JP2002172166A - Pre-filled syringe - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a pre-filled syringe with which a blood vessel is secured without a problem, a contamination due to a lubricant does not occur and also a metallic injector needle is easily divided from the other synthetic resin part and collected. SOLUTION: This pre-filled syringe is characterized by providing a liquid medicine cartridge 1 which is filled with a liquid medicine (m) inside and is clogged by a seal film 12 or a thin plate 14 having a small hole 15, a blind and cylindrical syringe body 2 where the injector needle is attached, a columnar body 3 erected along the center axis of a syringe body and a piston part 4 arranged in the tip part of the columnar body 3. Then the liquid medicine cartridge 1 is inserted to the syringe body 2 and the piston part 4 is put into the liquid medicine cartridge 1 with pressure and slid inside the cartridge 1 so that the liquid medicine (m) inside the cartridge 1 is injected from the tip of the injector needle 5 through a liquid passage 31 of the columnar body 3 in configuration.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a prefilled syringe in which a drug solution cartridge pre-filled with a drug solution can be directly mounted on a syringe main body and injected and administered.

[0002]

2. Description of the Related Art Conventionally, there has been proposed a prefilled syringe in which a drug solution cartridge pre-filled with a drug solution is mounted on a syringe body to perform injection administration. According to this prefilled syringe,
Compared with a normal syringe that performs drug administration by sucking and injecting a drug solution into a syringe from an ampoule or vial, it is possible to perform drug administration more quickly, and it is possible to reliably prevent contamination when filling the syringe with a drug solution.

[0003] As such a prefilled syringe, a cartridge is filled with a drug solution, the cartridge is closed with a rubber stopper serving also as a piston, and the cartridge is pressed by a columnar portion provided in the syringe body. Japanese Patent Application Laid-Open Nos. 6-98935, 8-155,028 and the like have proposed a type of syringe in which the liquid medicine inside the syringe is ejected from a syringe needle provided at the tip of the syringe body.

For example, as shown in FIG. 7, a syringe disclosed in Japanese Patent Application Laid-Open No. 6-98935 is composed of a liquid medicine cartridge b filled with a liquid medicine m and a syringe body a to which the liquid medicine cartridge b is mounted. The administration is performed as follows. That is, while inserting the drug solution cartridge b into the syringe body a,
A columnar body c erected along the axis line in the syringe main body a is inserted into the chemical solution cartridge b, and is provided on a rubber stopper d in the chemical solution cartridge b by a convex portion f provided at the tip of the columnar body c. The closed body e is pressed to open the chemical passage g provided in the rubber stopper d, and the chemical passage g communicates with the medicine passage h provided in the columnar body c. Although not shown, an injection needle is attached to the tip of the syringe main body a.

In this state, the liquid medicine cartridge b is pressed,
The rubber stopper d is inserted into the chemical cartridge b by the column c.
By sliding inside, the drug solution m in the drug solution cartridge b is ejected from a syringe needle (not shown) attached to the distal end of the syringe main body a through the drug solution passages g and h, thereby performing drug administration. Note that Japanese Patent Application Laid-Open No. 8-155
The syringe disclosed in Japanese Patent No. 028 also differs slightly in the shapes of the closing body e and the chemical solution passage g provided in the rubber stopper d.
It is configured to administer medication by a similar mechanism.

According to the prefilled syringe, as described above, the medicine can be promptly administered by a simple operation of merely mounting the drug solution cartridge b on the syringe body a, and contamination accompanying the filling of the drug solution is possible. Is prevented.

However, the prefilled syringe may be contaminated with the chemical solution b by a lubricant such as silicone grease used to improve the sliding of the rubber stopper d. That is, a lubricant such as silicone grease is usually applied or baked on the inner peripheral surface of the chemical liquid cartridge b or the outer peripheral surface of the rubber stopper d in order to smooth the sliding of the rubber stopper d. The lubricant such as silicone grease comes into contact with the drug solution m filled in the cartridge b for a long time, and the lubricant such as silicone grease is contained in the drug solution m during the preparation manufacturing process (step of filling the drug solution into the cartridge). There is a risk of mixing. Also, depending on the type of the chemical solution, it may be difficult to adopt a prefilled syringe form due to a lubricant such as silicone grease. Further, when the amount of the lubricant applied to the rubber stopper d is extremely small, since the chemical solution cartridge b and the rubber stopper d are always in contact, the lubricant diffuses over the contact surface with time, and the initial sliding is performed. This causes a problem that the resistance increases.

