JP2004321826A - Cap and pre-filled drug solution container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cap whose nozzle part can be perfectly sterilized, when being sterilized easily and securely dried after sterilization, and is hardly contaminated by microorganisms during use, and a pre-filled drug solution container to be equipped therewith. <P>SOLUTION: A pre-filled syringe comprises a syringe body having a nozle arranged on the distal side end of a columular body, and a cap for covering on the nozzle. The cap comprises a cap main body and a rubber film. A through-hole is formed on the central part of the distal end of the cap main body. The through-hole comprises a large diameter part 311 which is positioned to the distal end side and has a constant inner diameter, a small diameter part 313 which is positioned to the proximal end side and has an inner diameter smaller than that of the large diameter part 311, and a taper part 312 which is positioned between the large diameter part 311 and the small diameter part 313 and has a inner diameter made gradually smaller toward the proximal end. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a container (a so-called pre-filled syringe) filled with a drug solution in advance and a cap used for the container.

  Prior to administering an infusion to a patient, various drugs such as vitamins, minerals, and antibiotics are blended into the infusion filled in the infusion container as necessary.

  Further, in the field of emergency medical care, a plurality of autonomic nervous drugs, vasopressors and the like are used in combination and in large amounts by syringes.

  The compounding or administration of such a drug is performed by sucking a drug solution from a vial via a syringe and then injecting the drug solution into an infusion container or directly into a blood vessel. However, the compounding and administration of such a drug has the disadvantage that the operation is complicated, and the time required for compounding and the time required for administration are long. Furthermore, since the above operation is performed in a state of contact with the atmosphere, there is a risk of bacterial contamination and foreign matter contamination.

  As a solution to these problems, a so-called pre-filled syringe has been proposed in which a syringe is pre-filled with a drug solution and a nozzle at the tip is capped with a rubber cap. However, the conventional prefilled syringe is covered in such a manner that the syringe nozzle is in close contact with the cap. Therefore, at the time of high-pressure steam sterilization, steam did not enter between the nozzle and the cap, and this portion could not be sterilized. In order to solve this problem, a device has been proposed in which a gap is provided between the nozzle and the cap so that steam can enter.

  However, even if a gap is provided between the nozzle and the cap to allow steam to enter, drying is not easily performed after the sterilization step, and the remaining moisture may become a source of mold and the like. There was a problem.

  In addition, when the packaging material is opened and taken out, the device is exposed to the external atmosphere, so that the portion exposed on the surface is easily contaminated with bacteria.

  Therefore, an object of the present invention is to provide a cap that can completely sterilize the nozzle portion during sterilization, can easily and reliably dry after sterilization, and is less likely to be contaminated by bacteria even during use, and a pre-filled chemical liquid container provided with the same. To provide.

Such an object is achieved by the present invention described in the following (1) to (8).
(1) A cap which is provided with a nozzle for discharging a chemical solution, is covered by the nozzle of a chemical solution container filled with the chemical solution, and seals a tip end opening of the nozzle in a liquid-tight manner,
A cap body having a through hole in the center of the distal end, the base end being an open end, and having a locking portion that locks with the nozzle with a gap on the base end side;
A sealing member that is installed in the cap body so as to close a base end opening of the through hole, and seals a tip end opening of the nozzle in a liquid-tight manner with the locking portion locked to the nozzle. ,
The cap, wherein the through hole has a tapered portion whose inner diameter gradually decreases toward a base end.

(2) A cap which is provided with a nozzle for discharging a chemical solution, is covered by the nozzle of the chemical solution container filled with the chemical solution, and seals a tip end opening of the nozzle in a liquid-tight manner,
A cap body having a through hole in the center of the distal end, the base end being an open end, and having a locking portion that locks with the nozzle with a gap on the base end side;
A sealing member that is installed in the cap body so as to close a base end opening of the through hole, and seals a tip end opening of the nozzle in a liquid-tight manner with the locking portion locked to the nozzle. ,
The through hole is located at the distal end, the large diameter portion having a constant inner diameter, located at the base end side, the small diameter portion having an inner diameter smaller than the inner diameter of the large diameter portion, and the large diameter portion and the small diameter portion A cap which is located between and has a tapered portion whose inner diameter gradually decreases in a proximal direction.

