JP2000159657A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare an external preparation for the skin, having melanin production-inhibiting action, excellent in bleaching effect and capable of providing cosmetics excellent in stability and safety by including an extract from plants belonging to Passiflora. SOLUTION: This external preparation for the skin, capable of being used as cosmetics is prepared by including (A) an extract from plants belonging to Passiflora and, if needed, (B) an aqueous ingredient, an oil ingredient, a plant extract, an animal extract, powder, an surfactant, lubricant, an alcohol, coloring matter, perfumery or the like. Extract from Passiflora incarnata L. is preferably adopted as the ingredient A. The ingredient A is included in a quantity of 0.0001-20.0 wt.% (more preferably 0.01-5.0 wt.%) in terms of residue on evaporation to dryness. The ingredient A is prepared e.g. by extraction with a solvent such as water, ethyl alcohol or 1,3-butylene glycol under heating after starting the extraction at a lower temperature.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel cosmetic, and more particularly to a cosmetic containing a crude drug extract having an excellent whitening effect.
ssiflora Passion flower (Pa)
s-siflora jncarnata L. The present invention relates to an extract containing, as an active ingredient, a substance having a whitening effect based on a melanin production inhibitory action contained in an extract.

[0002]

2. Description of the Related Art It is thought that pigment melanin is deeply involved in skin darkening. That is, melanin is produced in the skin tissue of the skin under external stimuli such as ultraviolet rays,
Therefore, it is considered that blackening of the skin is promoted and symptoms such as spots and freckles are caused. As a method for confirming the skin whitening effect, it has been proposed to suppress the activity of tyrosinase involved in the production of melanin. Conventionally,
As a substance that suppresses the activity of tyrosinase, an extract of a natural product such as a crude drug has been blended in cosmetics for whitening cosmetics. Further, compounds such as ascorbic acid derivative, glutathione, and colloidal sulfur are compounded, and such whitening cosmetics have been used to obtain cosmetic effects such as prevention of skin darkening, spots and freckles.

[0003]

However, the ascorbic acid derivative itself is liable to be oxidized, so that not only is it difficult to exhibit the effect, but also the cosmetics to be discolored and discolored over time. In addition, glutathione and colloidal sulfur have problems in peculiar odor and stability, which hindered commercialization. On the other hand, crude drugs are expected to be useful because of their high safety, but many of them still have insufficient whitening effect.

[0004]

[Means to solve the problem] Therefore, excellent whitening effect,
The development of a material having no problem in safety and stability was desired. As a result of intensive studies, the present researchers and others have found that a flower of the genus Passi-flora (Passiflo-ra jncarnata).
L. ) Extract has a high melanin production inhibitory effect, and cosmetics containing these are found to be excellent in whitening effect, and also excellent in stability and safety, and completed the present invention. It was just.

That is, the present invention relates to a passive flora (Pa
ssiflora passion flower (P
assifora jncarn-ata L. The present invention also provides a cosmetic characterized by containing the extract of (1).

[0006] Passionflora (Passiflora jncar-nata), a flower of the genus Passiflora used in the cosmetic of the present invention.
L. The method for preparing the extract is not particularly limited. For example, the extract is extracted from a low temperature to a high temperature using various appropriate organic solvents. Examples of the extraction solvent include water; lower alcohols such as methyl alcohol and ethyl alcohol; liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol; ketones such as acetone and methyl ethyl ketone; Alkyl esters; hydrocarbons such as benzene and hexane; ethers such as diethyl ether; and one or more kinds of halogenated alkanes such as dichloromethane and chloroform can be used. In particular, one or a mixture of two or more of water, ethyl alcohol and 1,3-butylene glycol is particularly preferred.

[0007] Passion flower is extracted by extracting fresh or dried passion flower in a weight ratio of 1 to 10%.
In the case of room temperature extraction, a solvent is used at a temperature of 0 ° C. or more, particularly at 20 ° C. to 40 ° C. for 1 hour or more, particularly preferably 3 to 7 days. Also, 60 ~
You may heat-extract at 100 degreeC for 1 hour.

