|
US5801195A
(en)
*
|
1994-12-30 |
1998-09-01 |
Celgene Corporation |
Immunotherapeutic aryl amides
|
|
DE69624081T2
(de)
*
|
1995-12-20 |
2003-06-12 |
Agouron Pharmaceuticals, Inc. |
Matrix-metalloprotease Inhibitoren
|
|
US6747027B1
(en)
|
1996-07-22 |
2004-06-08 |
Pharmacia Corporation |
Thiol sulfonamide metalloprotease inhibitors
|
|
US6566384B1
(en)
|
1996-08-07 |
2003-05-20 |
Darwin Discovery Ltd. |
Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
|
|
ATE266000T1
(de)
*
|
1996-08-07 |
2004-05-15 |
Darwin Discovery Ltd |
Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung
|
|
PL332509A1
(en)
*
|
1996-09-27 |
1999-09-13 |
Upjohn Co |
Beta-sulphonyl-hydroxamic acids as inhibitors of intercellular substance metaloproteinases
|
|
US5977408A
(en)
*
|
1996-10-16 |
1999-11-02 |
American Cyanamid Company |
Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
US5929097A
(en)
*
|
1996-10-16 |
1999-07-27 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
US5962481A
(en)
|
1996-10-16 |
1999-10-05 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
US6228869B1
(en)
|
1996-10-16 |
2001-05-08 |
American Cyanamid Company |
Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
US6548524B2
(en)
|
1996-10-16 |
2003-04-15 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
HUP0000313A3
(en)
*
|
1996-12-19 |
2002-06-28 |
Aventis Pharmaceuticals Inc Co |
Process for the solid phase synthesis of aldehydes ,ketones, oximes, amines and hidroxamic acid compounds
|
|
AU768182B2
(en)
*
|
1996-12-19 |
2003-12-04 |
Aventis Pharmaceuticals Inc. |
Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha,beta-unsaturated carboxylic acid and aldehyde compounds
|
|
US6133409A
(en)
*
|
1996-12-19 |
2000-10-17 |
Aventis Pharmaceuticals Products Inc. |
Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
|
|
US6392010B1
(en)
|
1996-12-19 |
2002-05-21 |
Aventis Pharmaceuticals Inc. |
Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
|
|
EP1486486A3
(en)
*
|
1997-01-22 |
2009-06-10 |
Aventis Pharmaceuticals Inc. |
Substituted B-thiocarboxylic acids
|
|
AU5493598A
(en)
*
|
1997-02-07 |
1998-08-26 |
Pfizer Inc. |
N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
|
|
JP2001519777A
(ja)
*
|
1997-02-27 |
2001-10-23 |
アメリカン・サイアナミド・カンパニー |
マトリクス金属プロテイナーゼ阻害薬としてのn−ヒドロキシ−2−(アルキル、アリールまたはヘテロアリールスルファニル、スルフィニルまたはスルホニル)−3−置換アルキル、アリールまたはヘテロアリールアミド
|
|
US6362183B1
(en)
|
1997-03-04 |
2002-03-26 |
G. D. Searle & Company |
Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
|
|
US7115632B1
(en)
|
1999-05-12 |
2006-10-03 |
G. D. Searle & Co. |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
|
|
US6696449B2
(en)
|
1997-03-04 |
2004-02-24 |
Pharmacia Corporation |
Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
|
|
WO1998039315A1
(en)
|
1997-03-04 |
1998-09-11 |
Monsanto Company |
Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
|
|
US6794511B2
(en)
|
1997-03-04 |
2004-09-21 |
G. D. Searle |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
|
|
JP2002515900A
(ja)
*
|
1997-03-04 |
2002-05-28 |
モンサント カンパニー |
芳香族スルホニルアルファ−ヒドロキシヒドロキサム酸化合物
|
|
WO1998039316A1
(en)
|
1997-03-04 |
1998-09-11 |
Monsanto Company |
N-hydroxy 4-sulfonyl butanamide compounds
|
|
AUPO721997A0
(en)
*
|
1997-06-06 |
1997-07-03 |
Queensland Institute Of Medical Research, The |
Anticancer compounds
|
|
US6300514B1
(en)
|
1997-06-25 |
