JP2000290165A - Skin aging inhibitor and its use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin aging inhibitor which contains as an active ingredient the solvent extract of a specific plant and is formulated in cosmetics, medicines, quasi drugs, foods and the like, and to provide the use. SOLUTION: This skin aging inhibitor contains as an active ingredient the solvent extract of at least one plant selected from the group consisting of Pipturus argenteus(Forst.f.) (Indonesian name: Trembesi), Phyllanthus pulcher(Baill.)M.A. (Indonesian name: Naga buana) and Piper betle L. (Indonesian name: Daunsirih), especially the leaves, stems and barks of the Pipturus argenteus(Forst.f) (Indonesian name: Trembesi), the leaves of the Phyllanthus pulcher(Baill.)M.A. (Indonesian name: Naga buana), and the leaves, whole plant, stems and fruits of the Piper betle L. (Indonesian name: Daunsirih). The skin aging inhibitor is formulated to cosmetics, medicines, quasi drugs, foods and the like to utilize the excellent skin aging-inhibiting action.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin aging inhibitor, and more particularly, to a skin aging inhibitor comprising a solvent extract of a specific plant as an active ingredient, and a cosmetic or pharmaceutical containing the same. Quasi-drugs or foods.

[0002]

2. Description of the Related Art Skin aging mainly progresses due to deterioration of skin function due to aging and external environment such as ultraviolet rays and food. In an external environment, it is said that active oxygen and free radicals generated by ultraviolet rays, metabolism and the like derived from sunlight, and hyaluronidase activated by some kind of stimulus from inside and outside a living body promote skin aging.

[0003] The sunlight and the active oxygen and free radicals generated in the living body damage cells, biological components and tissues in the living body, resulting in reduced functions of cells and organs, resulting in arteriosclerosis and cerebrocardiovascular disorders. It has been shown to cause various diseases such as diabetes, cataract, spots and freckles, skin wrinkles and loosening, hypertension, senile dementia and cancer. In foods, lipid peroxides and polymers are formed, proteins are denatured, enzymes are degraded, and color components are degraded due to decomposition of pigment components. Has become.

[0004] On the other hand, hyaluronidase is usually present in an inactive state in tissues of a living body. Hyaluronidase is activated by some kind of stimulus from inside or outside the living body, and the high molecular hyaluronic acid as a substrate is reduced in molecular weight. It is said to be an inflammatory substance and inflammation progresses. In addition, it has been speculated that the reduction in molecular weight of hyaluronic acid causes a decrease in skin moisturizing property and tension, etc., for the skin.

[0005] Therefore, α-tocopherol, ascorbic acid, cysteine, glutathione and the like, which have an active oxygen and radical scavenging action, are used as skin aging inhibitors. α-Tocopherol is composed of a chroman ring and a side chain having 16 carbon atoms, and due to its properties, only a substance having fat solubility has an active oxygen eliminating action. In addition, ascorbic acid has an enediol group at the 2nd and 3rd carbon positions, which is a functional group for eliminating active oxygen, and is effective only for water-soluble substances due to its properties. Although these have an excellent active oxygen scavenging action, they have poor stability, and are decomposed by heat treatment or with time in a solution, so that a sufficient effect is not recognized.

Cysteine has particularly poor stability in an aqueous solution, changes to cystine in a few days, and precipitates are deposited. Glutathione is decomposed with time in a high-temperature and high-humidity environment, and an odor is generated. There is a disadvantage that. BHT (butyla) as a synthetic antioxidant and skin aging inhibitor
ted hydroxytoluene), BHA (butylated hydroxyani)
sole) has been attempted, but as a result of animal experiments,
The possibility of carcinogenesis has been pointed out.

[0007] Glutyl ricinic acid, sodium cromoglycate, baicalin, indomethacin, aspirin and the like, which have been confirmed to have a high hyaluronidase activity inhibitory activity in vitro, have been used. However, glycyrrhizic acid and baicalin have been used as natural products since ancient times and are said to be relatively high in safety, but they have a very small amount of sweetness or have a bright vermilion color. , Applications and concentrations used are limited. Fetal toxicity of sodium cromoglycate during pregnancy administration has been reported, and strict precautions for its use as a pharmaceutical are required. Indomethacin and aspirin have been observed to cause side effects such as rash and itch by topical use.

