JP3949124B2 - Cap and prefilled chemical container - Google Patents

Description

  The present invention relates to a container (so-called prefilled syringe) filled with a chemical solution in advance and a cap used therefor.

  Prior to administration of an infusion solution to a patient, various drugs such as vitamins, minerals, and antibiotics are blended into the infusion solution filled in the infusion container as necessary.

  Moreover, in the field of emergency medical care, multiple combined use and large-scale administration of an autonomic nerve action drug, a pressor medicine, etc. are performed with the syringe.

  Such compounding and administration of drugs are performed by sucking a drug solution from a vial with a syringe and then injecting the drug solution into an infusion container or directly into a blood vessel. However, the compounding and administration of such a drug has a drawback in that the operation is complicated, and it takes a long time for compounding and administration. Furthermore, since the above operation is performed in contact with the atmosphere, there is a risk of bacterial contamination or contamination.

  In order to solve these problems, a so-called prefilled syringe has been proposed in which a syringe is prefilled with a chemical solution and a nozzle cap is provided with a rubber cap. However, the conventional prefilled syringe is covered with the syringe nozzle in close contact with the cap. Therefore, during high-pressure steam sterilization, steam did not enter between the nozzle and the cap, and this portion could not be sterilized. In order to solve this problem, there has been proposed one in which a gap is provided between the nozzle and the cap so that steam enters.

  However, even when a gap is provided between the nozzle and the cap so that vapor can enter, drying is not easily performed after the sterilization process is completed, and the remaining moisture may become a source of mold and the like. There was a problem.

  Further, when the packaging material is opened and taken out, the instrument is exposed to the external atmosphere, so that the exposed parts on the surface are particularly easily contaminated with bacteria.

  Accordingly, an object of the present invention is to provide a cap that can completely sterilize the nozzle part during sterilization, can be easily and reliably dried after sterilization, and is hardly contaminated with bacteria even during use, and a prefilled chemical solution container equipped with the cap. It is to provide.

Such an object is achieved by the present inventions (1) to (6) below.
(1) A cap which is provided with a nozzle for discharging a chemical liquid and is covered with the nozzle of a chemical liquid container filled with the chemical liquid, and seals a tip opening of the nozzle in a liquid-tight manner,
A cap body having a through hole in the center of the distal end and a base end being an open end, and having a locking portion for locking with the nozzle in a state having a gap on the base end side;
The nozzle is installed in the cap body so as to close the proximal end opening of the through-hole, and is composed of a resealable rubber member that can be pierced with a hollow needle, and the nozzle is in a state where the locking portion is locked to the nozzle. And a sealing member for sealing the tip opening of the liquid-tight,
The through-hole has a tapered portion tapered such that the inner diameter gradually decreases in the proximal direction, and the inner surface of the tapered portion guides the hollow needle pierced by the sealing member A cap characterized by having a function.

(2) A cap that is provided with a nozzle for discharging a chemical solution and is covered with the nozzle of a chemical solution container filled with the chemical solution, and seals the tip opening of the nozzle in a liquid-tight manner,
A cap body having a through hole in the center of the distal end and a base end being an open end, and having a locking portion for locking with the nozzle in a state having a gap on the base end side;
The nozzle is installed in the cap body so as to close the proximal end opening of the through-hole, and is composed of a resealable rubber member that can be pierced with a hollow needle, and the nozzle is in a state where the locking portion is locked to the nozzle. And a sealing member for sealing the tip opening of the liquid-tight,
The through hole is located on the distal end side, a large diameter portion having a constant inner diameter, a proximal diameter side, a small diameter portion having an inner diameter smaller than the inner diameter of the large diameter portion, and the large diameter portion and the small diameter portion Consists of a tapered portion that is positioned between and tapered such that the inner diameter gradually decreases in the proximal direction.
An inner surface of the tapered portion has a function of guiding a hollow needle pierced by the sealing member.