[0008] The passion flower extract obtained under the above conditions may be used as it is as an extracted solution, but if necessary, it may be subjected to a treatment such as filtration, concentrated and powdered, and used appropriately. Can be used.

[0009] The passive flora (Pass) in the present invention.
ifflora Passion flower (Pass)
iflora incarnataL. ) Extract
It has an effect on suppressing the production of melanin in melanocytes. Therefore, an effect of improving black and white, spots, and freckles can be expected.

[0010] The amount of the passion flower extract in the cosmetic of the present invention is generally preferably 0.0001 to 20.0% by weight, particularly preferably 0.001 to 20.0% by weight, in terms of the amount of evaporating and drying.
The range of 1 to 5.0% by weight is optimal. Content 0.0
If the content is less than 001% by weight, a sufficient effect is not exhibited,
The effect is almost constant even if 0.0% by weight or more is added.

The cosmetic of the present invention comprises, in addition to the above essential components,
Aqueous components, oily components, plant extracts, animal extracts, powders, surfactants used in cosmetics, quasi-drugs, and pharmaceuticals,
Oils, alcohol, pH adjusters, preservatives, antioxidants,
It is prepared by mixing a thickener, a coloring matter, a fragrance and the like as needed and appropriately blending them. The dosage form of the cosmetic of the present invention is not particularly limited, and may be various dosage forms such as lotion, milky lotion, cream, pack, powder, spray, ointment, dispersion, and detergent.

[0012]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a passive flora (Pas) according to the present invention will be described.
sifora Passion flower (Pa)
ssiflora jncar-nata L. Example 1) shows a test example relating to the melanin production inhibitory effect of the extract, and describes an application example of a cosmetic using the material, but it is needless to say that the present invention is not limited to the example described here.

<Example 1> Measurement of melanin production inhibitory effect Regarding the whitening effect of passion flower, a test for inhibiting melanin production by mouse melanoma cells will be described, but it goes without saying that the present invention is not limited to the examples described herein.

(1) Preparation of sample solution and culture solution The passion flower extract is obtained by drying the whole plant above the ground.
Use a powdered product, and add 37%
Soaked for 1 week at ℃. The extract was dried, and dimethyl sulfoxide (DMSO) was added to 100 mg of the dry extract.
0 μl and 9.5 ml of PBS (−) were added and dissolved. Kojic acid and arbutin were prepared using commercially available reagents.
Dissolved in the S (-) solution. The passion flower water extract was prepared by adding 100 ml of water to 1 g of the dry powder and heating and extracting at 100 ° C. for 1 hour. The extract is dried, and the dried product is washed with PBS.
(-) Was used as a 1% solution. Culture solution is 10% fetal bovine serum
An Eagle MEM (E-MEM) medium to which was added.
The solution was sterilized and filtered through a 0.2 μm membrane filter.

(2) Cell culture Mouse melanoma cells B-16 F-10 cells were transferred to 15c
Planted in petri dishes of mφ. Planting amount is 4 × 10 ³
/ Cm ² . The day after planting, the extract solution prepared in (1) of Example 1 was adjusted to a dry matter concentration.

Addition was performed so that the concentration was as shown in Table 1, and the test was terminated three days after the addition.

(3) Evaluation method Cells grown in a 15 cm φ petri dish are collected by a cell scraper, put into a transparent centrifuge tube, and subjected to 1,000 rpm.
The cells were collected by centrifugation for 10 minutes. The color of the collected cell pellets was visually judged and displayed in five levels.

(Judgment criteria) 5: considerably black 4: black 3: slightly white 2: white 1: fairly white

[0018]

Table 1 shows the measurement results of the melanin production inhibitory effect test. The passion flower extract showed a higher melanin production inhibitory effect than the control group.