Further, the pre-filled syringe also has a problem in handling due to its structural reason. In other words, when performing intravenous injection, with a normal syringe, after inserting the injection needle into the blood vessel, the blood flowing through the blood vessel is caused to flow back into the syringe by slightly retracting the piston, so that the tip of the injection needle is securely inserted. A method of injecting a drug solution after confirming that it has been inserted into a blood vessel, that is, after securing a blood vessel, is employed. In the prefilled syringe shown in FIG. Since the rubber stopper d cannot be retracted, it is impossible to secure the blood vessel due to its structure.

On the other hand, a prefilled syringe capable of securing such a blood vessel is disclosed in Japanese Patent Publication No. 52-86.
No. 34 discloses a syringe. That is, as shown in FIG. 8, the syringe has screw portions j, which are screwed to both the distal end portion of the columnar body c provided in the syringe main body a and the piston d provided in the chemical solution cartridge b. j, and an injection needle k in the columnar body c.
And a liquid flow pipe p which communicates integrally with the pipe, and a tip of the liquid flow pipe p protrudes from a tip of the columnar body c. In this prefilled syringe, the liquid medicine cartridge b is inserted into the syringe body a, and the tip of the columnar body c is inserted into the liquid medicine cartridge b to screw the two screw parts j, j. In this way, the columnar body c and the piston d are connected, and the distal end of the liquid flow pipe p penetrates the partition wall r of the piston d to communicate the inside of the chemical cartridge b with the injection needle k. By pressing b and sliding the piston d, the chemical liquid m is ejected from the injection needle k.

According to this prefilled syringe, the column c and the piston d are connected by the screw portions j, j.
The piston d can be retracted, and the above-described operation of securing a blood vessel can be performed.

However, this prefilled syringe is also configured so that the piston d is previously inserted into the chemical solution cartridge b filled with the chemical solution, and thus causes the problem of contamination by the lubricant such as the silicone grease described above. It will be. In addition, since the prefilled syringe has a liquid flow pipe p, which is a metal pipe formed integrally with the injection needle k, embedded in the columnar body c, the metal injection needle k
There is also a problem that it is difficult to separate and collect the liquid flow pipe p, the syringe body a made of synthetic resin, and the chemical liquid cartridge b.

Further, in a conventional prefilled syringe,
As described above, the piston portion is pressed into the cartridge in order to close the drug solution cartridge.In this case, when the syringe body and the drug solution cartridge are joined to allow the inside of the cartridge to communicate with the drug solution passage of the syringe body, Coring may cause a problem of chemical solution leakage. For this reason, conventionally, in order to avoid this problem, Japanese Patent Publication No. Sho 56-12
No. 140 and the above-mentioned JP-A-6-98935 and 8
As shown in JP-A-155028, it is necessary to provide a special structure to the piston portion, which significantly increases the manufacturing cost, which is not practical in terms of manufacturing cost.

The present invention has been made in view of the above circumstances, has excellent handleability, can secure a blood vessel without any problem, does not cause a problem of contamination by a lubricant such as silicone grease, and further has an injection needle. It is an object of the present invention to provide a prefilled syringe capable of easily separating and collecting a metal part such as the above and other synthetic resin parts.

[0014]

In order to achieve the above object, the present invention provides, as a first invention, a bottomed cylindrical drug solution cartridge filled with a drug solution and sealed with a sealing film, and an injection needle. A cylindrical syringe main body having a bottom wall to which is attached, a columnar body having a chemical liquid passage that is erected from the bottom wall of the syringe main body along the central axis of the syringe main body and communicates with the injection needle, A piston provided on the outer periphery of the distal end of the body, wherein the medical solution cartridge is inserted into the syringe body, the seal film of the medical solution cartridge is pierced at the columnar body distal end, and the piston Is pressed into the liquid medicine cartridge, and the liquid medicine in the liquid medicine cartridge is moved by operating the liquid medicine cartridge in this state to slide the piston portion in the liquid medicine cartridge. Providing a pre-filled syringe, characterized by being configured so as to emit from the needle tip through the fluid passage.

