JP2006116223A - Pre-filled syringe - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a pre-filled syringe excellent in operability in performing a liquid sucking operation and a liquid discharging operation, while securing sanitation in the hollow barrel of the syringe when it is not used. <P>SOLUTION: This pre-filled syringe 1 includes a sealing member 5 for sealing the proximal end opening of the hollow barrel 2, having a through hole 51 for putting through a plunger 4. An adhesive sliding part 41 to adhere over a whole periphery is formed in the inner peripheral part of the through hole 51. Before usage, the adhesive sliding part 41 adheres onto the inner peripheral part of the through hole 51 so as to keep a sealing state in a second space 12 at the proximal end side of a gasket 3. When the plunger 4 is pulled in a proximal end direction from a state before usage, the sealing state of the second space 12 is released before the reduction rate of the volume of the second space 12 reaches 50%. When the plunger 4 is pushed in a distal end direction, the sealing state of the second space 12 is released before the increase rate of the volume of the second space 12 reaches 50% after the second space 12 is sealed again. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a syringe, and more particularly to a prefilled syringe in which a medicine is stored in advance.

  A prefilled syringe in which a powder preparation is previously stored is known. The prefilled syringe includes an outer cylinder having a mouth portion reduced in diameter on the distal end side, a gasket inserted into the outer cylinder from a proximal end opening of the outer cylinder, and a pusher (plunger rod) connected to the gasket. The powder formulation is stored in a sealed state in a space surrounded by the outer cylinder and the front end surface of the gasket.

  In such a prefilled syringe, after opening and taking out the packaging material, the mouth of the outer cylinder is connected to the infusion container, and the operation of pulling the pusher in the proximal direction is performed to move the gasket in the proximal direction in the outer cylinder. The infusion solution is sucked into the outer cylinder by sliding on the outer cylinder. Next, the powder preparation is dissolved in the inhaled infusion solution to obtain a drug solution. Thereafter, an operation of pushing the pusher in the distal direction is performed, and the gasket is slid in the distal direction in the outer cylinder, whereby the chemical liquid in the outer cylinder is discharged and the chemical liquid is injected.

  By the way, in such a prefilled syringe, outside air flows into the space on the base end side from the gasket in the outer cylinder during storage or after the packaging material is opened and before the powder formulation is dissolved, and dust is collected together with the outside air. Otherwise, foreign matter such as dust may enter or bacterial contamination may occur, which is disadvantageous in terms of hygiene.

  In view of this, a prefilled syringe is proposed that is configured so that a cap (cap 24, 13) that seals the proximal end opening is attached to the outer cylinder in an unused state (see, for example, Patent Document 1). ).

  In this prefilled syringe, since the proximal end opening of the outer cylinder (piston rod 14) is sealed when not in use, the outside air is placed in the space closer to the proximal end than the gasket in the outer cylinder during storage and transportation. Does not flow in, thus eliminating the above problem.

  However, this prefilled syringe has the disadvantages that, in use, it is necessary to remove the cap and attach a pusher to the gasket (small piston 23), which is complicated and troublesome.

  In addition, in order to eliminate the need to remove the cap and install the pusher as described above during use, the cap is provided with a hole through which the pusher is inserted in an airtight manner, and the pusher is inserted into the hole. It is also possible to apply.

  However, when such improvements are made, the following problems arise. That is, since the proximal end opening of the outer cylinder is hermetically sealed, a space closer to the proximal end than the gasket in the outer cylinder is performed in accordance with the operation of drawing the pusher in the proximal direction and sucking infusion. The pressure increases. And since the force which returns a gasket and a pusher to a front-end | tip direction acts by the increase in this pressure, the inhalation operation of infusion becomes difficult.

  Further, as the pusher is pushed in the distal direction to discharge (inject) the chemical liquid in the outer cylinder, the pressure in the space on the proximal end side from the gasket in the outer cylinder decreases. And since the force which returns a gasket and a pusher to a base end direction acts by the reduction | decrease of this pressure, discharge | emission (injection) operation of a chemical | medical solution becomes difficult.