  (3) The cap according to (1) or (2), wherein a ring-shaped rib is formed so as to protrude from a front end surface of the cap body so as to surround a front end opening of the through hole.

  (4) The cap according to any one of (1) to (3), wherein a groove extending in an axial direction is formed on an outer peripheral surface of the cap body.

  (5) The cap according to any one of (1) to (4), wherein the cap body and the sealing member have transparency.

(6) A container having a chemical solution storage section in which a space defined by the inner wall is filled with a chemical solution, a nozzle having an opening for discharging the chemical solution stored in the chemical solution storage section, and a chemical solution discharge mechanism for discharging the chemical solution The body,
An already-filled drug solution container comprising the cap according to any one of (1) to (5) above.

  According to the present invention, since there is a gap between the nozzle and the cap, the sterility of the injection needle mounting portion of the nozzle is maintained until just before the injection needle is mounted. As a result, moisture between the nozzle and the cap can be easily removed, clouding of this portion can be prevented, and generation of mold and bacteria due to residual moisture can be prevented.

  In addition, the present invention can continuously mix or administer pre-filled drug solution containers filled with different types of drugs having the same type of cap by combining with a holder having a double-ended needle combined with a re-seal tip on a needle tube. Can do.

  Moreover, since this invention has a through-hole in the front-end | tip center part of a cap, and it is comprised so that the base end of this through-hole may be sealed with a sealing member (reseal member), the double-ended needle ( The sealing member that is punctured with a hollow needle) exists in a position retracted from the distal end surface of the cap to the proximal end side by a predetermined distance. Sex is maintained.

  And since a through-hole is a shape which has a taper part, when puncturing a hollow needle in a sealing member, a hollow needle can be guided and guided appropriately by the taper surface of a taper part.

  First, an embodiment of the pre-filled chemical solution container of the present invention will be described. The pre-filled chemical solution container of the present invention can sterilize the nozzle with a cap that seals the nozzle of the container body containing the chemical solution discharged by the chemical solution discharge mechanism In this way, it is possible to eliminate the risk of generation of soot due to the cloudiness of the inner surface of the cap and the moisture remaining between the cap and the nozzle, which may occur in the case where there is a gap through which steam can pass between the nozzle and the nozzle. it can. That is, the cap has a sealing portion for liquid-tightly sealing the inside of the container body on the closed end side of the cap, and has a locking portion for locking with the nozzle in a state having a gap on the cap open end side. The space between the closed end and the open end of the cap has a space formed by the inner surface of the cap and the outer surface of the nozzle. After sterilization, water remaining between the inner surface of the cap and the outer surface of the nozzle can be easily removed. Can be transpiration. As a result, the possibility of cloudiness and wrinkles in the cap portion was eliminated.

  The chemical solution storage part is filled with chemical solutions such as vitamins, antibiotics, anticancer agents, etc. in the internal space according to the intended use. As the material for the chemical solution storage part, glass, polypropylene, polyethylene, polystyrene, synthetic resins such as various elastomers, or metals such as stainless steel and aluminum can be used, and an appropriate material should be selected according to the structure of the chemical solution discharge mechanism described later. However, it is preferable that the material is transparent so that the filled chemical solution can be visually observed. In addition, when the prefilled chemical solution container is filled with a chemical solution that is easily altered by gas or moisture such as oxygen contained in the atmosphere during sterilization or storage, select a material that is impermeable to gas and moisture impervious respectively. It is preferable to do. Examples of these include glass, metals such as stainless steel and aluminum, synthetic polyolefins such as cyclic polyolefin, polyvinyl alcohol, etc., and synthetic resins coated with silicon oxide, aluminum oxide or the gas / water impermeable resin described above, Furthermore, there is a multilayer structure in which these are used as one of layer components as required. In addition, since the prefilled chemical solution container is sterilized by moist heat, it is preferable to have heat resistance to withstand this.

