limited |
Squaric acid derivatives
|
WO2001010844A1
(en)
|
1999-08-05 |
2001-02-15 |
Meiji Seika Kaisha, Ltd. |
φ-AMINO-α-HYDROXYCARBOXYLIC ACID DERIVATIVES HAVING INTEGRIN αvβ3 ANTAGONISM
|
CN1352641A
(zh)
|
1999-09-29 |
2002-06-05 |
奥索-麦克尼尔药品公司 |
用于治疗整联蛋白介导的疾病的异哌啶甲酰胺
|
US6534513B1
(en)
|
1999-09-29 |
2003-03-18 |
Celltech R&D Limited |
Phenylalkanoic acid derivatives
|
AU7961200A
(en)
*
|
1999-10-29 |
2001-05-14 |
Kaken Pharmaceutical Co., Ltd. |
Urea derivative, process for producing the same, and medicine containing the urea derivative
|
EP1238971A4
(en)
*
|
1999-12-16 |
2003-02-26 |
Sumitomo Pharma |
SUBSTITUTED GUANIDINE DERIVATIVES
|
US6455539B2
(en)
|
1999-12-23 |
2002-09-24 |
Celltech R&D Limited |
Squaric acid derivates
|
US20030040531A1
(en)
*
|
2000-01-25 |
2003-02-27 |
Kazuyuki Fujishima |
Remedies for reperfusion injury containing integrin alphanubeta 3 antagonist
|
ATE464892T1
(de)
|
2000-02-03 |
2010-05-15 |
Eisai R&D Man Co Ltd |
Inhibitoren der integrinexpression
|
ATE375330T1
(de)
|
2000-04-17 |
2007-10-15 |
Ucb Pharma Sa |
Enamin-derivate als zell-adhäsionsmoleküle
|
GB0011817D0
(en)
|
2000-05-16 |
2000-07-05 |
Pharmacia & Upjohn Spa |
Antagonists of integrin receptors
|
US6545013B2
(en)
|
2000-05-30 |
2003-04-08 |
Celltech R&D Limited |
2,7-naphthyridine derivatives
|
US6403608B1
(en)
|
2000-05-30 |
2002-06-11 |
Celltech R&D, Ltd. |
3-Substituted isoquinolin-1-yl derivatives
|
DE10032256C2
(de)
*
|
2000-07-03 |
2003-06-05 |
Infineon Technologies Ag |
Chip-ID-Register-Anordnung
|
AU2001267753A1
(en)
|
2000-07-07 |
2002-01-21 |
Celltech R And D Limited |
Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
|
US7015216B2
(en)
|
2000-07-21 |
2006-03-21 |
Elan Pharmaceuticals, Inc. |
Heteroaryl-β-alanine derivatives as alpha 4 integrin inhibitors
|
AU2001275724A1
(en)
|
2000-08-02 |
2002-02-13 |
Celltech R&D Limited |
3-substituted isoquinolin-1-yl derivatives
|
US6723749B2
(en)
*
|
2000-08-02 |
2004-04-20 |
Smithkline Beecham Corporation |
Fatty acid synthase inhibitors
|
US7163681B2
(en)
|
2000-08-07 |
2007-01-16 |
Centocor, Inc. |
Anti-integrin antibodies, compositions, methods and uses
|
US7288390B2
(en)
|
2000-08-07 |
2007-10-30 |
Centocor, Inc. |
Anti-dual integrin antibodies, compositions, methods and uses
|
US6486174B2
(en)
|
2000-08-07 |
2002-11-26 |
3-Dimensional Pharmaceuticals, Inc. |
Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists
|
WO2002014272A1
(fr)
*
|
2000-08-09 |
2002-02-21 |
Kaken Pharmaceutical Co., Ltd. |
Derives de (thio)uree, procede de production correspondant et medicaments contenant ces derives
|
DZ3415A1
(fr)
|
2000-08-31 |
2002-03-07 |
Chiron Corp |
Guanidinobenzamides comme mc4-r agonistes.
|
ES2376161T3
(es)
*
|
2001-01-29 |
2012-03-09 |
Janssen Pharmaceuticals, Inc. |
Indoles sustituidos y su utilización como antagonistas de integrinas.
|
ITTO20010110A1
(it)
*
|
2001-02-08 |
2002-08-08 |
Rotta Research Lab |
Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva.
|
ATE348097T1
(de)
|
2001-04-09 |
2007-01-15 |
Chiron Corp |
Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten
|
US7081460B2
(en)
|
2001-04-09 |
2006-07-25 |
Ortho-Mcneil Pharmaceutical, Inc. |
Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
|
US6872730B2
(en)
|
2001-04-27 |
2005-03-29 |
3-Dimensional Pharmaceuticals, Inc. |
Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
|
KR20040058229A
(ko)
|
2001-10-22 |
2004-07-03 |
더 스크립스 리서치 인스티튜트 |
항체 표적화 화합물
|
US20030207814A1
(en)
*
|
2002-02-04 |
2003-11-06 |
Chiron Corporation |
Novel guanidinyl derivatives
|
US20030195187A1
(en)
*
|
2002-02-04 |
2003-10-16 |
Chiron Corporation |
Guanidino compounds
|
US20050124652A1
(en)
*
|
2002-02-04 |
2005-06-09 |
Rustum Boyce |
Guanidino compounds
|
US20070004743A1
(en)
*
|
2002-02-25 |
2007-01-04 |
Xiao Linda L |
Intranasal administration of mc4-r agonists
|
JP2005531583A
(ja)
|
2002-05-23 |
2005-10-20 |
カイロン コーポレイション |
置換キナゾリノン化合物
|
KR20060018217A
(ko)
*
|
2003-05-23 |
2006-02-28 |
카이론 코포레이션 |
Mc4-r 작용제로서 구아니디노-치환된 퀴나졸리논 화합물
|
ES2332135T3
(es)
*
|
2003-06-03 |
2010-01-27 |
Novartis Ag |
Inhibidores p-38 basados en heterociclo de 5 miembros.
|
CA2545601A1
(en)
*
|
2003-11-19 |
2005-06-09 |
Chiron Corporation |
Quinazolinone compounds with reduced bioaccumulation
|
US20070122408A1
(en)
*
|
2005-10-20 |
2007-05-31 |
The Scripps Research Institute |
Fc Labeling for Immunostaining and Immunotargeting
|
WO2007147763A1
(en)
|
2006-06-20 |
2007-12-27 |
F. Hoffmann-La Roche Ag |
Arylsulfonyl naphthalene derivatives and uses thereof
|
US8518927B2
(en)
|
2009-02-10 |
2013-08-27 |
The Scripps Research Institute |
Chemically programmed vaccination
|
US20140010783A1
(en)
*
|
2012-07-06 |
2014-01-09 |
Hoffmann-La Roche Inc. |
Antiviral compounds
|
MX2015000794A
(es)
|
2012-07-18 |
2015-10-12 |
Univ Saint Louis |
Derivados de aminoácido beta como antagonistas de integrina.
|
US8716226B2
(en)
|
2012-07-18 |
2014-05-06 |
Saint Louis University |
3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
|
EP3738953A1
(en)
|
2015-12-30 |
2020-11-18 |
Saint Louis University |
Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists with improved pharmacokinetic properties and methods for their manufacture
|
CN107652210B
(zh)
*
|
2017-09-30 |
2021-01-01 |
瑞阳(上海)新药研发有限公司 |
一种胍类化合物或其药学上可接受的盐、其制备方法和应用
|