In the prefilled syringe according to the first aspect of the invention, as described above, the liquid medicine cartridge is inserted into the syringe body, and the column provided on the syringe body is inserted into the liquid medicine cartridge. The liquid medicine in the liquid medicine cartridge is ejected from the injection needle attached to the distal end of the syringe body through the liquid medicine passage provided in the columnar body by sliding the piston part provided on the outer periphery of the tip part of the liquid medicine cartridge in the liquid medicine cartridge. It is.

In this case, in this prefilled syringe, the piston portion for pushing out the chemical solution by sliding in the chemical solution cartridge is provided at the tip of the columnar body side of the syringe body, so that the chemical solution cartridge set in the syringe body can be used. By moving the piston forward and backward, the piston portion can be moved forward and backward within the chemical liquid cartridge. Therefore, when performing intravenous injection, after inserting the injection needle into the blood vessel, by operating the drug solution cartridge to slightly retract the piston portion, the blood flowing through the blood vessel flows back into the syringe, It is possible to reliably confirm that the tip of the injection needle has been inserted into the blood vessel, and it is possible to reliably perform so-called blood vessel securing.

Further, in this prefilled syringe, the piston portion is provided on the columnar body of the syringe body, and only the drug solution is filled in the drug solution cartridge, which is sealed by the seal film. Even if a lubricant such as silicone grease is used to improve the slidability of the part, the chemical in the chemical cartridge will not come into contact with the lubricant such as silicone grease at all by applying it to the piston side. It can be formulated and stored in a state where it is not used, and it is possible to prevent the mixing of lubricants such as silicone grease as much as possible. Can also be expanded.

Further, in order to achieve the above object, the present invention provides, as a second invention, a thin plate having a small hole is slidably inserted and closed, and a chemical solution is provided inside the slide plate. And a cylindrical syringe body having a bottom wall to which an injection needle is attached, and a cylindrical syringe body having a bottom wall to which an injection needle is attached, and standing upright along the central axis of the syringe body from the bottom wall of the syringe body. A column having a drug solution passage communicating with the injection needle, and a piston portion provided on the outer periphery of the distal end portion of the columnar body, wherein the drug solution cartridge is inserted into the syringe body, and the piston portion is inserted. By press-fitting the liquid medicine into the liquid medicine cartridge and operating the liquid medicine cartridge in this state to slide the piston in the liquid medicine cartridge, the liquid medicine in the liquid medicine cartridge is filled with the small holes of the thin plate and the liquid medicine. Providing a pre-filled syringe, characterized by being configured so as to emit from the needle tip through the road.

The prefilled syringe according to the second invention uses a thin plate having small holes in place of the sealing film in the first invention, and is filled with a chemical solution by slidably inserting the thin plate. The liquid medicine cartridge is closed, and the column provided on the syringe body is inserted into the liquid medicine cartridge similarly to the prefilled syringe of the first invention, and the piston provided on the outer periphery of the distal end portion of the column is provided. Is slid in the liquid medicine cartridge, whereby the liquid medicine in the liquid medicine cartridge is ejected from the injection needle attached to the distal end of the syringe body through the liquid medicine passage provided in the columnar body.

In this case, in the prefilled syringe according to the second invention, the thin plate is pressed by the piston portion and slides with the piston portion, and is provided on the columnar body through a small hole provided in the thin plate. The chemical is pumped to the chemical passage. At this time, the medicinal solution is actually extruded from the medicament cartridge by the piston portion, and the thin plate is merely for holding the medicinal solution in the cartridge at the time of storage and distribution, and simply follows the piston portion at the time of administration. It only slides inside the chemical cartridge. Therefore, the thin plate inserted in the chemical liquid cartridge may be brought into close contact with the inner peripheral wall of the cartridge to such an extent that the leakage of the chemical liquid in the chemical liquid cartridge can be prevented, so that it is not particularly necessary to use a lubricant.

