JP2000319158A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin preparation for external use, made of natural product, excellent in safety and having effects for skin such as inhibitory action of free histamine. SOLUTION: This skin preparation for external use is characterized by including extract of Picrorhiza kurrooa Royle of Scrophulariaceae family. The extract of Picrorhiza kurrooa Royle of this invention shows excellent inhibitory action of free histamine and all of the skin preparations for external use including the extract have safe and excellent anti-inflammatory effect.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin which can suppress the release of histamine and prevent skin inflammation by incorporating an extract of a specific plant.

[0002]

2. Description of the Related Art In recent years, skin inflammation due to ultraviolet rays or the like is one of the causes of skin roughness, and anti-inflammatory agents which reduce the inflammation and improve skin roughness have been desired. As one of the treatment methods, there is a method of suppressing release of histamine, which is a proinflammatory substance generated during inflammation.

[0003]

Most of the conventional histamine release inhibitors contain substances obtained by chemical synthesis such as steroids. As a histamine release inhibitor, a natural raw material having less side effects is desired, instead of a chemically synthesized product such as a steroid.

[0004] From the above, natural products with excellent safety,
A substance having an effect on the skin such as a histamine release inhibitory action is desired.

[Means for Solving the Problems]

[0005] Under such circumstances, the present inventors have conducted intensive studies, and as a result, have found that an extract of cedar has an excellent histamine release inhibitory action. Furthermore, they found that a skin external preparation containing the extract had a safe and excellent anti-inflammatory action, and completed the present invention.

[0006] That is, the present invention is an external preparation for skin characterized by containing an extract of cedar. The external preparation for skin of the present invention is preferably an anti-inflammatory agent, and more preferably a histamine release inhibitor among the anti-inflammatory agents.

The spinach used in the present invention (scientific name: Pi)
(Crorhiza kurrooa Royle) is a perennial plant belonging to the genus Oleaceae, distributed mainly from the Himalayas to China.

[0008] The extract of sorghum used in the present invention is extracted from a part of a plant such as sorghum leaves, stems, bark, flowers, fruits, roots or whole plants. Preferably,
The one obtained by extracting from the rhizome is good. The preparation method is not particularly limited, and may be, for example, one extracted by heating or one extracted at ordinary temperature.

Examples of the solvent to be extracted include water, lower alcohols (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.) and liquid polyhydric alcohol (1,3-butylene glycol). ,
Propylene glycol, glycerin, etc.), ketones (acetone, methyl ethyl ketone, etc.), acetonitrile, esters (ethyl acetate, butyl acetate, etc.), hydrocarbons (hexane, heptane, liquid paraffin, etc.), ethers (ethyl ether, tetrahydrofuran, Propyl ether). Preferably, water, lower alcohol and liquid polyhydric alcohol are good, particularly preferably,
Water, ethanol, 1,3-butylene glycol and propylene glycol are good. These solvents may be used alone or in combination of two or more.

[0010] The extract of cucumber may be used as it is, or may be used after concentration, dilution, filtration, etc., if necessary. Further, the extracted solution may be subjected to a treatment such as concentration and drying, spray drying, and freeze drying to be used as a dried product.

The above-mentioned extract may be used as it is in the external preparation for skin of the present invention, and oils and fats, which are components used in ordinary external preparation for skin, may be used as long as the effects of the extract of cedar are not impaired. Waxes, hydrocarbons, fatty acids, alcohols, esters, surfactants, metal soaps, pH adjusters, preservatives, fragrances, humectants, powders, ultraviolet absorbers, thickeners, pigments, antioxidants Ingredients such as an agent, a whitening agent, a chelating agent and the like can also be added.

The external preparation for skin of the present invention can be used in any of cosmetics, quasi-drugs and pharmaceuticals. Examples of the dosage form include lotions, creams, emulsions, gels,
Aerosol, ointment, poultice, essence, pack,
Those applied to the skin, such as detergents, bath agents, foundations, powders, and lipsticks, may be mentioned.

The amount of the extract of cedar used in the present invention is 0.00001% by weight or more, preferably 0.00005 to 10% by weight, in terms of solids, based on the total amount of the external preparation for skin of the present invention.
Is good. If it is less than 0.00001% by weight, a sufficient effect cannot be expected. If the content is more than 10% by weight, the effect is not enhanced and it is uneconomical. The method of addition may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

[0014]

EXAMPLES In order to explain the present invention in detail, examples of the production of the extract used in the present invention, prescription examples of the present invention and experimental examples will be given below, but the present invention is not limited to these examples. Absent. The term "parts by weight" shown in Examples means parts by weight.

Production Example 1 Hot Water Extract of Knapweed 400 mL of purified water was added to 20 g of a dried rhizome of Knapweed.
After extraction at 100100 ° C. for 2 hours, the mixture was filtered, and the filtrate was concentrated and freeze-dried to obtain 2.5 g of a hot water extract of spinach.

