JP2000505080A5 - - Google Patents
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- Publication number
- JP2000505080A5 JP2000505080A5 JP1997526511A JP52651197A JP2000505080A5 JP 2000505080 A5 JP2000505080 A5 JP 2000505080A5 JP 1997526511 A JP1997526511 A JP 1997526511A JP 52651197 A JP52651197 A JP 52651197A JP 2000505080 A5 JP2000505080 A5 JP 2000505080A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59228296A | 1996-01-26 | 1996-01-26 | |
| US592,282 | 1996-01-26 | ||
| PCT/EP1997/000238 WO1997027197A1 (en) | 1996-01-26 | 1997-01-20 | Process for preparing ganciclovir derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000505080A JP2000505080A (ja) | 2000-04-25 |
| JP2000505080A5 true JP2000505080A5 (enExample) | 2004-11-11 |
| JP4094666B2 JP4094666B2 (ja) | 2008-06-04 |
Family
ID=24370063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52651197A Expired - Lifetime JP4094666B2 (ja) | 1996-01-26 | 1997-01-20 | ガンシクロビル誘導体の製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5840890A (enExample) |
| EP (1) | EP0885224B1 (enExample) |
| JP (1) | JP4094666B2 (enExample) |
| AU (1) | AU1593197A (enExample) |
| DE (1) | DE69717974T2 (enExample) |
| ES (1) | ES2187752T3 (enExample) |
| WO (1) | WO1997027197A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040446A (en) * | 1996-01-26 | 2000-03-21 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative |
| US6703394B2 (en) | 1996-02-16 | 2004-03-09 | Medivir Ab | Acyclic nucleoside derivatives |
| US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
| KR20000053226A (ko) * | 1996-11-12 | 2000-08-25 | 요나스 프릭 | 뉴클레오사이드 |
| CA2457835A1 (en) * | 2001-09-07 | 2003-03-20 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of valacyclovir hydrochloride |
| US20050043329A1 (en) * | 2002-09-06 | 2005-02-24 | Shlomit Wizel | Crystalline forms of valacyclovir hydrochloride |
| US20050059684A1 (en) * | 2002-10-16 | 2005-03-17 | Ben-Zion Dolitzky | Method for reducing residual alcohols in crystalline valacyclovir hydrochloride |
| US20070129385A1 (en) * | 2003-08-28 | 2007-06-07 | Sharma Mukesh K | Amorphous valganciclovir hydrochloride |
| JP2007513074A (ja) * | 2004-09-04 | 2007-05-24 | テバ ファーマシューティカル インダストリーズ リミティド | 単離されたバラシクロビル不純物、バラシクロビル不純物の調製方法および参照標準としての使用 |
| DK1853675T3 (da) * | 2005-01-25 | 2011-08-22 | Sigma Coatings Bv | Binderpræparat |
| ZA200702234B (en) * | 2006-03-21 | 2008-07-30 | Cipla Ltd | Preparation of ester of purine derivatives |
| EP1870411B1 (en) * | 2006-06-21 | 2016-03-16 | Fidia Farmaceutici S.p.A. | Process for the preparation and purification of valgancyclovir |
| CA2671470C (en) | 2006-12-13 | 2012-05-01 | F. Hoffmann-La Roche Ag | Powder formulation for valganciclovir |
| US20090076040A1 (en) * | 2007-09-15 | 2009-03-19 | Protia, Llc | Deuterium-enriched valganciclovir |
| WO2010036904A2 (en) * | 2008-09-26 | 2010-04-01 | Dr. Reddy's Laboratories Ltd. | Preparation of valganciclovir and its salts |
| IT1397233B1 (it) * | 2010-01-08 | 2013-01-04 | Fidia Farmaceutici | Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir. |