Japanese Patent Laid-Open No. 7-246238 (paragraph number 0007, FIGS. 1 and 2)

  The objective of this invention is providing the prefilled syringe excellent in the operativity at the time of the suction | inhalation operation and discharge | emission operation of a liquid, ensuring the sanitary property in the syringe outer cylinder at the time of unused.

Such an object is achieved by the present inventions (1) to (5) below.
(1) an outer cylinder having a mouth part through which liquid can enter and exit on the tip side;
A gasket that can slide in the outer cylinder;
A pusher connected to the gasket and moving the gasket in the longitudinal direction of the outer cylinder;
A sealing member that seals the proximal end opening of the outer cylinder and has an insertion hole for inserting the pusher;
An intimate sliding portion that is formed in the middle of the longitudinal direction of the pusher and in close contact with the inner peripheral portion of the insertion hole;
A drug housed in a first space surrounded by the gasket and the outer cylinder located on the leading end side of the gasket;
When the pusher is moved in the longitudinal direction of the outer cylinder, in a predetermined range between the state where the pusher comes to the most distal side and the state where the pusher comes to the most proximal side, When the close sliding part slides in close contact with the inner peripheral part of the insertion hole, the second cylinder is surrounded by the outer cylinder, the gasket, and the sealing member positioned on the proximal end side of the gasket. A prefilled syringe in which the sealed state of the space is maintained,
In a state before use, the pusher is in a position where the second space is sealed,
When the pusher is pulled in the proximal direction from the state before use, the sealed state of the second space is released before the volume reduction ratio of the second space reaches 50%, and When the pusher is pushed in the distal direction, the sealed state of the second space is released before the increasing rate of the volume of the second space after the second space is sealed again reaches 50%. It is comprised so that it may become. The prefilled syringe characterized by the above-mentioned.

  (2) The prefilled syringe according to (1) above, wherein the drug is a solid preparation.

  (3) By pulling the pusher in the proximal direction from the state before use, the liquid is sucked into the first space, and the drug is dissolved in the liquid to obtain a drug solution. The prefilled syringe according to (1) or (2), wherein the prefilled syringe is used so as to be discharged by pushing the pusher in the distal direction.

  (4) The pre-filled syringe according to any one of (1) to (3), wherein the contact sliding portion is formed at a position closer to a base end side than a center in a longitudinal direction of the pusher.

  (5) The prefilled syringe according to any one of (1) to (4), wherein the second space is in a decompressed state when in a state before use.

  According to the present invention, it is possible to ensure the hygiene in the syringe outer cylinder when not in use, and to easily operate the pusher at the time of inhaling and discharging the liquid with a light force. Excellent.

  Hereinafter, the prefilled syringe of this invention is demonstrated in detail based on suitable embodiment shown to an accompanying drawing.

  FIG. 1 is a longitudinal sectional view showing an embodiment of a prefilled syringe (state before use) of the present invention, and FIGS. 2 to 4 are longitudinal sectional views showing operations during use of the prefilled syringe shown in FIG. is there. For convenience of explanation, the upper side in FIGS. 1 to 4 is referred to as a “base end”, and the lower side is referred to as a “tip”.

  As shown in FIG. 1, a prefilled syringe (hereinafter simply referred to as “syringe”) 1 of the present embodiment is a syringe in which a medicine 6 is stored in advance inside a syringe, and an outer cylinder (syringe outer cylinder) 2, A gasket 3 that can slide in the outer cylinder 2, a pusher (plunger rod) 4 that moves the gasket 3, and a sealing member 5 that seals the proximal end opening of the outer cylinder 2 are provided. The gasket 3 is connected to the tip of the pusher 4.

  The outer cylinder 2 is formed of a bottomed cylindrical member, and a reduced diameter part 22 that is reduced in diameter relative to the body part of the outer cylinder 2 is integrally formed at the center of the bottom part 21. The reduced diameter portion 22 forms a mouth portion through which liquid can enter and exit.