  The nozzle has an internal passage through which the chemical liquid filled in the chemical liquid storage portion can be discharged to the outside, and both ends of the passage communicate with the outside and the chemical liquid storage portion, respectively. The nozzle is preferably formed of the same material integrally with the chemical solution storage unit.

  Next, the chemical solution discharge mechanism will be described. The chemical solution discharge mechanism is for discharging the filled chemical solution from the chemical solution storage part to the outside through the nozzle, and preferably has a structure for discharging by applying pressure to the chemical solution.

  Specifically, there is a configuration in which a chemical solution storage portion is formed flexibly with a synthetic resin or the like, and discharge is possible by applying an external pressure to the chemical solution storage portion to pressurize the chemical solution. Synthetic resins such as polyvinyl chloride, polypropylene, polyethylene, and various elastomers can be used as the material for forming the chemical solution storage section. When a slightly hard material is used, the chemical solution can be thinned to make it easier to press or additives. It is preferable to soften. In addition, when it is judged that the selected material for forming the chemical solution storage portion has insufficient hardness as a nozzle, the nozzle may be formed with a separate member and integrated with the drug storage portion.

  Moreover, a chemical solution discharge mechanism can also be provided to an already-filled chemical solution container by configuring the chemical solution storage portion in a so-called syringe shape. That is, the hard chemical storage part is formed into a cylindrical body that is open at one end and closed at the other end, and the open end is liquid-tightly sealed so that it can slide in the axial direction in a liquid-tight manner. And a nozzle on the other end side that is closed, so that the chemical solution in the chemical solution storage section can be discharged. It is preferable that a plunger is connected to the gasket in advance or immediately before use to facilitate the discharge of the chemical solution. In the case of being bonded in advance, the gasket and the plunger can be combined by fitting or integrally formed by integral molding. Moreover, when connecting both just before use, a pair of male and female screws can be provided on the gasket and the plunger, or a ratchet mechanism can be employed. The material forming the cylindrical body is a material that can harden the cylindrical body, and glass, stainless steel, aluminum and other metals, and synthetic resins such as polypropylene and cyclic polyolefin are preferable. As a material for forming the gasket, natural rubber, synthetic rubber, and various elastomers can be used. Further, the plunger forming material is formed of a hard material that can withstand the operation of discharging and sucking the chemical solution, and can be appropriately selected from various hard materials such as glass, metals such as stainless steel and aluminum, and hard synthetic resins such as polypropylene and polystyrene. .

  The cap of the present invention is mounted on the container body and seals so that the chemical liquid filled in the chemical liquid storage portion is not discharged from the nozzle until use. The cap is formed of a hollow body having a closed end (tip end) and an open end (base end opening), and the nozzle tip opening is liquid-tightly sealed on the closed end side.

  The cap body constituting the cap can be formed of a metal such as stainless steel or aluminum, a synthetic resin such as polyethylene or polypropylene, and the sealing member that is in contact with the tip opening of the nozzle is vulcanized natural rubber or Forming with an elastic body such as synthetic rubber and various elastomers is preferable because it can be more reliably sealed. Also, it is made of a material such as a synthetic resin or rubber that can be pierced with a needle at least in the center of the sealing member, preferably a material having resealability, or a material that does not easily cause coring in a hollow needle that has been pierced. If formed, it is possible to administer a drug solution by directly inserting a hollow needle such as a double-ended needle into the central portion of the sealing member while the cap is attached to the nozzle. At that time, if the central portion of the sealing member is provided at a position drawn from the outer peripheral edge of the cap tip, the portion that becomes the piercing portion of the hollow needle even if the cap or the pre-filled drug solution container with the cap is taken out of the packaging It can be prevented from being contaminated. The pull-in distance (= depth of the through hole) is preferably 2 mm or more.

