JP2000302656A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for external use for skin that has high preventing and recovering effects on skin damage by ultraviolet rays, can realize the application feeling of no greasiness by combining a preparation for external use for skin with a specific ingredient. SOLUTION: The objective preparation comprises (A) xylitol and (B) an ultraviolet light protection agent. The component (B) is preferably one or two or more selected from ultraviolet absorbers (preferably cinnamic derivatives, dibenzoylmethane derivatives, and the like) and an ultraviolet scattering agent (preferably titanium oxide, zinc oxide, and the like). The formulation of this preparation is 0.1-20.0 wt.% of the component A and 1.0-50.0 wt.% of the component B whereby the damage to skin by ultraviolet rays can be prevented or recovered with excellent application feeling without greasiness to skin.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention belongs to the technical field of external preparations for the skin, and more particularly, has excellent effect of preventing and recovering skin damage due to ultraviolet rays, and excellent use without stickiness. The present invention relates to a skin external preparation having a feeling.

[0002]

2. Description of the Related Art In recent years, attention has been paid to the adverse effects of ultraviolet rays on the skin, and various skin external preparations such as skin cosmetics for preventing ultraviolet rays have been put on the market.

[0003] One of the systems is based on the idea of preventing ultraviolet light itself to prevent skin damage due to ultraviolet light. Specifically, it is a skin external preparation having a function of preventing ultraviolet rays from reaching the skin by blending an appropriate type and amount of an ultraviolet absorber or an ultraviolet ray protective agent such as an ultraviolet scattering agent into a cream / emulsion base.

[0004] Another system is based on the idea that after ultraviolet rays reach the skin, the skin damaged by the ultraviolet rays is recovered and the condition of the skin is kept as healthy as possible. Specifically, by adding a melanin production inhibitory component, excessive melanin production is suppressed to prevent blackening of the skin, and by adding an anti-inflammatory agent, skin roughness caused by sunburn is improved. It is a skin external preparation that has the function of Recently, a skin external preparation having a function of suppressing a decrease in immune function due to ultraviolet rays has been launched and is becoming established in the market.

However, in the case of the former, a skin external preparation having a function of cutting off ultraviolet rays before reaching the skin, recently a particularly high ultraviolet ray prevention effect (high SPF value) tends to be required. Inevitably, the amount of the ultraviolet protective agent required to perform the treatment increases, and the amount of other components is limited to some extent from the viewpoint of the feeling of use of the external preparation for skin. That is, for example, in order to provide a skin external preparation having a high moisturizing effect at the same time as a high ultraviolet ray preventing effect, in addition to the ultraviolet ray protective agent, if an amount of the moisturizing agent necessary to bring about a high moisturizing effect is added, stickiness occurs. However, the feeling of use is remarkably inferior.

[0006] It is also possible to think that the latter, a skin external preparation having a function of recovering skin damaged by ultraviolet rays, is provided with a function of preventing ultraviolet rays itself. Many of the possessed drugs have remarkably inhibited stability due to the combination with the ultraviolet protective agent, and there were restrictions on the preparation.

As described above, no external preparation for skin which has a high effect of preventing ultraviolet light itself, has an excellent effect of recovering skin damaged by ultraviolet light, and has a good feeling upon use has not yet been provided.

[0008]

Accordingly, an object of the present invention is to solve the above-mentioned problems of the prior art, to prevent the skin from being damaged by ultraviolet rays, and to recover the damaged skin. It is an object of the present invention to provide an external preparation for skin which is excellent in effect and has excellent feeling of use without stickiness.

[0009]

Means for Solving the Problems The present inventors have conducted intensive studies to solve this problem, and as a result, have found that
A combination of xylitol and an ultraviolet protective agent, which is excellent in both the effect of preventing skin damage due to ultraviolet rays and the effect of recovering damaged skin, and also has an excellent feeling of use without stickiness The present inventors have found that an external preparation can be provided, and have completed the present invention.

That is, the present invention is to provide an external preparation for skin containing xylitol and an ultraviolet ray protective agent. In the external preparation for skin of the present invention, the UV protective agent is preferably one or more UV protective agents selected from UV absorbers and UV scattering agents.

[0011] Further, the ultraviolet absorber is a cinnamic acid derivative,
In the case of one or more ultraviolet absorbers selected from dibenzoylmethane derivatives, benzophenone derivatives and shea butter, the ultraviolet scattering agent may be titanium oxide, zinc oxide, or a hydrophobically treated product thereof. When one or two or more selected ultraviolet scattering agents are used, the intended effect of the present invention can be particularly favorably exhibited.