  A film 24 made of an elastic material is attached to the tip of the reduced diameter portion 22 as a sealing member, and the lumen 23 of the reduced diameter portion 22 is hermetically sealed.

  A cap 25 is fitted and fixed to the outside of the reduced diameter portion 22. An opening 26 is formed at the tip of the cap 25, and the membrane 24 is hermetically sealed by sandwiching the outer periphery of the membrane 24 between the edge of the opening 26 and the tip surface of the reduced diameter portion 22. Liquid-tight).

  The reduced diameter portion 22, the film 24, and the cap 25 are preferably bonded or fused together with an adhesive.

  The membrane 24 can be pierced by a needle body such as a double-ended needle described later. In this case, as long as the membrane 24 can be pierced by the needle body, the form is not limited to the membrane shape, and may be a block shape (plug body), for example.

  As the constituent material of the film 24, for example, those listed as constituent materials of the gasket 3 described later can be used.

  The cap 25 is used by being connected to a holder 7 described later, and also functions as a connection part with the holder 7.

  A plate-like flange 27 is integrally formed on the outer periphery of the base end of the outer cylinder 2. When the pusher 4 is moved relative to the outer cylinder 2, the operation can be performed by placing a finger on the flange 27.

  Further, a locking portion (fixing means) 28 for locking to the outer edge portion of the fixing portion 54 of the sealing member 5 to be described later and fixing the sealing member 5 is formed on the outer peripheral portion proximal end side of the flange 27. Has been. In the present embodiment, the locking portion 28 is formed in a ring shape over the entire circumference of the flange 27, but is not limited thereto, and may be formed partially such as a claw member, for example.

  As a constituent material of the outer cylinder 2, for example, polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, Various resins such as polyesters such as polyethylene terephthalate and polyethylene naphthalate, butadiene-styrene copolymers, and polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12) can be mentioned. Resins such as polypropylene, cyclic polyolefin, polyester, and poly- (4-methylpentene-1) are preferred because they are easy to mold.

  In addition, it is preferable that the constituent material of the outer cylinder 2 is substantially transparent in order to ensure internal visibility.

  In such an outer cylinder 2, a gasket 3 made of an elastic material is accommodated. A plurality of ring-shaped protrusions 31 and 32 are formed on the entire outer periphery of the gasket 3. By sliding the protrusions 31 and 32 in close contact with the inner peripheral surface 20 of the outer cylinder 2, the air tightness (liquid tightness) can be more reliably maintained and the slidability can be improved.

  In the present embodiment, two protrusions 31 and 32 are formed along the longitudinal direction of the gasket 3. That is, protrusions 31 and 32 are formed on the base end portion and the tip end portion of the gasket 3, respectively. In the present invention, the position and number of the protrusions 31 and 32, the cross-sectional shape, and the like are not limited thereto.

  The constituent material of the gasket 3 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide, Examples thereof include elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.

  The gasket 3 only needs to have at least an outer peripheral portion made of the elastic material as described above. For example, the gasket 3 has a core portion (not shown) made of a resin material. The thing of the structure by which the elastic material is arrange | positioned so that it may cover may be used.

  The gasket 3 is connected (attached) with a pusher 4 for moving the gasket 3 in the longitudinal direction within the outer cylinder 2.

  The pusher 4 has a main body portion 40, and a flange-like (plate-like) finger contact portion 45 is formed at the base end of the main body portion 40. A finger is applied to the distal end surface or the proximal end surface of the finger contact portion 45, and the pusher 4 is pulled toward the proximal end or pushed toward the distal end.

  The main body 40 is configured by a member having a cross-shaped cross section. The shape of the main body portion 40 (portion other than the close contact sliding portion 41) is not limited to this, and may be a shape in which a gas permeable groove (slit) is formed on the outer peripheral surface of the columnar member.

  A close contact sliding portion 41 is formed in the middle portion of the main body portion 40 in the longitudinal direction. The close contact sliding portion 41 has a solid round bar shape (or a hollow round bar shape) with a circular cross section. The outer peripheral surface of the close contact sliding portion 41 slides in close contact with the inner peripheral portion of the insertion hole 51 of the sealing member 5 to be described later over the entire periphery.