  Further, a convex portion may be formed on the inner surface of the cap closed end, and sealing may be performed between the convex portion and the inner surface of the nozzle in a state where the convex portion is fitted into the inner surface of the nozzle. In this case, the seal between them can be configured by taper fitting, or the convex portion can be an elastic body and can be brought into close contact with the inner surface of the nozzle.

  The cap further has a locking portion that locks with the nozzle at the proximal end. The locking portion has a gap for water vapor to enter between the cap and the nozzle during sterilization. As this gap, for example, a gap between screws generated by configuring the locking portion with a pair of male and female screws can be used.

  A space formed by the inner surface of the cap and the outer surface of the nozzle is provided at an intermediate portion between the closed end and the open end inside the cap. By this space portion, the water vapor introduced between the nozzle and the cap for sterilization can be easily discharged and dried after sterilization. The distance between the cap inner surface and the nozzle outer surface is preferably 0.2 to 1 mm.

  In addition, it is preferable that each part forming the cap has transparency so as to facilitate confirmation of liquid leakage or the like. Moreover, it is preferable that a nozzle and a chemical | medical solution storage part also have transparency for the same reason or confirmation of the contents.

Hereinafter, the present invention will be described in detail based on the prefilled syringe shown in the drawings.
FIG. 1 is a longitudinal sectional view of a prefilled syringe according to an embodiment of the present invention, and FIG. 2 is a longitudinal sectional view showing an embodiment of the cap of the present invention. The prefilled syringe 1 is composed of a syringe body 2 and a cap 3. The syringe body 2 includes a cylindrical body 21 filled with a chemical solution A, a nozzle 22, a gasket 23, and a plunger 24. The cylindrical body 21 is made of cylindrical polypropylene, cyclic olefin, or the like, and has a distal end closed and a proximal end opened. A pair of flanges 21a are provided opposite to the base end. A nozzle 22 is provided integrally with the cylindrical body 21 at the closed end, and has an internal passage 22 a through which the filled chemical A can be discharged through the nozzle 22. The nozzle 22 has a male screw 22b which forms a screwing part in a pair with the base end side of the cap 3 on the base end side outer surface. Further, the outer surface on the front end side from the male screw 22b is a luer taper to enable connection to a three-way stopcock or the like. The gasket 23 is inserted from the proximal end opening of the tubular body 21 so as to be slidable in the axial direction while maintaining liquid tightness with the inner surface of the tubular body, and the movement of the chemical A in the proximal direction of the tubular body is restricted. is doing. The gasket 23 is formed of butyl rubber, vulcanized natural rubber, or the like, and a lubricant such as silicone is applied as necessary to improve the slidability, or a synthetic resin such as a fluororesin having a low friction coefficient at the sliding portion. A resin may be arranged. A plunger 24 made of a material such as polypropylene is fixed to the base end of the gasket 23 by screw fitting. Therefore, since it can be removed from the gasket 23 before use, the storage space can be reduced.

  The cap 3 is composed of a cap body 31 and a rubber film (sealing member: a resealable rubber member that can be pierced with a hollow needle) 32. The nozzle 3 is covered with a cap 3, and a rubber film 32 seals the internal passage 22 a of the nozzle 22 at its front end opening, and the filled chemical solution A restricts movement in the front end direction of the cylindrical body.

  As shown in FIG. 2, the cap body 31 has a through hole 31 a at the center of the tip, and the through hole 31 a is tapered so that an injection needle (hollow needle) can be easily pierced. By forming the tip portion thick, the distance between both ends of the through-hole is increased, so that the rubber film 32 described later is not contaminated even when it is opened from a packaging material (not shown) and exposed to the external atmosphere. . On the inner surface of the base end portion of the cap body 31, there is a female screw (locking portion) 31b that makes a pair with the male screw 22b of the nozzle 22 described above. The male screw 22b and the female screw 31b have a gap B through which gas can flow in the axial direction in a screwed state, and sterilization water vapor can enter between the cap and the nozzle, and this part can be sterilized reliably. It is configured as follows. The rubber film 32 is fixed inside the cap body 31 so as to cover the base end opening of the through hole 31a, and when the cap 3 is screwed and locked to the nozzle 22, the tip opening of the nozzle 22 is liquid-tightly sealed. is doing. The rubber film 32 is made of vulcanized natural rubber, synthetic rubber or various elastomers and has resealability, and the thickness is preferably 0.1 to 1 mm.