Furthermore, in the external preparation for skin of the present invention, the amount of xylitol is 0.1 to 20.0% by weight,
When the compounding amount of the ultraviolet ray protective agent is 1.0 to 50.0% by weight, the intended effect of the present invention can be particularly favorably exhibited.

[0013]

Embodiments of the present invention will be described below. The skin external preparation of the present invention is a skin external preparation that exhibits an intended effect by being combined with xylitol and an ultraviolet protection agent.

Xylitol, which is incorporated in the skin preparation for external use of the present invention, is a 5-carbon sugar alcohol, and is naturally contained in raspberries, strawberries, cauliflower, spinach and the like, and is widely distributed. Xylitol began to attract attention because
It has been widely used as a sweetener effective in preventing dental caries in the Nordic region. In our country,
Since it was approved as a food additive in 1997, it has been incorporated into many oral products and gums. On the other hand, there is no example of application of xylitol to an external preparation for skin, and its dermatological utility has recently been clarified (for example, Japanese Patent Publication No. Hei 8-508745).

[0015] The amount of xylitol in the external preparation for skin of the present invention is preferably 0.1% based on the whole external preparation for skin.
To 20.0% by weight, more preferably 0.5 to 20.0% by weight.
１10.0% by weight. When the amount of xylitol is less than 0.1% by weight based on the total amount of the external preparation for skin, a sufficient effect of improving skin roughness caused by sunburn cannot be obtained. Further, the effect of improving skin roughness is not obtained, and the feeling of use tends to be impaired such as stickiness, which is not preferable.

The ultraviolet protective agent to be added to the external preparation for skin of the present invention together with xylitol is preferably one or more ultraviolet protective agents selected from ultraviolet absorbents and ultraviolet scattering agents.

Examples of the ultraviolet absorber include ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate, potassium paramethoxycinnamate and mono-diparamethoxycinnamate.
Cinnamic acid derivatives such as glyceryl 2-ethylhexanoate, glyceryl octyl diparamethoxycinnamate, and methyl bis (trimethylsiloxy) silyl isopentyl trimethoxycinnamate; dibenzoylmethane derivatives such as 4-tert-butyl-4'-methoxydibenzoylmethane , 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4
-Methoxybenzophenone-5-sulfonic acid, dihydroxydimethoxybenzophenone, 2,4-dihydroxybenzophenone, benzophenone derivatives such as tetrahydroxybenzophenone, paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate,
Amyl paradimethylaminobenzoate, benzoic acid derivatives such as octyl paradimethylaminobenzoate, amyl salicylate, octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, and salicylic acid derivatives such as myristyl salicylate. It is. Other examples include a vegetable ultraviolet absorber such as shea butter. Among these, preferred UV absorbers are one or more UV absorbers selected from cinnamic acid derivatives, dibenzoylmethane derivatives, benzophenone derivatives and shea butter.

The kind and amount of the ultraviolet absorber which can be blended in the external preparation for skin of the present invention are appropriately selected according to the required ultraviolet ray preventing effect. Examples of the ultraviolet scattering agent include titanium oxide, zinc oxide, and their hydrophobized products. Examples of the method of the hydrophobic treatment include a method of treating with a higher fatty acid such as myristic acid and stearic acid, and a method of treating with a silicone oil such as methyl hydrogen polysiloxane.

The type and amount of the ultraviolet light scattering agent that can be incorporated into the skin external preparation of the present invention are appropriately selected according to the required ultraviolet light blocking effect. The compounding amount of the ultraviolet ray protective agent in the skin external preparation of the present invention is preferably 1.0 to 50.0% by weight based on the whole skin external preparation, and more preferably,
3.0 to 40.0% by weight. When the compounding amount of the ultraviolet ray protective agent is less than 1.0% by weight based on the whole skin external preparation,
Not enough to prevent ultraviolet light, while 50.0%
If the amount is more than 10% by weight, no further effect of preventing ultraviolet rays can be obtained, and stickiness and creaking tend to occur, and the feeling of use tends to be impaired.

Thus, by combining xylitol and an ultraviolet ray protective agent as essential components of an external preparation for skin, an effect of preventing skin damage by ultraviolet rays,
A skin external preparation excellent in both effects of recovering skin damaged by ultraviolet rays and having an excellent feeling of use without stickiness is provided.

The external preparation for skin of the present invention may further contain, if necessary, various components which are generally added to the external preparation for skin, as long as the effects of the present invention are not impaired. Can be. As those components, for example,
Oily components, surfactants, humectants, higher alcohols, sequestering agents, natural and synthetic polymers, water-soluble and oil-soluble polymers, blood circulation promoters, various extracts, inorganic and organic pigments,
Inorganic and organic clay minerals, inorganic and organic pigments treated with metal soaps or silicones, coloring agents such as organic dyes, preservatives, antioxidants, pigments, thickeners, pH adjusters, fragrances, cooling agents, Examples include antiperspirants, bactericides, skin activators, and other agents.