  The contact sliding portion 41 is formed at a position closer to the base end side than the center in the longitudinal direction of the main body portion 40 of the pusher 4. That is, the center position of the close contact sliding portion 41 is located on the proximal side from the midpoint between the position of the proximal end surface of the finger pad portion 45 and the position of the proximal end surface 36 of the gasket 3.

  As shown in FIG. 1, in a state before using the syringe 1 (hereinafter simply referred to as “pre-use state”), the position of the pusher 4 is the inner peripheral portion of the insertion hole 51 of the sealing member 5 described later. The position is such that the close contact sliding portion 41 is in close contact. Thereby, there is no circulation of air in the insertion hole 51 in the state before use, that is, the state before the operation of pulling the pusher 4 in the proximal direction. Therefore, the second space 12 surrounded by the outer cylinder 2, the gasket 3, and the sealing member 5 positioned on the proximal end side of the gasket 3 is maintained in a shut-off state (sealed state) from the outside air. As a result, foreign matter such as dust, dust and the like can be prevented from entering the second space 12 together with outside air, and bacteria can be prevented from entering, and the hygienic (sterility) of the inner peripheral surface 20 of the outer cylinder 2 can be maintained. Is done.

  In the state before use, the second space 12 may be in a reduced pressure state equal to or lower than atmospheric pressure. When the second space 12 is in a decompressed state before use, when the operation of pulling the pusher 4 and sucking the liquid into the syringe 1 is performed, the second space 12 can be sucked in a short time.

  A head portion (connecting portion) 43 that is inserted into the hollow portion of the gasket 3 and connected to the gasket 3 is formed on the distal end side of the main body portion 40. On the outer periphery of the head portion 43, a male screw that can be screwed with a female screw formed on the inner surface of the hollow portion of the gasket 3 is formed. It is connected.

  As a constituent material of the pusher 4, for example, polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate, Various resins such as polyesters such as polyethylene naphthalate, butadiene-styrene copolymers, polyacetals, polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12) can be mentioned. In view of easiness, a resin such as polypropylene, polyester, or poly- (4-methylpentene-1) is preferable.

A sealing member 5 for sealing the proximal end opening of the outer cylinder 2 is installed at the proximal end portion of the outer cylinder 2. A circular insertion hole 51 through which the main body portion 40 and the close contact sliding portion 41 of the pusher 4 are inserted is formed in the central portion of the sealing member 5. The sealing member 5 is made of an elastic material at least near the insertion hole 51. As a result, the inner peripheral portion of the insertion hole 51 is slidable while being in close contact with the outer peripheral surface of the close contact sliding portion 41 of the pusher 4, while ensuring good slidability of the pusher 4, In the state before use, it is possible to maintain a blocking property (airtightness) from the outside air of the second space 12.
The sealing member 5 also has a function of preventing the gasket 3 from coming off from the outer cylinder 2.

  The cross-sectional shape of the close contact sliding portion 41 and the insertion hole 51 is preferably circular as in the present embodiment, but is not limited to this, and there is reliable sealing performance, moderate sliding performance, and appropriate sealing release performance. If it can be obtained, it may be oval, star, regular polygon or the like.

  The constituent material of the sealing member 5 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, and silicone rubber, polyurethane, polyester, polyamide Examples thereof include various thermoplastic elastomers such as olefins, olefins, and styrenes, or elastic materials such as a mixture thereof.

In the syringe 1, a medicine 6 is stored in advance in a first space 11 which is a space surrounded by the outer cylinder 2 and the gasket 3 and located on the distal end side of the gasket 3. Examples of the form of the drug 6 include solid preparations such as powder preparations. When it is set as a powder formulation, it can enclose by freeze-drying the chemical | medical solution inject | poured in the 1st space 11 from the reduced diameter part 22, for example. Specific examples of the drug 6 include vitamin preparations (total vitamin preparations), various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, antitumor agents, analgesics, cardiotonics, intravenous anesthetics, antiparkinson agents, Examples include ulcer treatment agents, corticosteroid agents, arrhythmia agents, correction electrolytes, protease inhibitors, thromboxane synthesis inhibitors, and the like. Needless to say, the present invention is not limited to these examples.
In addition, the 1st space 11 may be in the pressure reduction state below atmospheric pressure in the state before use.