[0008] As described above, the conventional skin aging inhibitor has problems in safety, quality, usefulness, and the like, and at present, it is only used for a part of drugs and the like whose use is restricted. Under these circumstances, it is safe for the human body to be applied and eaten on the skin, and it has an active oxygen / radical scavenging effect and / or markedly suppresses the reduction of hyaluronic acid to low molecular weight, and can be easily manufactured. It has been desired to develop a skin aging inhibitor that can be supplied stably.

[0009]

SUMMARY OF THE INVENTION An object of the present invention is to provide a skin aging inhibitor which is highly safe for the human body and has a strong active oxygen scavenging effect and / or a strong hyaluronidase activity inhibiting effect.

[0010]

DISCLOSURE OF THE INVENTION The present invention has been proposed to achieve the above object, and has been found as a result of a long-term study by the inventors of the present invention. The present invention has been completed based on the new finding that an extract extracted from a tree has an active oxygen scavenging action and / or a hyaluronidase activity inhibitory action.

That is, according to the present invention, scientific name: Piptur
us argenteus (Forst.f.) (Indonesia: Tremb
esi), scientific name: Phyllanthus pulcher (Baill.) MA
(Indonesia name: Naga buana) and Scientific name: Piper betle L. (Indonesia name: Daun si
a skin aging inhibitor comprising at least one solvent extract of a plant selected from the group consisting of rih) as an active ingredient.

According to the present invention, scientific name: Pipturus arg
enteus (Forst.f.) (Indonesia name: Trembes)
i) Leaf, stem and bark, scientific name: Phyllanthus pulcher
(Baill.) MA (Indonesia name: Naga buan
a) Leaf, scientific name: Piper betle L. (Indonesia name: D
aun sirih) A skin aging inhibitor comprising as an active ingredient at least one solvent extract of a plant selected from the group consisting of leaves, whole plants, stems and fruits. The above-mentioned skin aging inhibitor is usefully incorporated in cosmetics, pharmaceuticals, quasi-drugs, foods and the like.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION The above-mentioned specific plant used in the present invention is generally used as a crude drug in Indonesia, drinking a hot water extract of a plurality of mixtures and treating abdominal pain, headache and other symptoms in Indonesia. .

In the present invention, the roots of the above-mentioned specific plant,
Stems, leaves, fruits (seed), flower buds, bark, worms and the like are used, and it is important that this extract has an active oxygen scavenging action and / or a hyaluronidase activity inhibitory action. The extraction is carried out with a solvent. As the extraction solvent, a lower alcohol, a polyhydric alcohol, a low-polarity solvent and a polar solvent are used.

As the lower alcohol, methanol, ethanol, propanol, isopropyl alcohol and the like are used. Glycerin, polyethylene glycol and 1,3-butylene glycol as polyhydric alcohols, and pentane, hexane,
Saturated hydrocarbons such as heptane, octane, nonane and decane, unsaturated hydrocarbons such as hexene and heptene, and polar solvents such as water, acetone, ethyl acetate and methyl acetate are used alone or in combination of two or more. And used as an extraction solvent.

For the extraction, a solvent is added to Pipturus argenteus (Forst.f.) Or the like, and if necessary, 10 to 6 with stirring.
The extraction is carried out at 0 ° C., preferably below the boiling point of the solvent to room temperature. However, in the case of water, it may be extracted with boiling hot water. There is no particular limitation on the amount of the mixed solvent used, but as a rough guide, 1 to 20 parts of the solvent is used for 1 part of the dried plant (crushed material).
Parts, preferably about 5 to 10 parts. The extract thus obtained contains a high concentration of an active oxygen eliminating component and / or a hyaluronidase activity inhibitory component.

As the skin aging inhibitor according to the present invention, the extract extracted by the above method can be used as a useful component as it is, or a purified product of the extract can be used as a useful component. As the treated product, a concentrate, a paste, a dried product, and / or a diluted product of a useful component are widely used. For example, the extract is directly vacuum (freeze) dried, concentrated under reduced pressure, vacuum (freeze) dried, or concentrated under reduced pressure, and then fractionated with various solvents to remove active oxygen-eliminating components and / or hyaluronidase. A processed product may be produced by purifying the activity-inhibiting component and drying it under vacuum (freeze), or alternatively, loading the extract onto a column and then subjecting it to a concentration purification method using column chromatography of vacuum (freeze) drying. . In addition, as a processed material, it is also possible to stop the operation in each of the above-described steps before reaching the final drying step, and to select and use a shape and a concentrate according to the purpose.