The form of the external preparation for skin of the present invention may be a liquid, an emulsion,
Ointments, creams, gels, aerosols, and the like are not limited as long as they have properties applicable to the outer skin. Can be prepared. Further, the skin external preparation of the present invention can be applied to various fields such as pharmaceuticals, quasi-drugs, and cosmetics.

[0023]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. In addition,
Unless otherwise specified, the weight percentage of the ingredients is based on the weight of the ingredients.
It is.

First, prior to the disclosure of each embodiment, an evaluation method and evaluation criteria for examining the effect of preventing skin damage due to ultraviolet rays in these embodiments will be described.

Evaluation method The subjects were male and female panels, and each of the samples of Examples and Comparative Examples was 10 persons. The subject applied the sample to the face or arm after washing the face with cleansing foam,
Regarding the feeling of use during application, it was evaluated whether or not there was no stickiness and it was refreshing.

After the application of the sample, the subject exercised tennis or the like outdoors for two hours on a sunny day, and as an effect of preventing skin damage due to ultraviolet rays, whether redness or tingling occurred over the next day after exercise. As an effect of restoring the skin damaged by the ultraviolet rays, it was evaluated whether there was any skin roughness (such as dryness) due to sunburn after the next day.

The evaluation results of each sample were expressed using the following evaluation criteria. Evaluation criteria 1. Evaluation of feeling of use at the time of application ◎: 8 or more out of 10 panelists answered that there was no stickiness and refreshed ○: ６ 6 to 7 out of 10 △: ３ 3 to 5 out of 10 ×: ２ 2 or less out of 10 Evaluation of redness and tingling due to sunburn over the next day after exercise ◎: 8 or more out of 10 panelists answered that there was no redness or tingling ○: ６ 6 to 7 out of 10 △: 中 Out of 10 3 to 5 ×: ２ 2 or less out of 10 Evaluation of skin roughness due to sunburn (e.g., dryness) after the next day ◎: 8 or more out of 10 panelists answered that there was no skin roughness due to sunburn ○: ６ 6-7 out of 10 △: 〃 10 Medium 3 to 5 ×: ２ 2 or less of 10 [Examples 1 to 3, Comparative Examples 1 to 3] W / O emulsion (two-layer dispersion type) W / O emulsion (two-layer dispersion) having the following formulation (Dispersion type) was prepared by a conventional method, and evaluated by the above evaluation method. Table 1 also shows the evaluation results.

(Prescription) Ingredients (% by weight) (1) Dipropylene glycol 4.0 (2) Xylitol As shown in Table 1 (3) Potassium chloride 0.5 (4) Trisodium edetate 0.1 (5) Diglyceryl diisostearate 0.5 (6) POE-modified dimethylpolysiloxane 1.5 (7) Octamethylcyclotetrasiloxane residue (8) Glyceryl triisooctanoate 5.0 (9) Spherical polymethyl methacrylate (average 2.0 (10) Talc 5.0 (11) Trimethylsiloxysilicic acid 1.0 (12) UV absorber listed in Table 1 (13) UV scattering agent listed in Table 1 (14) Ion Exchange water 25.0

[0029]

[Table 1]

As is evident from Table 1, emulsions containing both xylitol and an ultraviolet protective agent (Examples 1 to 3)
Has the effect of preventing skin damage due to ultraviolet rays,
The emulsion containing only xylitol (Comparative Example 1) has an excellent effect of recovering skin damaged by ultraviolet rays and has excellent feeling of use without stickiness. Emulsion which cannot be prevented and contains only UV protection agent (Comparative Example 2)
Cannot recover skin damaged by ultraviolet light. In addition, instead of xylitol, a milky lotion in which glycerin, one of the representative humectants, was blended together with an ultraviolet protective agent (Comparative Example 3), prevented the skin from being damaged by ultraviolet rays, and was also damaged by ultraviolet rays. Skin can be recovered, but the feeling of use is extremely poor.

That is, by combining a skin external preparation with xylitol and an ultraviolet protection agent,
It is clear that the effect of preventing skin damage due to ultraviolet rays and the effect of recovering skin damaged by ultraviolet rays are remarkable, and that an excellent feeling of use without stickiness is produced.