Preparation Example 2 Ethanol Extract of Kouen To 1 g of ethanol was added to 100 g of dried rhizome rhizome.
After extraction at normal temperature for 7 days, the mixture was filtered, and the filtrate was concentrated to dryness to obtain 4.0 g of an ethanol extract of spinach.

Production Example 3 Extract of aqueous solution of Knapweed in 1,3-butylene glycol To 100 g of dried whole plant of Knapweed, 1 kg of purified water and 1 kg of 1,3-butylene glycol were added, extracted at room temperature for 7 days, and filtered. As a result, 1.9 kg of a 1,3-butylene glycol aqueous solution extract of spinach was obtained.

Example 1 Cream 1 Prescription Formulation Amount 1. Hot water extract of spinach (Preparation Example 1) 0.05 part 2. Squalane 5.5 3. Olive oil 3.0 4. Stearic acid 2.0 5. Beeswax 2.0 6. Octyldodecyl myristate 3.5 7. Polyoxyethylene cetyl ether (20E.O.) 3.0 8. Behenyl alcohol 1.5 9. Glycerin monostearate 2.5 10. Fragrance 0.1 11. 1,3-butylene glycol 8.5 12. Ethyl parahydroxybenzoate 0.05 13. Paraoxybenzoic acid Methyl 0.2 14. Make the total amount 100 with purified water. [Production method] Heat and dissolve components 2 to 9 and mix. Maintain at 70 ° C to obtain an oil phase. Components 1 and 11 to 14 are dissolved by heating and mixed, and kept at 75 ° C. to obtain an aqueous phase. Add the water phase to the oil phase, emulsify, cool with stirring, add component 10 at 45 ° C,
Cool to 30 ° C to obtain a product.

Comparative Example 1 Conventional Cream A conventional cream was prepared by replacing the hot water extract of cucumber with purified water in Example 1.

Example 2 Lotion Formulation Formulation amount 1. Ethanol extract of cedar (Preparation Example 2) 0.1 part 2. 1,3-butylene glycol 8.0 3. Glycerin 2.0 4. Xanthan gum 0.02 5. Citric acid 0.01 6. Citric acid Sodium acid salt 0.1 7. Ethanol 5.0 8. Methyl parahydroxybenzoate 0.1 9. Polyoxyethylene hydrogenated castor oil (40E.O.) 0.1 10. Perfume appropriate amount 11. Make the total amount 100 with purified water [Production method] Ingredient 1 66 and 11 and the components 7 そ れ ぞ れ 10 are uniformly dissolved, and the two are mixed and filtered to obtain a product.

Comparative Example 2 Conventional lotion The same procedure as in Example 2 was carried out except that the ethanol extract of spinach was replaced with purified water.

Example 3 Latex Formulation Formulation Amount 1. Aqueous 1,3-butylene glycol aqueous solution extract of spinach (Preparation Example 3) 1.0 part 2. Squalane 5.0 3. Olive oil 5.0 4. Jojoba oil 5.0 5. Cetanol 1.5 6. Mono Glycerin stearate 2.0 7. Polyoxyethylene cetyl ether (20E.O.) 3.0 8. Polyoxyethylene sorbitan monooleate (20E.O.) 2.0 9. Fragrance 0.1 10. Propylene glycol 1.0 11. Glycerin 2.0 12. Paraoxy Methyl benzoate 0.2 13. Make the total amount up to 100 with purified water. [Production method] Heat and dissolve components 2 to 8 and keep at 70 ° C to obtain an oil phase. Components 1 and 10 to 13 are dissolved by heating and mixed, and the mixture is kept at 75 ° C. to form an aqueous phase. Add the water phase to the oil phase, emulsify, cool with stirring, add component 9 at 45 ° C, and add
Cool to 0 ° C to obtain a product.

Example 4 Gel Formulation Formulation Amount 1. Hot water extract of spinach (Preparation Example 1) 0.1 part 2. Ethanol 5.0 3. Methyl parahydroxybenzoate 0.1 4. Polyoxyethylene hydrogenated castor oil (60E.O. 0.1 5. Fragrance appropriate amount 6. 1,3-butylene glycol 5.0 7. Glycerin 5.0 8. Xanthan gum 0.1 9. Carboxyvinyl polymer 0.2 10. Potassium hydroxide 0.2 11. Make the total amount to 100 with purified water. Components 2 to 5, and components 1 and 6 to 11 are each dissolved uniformly, and both are mixed to obtain a product.

Example 5 Ointment Formulation Amount 1. Aqueous 1,3-butylene glycol aqueous solution extract of Kourouen (Preparation Example 3) 1.0 part 2. Hot water extract of Knapweed (Preparation Example 1) 1.0 3. Polyoxyethylene cetyl Ether (30E.O.) 2.0 4. Glycerin monostearate 10.0 5. Liquid paraffin 5.0 6. Cetanol 6.0 7. Methyl parahydroxybenzoate 0.1 8. Propylene glycol 10.0 9. Make the total amount to 100 with purified water. ] Components 3 to 6 are dissolved by heating and mixed, and kept at 70 ° C to obtain an oil phase. Components 1, 2 and 7 to 9 are dissolved by heating and mixed, and kept at 75 ° C. to obtain an aqueous phase. Add the water phase to the oil phase, emulsify and cool to 30 ° C with stirring to obtain the product.