  Next, the shape of the through hole 31a will be described with reference to FIG. As shown in FIG. 2, the through-hole 31a has a large-diameter portion 311 located on the distal end side and a constant inner diameter, a small-diameter portion 313 located on the proximal end side and having an inner diameter smaller than the inner diameter of the large-diameter portion 311, The tapered portion 312 is provided between the large-diameter portion 311 and the small-diameter portion 313 and is tapered so that the inner diameter gradually decreases in the proximal direction. The inner surface (tapered surface) of the tapered portion 312 has a function of guiding and guiding the hollow needle when the hollow needle is punctured into the rubber film 32.

  A ring-shaped rib 31e is formed on the tip surface of the cap body 31 so as to surround the tip opening of the through hole 31a. Providing this rib 31e helps to prevent foreign substances and bacteria from entering the through hole 31a from the lateral direction. Moreover, after taking out a prefilled syringe from a packaging material, when a film etc. are affixed on the front end surface of the cap main body 31 just before use, there also exists an effect that this is easy to peel off.

  A groove 31 f extending in the axial direction is formed on the outer peripheral surface of the cap body 31. By installing the groove 31f, an anti-slip function is exhibited when the cap 3 is gripped and rotated.

  In the cap 3, the space C is formed by separating the inner side surface (inner peripheral surface) 31 c between the tip inner surface of the cap 3 and the female screw 31 b from the outer side surface (outer peripheral surface) of the nozzle 22. is there. With this space C, water vapor introduced between the nozzle and the cap during sterilization can be easily discharged after sterilization and dried.

  About this example, it experimented about the dry state after sterilization between a cap and a nozzle. A rubber film 32 made of butyl rubber having a thickness of 0.2 mm was fixed to the cap body 31, and a polypropylene cap 3 having a gap of 0.5 mm between the nozzle 22 and the inner surface of the cap was produced. This was attached to a 20 ml capacity syringe nozzle made of cyclic polyolefin filled with 20 ml of physiological saline. As a comparative example, a rubber cap closely attached to the outer surface of the nozzle instead of the cap was attached to the same physiological saline-filled syringe. For each of 25 Examples and Comparative Examples, high-pressure steam sterilization or spray sterilization at 105 ° C. was performed. With these two types of sterilization, the invasion of steam was confirmed in spray sterilization, and the dry state at the end of sterilization was confirmed in high pressure steam sterilization. The results are shown in Tables 1 and 2, respectively. The prefilled syringe according to the present invention was found to be well sterilized and dried between the cap and the nozzle.

  Next, the usage example of the prefilled syringe which concerns on this invention is demonstrated. There are two methods for mixing a liquid medicine filled in a prefilled syringe into an infusion bag or injecting directly into a patient's blood vessel. One is to remove the cap 3 to expose the nozzle 22 and connect a female luer connector such as a three-way stopcock or a tube, or a hub of an injection needle, for use in these applications. The other is to pierce the inner needle of the hollow needle through the rubber film 32 of the cap 3 and connect a holder having an outer needle or connector provided on the opposite side of the inner needle to the cap 3. FIG. 3 is a component diagram (longitudinal sectional view) of the holder 4, and the holder 4 includes a holder main body 41 and a multi-needle (double-ended needle) 42.