For this reason, as in the case of the first invention,
Even when a lubricant such as silicone grease is used to improve the slidability of the piston part, applying the lubricant to the piston part side ensures that the chemical solution in the chemical cartridge will not be used at all with the lubricant such as silicone grease. It can be formulated and stored in a state where it does not come in contact with it, and it can prevent the incorporation of lubricants such as silicone grease as much as possible. The range can also be expanded. In addition, the small hole formed in the thin plate does not hinder the extruding of the drug solution, and has such a diameter that the drug solution can be prevented from unexpectedly dropping due to the interfacial tension of the drug solution. However, if the pore diameter is 0.1 to 2 mm, it will be in a substantially closed state by the atmospheric pressure, the drug solution in the cartridge will not leak, and sufficient Although the liquid circulation volume can be secured,
In particular, it is preferable that the hole diameter is 0.3 to 1 mm.

In order to secure the above-mentioned blood vessels,
By slightly retreating the piston part by operating the liquid medicine cartridge, the blood flowing in the blood vessel is caused to flow back into the syringe similarly to the prefilled syringe of the first aspect of the present invention, so that the operation can be performed easily and reliably. .
In this case, the thin plate in the chemical liquid cartridge does not particularly slide, and the chemical liquid only flows through small holes provided in the thin plate.

Further, in any of the prefilled syringes according to the first and second aspects of the present invention, the columnar body is formed of a synthetic resin integrally with the syringe body, and an injection needle provided on the syringe body is detachable. Thus, the injection needle made of a metal material and the other member made of a synthetic resin can be easily separated and collected.

[0024]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described more specifically by showing examples. [First Embodiment] FIG. 1 shows an example of a prefilled syringe according to the first invention. As shown in FIG. 1, the prefilled syringe of the present embodiment includes a drug solution cartridge 1, a syringe body 2, , And a cover cap 6.

As shown in FIG. 1, the chemical liquid cartridge 1 is filled with a chemical in a container body 11 made of synthetic resin, and the chemical liquid is filled in the container main body 11 with a seal film 12 and a cover film 13. It is sealed.

The container main body 11 constituting the chemical liquid cartridge 1 is a cylindrical body having a bottom formed of synthetic resin, and has a bottom end provided with an end portion of a columnar body 3 provided on a syringe main body 2 described later. The open end portion of the container body 11 is formed to have a slightly larger diameter, and a circular step is formed along the circumferential direction on the inner peripheral surface of the boundary portion. Have been. The inside of the container main body 11 is sealed by a seal film 12 stretched over the step and a cover film 13 stretched on the opening end face, and the inside of the seal film 12 is filled with a chemical solution m. .

Here, the sealing film 12 is fixed to the step portion of the container body 11 and is not particularly limited, but may be polypropylene (PP), polyethylene terephthalate (PET), or cyclic polyolefin ( A resin film such as COC) can be used. In particular, a resin film of the same material as the container body 11 of the chemical liquid cartridge is preferably used.

On the other hand, the cover film 13 is usually
A laminated film of an aluminum foil and a synthetic resin film such as polyethylene (PE), polypropylene (PP), and ethylene vinyl alcohol (EVA), and a film in which a resin such as polyethylene, polypropylene, and ethylene vinyl alcohol is applied to an aluminum foil are used. And easy peeling state (easy peel) on the opening surface of the container body 11
It is stuck to. As shown in FIG. 1, the cover film 13 is provided with a knob 131 protruding from the periphery of the opening end of the container main body 11. Is to be peeled off.

Further, as shown in FIG. 1, the syringe main body 2 has a cylindrical main body 21 having a bottom wall, and a columnar body 3 having a columnar shape erected from a bottom surface thereof along a central axis. Things. At the center of the outer surface of the bottom wall of the cylindrical main body 21, a convex portion 22 for attaching the injection needle 5 is protruded, and a flange 23 in the form of a flange is integrally formed on the outer peripheral edge of the open end. .

