JP2000237312A - Drug housing kit - Google Patents

Abstract

PROBLEM TO BE SOLVED: To inexpensively provide a drug housing kit which does not require laborious preparation at all, is effectively prevented of contamination by the atmosphere air and can be extremely easily and rapidly set at a device, such as a dialyzer or syringe pump. SOLUTION: This drug housing hit has a syringe 1 which is housed with the drug (q) of a dry state in a hermetic sealing state and is projectingly provided with a nozzle 5 for discharge in a position deviating from the center at the front end face of a syringe outer barrel 2, a cylindrical body 6 which is inserted with the syringe outer barrel 2 of the syringe 1 from one end side and a first sealing member 7, intermediate sealing member 8 and second sealing member 9 which are successively freely slidably and tightly fitted into this cylindrical body 6. The discharge nozzle 5 for discharge described above is inserted through the first sealing member 7 and the front end 51 of the nozzle 5 for discharge is projected out in a front end direction. The second sealing member 9 is disposed on the other end side of the cylindrical body 6. A dissolving liquid (p) for dissolving the drug (q) is sealed between the second sealing member 9 and the intermediate sealing member 8. The front end 51 of the nozzle 5 for discharge is pressed to the intermediate sealing member 8 so that the intermediate sealing member 8 is thereby inverted.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a drug storage kit.

[0002]

2. Description of the Related Art In an extracorporeal circuit in an artificial dialyzer, a plasma separator, a blood circuit, or the like, blood is activated by a blood coagulation system due to contact with a substance or a bubble different from the intima of the blood vessel, stagnant blood flow, and the like. Therefore, it is necessary to introduce a drug for preventing blood coagulation. Examples of the drug include nafamostat mesilate (protease inhibitor).

[0003] In order to set the drug in the apparatus, for example, as shown in Figs. 21 to 23, first, a dissolving solution (for example, a 5% glucose dissolving solution) a is filled into a syringe b (see FIG. This is injected into a freeze-dried drug d distributed and stored in a glass container c, and the drug d is dissolved in the glass container c (see FIG. 22). Next, the drug solution (total drug amount: 10 to 300 mg) was filled into a syringe b, and this was set in a syringe mounting portion g of a dialyzer (or a syringe pump or the like) e (see FIG. 23).

[0004]

In the above-mentioned conventional method, as a preparatory operation, a solution a, a syringe b, and a glass container c must be prepared before use, which is very troublesome. In addition, as described above, the operation procedure for setting the device is to fill the dissolving solution a into the syringe b and inject the dissolving solution a into the drug d in the glass container c.
This requires a work of dissolving and a work of filling the syringe b with the drug d after dissolution, which is very complicated and troublesome. Therefore, in the meantime, the drug d and the solution a
There is a possibility that bacteria and foreign substances may be mixed in the air, and countermeasures have been required. Therefore, the present invention provides a low cost drug storage kit that does not require any troublesome preparation, reliably prevents air pollution, and can be set very easily and quickly in devices such as a dialyzer and a syringe pump. The purpose is to provide.

[0005]

In order to achieve the above-mentioned object, one of the drug storage kits of the present invention contains a drug in a dry state in a hermetically sealed state and has a distal end surface of a syringe barrel. A syringe having a discharge nozzle protruding at a position deviated from the center; a syringe outer cylinder of the syringe having a cylindrical body inserted from one end or a bottomed cylindrical body inserted from an opening side; The first slidably fitted to the first
A seal member, an intermediate seal member, a second seal member or a first seal member, and an intermediate seal member.
The discharge nozzle is inserted into the seal member, and the distal end of the discharge nozzle projects in the distal direction. The second seal member is disposed at the other end of the cylindrical body. A solution for dissolving the drug is sealed between the seal member or the bottom of the cylindrical body and the intermediate seal member, and the tip of the discharge nozzle is pressed against the intermediate seal member. The intermediate seal member is configured to fall over.