  The holder body 41 has a storage portion 41a for storing one cap 3 of the prefilled syringe, a holder female screw 41b for fixing the multi-needle 42, and a holder annular convex portion 41c on the inner peripheral surface of the holder. The multi-needle 42 has an inner needle 42a and an outer needle 42b made of stainless steel or synthetic resin, which are hollow needles having internal passages communicating with each other, and a hub 42c is provided therebetween, and the hub 42c has the holder described above. A male screw 42d that is screwed with the female screw 41b is formed. Further, a rubber chip 42e made of vulcanized natural rubber, synthetic rubber or various elastomers and having resealability is provided so as to cover the inner needle 42a. Accordingly, the inner needle 42a is not exposed even when the outer needle 42b is pierced into a mixed injection port such as an infusion bag, and the inner needle 42a is only inserted when the inner needle 42a is pierced through the rubber film 32 of the prefilled syringe 1. Therefore, a plurality of prefilled syringes can be continuously injected. Further, when the blood vessel is pierced, it is possible to prevent blood from flowing backward from the blood vessel through which the outer needle 42b is pierced. The holder annular convex portion 41c of the holder 4 engages with the cap annular convex portion 31d provided on the outer peripheral surface of the cap 3, and the rubber tip 42e is restored when the inner needle 42a is pierced through the rubber film 32 of the prefilled syringe. The force prevents the prefilled syringe from dropping from the holder 4.

  The procedure to be used is to puncture the outer needle 42b of the holder 4 in which the holder main body 41 and the multi-needle 42 are assembled into a mixed injection port such as an infusion container. Next, the portion of the cap 3 of the prefilled syringe 1 according to the present invention is inserted and stored in the storage portion 41a of the holder 4, and the annular convex portions 31d and 41c provided on both of them are engaged, and the prefilled syringe is inserted into the holder 4. Wear 1 At this time, the inner needle 42 a of the holder 4 penetrates the rubber tip 42 e and pierces the rubber film 32 of the cap 3. The state at this time is shown in FIG. Next, the chemical solution filled by the operation of the plunger 24 of the prefilled syringe 1 is injected into the infusion container or the like from the mixed injection port. After the injection is completed, the prefilled syringe 1 is removed from the holder 4 together with the cap 3, and when a plurality of chemical liquids are injected into the same infusion container or the like, other prefilled syringes filled with the chemical liquid are similarly attached to the holder 4 in order. Then inject chemicals. Further, the rubber chip 42e during the mixed injection operation of these chemical solutions is restored to its original shape every time the prefilled syringe is extracted from the holder 4 to prevent the liquid from being scattered or contaminated by floating bacteria.

  In this example, an experiment was conducted on contamination of the rubber film 32 located on the tip side of the cap 3. Created in the same manner as in the above experiment, the rubber film 32 is attached to the rubber film 32 of the prefilled syringe equipped with the cap 3 with the cap film 3 placed at a position 2 mm (= depth of the through hole 31a) from the tip surface of the cap body 31. The inner needle 42a was pierced. With the inner needle 42a penetrating the rubber tip 42e and the rubber film 32, the operation of pushing the plunger 24 of the prefilled syringe and discharging the drug solution in the prefilled syringe is the same as the mixed injection operation using the conventional syringe (comparative example). Comparison was made in terms of microbial contamination. In the comparative method, microorganisms were forcibly attached to the tip of the cap of the example and the tip of the syringe nozzle of the comparative example, and a mixed injection operation was performed using a holder or an injection needle to compare the invasion of the bacteria into the drug solution. Specifically, Staphylococcus Epidermidis (ATCC strain number: No. 14990 strain) that has been preserved is streaked on TSA medium and cultured at 37 ° C. for 24 hours, and then the bacteria are made to a uniform thickness with a conage rod. I prepared what was streaked. Next, in the examples, the tip of the cap was pressed perpendicularly to the bacterial growth medium, and in the comparative example, the tip of the nozzle was pressed in the same manner, and then the above mixed injection operation was performed to measure the number of mixed bacteria in the drug solution. The results are shown in Table 3. Since the prefilled syringe according to the present invention provided a rubber film at a position 2 mm from the cap tip surface to form a sealing member, it was confirmed that there was no contamination compared to the comparative example in which the tip was exposed.