[0019]

[Table 1]

<Example 2> Formulation example of cosmetics containing passion flower extract. (1) Cosmetic cream (% by weight) a) Beeswax {2.0 b) Stearyl alcohol} 5.0 c) stearic acid @ 8.0 d) squalane @ 10.0 e) Self-emulsifying glyceryl monostearate {3.0 f) Polyoxyethylene cetyl ether (20EO) {1.0 g) Passion flower water extract} {5.0 h) 1,3-butylene glycol {5.0 i) potassium hydroxide} 0.3 j) Preservatives / antioxidants (appropriate amount) k) Purified water (remainder) ) To f Until it dissolved by heating and kept at 80 ° C..
g) to k) are heated and melted, and kept at 80 ° C.
Add emulsification in addition to f) and cool with stirring to 40 ° C. (2) Emulsion (% by weight) a) Beeswax {0.5 b) Vaseline} ‥‥‥ 2.0 c) Squalane ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 8.0 d) Sorbitan sesquioleate ‥‥‥‥‥‥‥‥‥ 0.8 e) Poly Oxyethylene oleyl ether (20EO) {1.2 f) Passionflower 50% ethanol extract {3.0 g) 1,3-butylene glycol} 7.0 h) Carboxyvinyl polymer {0.2 i) Potassium hydroxide {0.1 j) Purified water} ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ Remainder k) Preservatives and antioxidants ‥‥‥‥‥‥‥‥‥‥‥‥‥‥ Appropriate amount l) Ethanol ‥‥‥‥ ‥‥‥‥‥‥‥‥‥‥‥‥‥ 7.0 Manufacturing method Heating and dissolving a) to e), and keeping at 80 ° C.
f) to k) are heated and dissolved, and kept at 80 ° C., and a) to
Emulsify in addition to e) and cool to 50 ° C. with stirring. At 50 ° C add l) and cool to 40 ° C. (3) Lotion (% by weight) a) Passion flower water extract {5.0 b) Glycerin} ‥‥ 5.0 c) Polyoxyethylene sorbitan monolaurate (20EO) ‥‥‥‥ 1.0 d) Ethanol ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 6 0.0 e) Fragrance {appropriate amount f) Preservative / antioxidant appropriate amount} ‥‥ Appropriate amount g) Purified water ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ Remainder Production method Mix a) to g) and dissolve uniformly. (4) Packing agent (% by weight) a) Passion flower 50% ethanol extract {3.0 b) Vinyl acetate resin emulsion {15.0 c) Polyvinyl alcohol} {10.0 d) olive oil {3.0 e) glycerin} {5.0 f) titanium oxide {8.0 g) kaolin} {7.0 h) ethanol 8.0 i) fragrance} ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ Appropriate amount j) Preservative and antioxidant ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ Appropriate amount k) Purified water ‥‥‥ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ Part process a) to k) until mixing, stirred well, a uniform dispersed.

Example 3 Use Effect Test An effect test was carried out on the whitening effect of the cosmetic composition of the present invention by a use test. The usage test consisted of 20 women, each aged 30-50 years old, as panelists.
The test was carried out by applying the test cosmetic to the face after washing the face for months. As the test cosmetic, the cream, milky lotion, and lotion of Example 2 were used. As a control, a cream, milky lotion, and lotion of Example 2 in which the passion flower extract was replaced with purified water was used. The result

The results are shown in Table 2. The evaluation criteria were evaluated according to the following criteria. <Evaluation criteria for whitening effect>-Effective spots and freckles became less noticeable.・ Slightly effective stains and freckles have become less noticeable. -Invalid.

[0022]

[Table 2]

[0023]

As is clear from the results shown in Table 2, the cosmetic of Example 3 was effective for the skin whitening effect.

[0024]

As described in detail above, the cosmetic of the present invention comprises:
It has excellent whitening effect, so the skin becomes black due to sunburn,
It can be widely applied for prevention and improvement of spots and freckles. The cosmetic of the present invention has high safety and can be used with confidence.

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Claims (3)

[Claims] 1. A passive flora (Passiflora)
An external preparation for skin comprising an extract of a genus plant as an active ingredient. 2. A passive Flora (Passiflora)
Genus plant, Passionflora (Passiflora)
jncarnata L. ) An external preparation for skin, characterized in that: 3. The external preparation for skin according to claim 1, which is a whitening cosmetic.