JP2000297020A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oral cavity composition which has an excellent oral cavity-cleaning force, by adding a water-insoluble polyvinyl pyrrolidone having an alkyl group as an oral cavity-cleaning agent. SOLUTION: This oral cavity composition contains a water-insoluble polyvinyl pyrrolidone having an alkyl group, for example, ANTARON (R), in an amount of 0.01 to 20 wt.% based on the total amount of the composition. The polyvinyl pyrrolidone having the alkyl group is obtained by alkylating polyvinyl pyrrolidone with an α-olefin, and has a structure of the formula [R1 to R4 are each H or an alkyl (for example, hexadecyl or eicosyl)] in the main chain of the polymer. The polyvinyl pyrrolidone having the alkyl group is a highly hydrophobic polymer, is insoluble in water, n-propanol, and hydrocarbons such as kerosene, and preferably exhibits a viscous liquid property at 25 deg.C.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for oral cavity which has an excellent oral cleansing power (cleaning power).

[0002]

2. Description of the Related Art It has been known that dental plaque is the cause of dental caries and periodontal disease, two major diseases in the oral cavity. Coloring of teeth derived from tobacco and food is a problem from the viewpoint of aesthetics. Therefore, for the purpose of removing plaque and stains on the tooth surface, the oral composition is coated with an abrasive such as calcium carbonate, aluminum hydroxide, dibasic calcium phosphate, anhydrous calcium phosphate, hydroxyapatite, or a dirt such as polyethylene glycol. Various products containing a solubilizer and the like are commercially available. However, brushing with a toothbrush in combination with a dentifrice was not sufficient to completely remove these stains, and there is a need for the development of an oral composition with a further enhanced cleaning effect.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide an oral composition having an improved cleaning effect.

[0004]

Means for Solving the Problems The inventors of the present invention have made intensive studies to solve the above-mentioned problems, and as a result, have found that the use of an oral composition containing water-insoluble polyvinylpyrrolidone having an alkyl group has resulted in the above-mentioned problems. They have found that the problem can be solved, and have completed the present invention. That is, according to the present invention, there is provided an oral cavity composition characterized by containing a water-insoluble polyvinylpyrrolidone having an alkyl group as an oral cleansing agent.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in more detail. The oral composition of the present invention includes dentifrice such as toothpaste, liquid dentifrice, liquid dentifrice, gel dentifrice, and mouthwash. , A coating agent, a mouthwash, a dental pasta, a denture cleaning agent, a denture care agent and the like.

[0006] The present invention is characterized in that polyvinylpyrrolidone having an alkyl group is blended in these various oral compositions. In this case, the polyvinyl pyrrolidone having the alkyl group has an average particle size of 0.1 in the composition.
It exists as oily liquid or solid fine particles of 5 to 10 μm. Polyvinylpyrrolidone having an alkyl group (hereinafter abbreviated as R-PVP) used in the present invention is a known substance, and is sold by International Specialty Products under the trade name "ANTARON". The polyvinylpyrrolidone having an alkyl group is an alkylated polymer obtained by subjecting polyvinylpyrrolidone to an α-olefin alkylation reaction, and has a structure represented by the following general formula (1) in the polymer main chain. .

Embedded image In the above formula, R ^{1 to} R ⁴ are hydrogen or an alkyl group, at least one of which is an alkyl group. The alkyl group has at least 4 carbon atoms, preferably at least 10 carbon atoms, more preferably at least 12 carbon atoms, and the upper limit thereof is not particularly limited, but is usually about 22. Specific examples thereof preferably include a hexadecyl group and an eicosyl group, and more preferably a hexadecyl group.

R-PVP, unlike polyvinylpyrrolidone, is a highly hydrophobic polymer, is a substance that is insoluble in water and n-propanol, and is soluble in hydrocarbon oils such as kerosene. The appearance of R-PVP at 25 ° C. indicates a viscous liquid or wax solid. Also, its R
The nitrogen content in the PVP is 2 to 5% by weight, preferably 2%;
４4% by weight. In the present invention, it is preferable to use R-PVP which shows a viscous liquid state at 25 ° C. The R-PV
Conventionally, P has been used in skin care products for the purpose of a moisture-resistant agent, a conditioning agent and the like, but the present invention is the first application to an oral composition.