  (3) The cap according to the above (1) or (2), wherein a ring-shaped rib is formed so as to protrude from a distal end surface of the cap body so as to surround a distal end opening of the through hole.

  (4) The cap according to any one of (1) to (3), wherein a groove extending in an axial direction is formed on an outer peripheral surface of the cap body.

  (5) The cap according to any one of (1) to (4), wherein the sealing member is formed of a re-sealable rubber member that can penetrate a hollow needle.

  (6) The cap according to any one of (1) to (5), wherein the inner surface of the tapered portion has a function of guiding a hollow needle penetrated by the sealing member.

  (7) The cap according to any one of (1) to (6) above, wherein the cap body and the sealing member have transparency.

(8) A container having a liquid medicine storage section in which a space defined by an inner wall is filled with a liquid medicine, a nozzle having an opening for discharging the liquid medicine stored in the liquid medicine storage section, and a liquid medicine discharge mechanism for discharging the liquid medicine. Body and
A pre-filled chemical liquid container comprising the cap according to any one of the above (1) to (7).

  ADVANTAGE OF THE INVENTION According to this invention, since it is a structure which has a space | gap between a nozzle and a cap, the sterility of the injection needle installation part of a nozzle is maintained until just before mounting of an injection needle. As a result, the water between the nozzle and the cap can be easily removed, clouding of this portion can be prevented, and the generation of mold and bacteria due to the remaining water can be prevented.

  In addition, the present invention combines a holder having a double-ended needle in which a reseal tip is combined with a needle tube to continuously co-inject or administer a pre-filled drug solution container having a different type of drug having the same type of cap. Can be.

  In addition, the present invention has a through hole at the center of the distal end of the cap, and is configured to seal the base end of the through hole with a sealing member (resealing member). The sealing member punctured by the hollow needle) is located at a position retracted from the distal end surface of the cap by a predetermined distance to the proximal end side. Sex is maintained.

  And since a through-hole is a shape which has a taper part, when piercing a hollow needle to a sealing member, a hollow needle can be guided and guided appropriately by the taper surface of a taper part.

  First, a description will be given of an embodiment of a pre-filled drug solution container of the present invention. The pre-filled drug solution container of the present invention can sterilize a cap for sealing a nozzle of a container body containing a drug solution discharged by a drug solution discharge mechanism. In order to eliminate the possibility of clouding of the inner surface of the cap and the possibility of mold generation due to moisture remaining between the cap and the nozzle, which may occur in the case where there is a gap through which steam can pass between the nozzle and the nozzle. it can. That is, the cap has a sealing portion on the closed end side for sealing the inside of the container in a liquid-tight manner, and has a locking portion for locking with the nozzle with a gap on the open end side of the cap, and the inside of the cap. The intermediate portion between the closed end and the open end of the cap is configured to have a space formed by the inner surface of the cap and the outer surface of the nozzle, so that moisture remaining between the inner surface of the cap and the outer surface of the nozzle after sterilization can be easily removed. Can evaporate. As a result, the possibility of clouding and mold generation at the cap portion was eliminated.