2001-10-09 |
Ono Pharmaceutical Co., Ltd. |
Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient
|
|
EA200000427A1
(ru)
*
|
1997-10-17 |
2001-02-26 |
Авентис Фармасьютикалз Продактс Инк. |
Терапевтические применения хинолиновых производных
|
|
CA2306460A1
(en)
|
1997-11-14 |
1999-05-27 |
G.D. Searle & Co. |
Aromatic sulfone hydroxamic acid metalloprotease inhibitor
|
|
US6750228B1
(en)
|
1997-11-14 |
2004-06-15 |
Pharmacia Corporation |
Aromatic sulfone hydroxamic acid metalloprotease inhibitor
|
|
US20010039287A1
(en)
*
|
1997-11-14 |
2001-11-08 |
Thomas E Barta |
Aromatic sulfone hydroxamic acid metalloprotease inhibitor
|
|
JP2001524462A
(ja)
|
1997-11-21 |
2001-12-04 |
ファーマシア・アンド・アップジョン・カンパニー |
マトリックスメタロプロテイナーゼインヒビターとしてのβ−スルホニルヒドロキサム酸のα−ヒドロキシ、−アミノ及びハロ誘導体
|
|
US6288063B1
(en)
*
|
1998-05-27 |
2001-09-11 |
Bayer Corporation |
Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
|
|
EP0965592A1
(en)
|
1998-06-18 |
1999-12-22 |
F. Hoffmann-La Roche Ag |
Process for preparing 3-arylsulfur hydroxamic acids
|
|
FR2780402B1
(fr)
|
1998-06-30 |
2001-04-27 |
Adir |
Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US6172064B1
(en)
*
|
1998-08-26 |
2001-01-09 |
Glaxo Wellcome Inc. |
Formamides as therapeutic agents
|
|
US6020358A
(en)
*
|
1998-10-30 |
2000-02-01 |
Celgene Corporation |
Substituted phenethylsulfones and method of reducing TNFα levels
|
|
WO2000044723A1
(en)
*
|
1999-01-27 |
2000-08-03 |
American Cyanamid Company |
Alkynyl containing hydroxamic acid derivatives, their preparation and their use as matrix metalloproteinase (mmp) inhibitors/tnf-alpha converting enzyme (tace) inhibitors
|
|
CN1216056C
(zh)
|
1999-02-08 |
2005-08-24 |
G.D.瑟尔有限公司 |
氨基磺酸基异羟肟酸金属蛋白酶抑制剂
|
|
US6800646B1
(en)
|
1999-02-08 |
2004-10-05 |
Pharmacia Corporation |
Sulfamato hydroxamic acid metalloprotease inhibitor
|
|
US6583299B1
(en)
|
1999-05-20 |
2003-06-24 |
G.D. Searle & Co. |
α-amino-β-sulfonyl hydroxamic acid compounds
|
|
US6869951B1
(en)
|
1999-07-16 |
2005-03-22 |
Pharmacia Corporation |
Method of changing conformation of a matrix metalloproteinase
|
|
AU777012B2
(en)
|
1999-08-21 |
2004-09-30 |
Takeda Gmbh |
Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
|
|
GB9922825D0
(en)
*
|
1999-09-25 |
1999-11-24 |
Smithkline Beecham Biolog |
Medical use
|
|
US6667316B1
(en)
*
|
1999-11-12 |
2003-12-23 |
Celgene Corporation |
Pharmaceutically active isoindoline derivatives
|
|
GB9929979D0
(en)
|
1999-12-17 |
2000-02-09 |
Darwin Discovery Ltd |
Hydroxamic acid derivatives
|
|
US6326388B1
(en)
|
1999-12-21 |
2001-12-04 |
Celgene Corporation |
Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
|
|
US6699899B1
(en)
|
1999-12-21 |
2004-03-02 |
Celgene Corporation |
Substituted acylhydroxamic acids and method of reducing TNFα levels
|
|
US6683093B2
(en)
|
2000-05-12 |
2004-01-27 |
Pharmacia Corporation |
Aromatic sulfone hydroxamic acids and their use as protease inhibitors
|
|
EP1292576A1
(en)
|
2000-05-15 |
2003-03-19 |
Darwin Discovery Limited |
Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
|
|
US6469020B2
(en)
|
2000-05-15 |
2002-10-22 |
Darwin Discovery, Ltd. |
Hydroxamic and carboxylic acid derivatives
|
|
FR2809623B1
(fr)
*
|
2000-06-05 |
2003-09-05 |
Sanjuan Benito Arranz |
Dans le traitement des maladies neurodegeneratives : (notamment alzheimer et parkinson), utilisation pour un medicament : du sildenafil (ou de ses derives)
