|
WO1998041229A1
(en)
*
|
1997-03-19 |
1998-09-24 |
F. Hoffmann-La Roche Ag |
USE OF IL-12p40 AS IMMUNOSTIMULANT
|
|
ES2590912T3
(es)
|
1997-12-08 |
2016-11-24 |
Merck Patent Gmbh |
Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario
|
|
US20030105294A1
(en)
*
|
1998-02-25 |
2003-06-05 |
Stephen Gillies |
Enhancing the circulating half life of antibody-based fusion proteins
|
|
HK1038882A1
(zh)
*
|
1998-04-15 |
2002-04-04 |
利思进药品公司 |
通过共同给予血管生成抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答
|
|
WO2000015249A1
(en)
*
|
1998-09-15 |
2000-03-23 |
Genetics Institute, Inc. |
Treatment of kaposi's sarcoma with il-12
|
|
US7067110B1
(en)
|
1999-07-21 |
2006-06-27 |
Emd Lexigen Research Center Corp. |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
SK782002A3
(en)
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
SK1842002A3
(en)
*
|
1999-08-09 |
2003-09-11 |
Lexigen Pharm Corp |
A fusion protein, a multi-function protein complex, a multi-function fusion protein, a nucleic acid, a cell, their use, method for preparing a fusion protein and method of targeting cytokines
|
|
US20030190305A1
(en)
*
|
1999-09-15 |
2003-10-09 |
Wyeth And National Institutes Of Health |
Treatment of Kaposi's sarcoma with IL-12
|
|
CA2387326A1
(en)
|
1999-10-11 |
2001-04-19 |
Needleless Ventures, Inc. |
Universal anti-infectious protector for needleless injectors
|
|
US7074210B2
(en)
*
|
1999-10-11 |
2006-07-11 |
Felton International, Inc. |
Universal protector cap with auto-disable features for needle-free injectors
|
|
CN1182874C
(zh)
*
|
1999-10-29 |
2005-01-05 |
安增子摩祺株式会社 |
糖尿病性局部缺血疾病的基因治疗制剂
|
|
CA2391080A1
(en)
|
1999-11-12 |
2001-05-25 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Erythropoietin forms with improved properties
|
|
US7887506B1
(en)
|
1999-11-23 |
2011-02-15 |
Pulse Needlefree Systems, Inc. |
Safety mechanism to prevent accidental patient injection and methods of same
|
|
US6770054B1
(en)
|
1999-11-23 |
2004-08-03 |
Felton International, Inc. |
Injector assembly with driving means and locking means
|
|
US7115712B1
(en)
|
1999-12-02 |
2006-10-03 |
Maxygen, Inc. |
Cytokine polypeptides
|
|
EP1252192B1
(en)
|
2000-02-11 |
2006-08-16 |
MERCK PATENT GmbH |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
US20040213798A1
(en)
*
|
2000-06-08 |
2004-10-28 |
Powderject Vaccines, Inc. |
Spray-dried alum compositions
|
|
US20020120228A1
(en)
*
|
2000-06-08 |
2002-08-29 |
Yuh-Fun Maa |
Powder compositions
|
|
PT1294401E
(pt)
*
|
2000-06-29 |
2007-11-09 |
Merck Patent Gmbh |
Aumento das respostas imunológicas mediadas por proteínas de fusão anticorpo-citoquina por tratamento combinado com agentes que aumentam a captação de imunocitoquinas
|
|
US20020086036A1
(en)
|
2000-12-05 |
2002-07-04 |
Allergan Sales, Inc. |
Methods for treating hyperhidrosis
|
|
US7255865B2
(en)
*
|
2000-12-05 |
2007-08-14 |
Allergan, Inc. |
Methods of administering botulinum toxin
|
|
BR0207854A
(pt)
*
|
2001-03-07 |
2004-08-24 |
Merck Patent Gmbh |
Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido
|
|
US6992174B2
(en)
*
|
2001-03-30 |
2006-01-31 |
Emd Lexigen Research Center Corp. |
Reducing the immunogenicity of fusion proteins
|
|
AU2002308562B2
(en)
|
2001-05-03 |
2008-01-24 |
Merck Patent Gmbh |
Recombinant tumor specific antibody and use thereof
|
|
CA2349506C
(en)
*
|
2001-06-14 |
2009-12-08 |
Duke University |
A method for selective expression of therapeutic genes by hyperthermia
|
|
RU2312677C9
(ru)
*
|
2001-12-04 |
2008-03-27 |
Мерк Патент Гмбх |
Иммуноцитокины с модулированной селективностью
|
|
RU2366664C2
(ru)
*
|
2002-12-17 |
2009-09-10 |
Мерк Патент Гмбх |
Гуманизированное антитело (н14.18) на основании антитела 14.18 мыши, связывающееся с gd2, и его слияние с il-2
|
|
US8420087B2
(en)
*
|
2004-01-05 |
2013-04-16 |
Antisoma Research Limited |
Interleukin-12 targeted to oncofoetal fibronectin
|
|
JP5175214B2
(ja)
*
|
2005-12-30 |
2013-04-03 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
改良された安定性を有するインターロイキン−１２ｐ４０変種
|
|
US7833754B2
(en)
*
|
2006-01-13 |
2010-11-16 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
IL-12 for expression in mammalian cell
|
|
NZ585190A
(en)
*
|
2007-10-08 |
2012-11-30 |
Intrexon Corp |
Engineered dendritic cells and uses for the treatment of cancer
|
|
CA2739902A1
(en)
|
2008-10-08 |
2010-04-15 |
Intrexon Corporation |
Engineered cells expressing multiple immunomodulators and uses thereof
|
|
US8556882B2
(en)
|
2009-04-30 |
2013-10-15 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Inducible interleukin-12
|
|
WO2010147971A2
(en)
*
|
2009-06-15 |
2010-12-23 |
New York University |
Il23 modified viral vector for recombinant vaccines and tumor treatment
|
|
JP7246930B2
(ja)
|
2016-05-18 |
2023-03-28 |
モデルナティエックス インコーポレイテッド |
インターロイキン－１２（ｉｌ１２）をコードするポリヌクレオチドおよびその使用
|
|
US11421011B2
(en)
|
2017-05-18 |
2022-08-23 |
Modernatx, Inc. |
Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof
|