The column 3 has a chemical passage 31 formed along the center line thereof. The chemical passage 31 penetrates the convex portion 22 of the cylindrical main body 21 and is formed at the tip of the convex portion 22. It is open. Further, a thick flange-shaped piston portion 4 protruding outward from an outer peripheral surface of the columnar body 3 is provided at a tip end of the columnar body 3 and penetrates the center of the piston portion 4. A penetrating tube 32 is integrally provided to protrude, and the penetrating tube 32 communicates with the drug solution passage 31,
The tip is sharply formed. Note that 32 in FIG.
Reference numerals 1 and 321 denote reinforcing ribs for reinforcing the perforated pipe 32.

The convex portion 22 of the syringe body 2 has
As shown in FIG. 1, an injection needle 5 is attached. The injection needle 5 is implanted at the top of a substantially hollow conical fitting body 51, and is detachably attached to the syringe body 2 by fitting the fitting body 51 to the projection 22. . As shown in FIG. 1, a hollow conical cover cap 6 is detachably attached to cover the injection needle 5.

Here, the container main body 11 and the syringe main body 2 are both made of synthetic resin, and the synthetic resin is polypropylene (PP),
Various synthetic resins such as polyethylene terephthalate (PET) and cyclic polyolefin (COC) are exemplified and can be appropriately selected. The resin forming the container body 11 is preferably selected in consideration of the following points. Excellent strength and hard to break. It is excellent in transparency and easy to inspect foreign matter after filling in a cartridge. Low water vapor permeability (hard to permeate). Has excellent heat resistance and can withstand sterilization by an autoclave. Little elution of additives. It is possible to obtain a cartridge which has less shrinkage during molding, has excellent molding dimensional accuracy, and has excellent adhesion (liquid tightness) to the piston portion 4 and excellent sliding properties.

Further, the piston portion 4 can be formed integrally with the columnar body 3 using the same material as the syringe body 21, but in order to improve the liquid tightness with the chemical liquid cartridge 1, It is preferable to use an elastic body. The elastic body is not particularly limited, and various rubbers and other elastomers can be used. In particular, butyl rubber or isoprene rubber is preferably used.
Further, it is preferable that a lubricant such as silicone grease is applied or baked on the outer periphery of the piston portion 4 in order to improve the slidability with the inner peripheral surface of the liquid medicine cartridge 1.

Next, a method of using the prefilled syringe and an operation at the time of use will be described. When performing injection using this pre-filled syringe, first, as shown in FIG.
Is peeled off, the opening end of the drug solution cartridge 1 is opened, and as shown in FIG. 2B, the drug solution cartridge 1 is inserted into the syringe body 2 from the opening end side, and the syringe body 2 The tip of the columnar body 3 is inserted into the liquid medicine cartridge 1.

In this state, the liquid medicine cartridge 1 is pressed into the syringe main body 2 and breaks through the sealing film 12 at the tip of the penetration tube 32 provided at the tip of the columnar body 3.
As shown in (C), the piston part 4 is press-fitted inside the step portion of the liquid medicine cartridge 1. in this case,
Piston part 4 inserted into opening of chemical liquid cartridge 1
Is in liquid-tight contact with the inner peripheral wall of the opening of the liquid medicine cartridge 1 to prevent the liquid medicine m from leaking out of the liquid medicine cartridge 1 when the seal film 12 is pierced. By being pressed inside,
It is loaded into the drug solution cartridge 1 while the liquid-tight state is reliably maintained.

At this time, as shown in FIG. 2C, by removing the cover cap 6 and slightly pushing the liquid medicine cartridge 1 with the injection needle 5 upward,
The liquid medicine m in the liquid medicine cartridge 1 is introduced into the liquid medicine passage 31 of the columnar body 3 through the penetrating tube 32, and a small amount of the liquid medicine m is discharged from the tip of the injection needle 5. The space up to the tip of the injection needle 5 is filled with the drug solution m.