Further, the skin aging inhibitor according to the present invention comprises:
It can be used for cosmetics, foods, pharmaceuticals, quasi-drugs, and the like. In cosmetics and skin external preparations of pharmaceuticals and quasi-drugs, various optional components known per se (for example, oils, humectants, thickeners, preservatives, emulsifiers, chelating agents, pigments, pH adjusters, A medicinal component, an ultraviolet absorber, and a fragrance can be appropriately blended to produce a cream, a milk lotion, a lotion, and the like.

The dosage form may be arbitrarily selected according to the purpose, such as foundation, pack, lotion, essence, ointment, gel, powder, lip balm, lipstick, sun care, bath salt, etc., in addition to the above. A whitening agent, an anti-inflammatory agent, an antioxidant, a hygroscopic agent, a humectant and the like can be appropriately added according to the purpose of the present invention within a range not to impair the purpose of the present invention.

Examples of the humectant include polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, mannitol, polyethylene glycol and dipropylene glycol, amino acids, NMF components such as sodium lactate and sodium pyrrolidonecarboxylate. , Hyaluronic acid, collagen, elastin, chondroitin sulfate, dermatan sulfate, fibronectin, heparin-like substances, and water-soluble polymer substances such as chitosan.

Examples of the thickener include natural polymer substances such as sodium alginate, xanthan gum, quince seed extract, tragacanth gum and starch, and semi-synthetic polymers such as methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, soluble starch and cationized cellulose. Examples thereof include compounds, synthetic polymer substances such as carboxyvinyl polymer and polyvinyl polymer.

Examples of preservatives include benzoate, salicylate, sorbate, dehydroacetate, paraoxybenzoate, and 2,4,4'-trichloro-2'-.
Examples include hydroxydiphenyl ether, 3,4,4'-trichlorocarbanide, benzalkonium chloride, hinokitiol, resorcinol, ethanol and the like.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, propyl gallate and ascorbic acid. Examples of ultraviolet absorbers / shielding agents include 4-methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycinnamate,
Examples include titanium oxide, kaolin, zinc oxide, and talc.

Further, as a chelating agent, for example, ethylenediaminetetraacetic acid, pyrophosphoric acid, hexametaphosphoric acid,
Examples thereof include citric acid, gluconic acid, tartaric acid, and salts thereof, and examples of the pH adjuster include sodium hydroxide, boric acid, borax, and potassium hydrogen phosphate.

[0025]

The present invention will be specifically described below with reference to examples. First, a production example of an extract such as Piper betle L. used in the present invention will be described, but the extraction method is not limited thereto.

[Production Example 1] Phyllanthus pulcher (Bail
l.) MA 100v crushed dry matter, 50v /
Add 1,000 mL of v% ethanol, and add
Stirring extraction was performed for a day. This is centrifuged and filtered under pressure,
An extract was obtained.

[Production Example 2] Pipturus argenteus (Forst.
f.) 100 g of dried leaf crushed product, 100 g of purified water
00 mL was added, and the mixture was stirred and extracted on a hot water bath for 1 hour. This was centrifuged and filtered under pressure to obtain an extract.

[Production Example 3] To 100 g of crushed dried Piper betle L. was added 1,000 mL of purified water, and the mixture was stirred and extracted on a hot water bath for 1 hour. This was centrifuged and filtered under pressure to obtain an extract.

[Production Example 4] To 100 g of crushed dried Piper betle L. leaf was added 1,000 mL of acetone, and the mixture was stirred and extracted in a dark place at room temperature for 7 days. This was centrifuged and filtered under pressure to obtain an extract.

[Production Example 5] Phyllanthus pulcher (Bail
l.) To 100 g of the crushed dried MA leaves, 1,000 mL of glycerin was added, followed by stirring and extraction at room temperature in a dark place for 7 days. This was centrifuged and filtered under pressure to obtain an extract.

[Example 1] Radical scavenging action test The radical scavenging action of the extract obtained in each of the production examples was measured under the following conditions.