| CN101955481B (zh) * | 2010-10-09 | 2016-04-20 | 广东肇庆星湖生物科技股份有限公司 | 一种盐酸缬更昔洛韦的制备方法 |
| EP2714691B1 (en) * | 2011-05-31 | 2016-09-07 | Pharmathen S.A. | Process for the preparation of 2-amino-9-((2-phenyl-1,3-dioxan-5-yloxy)methyl)-1h-purin-6(9h)-one compound useful in the preparation of valganciclovir |
| CN105732630B (zh) * | 2016-04-20 | 2018-11-30 | 安徽海康药业有限责任公司 | 一种cbz-缬更昔洛韦的制备方法 |
| CN105693722B (zh) * | 2016-04-20 | 2018-07-20 | 安徽海康药业有限责任公司 | 一种cbz-缬更昔洛韦的制备方法 |
| CN105693724B (zh) * | 2016-04-20 | 2017-08-11 | 安徽海康药业有限责任公司 | 一种cbz‑缬更昔洛韦的制备方法 |
| CN112409359A (zh) * | 2020-11-30 | 2021-02-26 | 沃德药业(安徽)股份有限公司 | 一种盐酸缬更昔洛韦制备方法 |
| CN113880838B (zh) * | 2021-11-15 | 2024-03-19 | 仁合益康集团有限公司 | 一种微通道反应器合成盐酸缬更昔洛韦的方法 |
| CN115286632B (zh) * | 2022-09-16 | 2023-05-09 | 河北医科大学 | 一种盐酸缬更昔洛韦的制备工艺 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
| US4355032B2 (en) * | 1981-05-21 | 1990-10-30 | 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent | |
| PT75406B (en) * | 1981-08-11 | 1985-11-15 | Wellcome Found | Antiviral compounds |
| NZ201662A (en) * | 1981-08-26 | 1986-07-11 | Merck & Co Inc | 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation |
| US4816447A (en) * | 1981-08-26 | 1989-03-28 | Merck & Co., Inc. | Anti-viral guanine compounds |
| US5250535A (en) * | 1982-02-01 | 1993-10-05 | Syntex Inc. | Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent |
| NL8202626A (nl) * | 1982-06-29 | 1984-01-16 | Stichting Rega V Z W | Derivaten van 9-(2-hydroxyethoxymethyl)guanine. |
| DE3376326D1 (en) * | 1982-10-14 | 1988-05-26 | Wellcome Found | Antiviral purine derivatives |
| AP55A (en) * | 1987-08-15 | 1989-09-26 | The Wellcome Foundation Ltd | Therapeutic Acyclic Nucleosides |
| ATE123285T1 (de) * | 1988-12-19 | 1995-06-15 | Wellcome Found | Antivirale pyrimidin- und purinverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate. |
| GB8829571D0 (en) | 1988-12-19 | 1989-02-08 | Wellcome Found | Antiviral compounds |
| US5831075A (en) * | 1993-06-10 | 1998-11-03 | Rolabo Sl | Amino acid ester of nucleoside analogues |
| PE32296A1 (es) * | 1994-07-28 | 1996-08-07 | Hoffmann La Roche | Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables |
| US5543414A (en) * | 1994-07-28 | 1996-08-06 | Syntex (Usa) Inc. | Achiral amino acid acyl esters of ganciclovir and its derivatives |
-
1997
- 1997-01-09 US US08/775,424 patent/US5840890A/en not_active Expired - Lifetime
- 1997-01-20 WO PCT/EP1997/000238 patent/WO1997027197A1/en not_active Ceased
- 1997-01-20 JP JP52651197A patent/JP4094666B2/ja not_active Expired - Lifetime
- 1997-01-20 EP EP97902187A patent/EP0885224B1/en not_active Expired - Lifetime
- 1997-01-20 AU AU15931/97A patent/AU1593197A/en not_active Abandoned
- 1997-01-20 DE DE69717974T patent/DE69717974T2/de not_active Expired - Lifetime
- 1997-01-20 ES ES97902187T patent/ES2187752T3/es not_active Expired - Lifetime
-
1998
- 1998-07-23 US US09/121,446 patent/US6103901A/en not_active Expired - Lifetime