In this state, the injection needle 5 is inserted into a predetermined part of the patient, and as shown in FIG. 1 to the bottom wall side, the chemical liquid m in the chemical liquid cartridge 1
Through the tip of the injection needle 5 and inject it into a predetermined site of the patient. Then, as shown in FIG. 2 (E), by pushing the liquid medicine cartridge 1 to the deepest part of the syringe main body 2, the penetration pipe 3 provided at the tip of the columnar body 3 is formed.
2 and the reinforcing ribs 321 and 321 are inserted into recesses provided in the bottom wall of the liquid medicine cartridge 1, and the piston portion 4 slides to a position where it comes into contact with the inner surface of the bottom wall of the liquid medicine cartridge 1 to fill the liquid medicine cartridge 1. Almost all of the drug solutions m are injected and administered to the patient. In this case, as shown in FIG. 2 (E), the chemical solution passage 31 and the fitting body 5 of the injection needle 5 are formed.
Since a small amount of the liquid medicine m remains in the liquid medicine 1, the amount of the liquid medicine to be filled in the liquid medicine cartridge 1 is set in consideration of the residual amount so as to conform to the "actual volume test of the injection". Just fine.

In the case of performing intravenous injection using the prefilled syringe of this example, the liquid medicine is filled up to the tip of the injection needle 5 by the same operation as shown in FIGS. 2A to 2C. In the state shown in FIG. 3A in which the air was evacuated, the injection needle 5 was inserted into a vein at a predetermined site of the patient, and as shown in FIG. By retracting, the piston portion 4 is slightly retracted to the open end side in the liquid medicine cartridge 1. Thus, if the tip of the injection needle 5 is inserted into the vein, the blood t in the blood vessel flows back into the syringe as shown in FIG.
To confirm that the tip of the injection needle 5 is securely inserted into the blood vessel. Then, after securing the blood vessel, the drug solution cartridge 1 is slowly pressed in similarly to the above, and the drug solution m is injected into the vein.

[Second Embodiment] FIG. 4 shows an example of a prefilled syringe according to the second invention.
In this prefilled syringe, the sealing film 12 in the prefilled syringe of the first embodiment is replaced with a thin plate 14, and a penetration pipe 32 (see FIG. 1) and a reinforcing rib 321 (see FIG. 1) are provided at the tip of the columnar body 3. Instead, the chemical solution passage 31 is directly opened at the center of the upper surface of the piston portion 4. Since other configurations are the same as those of the prefilled syringe of the first embodiment, the same portions are denoted by the same reference numerals as those of the first embodiment, and description thereof will be omitted.

As shown in FIG. 4, the thin plate 14 has a spherical concave portion formed in the central portion on one side and a slightly thin central portion, and a small hole 15 formed in the central portion. It is a disc-shaped thing perforated.

The thin plate 14 is slidably inserted into the chemical liquid cartridge 1 to close the chemical liquid cartridge 1 in the vicinity of the opening surface.
Is filled. In this case, the contact between the outer peripheral surface of the thin plate 14 and the inner peripheral surface of the chemical liquid cartridge 1 is relatively gently pressed within a range that does not cause liquid leakage, and relatively smoothly without using a lubricant such as silicone grease. It can slide inside the chemical liquid cartridge 1.

The small hole 15 of the thin plate 14 is
Has a hole diameter that allows a sufficient amount of liquid flow to be obtained at the time of administration, so that the liquid medicine m in the cartridge 1 does not leak from the small holes 15. The specific pore size of the small holes is appropriately set depending on the type of the liquid m, the dosage, the required dosage rate, and the like, and is not particularly limited, but is usually 0.1 to 2 mm, particularly 0.3 mm.
It is preferable that the thickness be set to 1 mm, whereby the leakage of the chemical liquid m can be reliably prevented, and a sufficient liquid circulation amount can be reliably ensured.

The material of the thin plate 14 is not particularly limited, and can be formed by using an appropriate synthetic resin. In particular, it is preferable to use the same resin as the resin forming the chemical liquid cartridge 1.