The R-PVP may be used alone or as a mixture of two or more R-PVPs. The amount of the R-PVP is 0.01 to 20% by weight of the composition. Is 0.1 to 10% by weight. If the amount is less than 0.01%, the cleaning effect may not be sufficient,
If the amount is larger, the taste of the oral composition may be deteriorated. The oral composition according to the present invention is applied as a toothpaste, a lubricating dentifrice, a liquid dentifrice, a mouthwash, a mouthwash or a base composition for preparing the same, but depending on the type thereof, as other components. Various abrasives, surfactants, sweeteners, flavors,
Coloring agents, preservatives, active ingredients and the like can be added. In each case, conventionally used components can be used in ordinary amounts.

Examples of the abrasive include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate and zirconosilicate, dibasic calcium phosphate dihydrate and anhydride, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina , Magnesium carbonate, tribasic magnesium phosphate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, zeolite, aluminum silicate, zirconium silicate, and a synthetic resin-based abrasive.

Examples of the thickener include glycerin, sorbitol, propylene glycol, polyethylene glycol and the like.

Examples of the binder include carrageenan, sodium hydroxyethylcellulose, sodium alginate, propylene glycol alginate, xanthan gum, polyacrylic acid, sodium polyacrylate, tara gum, guar gum, locust bean gum, hydroxyethyl cellulose, hydroxypropyl cellulose, Examples include methylcellulose, gellan gum, gelatin, curdlan, gum arabic, agar, pectin, polyvinyl alcohol, polyvinylpyrrolidone, pullulan and the like.

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant and the like are blended, and specific examples thereof include sodium lauryl sulfate, sodium α-olefin sulfonate, and N-acyl. Glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, pluronic, poly Oxyethylene sorbitan monostearate and the like can be mentioned.

As a sweetener, saccharin sodium,
Stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone,
And perillartin. As fragrances, terpenes such as 1-menthol, carvone, anethole, limonene and derivatives thereof and the like, and as coloring agents, blue No. 1, yellow 4
And titanium dioxide.

The active ingredient includes cationic fungicides such as chlorhexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride and decanium chloride, phenolic compounds such as triclosan, hinokitiol and biosol, dextranase, Mutanase, lysozyme amylase,
Proteases, lytic enzymes, enzymes such as superoxide dismutase, vitamins such as vitamin E and vitamin C,
Sodium monofluorophosphate, alkali metal monofluorophosphates such as calcium monofluorophosphate, insoluble fluorides such as sodium fluoride and stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyallantoin, dihydro Cholesterol, glycyrrhizic acid, glycyrrhetinic acid, bisabolol, glycerophosphate, chlorophyll, sodium chloride, water-soluble inorganic phosphate compounds, copper compounds such as copper gluconate, aluminum lactate, strontium chloride,
Potassium nitrate, verperin, hydroxamic acid and derivatives thereof, sodium tripolyphosphate, zeolite, dextranase, mutanase, amylase, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone,
Epidihydrocholesterine, benzethonium chloride, sodium chloride, dihydrocholesterol, trichlorocarbanide, zinc citrate, soft cucumbers extract, oak extract, camil, clove, rosemary, ogre, safflower and other known active ingredients One or more kinds may be blended.

As fragrances, 1-menthol, carvone,
Perfume ingredients such as anethole, cineole, methyl salicylate, limonene methyl salicylate, ethyl butyrate, eugenol, thymol, cinamic aldehyde, and derivatives thereof, and blue 1 and yellow 4 as colorants
No. 3, green No. 3 and the like.

The amount of the above components can be a usual amount as long as the effects of the present invention are not impaired.

[0017]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to Examples, but the present invention is not limited to the following Examples. In addition,% in each example shows weight%.

Examples 1 and 2, Comparative Example 1 An oral composition (dentifrice) containing R-PVP was prepared, and its cleaning power was evaluated. The cleaning power in this case is determined by the CF method (Cleaning method) which shows the effect of removing tobacco dust.
(Factor method).