  The chemical solution storage section is filled with a chemical solution such as a vitamin agent, an antibiotic, an anticancer agent, or the like according to the application in the internal space. The material of the chemical solution storage portion can be made of glass, polypropylene, polyethylene, polystyrene, a synthetic resin such as various elastomers, or a metal such as stainless steel or aluminum.Select an appropriate material according to the structure of the chemical solution discharge mechanism described later. However, it is preferable that the material is transparent so that the filled liquid medicine can be visually checked. In addition, when the filled chemical solution container is filled with a chemical solution that is easily degraded by gas or moisture such as oxygen contained in the atmosphere during sterilization or during storage, select a material that is gas-impermeable and moisture-impermeable. Is preferred. Examples of these are glass, metals such as stainless steel and aluminum, and synthetic resins such as cyclic polyolefin and polyvinyl alcohol are preferable, and those obtained by coating a synthetic resin with silicon oxide, aluminum oxide, or the above-described gas / water-impermeable resin, Further, if necessary, there is a type having a multilayer structure as one of the layer components. Further, since the filled chemical solution container is sterilized by wet heat, it is preferable that the already-filled chemical solution container has heat resistance to withstand the sterilization.

  The nozzle has an internal passage through which the liquid medicine filled in the liquid medicine storage section can be discharged to the outside, and both ends of the path communicate with the outside and the liquid medicine storage section, respectively. The nozzle is desirably formed of the same material integrally with the chemical solution storage unit.

  Next, the chemical solution discharging mechanism will be described. The chemical solution discharge mechanism is for discharging the filled chemical solution from the chemical solution storage portion to the outside via the nozzle, and preferably has a structure in which the chemical solution is discharged by applying pressure to the chemical solution.

  Specifically, there is a configuration in which a chemical solution storage portion is formed of a synthetic resin or the like flexibly, and an external pressure is applied to the chemical solution storage portion to pressurize the chemical solution, thereby enabling discharge. Examples of the material for forming the chemical solution storage portion include synthetic resins such as polyvinyl chloride, polypropylene, polyethylene, and various elastomers. When a slightly hard material is used, the chemical solution is thinned so as to easily pressurize the chemical solution, and an additive is used. Is preferred. When it is determined that the hardness of the nozzle is insufficient with the selected material for forming the chemical solution storage section, the nozzle may be formed of a separate member and integrated with the drug storage section.

  Further, by configuring the chemical liquid storage section in a so-called syringe shape, a chemical liquid discharge mechanism can be provided to the already filled chemical liquid container. That is, a hard chemical solution storage part is formed in a cylindrical body having one end opened and the other end closed, and the open one end is liquid-tightly sealed and slidable axially and liquid-tight within the cylindrical body. By providing a gasket to be closed and a nozzle at the other end that is closed, the liquid medicine in the liquid medicine storage section can be discharged. It is preferable that a plunger is connected to the gasket in advance or immediately before use to facilitate discharge of the chemical solution. In the case where the gasket and the plunger are connected in advance, the gasket and the plunger can be connected by fitting, or can be integrally formed by integral molding. In the case where the two are connected immediately before use, a pair of male and female screws may be provided on the gasket and the plunger, or a ratchet mechanism may be employed. The material forming the tubular body is a material that can make the tubular body hard, and is preferably glass, a metal such as stainless steel or aluminum, or a synthetic resin such as polypropylene or cyclic polyolefin. As a material for forming the gasket, natural rubber, synthetic rubber, and various elastomers can be used. Further, the material for forming the plunger is formed of a hard material that can withstand the operation of discharging or sucking a chemical solution, and can be appropriately selected from various hard materials such as glass, metals such as stainless steel and aluminum, and hard synthetic resins such as polypropylene and polystyrene. .

  The cap of the present invention is mounted on the container main body and seals the chemical liquid filled in the chemical liquid storage part so as not to be discharged from the nozzle until use. This cap is formed of a hollow body having a closed end (distal end) and an open end (base end opening), and closes the nozzle distal end opening in a liquid-tight manner on the closed end side.