In addition, a syringe in which a drug in a dry state is stored in a sealed state, and a discharge nozzle protrudes from a distal end surface of the syringe outer cylinder at a position deviated from the center, and a syringe outer cylinder of the syringe Are a cylindrical body inserted from one end side or a bottomed cylindrical body inserted from the opening side, and a first sealing member, an intermediate sealing member, a second sealing member or A first seal member and an intermediate seal member, wherein a tip of the discharge nozzle is fitted to one side surface of the first seal member, and the discharge nozzle is opened toward the other side surface. At the same time, a projection is provided at a position deviated from the center of the other side surface of the first seal member, and the second seal member is disposed on the other end side of the cylindrical body, and the second seal member Alternatively, the cylinder bottom and the intermediate seal Between the wood, solution for dissolving the drug is enclosed, the protrusion, by being pressed against the intermediate seal member, the intermediate seal member is configured to fall.

[0007] Alternatively, a syringe having a discharge nozzle protruding at a position deviated from the center of the distal end surface of the syringe outer cylinder, and a syringe outer cylinder of the syringe having a cylindrical body inserted from one end side or an opening side. An inserted bottomed cylinder,
A first seal member, an intermediate seal member, a second seal member or a first seal member and an intermediate seal member sequentially and slidably fitted in the cylindrical body; The discharge nozzle is penetrated to open a distal end portion of the discharge nozzle in the distal direction, and the second seal member is disposed on the other end side of the cylindrical body, and the second seal member or the cylindrical body A solution for dissolving the drug is sealed between the bottom and the intermediate seal member, and between the intermediate seal member and the first seal member,
At the position between the intermediate seal member and the medicine, a bypass groove protruding in the outer peripheral direction is formed at the position between the intermediate seal member and the medicine.

[0008] Further, a syringe in which a solution for dissolving a drug in a dry state is sealed, and a discharge nozzle protrudes from a center of the distal end surface of the syringe outer cylinder, and a syringe is provided. The syringe outer cylinder includes a bottomed cylindrical body inserted from the opening side, a seal member and an intermediate seal member which are slidably and closely fitted in the bottomed cylindrical body sequentially, and the seal member includes The discharge nozzle is inserted and the tip of the discharge nozzle protrudes in the distal direction, and the medicine is stored between the intermediate sealing member and the bottom of the cylindrical body. The portion is pressed against the intermediate seal member so that the intermediate seal member falls down.

[0009] Alternatively, a syringe in which a solution for dissolving a drug in a dry state is sealed, and a discharge nozzle protrudes at a position deviated from the center of the distal end surface of the syringe outer cylinder; The syringe outer cylinder includes a bottomed cylinder inserted from the opening side, a seal member and an intermediate seal member that are slidably and closely fitted in the bottomed cylinder sequentially, and one side of the seal member. The tip of the discharge nozzle is fitted, the discharge nozzle is opened toward the other side, and a projection is provided at a position offset from the center of the other side of the seal member. The medicine is stored between the intermediate sealing member and the bottom of the cylindrical body, and the projecting portion is pressed against the intermediate sealing member so that the intermediate sealing member falls down. Have been.

[0010]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail with reference to the drawings showing embodiments. FIG. 1 is a partial cross-sectional view showing the configuration of a drug storage kit K, wherein 1 is a syringe, 2 is a plastic syringe outer cylinder, 21 is a flange of the outer cylinder 2, 3 is a plastic plunger, Is an elastic stopper made of a rubber material, plastic, or the like attached to the tip of the plunger 3.

At the distal end of the syringe 1, a predetermined amount of a drug q in a dry state is measured and stored in a sealed state.
A discharge nozzle 5 is provided at a position deviated from the center of the distal end surface of the syringe outer cylinder 2, and the distal end of the syringe outer cylinder 2 is connected to one end of a cylindrical body 6 made of a glass tube or a plastic tube. Slidably fitted and inserted. In the present invention, the “drug” basically refers to the above-mentioned nafamostat mesilate (protease inhibitor).

A first seal member 7, an intermediate seal member 8, and a second seal member 9 are successively slidably and closely fitted in the cylindrical body 6 described above. The seal member 7 has a through hole 71 through which the discharge nozzle 5 is inserted. The discharge nozzle 5 is inserted into the through hole 71, and the distal end portion 51 slightly projects in the distal direction.
The first seal member 7, the intermediate seal member 8, and the second
The seal member 9 is formed in a disc shape by an elastic member such as a rubber material or a plastic material, and peripheral ridges for sealing are integrally formed on both end edges.

