JP2000512134A5 - - Google Patents

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Publication number
JP2000512134A5
JP2000512134A5 JP1997543023A JP54302397A JP2000512134A5 JP 2000512134 A5 JP2000512134 A5 JP 2000512134A5 JP 1997543023 A JP1997543023 A JP 1997543023A JP 54302397 A JP54302397 A JP 54302397A JP 2000512134 A5 JP2000512134 A5 JP 2000512134A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1997543023A
Other languages
English (en)
Japanese (ja)
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JP2000512134A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/009407 external-priority patent/WO1997045143A1/en
Publication of JP2000512134A publication Critical patent/JP2000512134A/ja
Publication of JP2000512134A5 publication Critical patent/JP2000512134A5/ja
Pending legal-status Critical Current

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JP09543023A 1996-05-31 1997-05-30 Jagged/Notchタンパク質および核酸に基づく治療および診断の方法および組成物 Pending JP2000512134A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1884196P 1996-05-31 1996-05-31
US60/018,841 1996-05-31
PCT/US1997/009407 WO1997045143A1 (en) 1996-05-31 1997-05-30 Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids

Publications (2)

Publication Number Publication Date
JP2000512134A JP2000512134A (ja) 2000-09-19
JP2000512134A5 true JP2000512134A5 (enExample) 2005-01-13

Family

ID=21790044

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09543023A Pending JP2000512134A (ja) 1996-05-31 1997-05-30 Jagged/Notchタンパク質および核酸に基づく治療および診断の方法および組成物

Country Status (6)

Country Link
US (2) US6433138B1 (enExample)
EP (1) EP0921818A4 (enExample)
JP (1) JP2000512134A (enExample)
AU (1) AU720890B2 (enExample)
CA (1) CA2256481A1 (enExample)
WO (1) WO1997045143A1 (enExample)

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US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
EP0861261B9 (en) 1995-06-28 2010-02-24 Imperial Cancer Research Technology Limited Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
WO1997045143A1 (en) * 1996-05-31 1997-12-04 The National American Red Cross Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
US6136952A (en) * 1997-06-25 2000-10-24 University Of Washington Human jagged polypeptide, encoding nucleic acids and methods of use
AU1054900A (en) * 1998-10-30 2000-05-22 Smith & Nephew Plc Compositions comprising notch receptor manipulating agents
US20030196885A1 (en) * 1999-05-17 2003-10-23 Marchitto Kevin S. Electromagnetic energy driven separation methods
FR2798674B1 (fr) * 1999-09-21 2004-01-30 Mahmood Salman Al Procede d'identification de nouveaux genes impliques dans la regulation de l'angiogenese, etude de ces genes et leur utilisation a des fins therapeutiques
DE60124380T2 (de) * 2000-03-22 2007-10-11 Curagen Corp., New Haven Angiogenese-assoziierte proteine und dafür kodierende nukleinsäure
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
WO2002018544A2 (en) * 2000-08-31 2002-03-07 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
WO2003011317A1 (en) * 2001-07-25 2003-02-13 Lorantis Limited Modulators of notch signalling for use in immunotherapy
GB0118223D0 (en) * 2001-07-26 2001-09-19 Univ Sheffield Stem loop RNA
WO2004078944A2 (en) 2003-03-05 2004-09-16 Maine Medical Center Research Institute Thrombin, soluble jaggedi, and trap and growth of stem cells
US20060084599A1 (en) * 2003-03-05 2006-04-20 Maine Medical Center Compositions, methods and kits relating to notch signaling
WO2005014854A1 (en) * 2003-08-08 2005-02-17 Licentia, Ltd. Materials and methods for colorectal cancer screening, diagnosis, and therapy
CA2554779A1 (en) * 2004-02-03 2005-08-18 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
US7794742B2 (en) * 2005-02-08 2010-09-14 University Of Washington Devices for promoting epithelial cell differentiation and keratinization
WO2006125001A2 (en) * 2005-05-17 2006-11-23 Maine Medical Center Research Institute Compositions and methods related to the intracellular effects of intracellular domains of delta1 and jagged1
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
WO2007053648A2 (en) 2005-10-31 2007-05-10 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
ES2641087T3 (es) 2005-10-31 2017-11-07 Oncomed Pharmaceuticals, Inc. Composiciones y métodos para el diagnóstico y el tratamiento del cáncer
EP1998785A4 (en) * 2006-02-21 2009-06-17 Univ Michigan TREATMENT OF CANCER BY AN ANTAGONIST OF THE HEDGEHOG SIGNALING PATH
ES2413087T3 (es) 2006-06-13 2013-07-15 Oncomed Pharmaceuticals, Inc. Composiciones y métodos para el diagnóstico y tratamiento del cáncer
JP5618544B2 (ja) 2007-01-24 2014-11-05 オンコメッドファーマシューティカルズ インコーポレイテッド 癌の診断および処置のための組成物および方法
US8148147B2 (en) 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
WO2008100563A2 (en) * 2007-02-14 2008-08-21 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
US7998110B2 (en) * 2007-04-25 2011-08-16 Hong Kong Polytechnic University Medical device for delivering drug and/or performing physical therapy
WO2008140826A1 (en) * 2007-05-15 2008-11-20 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
ME02069B (me) 2008-07-08 2015-05-20 Oncomed Pharm Inc Vezujuci agensi notch1 receptora i postupci njihove primene
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
BRPI0919473A2 (pt) 2008-09-26 2017-08-29 Oncomed Pharm Inc Agentes de ligação frizzled e usos dos mesmos
US8945569B2 (en) 2009-11-19 2015-02-03 Oncomed Pharmaceuticals, Inc. Jagged-binding agents and uses thereof
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt拮抗劑及治療和篩選方法
MX2012008085A (es) 2010-01-13 2012-09-12 Oncomed Pharm Inc Agentes de union notch1 y metodos de uso de los mismos.
EP2552953B1 (en) 2010-04-01 2017-05-17 OncoMed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
AU2011336707A1 (en) * 2010-11-29 2013-07-04 Dako Denmark A/S Methods and systems for analyzing images of specimens processed by a programmable quantitative assay
EP2863948B1 (en) 2012-06-22 2018-10-24 Cytomx Therapeutics Inc. Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof
AU2013334790A1 (en) 2012-10-23 2015-04-30 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using Wnt pathway-binding agents
CN105073195A (zh) 2013-02-04 2015-11-18 昂科梅德制药有限公司 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
CN104761622A (zh) * 2015-03-31 2015-07-08 苏州普罗达生物科技有限公司 关于Jaggedl激动剂多肽及其应用
CN104693278A (zh) * 2015-03-31 2015-06-10 苏州普罗达生物科技有限公司 一种Jaggedl激动剂多肽及其应用
CN104672313A (zh) * 2015-03-31 2015-06-03 苏州普罗达生物科技有限公司 Jaggedl激动剂多肽及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663278A (en) 1982-04-30 1987-05-05 Syva Company Agglutination dependent enzyme channeling immunoassay
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
WO1997045143A1 (en) * 1996-05-31 1997-12-04 The National American Red Cross Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids

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