  The cap body that constitutes the cap can be formed of a metal such as stainless steel or aluminum, a synthetic resin such as polyethylene or polypropylene, or the like. It is preferable to use an elastic body such as a synthetic rubber or various elastomers, since the sealing can be more reliably performed. Further, at least the central portion of the sealing member is made of a material such as synthetic resin or rubber that can be pierced with a needle, preferably a material having resealability or a material that does not easily cause coring in the pierced hollow needle. If formed, a hollow needle such as a double-ended needle can be directly pierced into the center of the sealing member while the cap is attached to the nozzle to administer the drug solution. At that time, if the central portion of the sealing member is provided at a position retracted from the outer peripheral edge of the tip of the cap, the portion that becomes the piercing portion of the hollow needle even when the cap or the already-filled drug solution container with the cap is removed from the packaging. It can be protected from contamination. The drawing distance (= depth of the through hole) is preferably 2 mm or more.

  Alternatively, a convex portion may be formed on the inner surface of the closed end of the cap, and sealing may be performed between the convex portion and the inner surface of the nozzle with the convex portion fitted into the inner surface of the nozzle. In this case, the sealing between them can be made by taper fitting or by making the protruding portion an elastic body and closely contacting the inner surface of the nozzle.

  The cap further has a locking portion for locking the nozzle at the base end. The locking portion has a gap for allowing steam to enter between the cap and the nozzle during sterilization. The gap can be, for example, a gap between screws formed by forming the locking portion with a pair of male and female screws.

  A space formed by the inner surface of the cap and the outer surface of the nozzle is provided at an intermediate portion between the closed end and the open end inside the cap. With this space, the steam introduced between the nozzle and the cap for sterilization can be easily discharged and dried after sterilization. The distance between the inner surface of the cap and the outer surface of the nozzle is preferably 0.2 to 1 mm.

  In addition, it is preferable that all the components forming the cap have transparency in order to facilitate confirmation of liquid leakage and the like. Further, it is preferable that the nozzle and the chemical solution storage portion have transparency for the same reason or for confirming the contents.

Hereinafter, the present invention will be described in detail based on the illustrated prefilled syringe.
FIG. 1 is a longitudinal sectional view of a prefilled syringe according to one embodiment of the present invention, and FIG. 2 is a longitudinal sectional view showing one embodiment of a cap of the present invention. The prefilled syringe 1 includes a syringe main body 2 and a cap 3. The syringe body 2 has a cylindrical body 21 filled with the chemical solution A, a nozzle 22, a gasket 23, and a plunger 24. The tubular body 21 is made of tubular polypropylene, cyclic olefin, or the like, and has a closed front end and an open base end. A pair of flanges 21a are provided at the base end so as to face each other. At the closed end, a nozzle 22 is provided integrally with the tubular body 21, and has an internal passage 22 a through which the filled chemical solution A can be discharged through the nozzle 22. The nozzle 22 has a male screw 22b on the base end side outer surface that forms a threaded part in a pair with the base end side of the cap 3. The outer surface on the tip side from the male screw 22b is a luer taper to enable connection to a three-way cock. The gasket 23 is inserted from the base end opening of the cylindrical body 21 so as to be slidable in the axial direction while maintaining the liquid tightness with the inner surface of the cylindrical body, thereby restricting the movement of the chemical solution A in the base direction of the cylindrical body. are doing. The gasket 23 is formed of butyl rubber, vulcanized natural rubber, or the like, and may be coated with a lubricant such as silicone as necessary to improve the sliding property, or may be formed of a synthetic resin such as a fluororesin having a low friction coefficient on the sliding portion. A resin may be provided. A plunger 24 made of a material such as polypropylene is fixed to the base end of the gasket 23 by screw fitting. Therefore, the storage space can be reduced since the gasket 23 can be removed before use.

  The cap 3 includes a cap body 31 and a rubber film (sealing member: a resealable rubber member capable of penetrating a hollow needle) 32. The nozzle 22 is covered with the cap 3, the rubber film 32 seals the internal passage 22 a of the nozzle 22 at the opening at the end, and restricts the movement of the filled chemical solution A toward the end of the cylindrical body.