A second sealing member 9 is provided at the other end of the cylindrical body 6.
Are provided, and the second seal member 9 and the intermediate seal member 8 are provided.
And a dissolving solution for dissolving the drug q (for example,
A required amount of 5% glucose solution) p is enclosed. The intermediate seal member 8 is formed to be relatively thin, and as described later, pushes the syringe outer cylinder 2 and presses the distal end portion 51 of the discharge nozzle 5 against the lower part of one side surface, thereby forming the inside of the cylindrical body 6. (See FIG. 2). In addition,
Although not shown, a cylindrical body with a bottom may be used instead of the cylindrical body 6.

In the drug storage kit K configured as described above (in FIGS. 1 to 4), the drug q and the solution p
Is stored in advance in a sealed state, so that there is no need to separately prepare anything, and the drug q is easily and quickly dissolved in the solution p by extremely easy workability. r (see FIG. 3) can be obtained and set on the device. Moreover, during the work up to the setting, the drug q, the dissolving solution p and the drug dissolving solution r do not come into contact with the outside air. Can be prevented. In addition, since the configuration is extremely simple, it can be easily manufactured, mass-produced, and provided at low cost.

In such a drug storage kit K, in order to further ensure the sealed state of the drug q, the solution p and the drug solution r, illustration is omitted, but for example, FIG. In the initial state shown, the syringe outer cylinder 2 and the plunger 3, the syringe outer cylinder 2 and the cylindrical body 6, and the cylindrical body 6 and the second seal member 9 are temporarily fixed to each other with a tape or a temporary fixing adhesive. This may be stored aseptically in a separately prepared hermetically sealed bag made of an aluminum vapor-deposited film material with a gore. This can be delivered to each hospital or the like, stored there, and used as needed as appropriate.

In order to set the drug storage kit K in the apparatus, first, the syringe 1 (the syringe outer cylinder 2 and the plunger 3) is kept in the cylindrical state from the initial state as shown in FIG. And into it, as shown in FIG.
The distal end portion 51 of the discharge nozzle 5 is brought into contact with one side surface of the intermediate seal member 8 and the intermediate seal member 8 is turned over.
Thereby, the filling of the solution p is released, and the solution p overflows between the first seal member 7 and the second seal member 9.

Next, as shown in FIG. 3, by pulling out the plunger 3 in the pulling-out direction, the solution p is sucked and introduced into the syringe outer cylinder 2, and the solution p is introduced into the syringe outer cylinder 2. The drug q stored in advance is dissolved. As a result, a drug solution r which can be charged into a device 15 (FIGS. 18, 19, 20) such as a dialyzer (or a syringe pump) can be obtained in the syringe outer cylinder 2. Therefore, by pulling out the syringe outer cylinder 2 from the cylindrical body 6 in the state as it is, the syringe 1 can be separated from the cylindrical body 6 and can be immediately set in the device 15.

In each operation process from the initial state shown in FIG. 1 to setting the syringe 1 on the device 15,
Since the drug q, the solution p, and the drug solution r do not come into contact with the outside air, there is no possibility that bacteria or foreign matter is mixed therein, and the contamination by the atmosphere can be extremely effectively prevented.

In the case of the dialyzer 15, for example, FIG.
As shown in FIG. 9, a pair of grooves 161 and 16 for fitting the syringe outer cylinder 2 is formed in the syringe mounting portion 16.
1 and a hook groove 162 for hooking the flange 21
And a fixing member 1 for holding and fixing the syringe outer cylinder 2
63 and a moving arm 164 for pushing and moving the base of the plunger 3. The moving arm 164 is operated to move in the guide groove 165 by a driving source provided in the main body of the dialyzer 15, and moves the drug solution r in the set syringe outer cylinder 2 per predetermined unit time. It can be supplied at a discharge amount (constant discharge speed).

FIG. 20 shows a circuit during dialysis (extracorporeal circuit 4).
1), 42 is an arterial circuit, 43 is a venous circuit, 4
4 is a heparin circuit, 45 is a bypass circuit, 46 is a physiological saline solution, 47 is a blood pump, 48 is an air trap, 49
Is a dialyzer, 50 is a pressure meter, 52 is an air trap, 53 is a bypass circuit, and the syringe outer cylinder 2 is
By being connected to the heparin circuit 44 and inhibiting the proteolytic enzyme activity in the extracorporeal circuit 41 by the drug q, blood coagulation can be effectively prevented.