  Next, based on FIGS. 2-4, an example of the usage method of the syringe 1 is demonstrated. In the method described below, a holder (a holder with a double-ended needle) 7 is connected to the syringe 1, the infusion in the infusion container 8 is inhaled to dissolve the medicine 6, and the medicinal solution 9 obtained thereby is placed in the infusion container 8. It is an example in the case of mixed injection.

  As shown in FIG. 2, the holder 7 connected to the syringe 1 includes a bottomed cylindrical holder body 71, a double-ended needle (needle tube) 72 having sharp needle points 73 and 74 at both ends, and a double-ended needle 72. And a hub (support member) 75 for supporting the. The double-ended needle 72 is fixed to a hub 75, and the hub 75 is attached to the center of the bottom of the holder body 71 by screwing.

  The infusion container 8 has, for example, a bottle shape or a bag shape, and an infusion solution 82 is housed in a liquid-tight manner inside. A stopper 81 made of an elastic material is attached to the mouth of the infusion container 8. With the stopper 81, the infusion container 8 is sealed in a liquid-tight manner.

  The plug body 81 can be pierced by a double-ended needle 72 or other needle tube such as a bottle needle. When the needle tube is pulled out, the piercing hole is closed due to self-occlusion and ensures liquid tightness.

[1] The holder 7 and the infusion container 8 as described above are prepared. First, the needle tip 74 of the holder 7 is inserted into the stopper 81 of the infusion container 8.

  Next, the holder main body 71 of the holder 7 is fitted (covered) on the cap 25. As a result, the needle tip 73 penetrates the membrane 24 and enters the lumen 23 of the reduced diameter portion 22. In this state, the first space 11 of the syringe 1 and the internal space of the infusion container 8 communicate with each other via the double-ended needle 72.

  Note that the piercing of the needle tip 74 into the plug 81 and the piercing of the needle tip 73 into the membrane 24 may be performed in the reverse order.

[2] Next, a finger is applied to the finger contact portion 45 of the pusher 4 and the pusher 4 is pulled in the proximal direction. As a result, the gasket 3 connected to the pusher 4 slides in the proximal direction in the outer cylinder 2, and the infusion solution 82 is sucked into the first space 11.

  At this time, since the second space 12 is sealed while the outer peripheral surface of the close contact sliding portion 41 of the pusher 4 slides with the inner peripheral portion of the insertion hole 51 of the sealing member 5, As the volume of the second space 12 decreases, the pressure in the second space 12 increases.

  When the pusher 4 further moves in the proximal direction, as shown in FIG. 2, the sealed state of the second space 12 is released at the moment when the contact sliding portion 41 passes through the insertion hole 51 toward the proximal end, The second space 12 communicates through a gap between the insertion hole 51 and the main body portion 40 of the pusher 4 so that the air in the second space 12 flows out and the second space 12 becomes atmospheric pressure.

  In the syringe 1 of the present invention, when the pusher 4 is pulled in the proximal direction from the state before use, the sealed state of the second space 12 is reduced before the reduction ratio of the volume of the second space 12 reaches 50%. The formation range of the close contact sliding portion 41 is adjusted so as to be released.

That is, when the volume of the second space 12 in the state before use shown in FIG. 1 is V ₀ and the pusher 4 is pulled therefrom to release the sealed state of the second space 12 (state shown in FIG. 2) when the volume of the second space 12 of) was _{V 1,} satisfies _{(V 0 -V 1) / V} 0 × 100 <50 the relationship.

  Thereby, when the pusher 4 is pulled in the proximal direction from the state before use, the pressure in the second space 12 does not become excessive. Therefore, the pusher 4 and the gasket 3 are caused by the pressure in the second space 12. Therefore, the operation of inhaling a liquid such as the infusion 82 into the syringe 1 is easy, and excellent operability is obtained.