The administration with the prefilled syringe according to the second embodiment may be performed in the same manner as in the first embodiment. That is, as shown in FIG. 5, the cover film 13 attached to the opening of the chemical liquid cartridge 1 is peeled off (FIG. 5).
(A)), the liquid medicine cartridge 1 is inserted into the syringe body 2, and the piston 4 provided at the tip of the columnar body 3 of the syringe body 2 is pressed into the liquid medicine cartridge 1 (FIG. 5B). After removing air from the syringe by removing the cover cap 6 and slightly pressing the liquid medicine cartridge 1, the injection needle 5 is inserted into a predetermined part of the patient, and the liquid medicine cartridge 1 is inserted into the syringe body 2. By pushing in, the piston part 4 is slid in the drug solution cartridge 1 and the drug solution m in the drug solution cartridge 1 is injected from the tip of the injection needle 5 through the drug solution passage 31 to a predetermined site of the patient (FIG. 5 (D) (E)). ))

In this case, in the prefilled syringe of this embodiment, the thin plate 14 comes into contact with the surface of the piston portion 4 pressed into the chemical liquid cartridge 1, and the thin plate 14 slides with the sliding operation of the piston portion 4. Then, the chemical liquid m in the chemical liquid cartridge 1 flows into the chemical liquid passage 31 through the small hole of the thin plate 14, and is ejected from the injection needle 5.

Also, when performing intravenous injection using this pre-filled syringe, it may be performed in the same manner as in the first embodiment. That is, after the injection needle 5 is inserted into a vein at a predetermined site of a patient in a state where air is evacuated (the same state as that in FIG. 5C) shown in FIG. As shown in (2), the chemical liquid cartridge 1 is slightly retracted, and the piston portion 4 is slightly retracted in the chemical liquid cartridge 1.
As shown in the figure, the blood t in the blood vessel is caused to flow back into the syringe and the blood t is confirmed, thereby confirming that the tip of the injection needle 5 is securely inserted into the blood vessel. is there. As shown in FIG. 6 (B), when securing the blood vessel, the pre-filled syringe of the present embodiment uses:
The thin plate 14 does not slide (retreat), and only the piston portion 4 retreats.

As described above, in the prefilled syringes of the first and second embodiments, the liquid medicine cartridge 1 is inserted into the syringe body 2 and the columnar body 3 provided on the syringe body 2 is filled with the liquid medicine. By inserting into the cartridge 1 and sliding the piston portion 4 provided on the outer periphery of the distal end portion of the columnar body 3 in the chemical liquid cartridge 1,
The liquid medicine m in the liquid medicine cartridge 1 is ejected from the injection needle 5 attached to the tip of the syringe main body 2 through the liquid medicine passage 31 provided in the columnar body 3.

In this case, with these prefilled syringes, the chemical liquid m
The piston part 4 that pushes out the columnar body 3 on the syringe body 2 side
Since it is provided at the distal end, the piston portion 4 can be advanced and retracted in the medical solution cartridge 1 by moving the medical solution cartridge 1 set in the syringe body 2 forward and backward. Therefore, when an intravenous injection is performed, after the injection needle is inserted into the blood vessel, the drug solution cartridge 1 is operated to slightly retract the piston portion 1 as described above, so that the blood flowing through the blood vessel is syringed. It is possible to confirm that the tip of the injection needle 5 is securely inserted into the blood vessel by flowing back into the blood vessel, so that a so-called blood vessel can be reliably secured.

Further, in this prefilled syringe, the piston portion 4 is provided on the columnar body 3 of the syringe main body 2, only the drug solution is filled in the drug solution cartridge 1, and the drug solution cartridge 1 is formed by the seal film 12 or the thin plate 14. Can be closed and sealed with the cover film 13. Therefore, even when a lubricant such as silicone grease is used to improve the slidability of the piston portion 4, the lubricant is applied to the piston portion 4 side. By doing so, the drug solution in the drug solution cartridge 1 can be formulated and distributed and stored in a state where it does not come into contact with any lubricant such as silicone grease, and the mixing of lubricant such as silicone grease can be prevented as much as possible. In addition, the influence of these lubricants is hardly considered, so that the range of applicable drugs can be expanded.

Further, in these pre-filled syringes, since the columnar body 3 is formed of a synthetic resin integrally with the syringe main body 2 and the injection needle 5 is detachably attached to the syringe main body 2, the prefilled syringe is made of metal. The injection needle 5 made of a material and another member made of a synthetic resin can be easily separated and collected.

The prefilled syringe of the present invention
The present invention is not limited to the first and second embodiments, and the shapes, arrangements, combinations, materials, and the like of the respective members may be appropriately changed without departing from the gist of the present invention.