FIGS. 5 and 6 show different forms of the first seal member. In this case, the intermediate seal member 8 is provided on the side surface immediately below the through hole 171 for inserting the discharge nozzle 5 of the syringe 1. Is formed integrally with the first seal member 17. Although not shown, the tip of the discharge nozzle 5 is connected to the through hole 171.
May be slightly protruded.

FIGS. 7 and 8 show another embodiment of the first seal member. In this case, a slightly tapered cylindrical body is provided at the tip end of a through hole 271 for inserting the discharge nozzle 5 of the syringe 1. Are formed integrally on the side surface of the first seal member 27. Although not shown, the tip of the discharge nozzle 5 may slightly protrude from the through-hole 271.

In each of the above embodiments, the first seal member 7, 17, 27, the intermediate seal member 8, the second seal member 9
, Respectively, are integrally formed with peripheral ridges for sealing at both ends thereof. The number of the peripheral ridges may be three, or only one. . In particular, it is preferable that the intermediate seal member 8 has only one central portion in order to easily fall. Or, instead of the circumferential ridge, O
A separate member such as a ring may be fitted to the body of each seal member. The cylindrical body 6 or the bottomed cylindrical body may be formed using a material such as plastic instead of glass.

9 to 12 show different embodiments of the drug storage kit K. In this case, the drug q is sealed and stored between the first seal member 7 and the intermediate seal member 8, and
A bypass groove 11 protruding in the outer peripheral direction is formed on the inner surface of the cylindrical body 6 at a position between the intermediate seal member 8 and the drug q.

In the setting operation, first, as shown in FIG. 10, the plunger 3 is slightly pulled outward from the initial state as shown in FIG. 9, and the second seal member 9 is pushed slightly inward. , The intermediate seal member 8 and the bypass groove 1
Move to position 1. As a result, both sides of the intermediate seal member 8 are placed in a flowing state through the bypass groove 11, and the solution p flows toward the drug q, and the drug q is dissolved by the solution p to form a solution r with the drug solution r. Become.

Next, as shown in FIG. 11, by pulling out the plunger 3 further in the pulling-out direction, the drug solution r is sucked and introduced into the syringe outer cylinder 2 to obtain the device 15 (FIGS. 18 and 19). , 20) can be obtained in the syringe barrel 2 in a state in which the drug solution r can be set. Therefore, by pulling out the syringe outer cylinder 2 from the cylindrical body 6 in this state (separating the syringe 1 from the cylindrical body 6), the syringe outer cylinder 2 can be immediately set in the device 15. Also in this case, the syringe 1 is moved from the initial state shown in FIG.
In each working process up to setting in the device 15, the drug q, the dissolving solution p and the drug dissolving solution r do not come into contact with the outside air, so that there is no danger of bacteria or foreign matter entering,
Air pollution can be reliably prevented. In addition,
Although not shown, a cylindrical body with a bottom may be used instead of the cylindrical body 6.

FIGS. 13 to 17 show another embodiment of the drug storage kit K. In this case, a cylinder 13 with a bottom is used in place of the cylinder 6, and the bottom 131 and the intermediate sealing member 8 are used.
In the meantime, while the drug q is stored in a sealed state, the solution p is sealed in the syringe outer cylinder 2. The bottomed cylindrical body 13 is not limited to the structure in which the bottom 131 is integrally formed as shown in FIGS. 13 to 17. For example, the second seal member 9 shown in FIG. The case where the bottom is formed by being fixed is also included.

In the setting operation, first, from the initial state as shown in FIG.
Then, the plunger 3) is pushed into the bottomed cylindrical body 13 as it is, and the distal end portion 51 of the discharge nozzle 5 is brought into contact with one side surface of the intermediate seal member 8 as shown in FIG. The intermediate seal member 8 is turned over. This allows
The sealed state of the drug q is released, and the solution q can be injected into the drug q.