  As shown in FIG. 2, the cap body 31 has a through hole 31a at the center of the tip, and the through hole 31a is tapered so that an injection needle (hollow needle) can be easily pierced. By forming the tip portion to have a large thickness, the distance between both ends of the through hole is increased, so that the rubber film 32 described below is not contaminated even when it is opened from a packaging material (not shown) and exposed to the outside atmosphere. . The inner surface of the base end of the cap body 31 has a female screw (locking portion) 31b that is paired with the male screw 22b of the nozzle 22 described above. The male screw 22b and the female screw 31b have a gap B in which gas can flow in the axial direction in a screwed state, and steam for sterilization can enter between the cap and the nozzle, and this portion can be surely sterilized. It is configured as follows. The rubber film 32 is fixed to the inside of the cap body 31 so as to cover the base end opening of the through hole 31a, and when the cap 3 is screwed into the nozzle 22 and locked, the tip end opening of the nozzle 22 is liquid-tightly sealed. are doing. The rubber film 32 is made of vulcanized natural rubber, synthetic rubber or various elastomers and has resealability, and preferably has a thickness of 0.1 to 1 mm.

  Next, the shape of the through hole 31a will be described with reference to FIG. As shown in FIG. 2, the through-hole 31 a has a large-diameter portion 311 located at the distal end and having a constant inner diameter, a small-diameter portion 313 located at the base end and having an inner diameter smaller than the inner diameter of the large-diameter portion 311, The tapered portion 312 is located between the large diameter portion 311 and the small diameter portion 313 and is tapered such that the inside diameter gradually decreases toward the base end. The inner surface (tapered surface) of the tapered portion 312 has a function of guiding and guiding the hollow needle when the hollow needle is punctured into the rubber film 32.

  A ring-shaped rib 31e protrudes from the distal end surface of the cap body 31 so as to surround the distal end opening of the through hole 31a. The provision of the rib 31e helps to prevent foreign substances and bacteria from entering the through hole 31a from the lateral direction. In addition, after the prefilled syringe is taken out of the packaging material, if a film or the like is stuck to the tip surface of the cap body 31 until immediately before use, there is also an effect that the film is easily peeled off.

  A groove 31 f extending in the axial direction is formed on the outer peripheral surface of the cap body 31. By providing the groove 31f, a non-slip function is exhibited when the cap 3 is gripped and rotated.

  In the cap 3, a space C is formed by separating the inner surface (inner peripheral surface) 31c between the inner surface of the tip of the cap 3 and the female screw 31b from the outer surface (outer peripheral surface) of the nozzle 22. is there. This space C makes it possible to easily discharge and dry the steam introduced between the nozzle and the cap during sterilization after sterilization.

  For this example, an experiment was conducted on the dry state after sterilization between the cap and the nozzle. A rubber film 32 made of butyl rubber having a thickness of 0.2 mm was fixed to the cap body 31, and a cap 3 made of polypropylene having a gap of 0.5 mm between the nozzle 22 and the inner surface of the cap was prepared. This was attached to a 20 ml syringe nozzle made of cyclic polyolefin filled with 20 ml of physiological saline. As a comparative example, instead of the cap, a rubber cap closely attached to the outer surface of the nozzle was attached to the same syringe filled with physiological saline. High-pressure steam sterilization or spray sterilization at 105 ° C. was performed on each of 25 tubes in each of Examples and Comparative Examples. The two types of sterilization were used to confirm the invasion of steam in spray sterilization, and to confirm the dry state at the end of sterilization in high-pressure steam sterilization. The results are shown in Tables 1 and 2, respectively. It has been found that the prefilled syringe according to the present invention can perform both sterilization and drying between the cap and the nozzle satisfactorily.

  Next, an example of use of the prefilled syringe according to the present invention will be described. There are two methods for injecting a drug solution filled in a prefilled syringe into an infusion bag or injecting directly into a patient's blood vessel. One is to remove the cap 3 to expose the nozzle 22 and connect a female luer connector such as a three-way cock or a tube, or a hub of an injection needle to the nozzle 22 for these uses. The other is to pierce the rubber film 32 of the cap 3 with an inner needle of a hollow needle and connect the holder having an outer needle or a connector provided on the side opposite to the inner needle to the cap 3. FIG. 3 is a component diagram (longitudinal sectional view) of the holder 4. The holder 4 includes a holder main body 41 and a multi-needle (double-ended needle) 42.