(1) Measurement method 2 mL of ethanol and 0.5 mM α, α-diphenyl were added to 2 mL of 0.1 M acetate buffer (pH 5.5) containing the sample.
1 mL of an ethanol solution of -β-picrylhydral (DPPH •) was added, and after 30 minutes, the absorbance was measured at a wavelength of 517 nm. Samples were diluted to 0.2% in acetate buffer. Radical scavenging rate (%) = OD Blank OD-(
OD-OD with 0.02% BHT added) x 100 mm / (Blank OD-
OD when 0.02% BHT is added) BHT: butylhydroxytoluene

(2) Measurement results The results of the radical scavenging action of the plant extract are shown in Table 1.
Each extract was found to have a radical scavenging action corresponding to a concentration of 100 μM α-tocopherol.

(3) Discussion An extract such as Phyllanthus pulcher (Baill.) MA is extracted at a concentration of 10% with respect to a dry sample. 02% or less. On the other hand, 100 μM α-tocopherol
The weight concentration is about 0.004%. From this result, each extract contains about 20% or more of a radical scavenging component corresponding to α-tocopherol, and these extracts can be used as active oxygen scavengers in a very small amount. Can be used.

[0035]

[Example 2] SOD-like activity The SOD-like activity of the extract obtained in each Preparation Example was measured under the following conditions.

(1) Measurement method 0.05 M sodium carbonate buffer (pH 10.2)
In 4 mL, 3 mM xanthine, 3 mM EDTA, 0.1
Add 0.1 mL each of 5% bovine serum albumin and 0.75 mM nitro blue tetrazolium. This is SO
A sample containing the D-like active ingredient was added, left at 25 ° C. for 10 minutes, and then added with a xanthine oxidase solution and incubated at 25 ° C. After 20 minutes, 0.1 mL of 6 mM copper chloride solution
Was added to stop the reaction, and the absorbance at 560 nm was measured.
The concentration at which 50% of the absorbance when no sample is added is 1 unit / m
L, and the SOD-like activity was measured by the dilution factor.

(2) Measurement Results The results of the SOD-like activity of the plant extract are shown in Table 2. Each extract showed a high activity of 20,000 units / mL or more.

[0039]

(3) Discussion SOD is an enzyme that eliminates superoxide anions, and deactivates with heating, sugar addition, and time. Also,
It cannot be orally and percutaneously absorbed due to its high molecular weight.
However, the above-mentioned active oxygen-scavenging component derived from plants has low molecular weight and good stability. Oral and transdermal absorption is also expected.

Example 3 Hyaluronidase activity inhibitory test The extract obtained in each of the production examples was measured for the hyaluronidase activity inhibitory activity under the following conditions.

(1) Measurement method A sample was diluted to 10% with 0.1 M acetate buffer (pH 4.0), and 0.2 mL of the diluted solution was diluted with hyaluronidase (Ty).
pe IV-S) solution was added and incubated at 37 ° C for 20 minutes. Thereafter, 0.2 mL of the reagent was added, the mixture was further incubated at 37 ° C for 20 minutes, 0.5 mL of 0.6% hyaluronic acid was added, and the mixture was incubated at 37 ° C for 40 minutes. The reaction is stopped by adding 0.2 mL of a 0.4 N sodium hydroxide solution. Thereafter, 0.2 mL of a boric acid reagent is added, and the mixture is heated in a water bath for 3 minutes. 5 mL of a p-DAB reagent (p-dimethylaminobenzaldehyde 10% hydrochloric acid-acetic acid solution) was added, the mixture was incubated at 37 ° C. for 20 minutes, the absorbance was measured at 585 nm, and the inhibition rate was calculated from the following inhibition rate calculation formula. %). Hyaluronidase activity inhibition rate (%) = 100 − {(OD when no sample is added−OD when sample is added) / OD when no sample is added} × 100

(2) Measurement Results Table 3 shows the results of the hyaluronidase activity inhibitory action of the plant extract. Each extract was found to have a hyaluronidase activity inhibitory effect corresponding to a 20% concentration of sodium cromoglycate.

[0044]

(3) Discussion Extracts such as Pipturus argenteus (Forst.f.) Are extracted at a concentration of 10% with respect to a dry sample. 1
0% or less. On the other hand, sodium cromoglycate
At a concentration of 0.2%, the same degree of inhibition as when 10% of a plant extract is added is obtained. From these results, each extract contains about 20% or more of a hyaluronidase activity inhibitory component corresponding to sodium cromoglycate, and these extracts can be added with a very small amount of a hyaluronidase activity inhibitor. Can be used as raw material.