It is a longitudinal cross-sectional view of the prefilled syringe which concerns on this invention. It is a longitudinal cross-sectional view of the cap which concerns on this invention. It is a longitudinal cross-sectional view of the holder with which the prefilled syringe which concerns on this invention is mounted | worn and used. It is explanatory drawing which shows the use condition of the prefilled syringe which concerns on this invention.

Explanation of symbols

1 Prefilled syringe (filled chemical container)
2 Syringe body 21 Tubular body 21a Flange 22 Nozzle 22a Internal passage 22b Male screw 23 Gasket 24 Plunger 3 Cap 31 Cap body 31a Through hole 311 Large diameter portion 312 Tapered portion 313 Small diameter portion 31b Female screw 31c Inner side surface 31d Cap annular convex Part 31e Rib 31f Groove 32 Rubber film A Chemical solution B Crevice C Space (space part)
4 Holder 41 Holder body 41a Storage part 41b Female thread 41c Holder annular convex part 42 Multi needle 42a Inner needle 42b Outer needle 42c Hub 42d Male screw 42e Rubber tip

Claims (6)

A cap that is provided with a nozzle for discharging a chemical solution and is crowned by the nozzle of a chemical solution container filled with the chemical solution, and seals the tip opening of the nozzle in a liquid-tight manner,
A cap body having a through hole in the center of the distal end and a base end being an open end, and having a locking portion for locking with the nozzle in a state having a gap on the base end side;
The nozzle is installed in the cap body so as to close the proximal end opening of the through-hole, and is composed of a resealable rubber member that can be pierced with a hollow needle, and the nozzle is in a state where the locking portion is locked to the nozzle. And a sealing member for sealing the tip opening of the liquid-tight,
The through-hole has a tapered portion tapered such that the inner diameter gradually decreases in the proximal direction, and the inner surface of the tapered portion guides the hollow needle pierced by the sealing member A cap characterized by having a function . A cap that is provided with a nozzle for discharging a chemical solution and is crowned by the nozzle of a chemical solution container filled with the chemical solution, and seals the tip opening of the nozzle in a liquid-tight manner,
A cap body having a through hole in the center of the distal end and a base end being an open end, and having a locking portion for locking with the nozzle in a state having a gap on the base end side;
The nozzle is installed in the cap body so as to close the proximal end opening of the through-hole, and is composed of a resealable rubber member that can be pierced with a hollow needle, and the nozzle is in a state where the locking portion is locked to the nozzle. And a sealing member for sealing the tip opening of the liquid-tight,
The through hole is located on the distal end side, a large diameter portion having a constant inner diameter, a proximal diameter side, a small diameter portion having an inner diameter smaller than the inner diameter of the large diameter portion, and the large diameter portion and the small diameter portion Consists of a tapered portion that is positioned between and tapered such that the inner diameter gradually decreases in the proximal direction.
An inner surface of the tapered portion has a function of guiding a hollow needle pierced by the sealing member .   3. The cap according to claim 1, wherein a ring-shaped rib protrudes from a tip surface of the cap body so as to surround a tip opening of the through hole.   The cap according to any one of claims 1 to 3, wherein a groove extending in an axial direction is formed on an outer peripheral surface of the cap body. The cap according to any one of claims 1 to 4 , wherein the cap body and the sealing member have transparency. A container main body having a chemical liquid storage section filled with a chemical liquid in a space defined by the inner wall, a nozzle having an opening for discharging the chemical liquid stored in the chemical liquid storage section, and a chemical liquid discharge mechanism for discharging the chemical liquid;
An already-filled drug solution container comprising the cap according to any one of claims 1 to 5 .

Images