JP2000512134A5 - - Google Patents

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Publication number
JP2000512134A5
JP2000512134A5 JP1997543023A JP54302397A JP2000512134A5 JP 2000512134 A5 JP2000512134 A5 JP 2000512134A5 JP 1997543023 A JP1997543023 A JP 1997543023A JP 54302397 A JP54302397 A JP 54302397A JP 2000512134 A5 JP2000512134 A5 JP 2000512134A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1997543023A
Other languages
English (en)
Japanese (ja)
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JP2000512134A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/009407 external-priority patent/WO1997045143A1/en
Publication of JP2000512134A publication Critical patent/JP2000512134A/ja
Publication of JP2000512134A5 publication Critical patent/JP2000512134A5/ja
Pending legal-status Critical Current

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JP09543023A 1996-05-31 1997-05-30 Ｊａｇｇｅｄ／Ｎｏｔｃｈタンパク質および核酸に基づく治療および診断の方法および組成物 Pending JP2000512134A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1884196P 1996-05-31 1996-05-31
US60/018,841 1996-05-31
PCT/US1997/009407 WO1997045143A1 (en) 1996-05-31 1997-05-30 Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids

Publications (2)

Publication Number Publication Date
JP2000512134A JP2000512134A (ja) 2000-09-19
JP2000512134A5 true JP2000512134A5 (Direct) 2005-01-13

Family

ID=21790044

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09543023A Pending JP2000512134A (ja) 1996-05-31 1997-05-30 Ｊａｇｇｅｄ／Ｎｏｔｃｈタンパク質および核酸に基づく治療および診断の方法および組成物

Country Status (6)

Country Link
US (2) US6433138B1 (Direct)
EP (1) EP0921818A4 (Direct)
JP (1) JP2000512134A (Direct)
AU (1) AU720890B2 (Direct)
CA (1) CA2256481A1 (Direct)
WO (1) WO1997045143A1 (Direct)

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* Cited by examiner, † Cited by third party
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US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US6262025B1 (en) 1995-06-28 2001-07-17 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
CA2256481A1 (en) * 1996-05-31 1997-12-04 The National American Red Cross Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
US6136952A (en) * 1997-06-25 2000-10-24 University Of Washington Human jagged polypeptide, encoding nucleic acids and methods of use
WO2000025809A1 (en) * 1998-10-30 2000-05-11 Smith & Nephew Plc Compositions comprising notch receptor manipulating agents
US20030196885A1 (en) * 1999-05-17 2003-10-23 Marchitto Kevin S. Electromagnetic energy driven separation methods
FR2798674B1 (fr) * 1999-09-21 2004-01-30 Mahmood Salman Al Procede d'identification de nouveaux genes impliques dans la regulation de l'angiogenese, etude de ces genes et leur utilisation a des fins therapeutiques
JP2004514404A (ja) * 2000-03-22 2004-05-20 キュラゲン　コーポレイション 血管形成関連タンパク質及びこれをコードする核酸
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
AU2001288628A1 (en) * 2000-08-31 2002-03-13 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
WO2003012441A1 (en) * 2001-07-25 2003-02-13 Lorantis Limited Method for detecting modulators of notch signalling
GB0118223D0 (en) * 2001-07-26 2001-09-19 Univ Sheffield Stem loop RNA
US20060084599A1 (en) * 2003-03-05 2006-04-20 Maine Medical Center Compositions, methods and kits relating to notch signaling
WO2004078944A2 (en) 2003-03-05 2004-09-16 Maine Medical Center Research Institute Thrombin, soluble jaggedi, and trap and growth of stem cells
EP1654383A1 (en) * 2003-08-08 2006-05-10 Licentia, Ltd. Materials and methods for colorectal cancer screening, diagnosis, and therapy
US20050232927A1 (en) * 2004-02-03 2005-10-20 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
US7794742B2 (en) * 2005-02-08 2010-09-14 University Of Washington Devices for promoting epithelial cell differentiation and keratinization
WO2006125001A2 (en) * 2005-05-17 2006-11-23 Maine Medical Center Research Institute Compositions and methods related to the intracellular effects of intracellular domains of delta1 and jagged1
WO2007053648A2 (en) 2005-10-31 2007-05-10 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP2511298B1 (en) 2005-10-31 2019-01-16 Oncomed Pharmaceuticals, Inc. Compositions and Methods for Treating Cancer based on human FZD receptors
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP1998785A4 (en) * 2006-02-21 2009-06-17 Univ Michigan TREATMENT OF CANCER BY AN ANTAGONIST OF THE HEDGEHOG SIGNALING PATH
PL2032166T3 (pl) 2006-06-13 2013-09-30 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworów
EP2106439B1 (en) 2007-01-24 2014-11-12 The Regents of the University of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
AU2008209482B2 (en) 2007-01-24 2014-05-01 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
US20090208491A1 (en) * 2007-02-14 2009-08-20 Austin Gurney Compositions and Methods for Diagnosing and Treating Cancer
US7998110B2 (en) * 2007-04-25 2011-08-16 Hong Kong Polytechnic University Medical device for delivering drug and/or performing physical therapy
US8802103B2 (en) * 2007-05-15 2014-08-12 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
JP5560270B2 (ja) 2008-07-08 2014-07-23 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｎｏｔｃｈ結合剤およびアンタゴニストならびにその使用方法
BRPI0919473A2 (pt) 2008-09-26 2017-08-29 Oncomed Pharm Inc Agentes de ligação frizzled e usos dos mesmos
US8945569B2 (en) 2009-11-19 2015-02-03 Oncomed Pharmaceuticals, Inc. Jagged-binding agents and uses thereof
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
EP2523682B1 (en) 2010-01-13 2015-12-16 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
NZ602700A (en) 2010-04-01 2014-10-31 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
EP2646795B1 (en) * 2010-11-29 2019-02-20 Dako Denmark A/S Methods for analyzing images of specimens processed by a programmable quantitative assay
JP2015521625A (ja) 2012-06-22 2015-07-30 シトムクス セラピューティクス，インコーポレイティド 抗−Ｊａｇｇｅｄ１／Ｊａｇｇｅｄ２交差反応性抗体、活性化可能抗−Ｊａｇｇｅｄ抗体及びそれらの使用方法
JP2015536933A (ja) 2012-10-23 2015-12-24 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法
AU2014212081A1 (en) 2013-02-04 2015-08-13 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a Wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
CN104761622A (zh) * 2015-03-31 2015-07-08 苏州普罗达生物科技有限公司 关于Jaggedl激动剂多肽及其应用
CN104672313A (zh) * 2015-03-31 2015-06-03 苏州普罗达生物科技有限公司 Jaggedl激动剂多肽及其应用
CN104693278A (zh) * 2015-03-31 2015-06-10 苏州普罗达生物科技有限公司 一种Jaggedl激动剂多肽及其应用

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US4663278A (en) 1982-04-30 1987-05-05 Syva Company Agglutination dependent enzyme channeling immunoassay
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
CA2256481A1 (en) * 1996-05-31 1997-12-04 The National American Red Cross Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids

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