[Example 4] Test of degree of skin improvement by ultraviolet irradiation method of hairless mouse From the results of Examples 1, 2 and 3, it was expected that these plant extracts could improve skin loosening and rough skin. Therefore, a skin improvement test was conducted on Example 5, Formulation Example 1 and Formulation Example 3 by a hairless mouse ultraviolet irradiation method. (1) Test method A hairless mouse in which a certain amount of ultraviolet light (UVA-BLB lamp) was radiated in advance for a period of 4 months a day to induce loosening and rough skin was produced. These hairless mice (HR-
1 female) into 5 groups (8 animals per group), and apply creams, emulsions, etc. as prescribed in Table 4 twice daily in the morning and evening to the back of the hairless mouse, and after 3 months, improve skin looseness and rough skin The degree was examined based on the criteria shown in Table 5. Separately, side effects such as rash and erythema in continuous application were also examined.

[0047]

[0048]

(2) Test Results The effects were shown as the sum total, with “improvement degree +” being 1+ and “improvement degree 2+” being 2+. The No. 2 sample and the No. 4 sample of the extract formulation showed remarkable loosening and rough skin improvement effects even when compared with the respective bases. These samples did not show any skin abnormality even after continuous use (Table 6).

[0050]

(3) Discussion Phyllanthus pulcher (Baill.) MA and Piper betle
L. The extract-containing cosmetics were found to have a remarkable effect of improving skin looseness and roughness without side effects. Similar improvements can be expected in other extracts having an active oxygen scavenging action and / or a hyaluronidase activity inhibitory action.

Example 5 Preparation of an external preparation for skin An external preparation for skin having the following composition was prepared using the extract obtained in Production Example as an active ingredient. During the formulation of the prescription example,
“Appropriate amount” means an amount that becomes 100% by weight in total.

<Formulation Example 1 Cream> A (% by weight) Polyethylene glycol monostearate (40E.O.) 2.0 Self-emulsifying glyceryl monostearate 5.0 Stearic acid 5.0 Behenyl alcohol 1.0 Liquid paraffin 10 0.0 Glyceryl trioctanoate 10.0 B Glycerin 5.0 Ethyl paraben 0.1 Extract obtained in Production Example 2.0 Purified water Amount The components belonging to A are dissolved by heating. Separately, the components belonging to B are dissolved by heating. B was added to A, stirred, emulsified and then cooled to produce a cream.

<Formulation Example 2 Cream> A (% by weight) Polyethylene glycol monostearate (40E.O.) 2.0 Self-emulsifying glyceryl monostearate 5.0 Stearic acid 5.0 Behenyl alcohol 1.0 Liquid paraffin 10 0.0 Glyceryl trioctanoate 10.0 Extract obtained in Production Example 2 1.0 B Glycerin 5.0 Ethylparaben 0.1 Purified water Amount The components belonging to A are dissolved by heating. Separately, the components belonging to B are dissolved by heating. B was added to A, stirred, emulsified and then cooled to produce a cream.

<Formulation Example 3 Emulsion> A (% by weight) Polyoxyethylene sorbitan monostearate (20E.O.) 1.0 Polyoxyethylene sorbitan monostearate (60E.O.) 0.5 Lipophilic type mono Glycerin stearate 1.0 Stearic acid 0.5 Behenyl alcohol 0.5 Avocado oil 4.0 Glyceryl trioctanoate 4.0 B 1,3-butylene glycol 5.0 Extract obtained in Production Example 3 2.0 Ethyl paraben 0.1 Purified water qs The components belonging to A are dissolved by heating. Separately, the components belonging to B are dissolved by heating. B was added to A, stirred, emulsified, and cooled to produce an emulsion.

<Formulation Example 4 Lotion> (% by weight) Ethanol 15.0 Extract obtained in Production Example 1 1.0 Ethylparaben 0.1 Citric acid 0.1 Sodium citrate 0.3 1,3- Butylene glycol 4.0 Disodium edetate 0.01 Purified water Appropriate amount The above components were mixed, uniformly stirred and dissolved to produce a lotion.