Hereinafter, still another formulation example of the skin external preparation of the present invention will be shown. [Example 4] O / W emulsification type emulsion component amount (% by weight) (1) ethyl alcohol 2.0 (2) 1,3-butylene glycol 5.0 (3) xylitol 0.5 (4) hydroxy Ethyl cellulose 0.3 (5) triethanolamine 0.8 (6) stearic acid 2.0 (7) sorbitan monooleate 2.0 (8) cetanol 1.5 (9) liquid paraffin 5.0 (10) Dimethylpolysiloxane 3.0 (11) Shea butter 2.0 (12) 2-Hydroxy-4-methoxybenzophenone 0.5 (13) 4-tert-butyl-4'-methoxydibenzoylmethane 0.5 (14) Trisodium edetate 0.05 (15) Ethyl paraben 0.1 (16) Fragrance 0.1 (17) Residual amount of ion-exchanged water <Production method> An emulsion was obtained by an ordinary method.

The emulsion obtained had a high effect of preventing skin damage due to ultraviolet rays and recovering skin damaged by ultraviolet rays, and had an excellent feeling of use without stickiness.

Example 5 O / W emulsified type cream compounding ingredients (% by weight) (1) glycerin 10.0 (2) xylitol 0.1 (3) POE (25) cetyl alcohol ether 3.0 ( 4) Glycerin monostearate 2.0 (5) Stearyl alcohol 3.0 (6) Solid paraffin 2.0 (7) Vaseline 4.0 (8) Methylphenyl polysiloxane 3.0 (9) Jojoba oil 7.0 (10) Glyceryl octyl diparamethoxycinnamate 5.0 (11) Methyl bis (trimethylsiloxy) silyl isopentyl trimethoxycinnamate 1.0 (12) Titanium oxide 5.0 (13) Butylparaben 0.2 (14) Edetate 3 Sodium 0.05 (15) Fragrance 0.2 (16) Residual amount of ion-exchanged water <Production method> It was obtained.

The obtained cream had a high effect of preventing skin damage due to ultraviolet rays and recovering the skin damaged by ultraviolet rays, and had an excellent feeling without stickiness.

[Example 6] W / O emulsified type cream blending component blending amount (% by weight) (1) polyethylene glycol 1500 5.0 (2) xylitol 5.0 (3) sodium chloride 0.5 (4) edet Trisodium acid 0.1 (5) Diglyceryl diisostearate 1.5 (6) Liquid paraffin 10.0 (7) Decamethylcyclopentasiloxane 15.0 (8) Octyl paramethoxycinnamate 10.0 (9) Methylhydro Genpolysiloxane-treated zinc oxide 15.0 (10) Methylhydrogenpolysiloxane-treated titanium oxide 15.0 (11) Organically modified montmorillonite 1.5 (12) Methylparaben 0.1 (13) Fragrance 0.05 (14) Ions Exchange water residue <Production method> A cream was obtained by a conventional method.

The obtained cream had a high effect of preventing skin damage due to ultraviolet rays and recovering skin damaged by ultraviolet rays, and had an excellent feeling of use without stickiness.

Example 7 Powdered Lotion (Two-Layer Type) Compounding Components (Weight%) (1) Ethyl Alcohol 15.0 (2) Sorbit 1.0 (3) Xylitol 20.0 (4) Kaolin 0.5 (5) Zinc oxide 0.5 (6) Titanium oxide 0.5 (7) Sodium sulfocarbonate 0.2 (8) Camphor 0.2 (9) Methyl paraben 0.1 (10) Fragrance 0.05 (11) Residual amount of ion-exchanged water <Production method> Powdered lotion was obtained by an ordinary method.

The obtained lotion was highly effective in preventing skin damage due to ultraviolet rays and for recovering skin damaged by ultraviolet rays, and had an excellent feeling of use without stickiness.

[0040]

Industrial Applicability According to the present invention, there is provided a skin external preparation having an excellent effect of preventing skin damage due to ultraviolet rays and recovering damaged skin and having an excellent feeling of use without stickiness. .

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Claims (5)

[Claims] 1. An external preparation for skin containing xylitol and an ultraviolet protection agent. 2. The external preparation for skin according to claim 1, wherein the ultraviolet protective agent is one or more ultraviolet protective agents selected from ultraviolet absorbers and ultraviolet scattering agents. 3. The external use for skin according to claim 2, wherein the ultraviolet absorber is one or more ultraviolet absorbers selected from cinnamic acid derivatives, dibenzoylmethane derivatives, benzophenone derivatives and shea butter. Agent. 4. The ultraviolet scattering agent is one or two selected from titanium oxide, zinc oxide, and a hydrophobized product thereof.
The skin external preparation according to claim 2 or 3, which is at least one ultraviolet scattering agent. 5. The amount of xylitol is 0.1 to 20.
0% by weight, and the compounding amount of the ultraviolet ray protective agent is 1.0 to 5%.
The external preparation for skin according to any one of claims 1 to 4, which is 0.0% by weight.