  The holder main body 41 has a storage portion 41a for storing one cap 3 of the prefilled syringe, a female female screw 41b for fixing the multi-needle 42, and a holder annular convex portion 41c on the inner peripheral surface of the holder. The multi-needle 42 has an inner needle 42a and an outer needle 42b made of stainless steel or synthetic resin, which are hollow needles having internal passages communicating with each other, and a hub 42c is provided between the two needles. A male screw 42d screwed with the female screw 41b is formed. A rubber chip 42e made of vulcanized natural rubber, synthetic rubber, or various elastomers and having resealability is provided so as to cover the inner needle 42a. Therefore, the inner needle 42a is not exposed even when the outer needle 42b is punctured into the co-infusion port of the infusion bag or the like, and the inner needle 42a is inserted into the rubber tip 42e only when the inner needle 42a is pierced through the rubber film 32 of the prefilled syringe 1. Therefore, a plurality of prefilled syringes can be continuously injected. In addition, when piercing the blood vessel, it is possible to further prevent reverse outflow of blood from the blood vessel pierced by the outer needle 42b. Note that the holder annular projection 41c of the holder 4 engages with the cap annular projection 31d provided on the outer peripheral surface of the cap 3, and restores the rubber tip 42e when the inner needle 42a pierces the rubber film 32 of the prefilled syringe. The force prevents the prefilled syringe from dropping from the holder 4.

  First, the outer needle 42b of the holder 4 in which the holder body 41 and the multi-needle 42 are assembled is punctured into a co-infusion port of an infusion container or the like. Next, the portion of the cap 3 of the prefilled syringe 1 according to the present invention is inserted and stored in the storage portion 41a of the holder 4, and the annular convex portions 31d and 41c provided on both sides are engaged, and the prefilled syringe is attached to the holder 4. 1 is attached. At this time, the inner needle 42a of the holder 4 penetrates the rubber chip 42e and penetrates the rubber film 32 of the cap 3. The state at this time is shown in FIG. Next, the liquid medicine filled by the operation of the plunger 24 of the prefilled syringe 1 is injected into the infusion container or the like from the co-injection port. After the injection is completed, the pre-filled syringe 1 is removed together with the cap 3 from the holder 4, and when a plurality of liquid medicines are to be injected into the same infusion container or the like, other pre-filled syringes filled with the liquid medicines are similarly sequentially attached to the holder 4. And inject the drug solution. Further, the rubber tip 42e during the co-injection operation of these chemicals is restored to the original shape each time the prefilled syringe is extracted from the holder 4, thereby preventing the liquid from scattering and contamination by floating bacteria.

  In this example, an experiment was conducted on the contamination of the rubber film 32 located on the tip side of the cap 3. In the same manner as in the above experiment, the rubber film 32 was attached to the rubber film 32 of the prefilled syringe with the cap 3 attached at a position 2 mm (= depth of the through hole 31a) from the tip end surface of the cap body 31. The inner needle 42a was pierced. With the inner needle 42a penetrating the rubber tip 42e and the rubber film 32, the operation of pushing the plunger 24 of the prefilled syringe and discharging the chemical solution in the prefilled syringe differs from the co-injection operation using the conventional syringe (comparative example). A comparison was made in terms of microbial contamination. In the comparative method, microorganisms were forcibly attached to the tip of the cap of the example and the tip of the syringe nozzle of the comparative example, and a co-injection operation was performed using a holder or an injection needle to compare the invasion of the bacteria into the drug solution. Specifically, the stored Staphylococcus Epidermidis (ATCC strain number: No. 14990 strain) is streaked on a TSA medium and cultured at 37 ° C. for 24 hours. I prepared a stitched image. Next, in the example, the tip of the cap was pressed vertically against the bacterial growth medium, and in the comparative example, the tip of the nozzle was pressed in the same manner, and then the above-described co-injection operation was performed to measure the number of bacteria mixed into the drug solution. Table 3 shows the results. Since the prefilled syringe according to the present invention provided a sealing member with a rubber film disposed at a position 2 mm from the tip end surface of the cap, it was confirmed that there was no contamination as compared with the comparative example in which the tip end was exposed.