Next, as shown in FIG. 15, by pushing the plunger 3, the dissolving solution p is discharged into the bottomed cylindrical body 13 partitioned by the first seal member 7, and the drug q is dissolved and the drug q is dissolved. After the solution r is drawn, the plunger 3 is pulled out in the pull-out direction, whereby the drug solution r is sucked and introduced into the syringe outer cylinder 2. Then, by pulling out the syringe outer cylinder 2 from the bottomed cylindrical body 13, the syringe 1 can be separated and immediately set in the device 15 shown in FIG.

Also in this case, in the process from the initial state until the syringe 1 is set in the device 15, the drug q, the solution p, and the drug solution r do not come into contact with the outside air, so that bacteria and foreign matter are not exposed. There is no risk of contamination by air, and air pollution can be reliably prevented. In the initial state, the drug q does not necessarily have to be stored in contact with the bottom 131 of the bottomed cylindrical body 13 as shown in FIG. What is necessary is just to be stored in between. Also in this case, the first seal member 7 is replaced with the first seal member 7 shown in FIGS.
You may use the sealing members 17 and 27.

[0031]

Since the present invention is configured as described above, it has the following effects. Claims 1, 2, 3, 4, and 5
According to the invention described in the above, the drug q in a dry state and a solution p for dissolving the drug q are sealed in a drug storage kit K so as not to touch the outside air, and under the sealed state,
The drug q is dissolved in the solution p to obtain a drug solution r, which can be set as it is in a device 15 such as a dialyzer or a syringe pump. Therefore, there is no need to prepare anything separately, and the setting operation can be performed very easily and quickly without skill, and (for the drug q, the solution p, and the drug solution r) Air pollution can be reliably prevented. In addition, since all of the components are extremely simple in configuration including the syringe 1 and the cylindrical body 6 or the bottomed cylindrical body 13, etc., they can be easily manufactured, mass-produced, and inexpensively provided. Can be.

[Brief description of the drawings]

FIG. 1 is a partial sectional view of an initial state showing an embodiment of a drug storage kit K of the present invention.

FIG. 2 is a partial cross-sectional view of a state where an intermediate seal member is turned over.

FIG. 3 is a partial cross-sectional view showing a state in which a drug solution is sucked into a syringe outer cylinder.

FIG. 4 is an exploded perspective view.

FIG. 5 is a perspective view showing a different form of the first seal member.

FIG. 6 is a sectional view of a first seal member.

FIG. 7 is a perspective view showing another form of the first seal member.

FIG. 8 is a cross-sectional view of the first seal member.

FIG. 9 is a partial sectional view of an initial state showing a different embodiment of the drug storage kit K.

FIG. 10 is a partial cross-sectional view showing a state where an intermediate seal member is moved to a bypass groove.

FIG. 11 is a partial cross-sectional view showing a state where a drug solution is sucked into a syringe outer cylinder.

FIG. 12 is an exploded perspective view.

FIG. 13 is a partial sectional view of an initial state showing another embodiment of the drug storage kit K.

FIG. 14 is a partial cross-sectional view illustrating a state in which the intermediate seal member is turned over.

FIG. 15 is a partial cross-sectional view showing a state where a drug solution is discharged into a syringe outer cylinder.

FIG. 16 is a partial cross-sectional view showing a state where a drug solution is sucked into a syringe outer cylinder.

FIG. 17 is an exploded perspective view.

FIG. 18 is a perspective view showing a state in which a syringe is set in a syringe attachment portion of the dialyzer.

FIG. 19 is a plan view of a syringe mounting portion to which a syringe is mounted.

FIG. 20 is a circuit diagram showing an extracorporeal circuit.

FIG. 21 is an explanatory view of an operation of injecting a solution into a syringe barrel in a conventional method.

FIG. 22 is an explanatory diagram of an operation of injecting the same solution into a drug container and then filling the syringe solution with the solution of the drug.

