JP2000506168A5 - - Google Patents

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Publication number
JP2000506168A5
JP2000506168A5 JP1997531987A JP53198797A JP2000506168A5 JP 2000506168 A5 JP2000506168 A5 JP 2000506168A5 JP 1997531987 A JP1997531987 A JP 1997531987A JP 53198797 A JP53198797 A JP 53198797A JP 2000506168 A5 JP2000506168 A5 JP 2000506168A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1997531987A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000506168A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/003641 external-priority patent/WO1997032850A1/en
Publication of JP2000506168A publication Critical patent/JP2000506168A/ja
Publication of JP2000506168A5 publication Critical patent/JP2000506168A5/ja
Ceased legal-status Critical Current

Links

JP9531987A 1996-03-08 1997-03-07 Cc―1065及びデュオカマイシンのmcbi類似体 Ceased JP2000506168A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1302496P 1996-03-08 1996-03-08
US60/013,024 1996-03-08
PCT/US1997/003641 WO1997032850A1 (en) 1996-03-08 1997-03-07 Mcbi analogs of cc-1065 and the duocarmycins

Publications (2)

Publication Number Publication Date
JP2000506168A JP2000506168A (ja) 2000-05-23
JP2000506168A5 true JP2000506168A5 (show.php) 2004-12-02

Family

ID=21757922

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9531987A Ceased JP2000506168A (ja) 1996-03-08 1997-03-07 Cc―1065及びデュオカマイシンのmcbi類似体

Country Status (9)

Country Link
US (1) US5985908A (show.php)
EP (1) EP0888301B1 (show.php)
JP (1) JP2000506168A (show.php)
AT (1) ATE301639T1 (show.php)
AU (1) AU711974B2 (show.php)
CA (1) CA2246783C (show.php)
DE (1) DE69733942T2 (show.php)
ES (1) ES2244991T3 (show.php)
WO (1) WO1997032850A1 (show.php)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3217897A (en) * 1996-05-31 1998-01-05 Scripps Research Institute, The Analogs of cc-1065 and the duocarmycins
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
ATE310725T1 (de) * 1996-09-12 2005-12-15 Auckland Uniservices Ltd Kondensierte n-acylindole als antitumormittel
WO1998025900A1 (en) * 1996-12-13 1998-06-18 Shionogi & Co., Ltd. Compounds having antitumor activity
JP3649617B2 (ja) 1999-03-26 2005-05-18 独立行政法人科学技術振興機構 2本鎖dnaを切断できる化合物及びその使用方法
DE60115265T2 (de) * 2000-09-19 2006-08-10 Lee, Moses, Holland Zusammensetzungen und verfahren zur verwendung achiraler analoge von cc-1065 und den duocarmycinen
JP2004529887A (ja) * 2001-02-22 2004-09-30 スクール オブ ファーマシー, ユニヴァーシティ オブ ロンドン 腫瘍治療のためのプロドラッグとしてのピロロ−インドールおよびピロロ−キノリン誘導体
DE60211905T2 (de) * 2001-02-22 2007-01-18 School Of Pharmacy, University Of London Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung
NZ529788A (en) * 2001-05-31 2003-12-19 Medarex Inc Cytotoxins, prodrugs, linkers and stabilizers useful therefor
JP2006505571A (ja) * 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びhcv阻害剤としてのその使用
EP1731519A4 (en) * 2004-03-13 2008-10-15 Tmrc Co Ltd A NEW INDOLE DERIVATIVE FOR ALKYLATING SPECIFIC DNA BASE SEQUENCES AND ALKYLATIVES AND MEDICAMENTS THEREOF CONTAINING THEM EACH
US7691962B2 (en) * 2004-05-19 2010-04-06 Medarex, Inc. Chemical linkers and conjugates thereof
EP1747021B1 (en) * 2004-05-19 2015-09-09 E. R. Squibb & Sons, L.L.C. Self-immolative linkers and drug conjugates
US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
EA015324B1 (ru) * 2005-10-26 2011-06-30 Медарекс, Инк. Способы и соединения для получения аналогов сс-1065
WO2007059404A2 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
TW200900059A (en) 2007-02-21 2009-01-01 Medarex Inc Chemical linkers with single amino acids and conjugates thereof
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
RU2562232C2 (ru) 2008-11-03 2015-09-10 Синтарга Б.В. Новые аналоги сс-1065 и их конъюгаты
HUE030846T2 (en) 2010-04-21 2017-06-28 Syntarga Bv Conjugates of cc-1065 analogs and bifunctional linkers
EP2762472B1 (en) 2011-09-28 2017-05-24 Industry-Academia Cooperation Group of Sejong University Selenophene-fused aromatic compound and manufacturing method thereof
WO2014080251A1 (en) 2012-11-24 2014-05-30 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
MY169117A (en) 2012-12-21 2019-02-18 Bioalliance Cv Hydrophilic self-immolative linkers and conjugates thereof
PL3092010T3 (pl) 2014-01-10 2019-01-31 Synthon Biopharmaceuticals B.V. Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek
AU2014384434B2 (en) 2014-02-28 2016-11-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
AU2015276821A1 (en) 2014-06-20 2017-01-12 Abgenomics International Inc. Anti-folate receptor aplha (FRA) antibody-drug conjugates and methods of using thereof
JP6759326B2 (ja) 2015-07-12 2020-09-23 ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. 細胞結合分子の共役のための架橋連結体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
MX395252B (es) 2016-01-08 2025-03-25 Altrubio Inc Anticuerpos tetravalentes anti ligando-1 de glicoproteina p-selectina (psgl-1) y usos de estos.
CN110099682B (zh) 2016-11-14 2023-03-31 杭州多禧生物科技有限公司 偶联连接体,含有此连接体的细胞结合分子-药物偶联物及其制备和应用
JP7726628B2 (ja) 2020-01-30 2025-08-20 エイムドバイオ株式会社 ベンゾセレノフェン系化合物、これを含む薬学的組成物及び抗体-薬物複合体
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

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