<Formulation Example 5 Hydrophilic ointment> A (% by weight) Polyoxyethylene cetyl ether 2.0 Glycerin monostearate 10.0 Liquid paraffin 10.0 Vaseline 4.0 Cetanol 5.0 Obtained in Production Example 2 Extract 1.0B Propylene glycol 10.0 Methyl paraben 0.1 Purified water Appropriate amount Components belonging to A are dissolved by heating. Separately, the components belonging to B are dissolved by heating. B was added to A, stirred, emulsified, and cooled to produce a hydrophilic ointment.

[Example 6] Preparation of dressing Using the extract obtained in Production Example 3, a dressing was prepared with the following composition. <Formulation Example 1 Dressing> (% by weight) Purified water 53.0 Sesame oil 45.0 Extract obtained in Production Example 3 2.0 The extract obtained in Production Example 3 is mixed and dissolved in purified water. Thereafter, sesame oil was added and mixed by stirring to produce a dressing.

Example 7 Preparation of Oral Preparation Using the extract obtained in Production Example 2, an oral preparation was prepared with the following composition. <Formulation Example 1 Granule> (% by weight) Extract obtained in Production Example 2 1.0 Lactose 30.0 Corn starch 60.0 Crystalline cellulose 8.0 Polyvinylpyrrolidone 1.0 Polyvinylpyrrolidone is dissolved in 50% ethanol And add this to lactose, microcrystalline cellulose, corn starch,
Mix uniformly and granulate using a granulator. After drying, the granules were sized to produce granules.

Example 8 Preparation of Tablet Confectionery Using the extract obtained in Production Example 2, tablet confectionery was prepared with the following composition. <Formulation Example 1 Tablets> (% by weight) Citric acid 1.0 Skim milk powder 15.0 Sucrose ester 1.0 Fleaver 0.8 Powdered sugar 20.0 Extract obtained in Production Example 2 1.0 Lactose 61 .2 The above raw materials were mixed uniformly, an appropriate amount of a 50% ethanol solution was added, and the mixture was granulated using a granulator. After drying, it was tableted to produce tablet confections.

[0061]

EFFECTS OF THE INVENTION The extract obtained from the plant according to the present invention has an excellent active oxygen scavenging action and / or a hyaluronidase activity inhibitory action and is highly safe. The effect can be exerted by applying it to any field for the purpose of preventing skin aging such as foreign products.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 31/00 639 A61K 31/00 639C 4H025 35/78 35/78 C C09K 15/34 C09K 15/34 / / A23L 1/24 A23L 1/24 A61K 9/06 A61K 9/06 (72) Inventor Koichi Oshima 4-7-128 Kitahama, Chuo-ku, Osaka Sumitomo Forestry Co., Ltd. F-term (reference) 4B018 LB01 LB09 MD48 ME06 ME10 MF01 4B047 LB03 LB09 4C076 AA06 AA31 BB01 BB31 CC18 DD09 DD34 DD38 DD46 DD67 EE16 EE31 EE38 4C083 AA111 AA112 AA122 AB052 AC012 AC022 AC072 AC102 AC122 AC182 AC242 AC302 AC392 AC392 AC402 AC04 CC054 BA09 CA05 CA07 CA08 MA28 MA41 MA52 MA63 NA14 ZA89 ZC20 4H025 AA15 AA19 AA20 AA82 AC05 AC07 BA01

Claims (6)

[Claims] [Claim 1] Scientific name: Pipturus argenteus (Forst.f.)
(Indonesia: Trembesi) Scientific name: Phylla
nthus pulcher (Baill.) MA (Indonesia name: Nag
a buana) and a scientific name: Piper betle L. (Indonesia name: Daun sirih) A skin aging inhibitor comprising as an active ingredient at least one solvent extract of a plant selected from the group consisting of Daun sirih. 2. Scientific name: Pipturus argenteus (Forst.f.)
(Indonesia name: Trembesi) Leaf, stem and bark, Scientific name: Phyllanthus pulcher (Baill.) MA (Indonesia name: Naga buana) Leaf, Scientific name: Pipe
r betle L. (Indonesia name: Daun sirih)
The skin aging inhibitor according to claim 1, comprising a solvent extract of at least one plant selected from the group consisting of leaves, whole plants, stems and fruits as an active ingredient. 3. A cosmetic comprising the skin aging inhibitor according to claim 1 or 2. 4. A pharmaceutical comprising the skin aging inhibitor according to claim 1 or 2. A quasi-drug containing the skin aging inhibitor according to claim 1 or 2. 6. A food containing the skin aging inhibitor according to claim 1 or 2.