FIG. 23 is a perspective view showing a state where a syringe is attached to a syringe attachment portion of the dialyzer.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Syringe 2 Syringe outer cylinder 5 Discharge nozzle 51 Tip part 6 Cylindrical body 7 First seal member 8 Intermediate seal member 9 Second seal member 11 Bypass groove 13 Bottom cylinder 131 Bottom part 17 First seal member 172 Projection part 27 1 Seal member 272 Projection q Drug p Dissolution r Drug dissolution K Drug storage kit

Claims (5)

[Claims] 1. A syringe in which a drug in a dry state is housed in a sealed state, and a discharge nozzle protrudes from a center of a distal end surface of the syringe outer cylinder, and a syringe outer cylinder of the syringe. A cylindrical body inserted from one end or a bottomed cylindrical body inserted from the opening side, and a first seal member, an intermediate seal member, and a second seal member which are slidably and closely fitted in the cylindrical body in sequence. Alternatively, a first seal member and an intermediate seal member are provided, and the discharge nozzle is inserted into the first seal member so that a distal end portion of the discharge nozzle protrudes in a distal direction, and the second seal member is provided. Is disposed on the other end side of the cylindrical body, and a dissolving solution for dissolving the drug is sealed between the second seal member or the bottom of the cylindrical body and the intermediate seal member. The tip of the nozzle is A drug storage kit, wherein the intermediate seal member is configured to fall down when pressed against the intermediate member. 2. A syringe in which a drug in a dry state is stored in a hermetically sealed state, and a discharge nozzle protrudes from a center of a distal end surface of the syringe outer cylinder from a center, and a syringe outer cylinder of the syringe. A cylindrical body inserted from one end or a bottomed cylindrical body inserted from the opening side, and a first seal member, an intermediate seal member, and a second seal member which are slidably and closely fitted in the cylindrical body in sequence. Alternatively, a first seal member and an intermediate seal member are provided, and one end of the discharge nozzle is fitted to one side surface of the first seal member, and the discharge nozzle is opened toward the other side. At the same time, a projection is provided at a position deviated from the center of the other side surface of the first seal member, and the second seal member is disposed at the other end of the cylindrical body, and Member or cylindrical bottom and intermediate seal member And a dissolving solution for dissolving the drug is sealed therein, and the protrusion is pressed against the intermediate seal member so that the intermediate seal member falls down. Drug storage kit. 3. A syringe having a discharge nozzle protruding at a position deviated from the center of the distal end face of the syringe outer cylinder, and a syringe having a syringe outer cylinder inserted from one end side or from an opening side. An inserted bottomed cylindrical body, and a first seal member, an intermediate seal member, a second seal member or a first seal member, and an intermediate seal member sequentially and slidably and closely fitted in the cylindrical body; In the first seal member, the discharge nozzle is inserted, and the distal end of the discharge nozzle is opened in the distal direction. The second seal member is disposed on the other end side of the cylindrical body. A solution for dissolving the drug is sealed between the second seal member or the bottom of the cylindrical body and the intermediate seal member, and between the intermediate seal member and the first seal member. , Containing the drug in the dry state, A drug storage kit, wherein a bypass groove protruding in an outer peripheral direction is formed on the inner surface of the cylinder at a position between a seal member and the drug. 4. A syringe in which a dissolving solution for dissolving a drug in a dry state is sealed, and a discharge nozzle protrudes at a position deviated from the center of the distal end surface of the syringe outer cylinder;
The syringe outer cylinder of the syringe includes a bottomed cylindrical body inserted from the opening side, a seal member and an intermediate seal member that are slidably and closely fitted in the bottomed cylinder sequentially, and the seal member includes: The discharge nozzle is inserted and the tip of the discharge nozzle protrudes in the tip direction, and the medicine is stored between the intermediate seal member and the bottom of the cylindrical body,
A drug storage kit, wherein the tip of the discharge nozzle is pressed against the intermediate seal member so that the intermediate seal member falls down. 5. A syringe in which a solution for dissolving a drug in a dry state is sealed, and a discharge nozzle is projected from a position deviated from the center of the distal end surface of the syringe outer cylinder;
The syringe outer cylinder of the syringe includes a bottomed cylindrical body inserted from the opening side, a seal member and an intermediate seal member which are sequentially slidably and closely fitted in the bottomed cylindrical body, and On one side, the tip of the discharge nozzle is fitted, the discharge nozzle is opened toward the other side, and the seal member protrudes from the center of the other side. A portion is provided, between the intermediate seal member and the bottom of the cylindrical body, the drug is stored, and the protrusion is pressed against the intermediate seal member, whereby the intermediate seal member falls down A drug storage kit characterized by being configured as described above.