  When the pusher 4 is pulled in the proximal direction from the state before use, the reduction ratio of the volume of the second space 12 until the sealed state of the second space 12 is released is less than 50% as described above. Then, sufficiently excellent operability can be obtained at the time of liquid inhalation, but it is more preferably less than 30%. Thereby, the further excellent operativity is obtained.

  Further, when the pusher 4 is pulled in the proximal direction from the state before use, the reduction rate of the volume of the second space 12 until the sealed state of the second space 12 is released is 5% or more. Is preferred. Thereby, even if the pusher 4 is moved unintentionally due to an impact or the like during storage, the sealed state of the second space 12 can be reliably maintained.

[3] After the pusher 4 is further pulled in the proximal direction from the state shown in FIG. 2 and a sufficient amount of the infusion solution 82 is sucked into the first space 11, the syringe 1 is swung or vibrated and introduced. The drug 6 is dissolved in the infusion solution 82 to obtain the drug solution 9.

[4] When the drug 6 is sufficiently dissolved in the infusion solution 82 and the drug solution 9 is obtained, the pusher 4 is pressed in the distal direction. Thereby, the chemical | medical solution 9 in the 1st space 11 passes through the double-ended needle 72, and is gradually inject | poured and mix | blended with the infusion solution 82 of the infusion container 8. FIG.

  When the pusher 4 moves in the distal direction to the state shown in FIG. 3, the distal end portion of the close contact sliding portion 41 comes into close contact with the inner peripheral portion of the insertion hole 51 of the sealing member 5, so that the second space 12 is again formed. Sealed.

  When the pusher 4 further moves in the distal direction from the state shown in FIG. 3, while the outer peripheral surface of the close contact sliding portion 41 slides with the inner peripheral portion of the insertion hole 51 of the sealing member 5, the second Since the space 12 is sealed, as the volume of the second space 12 increases, the pressure in the second space 12 decreases and becomes a negative pressure.

  Then, as shown in FIG. 4, at the moment when the contact sliding portion 41 passes through the insertion hole 51 toward the distal end side, the sealed state of the second space 12 is released, and the second space 12 is connected to the insertion hole 51. Communicating with the main body 40 of the pusher 4 through a gap, outside air flows into the second space 12 and the second space 12 becomes atmospheric pressure.

  In the syringe 1 of the present invention, when the pusher 4 is pushed in the distal direction as described above, the increase rate of the volume of the second space 12 after the second space 12 is sealed again reaches 50%. The formation range of the contact sliding portion 41 is adjusted so that the sealed state of the second space 12 is released before.

That is, the volume of the second space 12 at the moment when the first space 12 is sealed again (the state shown in FIG. 3) is V _2, and the pusher 4 is further pushed from there to change the sealed state of the second space 12. When the volume of the second space 12 when released (state shown in FIG. 4) is V ₃ , the relationship of (V ₃ −V ₂ ) / V ₂ × 100 <50 is satisfied.

  As a result, when the pusher 4 is pushed in the distal direction, the pressure in the second space 12 does not become too negative, so the negative pressure in the second space 12 causes the pusher 4 and the gasket 3 to move in the distal direction. Therefore, it is easy to discharge the liquid such as the chemical liquid 9 in the syringe 1, and excellent operability is obtained.

  As described above, if the volume increase rate of the second space 12 after the second space 12 is sealed again until the sealed state of the second space 12 is released is less than 50%, the liquid is discharged. Although sufficiently excellent operability can be obtained, it is more preferably less than 30%. Thereby, the further excellent operativity is obtained.

  Moreover, it is preferable that the increase rate of the volume of the 2nd space 12 after the 2nd space 12 is sealed again until the sealed state of the 2nd space 12 is cancelled | released is 10% or more. Thereby, even if the pusher 4 is moved unintentionally due to an impact or the like during storage, the sealed state of the second space 12 can be reliably maintained.