|
|
US8030343B2
(en)
|
2000-06-08 |
2011-10-04 |
Celgene Corporation |
Pharmaceutically active isoindoline derivatives
|
|
US7314953B2
(en)
*
|
2001-03-27 |
2008-01-01 |
Errant Gene Therapeutics, Llc |
Treatment of lung cells with histone deacetylase inhibitors
|
|
US7312247B2
(en)
*
|
2001-03-27 |
2007-12-25 |
Errant Gene Therapeutics, Llc |
Histone deacetylase inhibitors
|
|
US7842727B2
(en)
*
|
2001-03-27 |
2010-11-30 |
Errant Gene Therapeutics, Llc |
Histone deacetylase inhibitors
|
|
US6495719B2
(en)
*
|
2001-03-27 |
2002-12-17 |
Circagen Pharmaceutical |
Histone deacetylase inhibitors
|
|
US8026280B2
(en)
|
2001-03-27 |
2011-09-27 |
Errant Gene Therapeutics, Llc |
Histone deacetylase inhibitors
|
|
WO2002092588A2
(en)
|
2001-05-11 |
2002-11-21 |
Pharmacia Corporation |
Aromatic sulfone hydroxamates and their use as protease inhibitors
|
|
US6683078B2
(en)
|
2001-07-19 |
2004-01-27 |
Pharmacia Corporation |
Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
|
|
PE20030701A1
(es)
|
2001-12-20 |
2003-08-21 |
Schering Corp |
Compuestos para el tratamiento de trastornos inflamatorios
|
|
TW200406197A
(en)
*
|
2002-04-25 |
2004-05-01 |
Ono Pharmaceutical Co |
Therapelitic agent for inflammatory bowel disease containing hydroxamic acid as effective component
|
|
WO2003091247A2
(en)
|
2002-04-25 |
2003-11-06 |
Pharmacia Corporation |
Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
|
|
AU2003243272A1
(en)
*
|
2002-05-22 |
2003-12-12 |
Errant Gene Therapeutics, Llc |
Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
|
|
US20040167182A1
(en)
*
|
2002-06-25 |
2004-08-26 |
Becker Daniel P. |
Hydroxamic acid and amide compounds and their use as protease inhibitors
|
|
WO2004060346A2
(en)
|
2002-12-30 |
2004-07-22 |
Angiotech International Ag |
Drug delivery from rapid gelling polymer composition
|
|
US7135493B2
(en)
|
2003-01-13 |
2006-11-14 |
Astellas Pharma Inc. |
HDAC inhibitor
|
|
WO2004087211A2
(en)
|
2003-04-01 |
2004-10-14 |
Applied Research Systems Ars Holding N.V. |
Inhibitors of phosphodiesterases in infertility
|
|
ATE517926T1
(de)
|
2003-04-04 |
2011-08-15 |
Yeda Res & Dev |
Antikörper zur hemmung der aktivität von mmp-2 und mmp-9
|
|
US7244759B2
(en)
|
2004-07-28 |
2007-07-17 |
Celgene Corporation |
Isoindoline compounds and methods of making and using the same
|
|
EP1817020A4
(en)
*
|
2004-11-08 |
2012-11-21 |
Errant Gene Therapeutics Inc |
INHIBITORS OF HISTONATE ACETYLASE
|
|
EP1981877B1
(en)
|
2006-02-07 |
2012-04-18 |
Astellas Pharma Inc. |
N-hydroxyacrylamide compounds
|
|
US7807720B2
(en)
|
2007-02-01 |
2010-10-05 |
Panthera Biopharma, Llc |
Hydroxamic acid derivatives of 3-phenyl propionic acids useful as therapeutic agents for treating anthrax poisoning
|
|
WO2009008905A1
(en)
*
|
2007-02-01 |
2009-01-15 |
Panthera Biopharma, Llc. |
Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning
|
|
WO2008102359A1
(en)
|
2007-02-23 |
2008-08-28 |
Yeda Research And Development Co. Ltd. |
Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins
|
|
WO2016128131A1
(en)
*
|
2015-02-09 |
2016-08-18 |
National And Kapodistrian University Of Athens |
Beta-lactone inhibitors of phospholipase a2 and uses thereof
|
|
EP3860608A1
(en)
|
2018-10-04 |
2021-08-11 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Egfr inhibitors for treating keratodermas
|