[0052]

As described above, according to the pre-filled syringe of the present invention, the blood vessel can be secured easily without any problem and the problem of contamination by a lubricant such as silicone grease does not occur. Further, the metal portion such as the injection needle and the other synthetic resin portion can be easily separated and collected.

[Brief description of the drawings]

FIG. 1 is a schematic sectional view showing a prefilled syringe according to one embodiment of the present invention.

FIG. 2 is a schematic cross-sectional view for sequentially explaining an operation and an operation at the time of dispensing using the prefilled syringe.

FIG. 3 is a schematic cross-sectional view illustrating an operation and an operation for securing a blood vessel when performing intravenous injection using the prefilled syringe.

FIG. 4 is a schematic sectional view showing a prefilled syringe according to another embodiment of the present invention.

FIG. 5 is a schematic cross-sectional view for sequentially explaining an operation and an operation at the time of dispensing using the prefilled syringe.

FIG. 6 is a schematic cross-sectional view illustrating an operation and an operation for securing a blood vessel when performing intravenous injection using the prefilled syringe.

FIG. 7 is a schematic sectional view showing an example of a conventional prefilled syringe.

FIG. 8 is a schematic sectional view showing another example of a conventional prefilled syringe.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Chemical liquid cartridge 11 Container main body 12 Seal film 13 Cover film 14 Thin plate 15 Small hole 2 Syringe main body 21 Cylindrical main body 3 Columnar body 31 Chemical liquid passage 32 Penetration tube 4 Piston part 5 Injection needle 6 Cover cap m Chemical liquid t Blood

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Kaori Ikeda 2-1-3 Kouse Terajima, Amagasaki City, Hyogo Prefecture Shionogi F-term (reference) 4C066 AA09 BB01 CC01 DD07 EE06 FF05 GG07 GG18

Claims (6)

[Claims] 1. A bottomed cylindrical drug solution cartridge filled with a drug solution and sealed with a sealing film, a cylindrical syringe body having a bottom wall to which an injection needle is attached, and a bottom wall of the syringe body. A cartridge having a columnar body standing upright along the central axis of the syringe main body and having a chemical solution passage communicating with the injection needle, and a piston portion provided on the outer periphery of the distal end portion of the columnar body. Is inserted into the syringe body, the seal film of the liquid medicine cartridge is pierced at the tip of the columnar body, and the piston portion is pressed into the liquid medicine cartridge. In this state, the liquid medicine cartridge is operated to operate the liquid medicine cartridge. The piston is slid within the cartridge so that the liquid medicine in the liquid medicine cartridge is ejected from the tip of the injection needle through the liquid medicine passage. Prefilled syringe. 2. The prefilled syringe according to claim 1, wherein said seal film is a film made of polypropylene, polyethylene terephthalate, or cyclic polyolefin. A thin plate having a small hole is slidably inserted and closed, and a bottomed cylindrical drug solution cartridge filled with a drug solution inside the sliding plate, and an injection needle are attached. A cylindrical syringe body having a bottom wall provided, a columnar body standing upright from the bottom wall of the syringe body along the central axis of the syringe body, and having a drug solution passage communicating with the injection needle; And a piston portion provided on the outer periphery of the distal end portion.The medicinal solution cartridge is inserted into the syringe body, the piston portion is pressed into the medicinal solution cartridge, and the medicinal solution cartridge is operated in this state. By sliding the piston portion in the chemical liquid cartridge, the chemical liquid in the chemical liquid cartridge is ejected from the tip of the injection needle through the small hole of the thin plate and the chemical liquid passage. A prefilled syringe characterized by the following. 4. The small hole provided in said thin plate has a hole diameter of 0.
The pre-filled syringe according to claim 3, which is 1 to 2 mm. 5. The sealing film or the thin plate is disposed slightly inside the opening surface of the liquid medicine cartridge, and the opening surface of the liquid medicine cartridge is opened and sealed by a cover film. The prefilled syringe according to any one of claims 1 to 4, wherein the inside is sterilized. 6. The prefilled syringe according to claim 1, wherein an injection needle attached to the syringe body is detachable.