[5] From the state shown in FIG. 4, the pusher 4 is further pushed in the distal direction, and the distal end surface of the gasket 3 is brought into contact (or approached) with the bottom 21 of the outer cylinder 2. Thereby, the remaining liquid amount in the syringe 1 of the chemical | medical solution 9 can be decreased as much as possible, and the chemical | medical solution 9 can be mix | blended (inject | pouring) into the infusion solution 82 without waste.

  As mentioned above, although illustrated embodiment of the prefilled syringe of this invention was described, this invention is not limited to this, Each part which comprises a prefilled syringe of the arbitrary structures which can exhibit the same function Can be substituted. Moreover, arbitrary components may be added.

  Moreover, the prefilled syringe of the present invention may be a combination of any two or more configurations (features) of the above embodiments.

It is a longitudinal cross-sectional view which shows embodiment of the prefilled syringe (state before use) of this invention. It is a longitudinal cross-sectional view which shows the operation | movement at the time of use of the prefilled syringe shown in FIG. It is a longitudinal cross-sectional view which shows the operation | movement at the time of use of the prefilled syringe shown in FIG. It is a longitudinal cross-sectional view which shows the operation | movement at the time of use of the prefilled syringe shown in FIG.

Explanation of symbols

1 Syringe (Prefilled syringe)
2 Outer cylinder 20 Inner peripheral surface 21 Bottom portion 22 Reduced diameter portion 23 Lumen 24 Membrane 25 Cap 26 Opening 27 Flange 28 Locking portion 3 Gasket 31 Protruding portion 32 Protruding portion 36 Base end surface 4 Pusher 40 Main body portion 41 Adhering sliding portion 43 head part 45 finger contact part 5 sealing member 51 insertion hole 54 fixing part 6 medicine 7 holder 71 holder main body 72 double-ended needle 73 needle tip 74 needle tip 75 hub 8 infusion container 81 plug body 82 infusion 9 medicinal solution 11 first space 12 Second space

Claims (5)

An outer cylinder having a mouth part through which liquid can enter and exit on the tip side;
A gasket that can slide in the outer cylinder;
A pusher connected to the gasket and moving the gasket in the longitudinal direction of the outer cylinder;
A sealing member that seals the proximal end opening of the outer cylinder and has an insertion hole for inserting the pusher;
An intimate sliding portion that is formed in the middle of the longitudinal direction of the pusher and in close contact with the inner peripheral portion of the insertion hole;
A drug housed in a first space surrounded by the gasket and the outer cylinder located on the leading end side of the gasket;
When the pusher is moved in the longitudinal direction of the outer cylinder, in a predetermined range between the state where the pusher comes to the most distal side and the state where the pusher comes to the most proximal side, When the close sliding part slides in close contact with the inner peripheral part of the insertion hole, the second cylinder is surrounded by the outer cylinder, the gasket, and the sealing member positioned on the proximal end side of the gasket. A prefilled syringe in which the sealed state of the space is maintained,
In a state before use, the pusher is in a position where the second space is sealed,
When the pusher is pulled in the proximal direction from the state before use, the sealed state of the second space is released before the volume reduction ratio of the second space reaches 50%, and When the pusher is pushed in the distal direction, the sealed state of the second space is released before the increasing rate of the volume of the second space after the second space is sealed again reaches 50%. It is comprised so that it may become. The prefilled syringe characterized by the above-mentioned.   The prefilled syringe according to claim 1, wherein the drug is a solid preparation.   By pulling the pusher in the proximal direction from the state before use, the liquid is sucked into the first space, and the drug is dissolved in the liquid to obtain a drug solution. The prefilled syringe according to claim 1, wherein the prefilled syringe is used so as to be discharged by pushing in a distal direction.   The pre-filled syringe according to any one of claims 1 to 3, wherein the contact sliding portion is formed at a position closer to a base end side than a center in a longitudinal direction of the pusher.   The prefilled syringe according to any one of claims 1 to 4, wherein the second space is in a decompressed state when in a state before the use.

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