Example 6 Pack Prescription Formulation amount 1. Hot water extract of coconut (Preparation Example 1) 0.1 part 2. Ethanol extract of coconut (Preparation Example 2) 0.1 3. Polyvinyl alcohol 12.0 4. Ethanol 5.0 5.1 , 3-butylene glycol 8.0 6. Methyl parahydroxybenzoate 0.2 7. Polyoxyethylene hydrogenated castor oil (20E.O.) 0.5 8. Citric acid 0.1 9. Sodium citrate 0.3 10. Appropriate perfume 11. Total amount in purified water [Production method] Components 1 to 11 are uniformly dissolved to give a product.

Example 7 Foundation prescription Formulation amount 1. Aqueous 1,3-butylene glycol aqueous extract (Preparation Example 3) 1.0 part 2. Stearic acid 2.4 3. Polyoxyethylene sorbitan monostearate (20E.O.) 1.0 4. Polyoxyethylene cetyl ether (20E.O.) 2.0 5. Cetanol 1.0 6. Liquid lanolin 2.0 7. Liquid paraffin 3.0 8. Isopropyl myristate 6.5 9. Butyl paraoxybenzoate 0.1 10. Sodium carboxymethyl cellulose 0.1 11. Bentonite 0.5 12. Propylene glycol 4.0 13. Triethanolamine 1.1 14. Methyl parahydroxybenzoate 0.2 15. Titanium dioxide 8.0 16. Talc 4.0 17. Bengala 1.0 18. Yellow iron oxide 2.0 19. Perfume Appropriate amount 20. Make the total amount 100 with purified water. Swell the ingredient 10 well to the ingredient 20, followed by the ingredient
Add 1 and 11-14 and mix uniformly. Add the ingredients 15 to 18 crushed and mixed with a crusher, and stir with a homomixer.
Keep at 75 ° C to make the aqueous phase. Add the oil phase to this aqueous phase while stirring, cool, add component 19 at 45 ° C, and stir
Cool to 30 ° C to obtain a product.

Example 8 Bath agent Prescription Compounding amount 1. Hot water extract of coconut (Preparation Example 1) 1.0 part 2. Sodium hydrogen carbonate 50.0 3. Yellow 202 (1) qs 4. Fragrance qs 5. Anhydrous sodium sulfate [Production method] Components 1 to 5 are uniformly mixed to give a product.

Next, experimental examples will be described in order to explain the effects of the present invention in detail.

Experimental Example 1 Histamine Release Inhibiting Activity (Anti-Inflammatory Activity) Using Production Examples 1 and 2 as samples, the effect of inhibiting the release of histamine, which is a proinflammatory substance produced during inflammation, was measured. Indomethacin was used as a positive control.

Method for Measuring Histamine Release Inhibition Rate The effect of inhibiting histamine release was measured using mast cells collected from the peritoneal cavity of male Spraque-Dawley rats. That is, the effect of suppressing the release of histamine from mast cells by 1 μg / mL Compound 48/80 was determined as the release inhibition rate. Mast cells can be obtained by the method of Sullivan et al. (J. Immunology, 19
75, 114, 1473), and histamine was quantified by the method of May et al. (J. Allergy, 1970, 46, 12).

The results of these experiments are shown in Table 1. As a result, the extract of cucumber showed excellent histamine release inhibitory action.

[0032]

[Table 1]

EXPERIMENTAL EXAMPLE 2 Usage Test Using the cream of Example 1, the conventional cream of Comparative Example 1, the lotion of Example 2, and the conventional lotion of Comparative Example 2, 30 women (30 to 45 years old) were used, respectively. ) Was subjected to a one-month use test. After use, the anti-inflammatory effect was determined by a questionnaire survey on improvement of rough skin. As a result, an external preparation for skin characterized by containing an extract of cedar showed excellent anti-inflammatory action (Table 2). There was no skin trouble during the test, and there was no problem in safety.

[0034]

[Table 2]

The use tests were also performed on the emulsion of Example 3, the gel of Example 4, the ointment of Example 5, the pack of Example 6, the foundation of Example 7, and the bath agent of Example 8, and the safety was confirmed. Showed excellent anti-inflammatory action.

[0036]

As described above, the extract of cucurbits of the present invention exhibited an excellent histamine release inhibitory action. Furthermore, the skin external preparation containing the extract showed a safe and excellent anti-inflammatory action.

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Claims (3)

[Claims] 1. An external preparation for skin characterized by containing an extract of spinach. 2. The external preparation for skin according to claim 1, which is an anti-inflammatory agent. 3. A histamine release inhibitor.
The topical skin preparation according to the above.