It is a longitudinal section of a prefilled syringe concerning the present invention. It is a longitudinal section of a cap concerning the present invention. It is a longitudinal section of a holder attached to and used for the prefilled syringe concerning the present invention. It is an explanatory view showing a use state of a prefilled syringe concerning the present invention.

Explanation of reference numerals

1 prefilled syringe (prefilled drug solution container)
2 Syringe body 21 Cylindrical body 21a Flange 22 Nozzle 22a Internal passage 22b Male screw 23 Gasket 24 Plunger 3 Cap 31 Cap body 31a Through hole 311 Large diameter portion 312 Tapered portion 313 Small diameter portion 31b Female screw 31c Inner side surface 31d Cap annular convex Part 31e rib 31f groove 32 rubber film A chemical liquid B gap C space (space part)
4 Holder 41 Holder body 41a Storage portion 41b Female screw 41c Holder annular convex portion 42 Multi needle 42a Inner needle 42b Outer needle 42c Hub 42d Male screw 42e Rubber tip

Claims (8)

A cap that is provided with a nozzle that discharges a chemical liquid and is covered by the nozzle of the chemical liquid container filled with the chemical liquid, and seals a tip opening of the nozzle in a liquid-tight manner,
A cap body having a through hole in the center of the distal end, the base end being an open end, and having a locking portion that locks with the nozzle with a gap on the base end side;
A sealing member that is installed in the cap body so as to close a base end opening of the through hole, and seals a tip end opening of the nozzle in a liquid-tight manner with the locking portion locked to the nozzle. ,
The cap, wherein the through hole has a tapered portion whose inner diameter gradually decreases toward a base end. A cap that is provided with a nozzle that discharges a chemical liquid and is covered by the nozzle of the chemical liquid container filled with the chemical liquid, and seals a tip opening of the nozzle in a liquid-tight manner,
A cap body having a through hole in the center of the distal end, the base end being an open end, and having a locking portion that locks with the nozzle with a gap on the base end side;
A sealing member that is installed in the cap body so as to close a base end opening of the through hole, and seals a tip end opening of the nozzle in a liquid-tight manner with the locking portion locked to the nozzle. ,
The through-hole is located at the distal end, the large diameter portion having a constant inner diameter, located at the base end, the small diameter portion having an inner diameter smaller than the inner diameter of the large diameter portion, and the large diameter portion and the small diameter portion A cap which is located between and has a tapered portion whose inner diameter gradually decreases in a proximal direction.   3. The cap according to claim 1, wherein a ring-shaped rib protrudes from a distal end surface of the cap body so as to surround a distal end opening of the through hole. 4.   The cap according to any one of claims 1 to 3, wherein a groove extending in an axial direction is formed on an outer peripheral surface of the cap body.   The cap according to any one of claims 1 to 4, wherein the sealing member is formed of a resealable rubber member through which a hollow needle can be pierced.   The cap according to any one of claims 1 to 5, wherein an inner surface of the tapered portion has a function of guiding a hollow needle penetrated by the sealing member.   The cap according to any one of claims 1 to 6, wherein the cap body and the sealing member have transparency. A container body having a liquid medicine storage section filled with a liquid medicine in a space defined by the inner wall, a nozzle having an opening for discharging the liquid medicine stored in the liquid medicine storage section, and a liquid medicine ejection mechanism for discharging the liquid medicine,
A pre-filled chemical liquid container comprising the cap according to any one of claims 1 to 7.

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