(CF method) (1) Tar is extracted from tobacco using a smoking apparatus. (2) The extract is concentrated using a rotary evaporator. (3) The operation of applying to a white dental tile of 14 mm × 14 mm with a brush and then drying is repeated five times to obtain a coating product on the tile of the tar. (4) After dipping the coated product of tiles in tiled water for 4 days, the coated product is dried in a thermostat at 140 ° C. for 24 hours. (5) The coating material on the tile of the poorly water-soluble varnish obtained in this way is brushed with an abrasive solution having an RDA value of 60, 140, or 220 at a pressing force of 200 g, and each stain removal area is evaluated. It is used as a reference and has 2, 4, and 6 points respectively. (6) Separately, 10 g of the oral composition having the component composition (% by weight) shown in Table 1 was similarly brushed with a liquid in which 15 g of a 60 wt% glycerin aqueous solution was dispersed, and the stain removal area was evaluated by comparing with the above reference. (The score is the average of 10 repetitions).

The measured value (CF) obtained by the CF method
The value) indicates that the larger the value, the higher the oral cleansing power of the oral composition.

[0021]

[Table 1]

Note that "ANTARON V" shown in Table 1 is used.
-220 "is a product obtained by alkylating polyvinylpyrrolidone with eicosene, and shows a wax solid at 25 ° C;
Its nitrogen content is 2.9-3.6% by weight. on the other hand,
"ANTARON V-216" is obtained by alkylating polyvinylpyrrolidone with hexadecene, shows a viscous liquid at 25 ° C, and has a nitrogen content of 2 to 3% by weight.

Next, the score (C) obtained by the CF method
F value) is shown below. Example 1: 3.3 Example 2: 3.7 Comparative Example: 1.6 From the above results, it can be seen that the oral composition containing R-PVP according to the present invention has a high oral cleansing power.

Next, with respect to specific examples of the oral composition of the present invention, examples of the component composition (% by weight) will be shown. Examples 3 to 10 Tables 2 and 3 show the component compositions (% by weight) of the dentifrice compositions.

[0025]

[Table 2]

[0026]

[Table 3]

Example 11 (Jun Toothpaste) ANTARON V-216 0.5 (%) Sodium Pyrophosphate 3.0 Butylparaben 0.02 Calcium Carbonate 70 Sorbitol 2 Glycerin 8 Saccharin Sodium 0.08 Sodium Lauryl Sulfate 2.0 Purification Water rest

Example 12 (Mouthwash) ANTARON V-216 1.0 (%) Sodium pyrophosphate 5.0 Ethanol 10.0 Glycerin 8.0 Saccharin sodium 0.1 Polyoxyethylene hydrogenated castor oil 1.0 Benzoic acid Sodium 0.3 Fragrance 0.5 Purified water Remaining

Example 13 (Mouthwash) ANTARON V-220 2.0 (%) Aluminum lactate 0.5 Ethanol 5.0 Sorbitol 10.0 Saccharin sodium 0.1 Pluronic F127 2.0 Sodium benzoate 0.3 citrate Sodium acid 0.5 Perfume 0.4 Purified water Remaining

Example 14 (Mouthwash) ANTARON V-220 1.0 (%) Allantoin 0.5 Ethanol 8.0 Glycerin 12.0 Saccharin Sodium 0.1 Polyoxyethylene hydrogenated castor oil 1.2 Sodium Benzoate 0 .3 Perfume 0.5 Purified water Remaining

Example 15 (Mouth Refreshing Agent) ANTARON V-216 0.8 (%) Sodium Pyrophosphate 2.0 Ethanol 30.0 Glycerin 15.0 Saccharin Sodium 0.3 Polyoxyethylene Hardened Castor Oil 3.0 Fragrance 1 0.0 Purified water Remaining

[0032]

The oral composition of the present invention contains a water-insoluble polyvinylpyrrolidone having an alkyl group, has a high effect of cleaning the mouth by removing plaque, removing tar, etc., and has high commercial value. .

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C083 AA012 AB052 AB172 AB222 AB242 AB282 AB322 AB352 AB472 AC102 AC122 AC132 AC302 AC312 AC432 AC482 AC622 AC682 AC782 AC862 AD042 AD071 AD092 AD272 AD352 BB55 CC41 DD22 DD23 DD27 EE35 EE36

Claims (2)

[Claims] 1. An oral composition comprising a water-insoluble polyvinylpyrrolidone having an alkyl group as an oral cleansing agent. 2. The oral composition according to claim 1, which comprises a polyvinylpyrrolidone having an eicosyl group or a hexadecyl group.