JP2000159623A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin preparation for external use, having good suppression of melanin generation, excellent in skin bleaching effect, safety and stability and useful for prevention of tanning of the skin, generation of stains and freckles due to sunburn by including an extract of the genus Eucommia as an active ingredient. SOLUTION: This preparation is obtained by including an extract of Eucommia ulmoides Oliver of the genus Eucommia. The extraction of the Eucommia ulmoides Oliver is preferably performed by using a solvent such as ethanol in an amount of 1-1,000 preferably 10-100 times as much as that of the crude or dry Eucommia ulmoides Oliver. In the case of the normal temperature extraction, the extraction is performed at >=0 deg.C preferably 20-40 deg.C, for >=1 hr preferably 3-7 days. It is preferable that the proportion of the blended extract of the Eucommia ulmoides Oliver is generally 0.0001-20.0 wt.%, especially 0.01-5.0 wt.% expressed in terms of the evaporated and dried quantity when the preparation for external use is used as cosmetics.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel cosmetic, and more particularly to a cosmetic containing a crude drug extract having an excellent whitening effect, and more particularly to Eucoia.
mmia) The present invention relates to an extract containing a substance having a whitening effect based on an inhibitory action on melanin production as an active ingredient, which is contained in a forest extract of a genus plant.

[0002]

2. Description of the Related Art It is thought that pigment melanin is deeply involved in skin darkening. That is, melanin is produced in the skin tissue of the skin under external stimuli such as ultraviolet rays,
Therefore, it is considered that blackening of the skin is promoted and symptoms such as spots and freckles are caused. As a method for confirming the skin whitening effect, it has been proposed to suppress the activation of tyrosinase involved in the production of melanin. Conventionally, as a substance that suppresses the activity of tyrosinase, an extract of a natural product such as a crude drug has been blended into a whitening cosmetic. Further, compounds such as ascorbic acid derivative, glutathione, and colloidal sulfur are compounded, and such whitening cosmetics have been used to obtain cosmetic effects such as prevention of skin darkening, spots and freckles.

[0003]

However, the ascorbic acid derivative itself is liable to be oxidized, so that not only is it difficult to exhibit the effect, but also the cosmetics to be discolored and discolored over time. In addition, glutathione and colloidal sulfur have problems in peculiar odor and stability, which hindered commercialization. On the other hand, crude drugs are expected to be useful because of their high safety, but many of them still have insufficient whitening effect.

[0004]

[Means to solve the problem] Therefore, excellent whitening effect,
The development of a material having no problem in safety and stability was desired. As a result of intensive studies, the present researchers have found that an extract of Tochu belonging to the genus Eucommia has a high inhibitory effect on melanin production, and that a cosmetic containing these has an excellent whitening effect, In addition, they have found that they are excellent in stability and safety, and have completed the present invention.

[0005] That is, the present invention relates to Eucomia.
mmia) It is intended to provide a cosmetic characterized by containing an extract of Tochu of a genus plant.

[0006] Eucomia (Eu) used in the cosmetic of the present invention.
commia) The method for preparing the extract of the plant genus Tochu is not particularly limited. For example, the extract is extracted from a low temperature to a high temperature using various suitable organic solvents. Examples of the extraction solvent include water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; glycerin, propylene glycol,
Liquid polyhydric alcohols such as 1,3-butylene glycol;
Ketones such as acetone and methyl ethyl ketone; alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexane; ethers such as diethyl ether; and one or more kinds of halogenated alkanes such as dichloromethane and chloroform can be used. . In particular, one or two of water, ethyl alcohol, 1,3-butylene glycol
Mixed solvents of more than one species are particularly preferred.

[0007] Tochu is extracted from raw or dried Tochu using a solvent in a weight ratio of 1 to 1000 times, especially 10 to 100 times the amount of solvent.
It is preferable to carry out at 0 ° C. to 40 ° C. for 1 hour or more, especially for 3 to 7 days. Moreover, you may heat-extract at 60-100 degreeC for 1 hour.

The eucalypt extract obtained under the above conditions may be used as it is in the form of an extracted solution, but if necessary, it may be subjected to a treatment such as filtration, concentrated and powdered, and appropriately used. Can be used.

In the present invention, Eucomm (Eucomm)
ia) An extract of the genus plant Tochu has an effect on suppressing melanin production in melanocytes.
Therefore, an effect of improving black and white, spots, and freckles can be expected.

The amount of the Tonaka extract in the cosmetic composition of the present invention is generally 0.0001 to 2 in terms of the amount of the evaporative dry matter.
0.0% by weight is preferred, and especially 0.01 to 5.0% by weight.
Is optimal. If the content is less than 0.0001% by weight, a sufficient effect is not exhibited, and even if added at 20.0% by weight or more, the effect is almost constant.

The cosmetic of the present invention comprises, in addition to the above essential components,
Aqueous components, oily components, plant extracts, animal extracts, powders, surfactants used in cosmetics, quasi-drugs, and pharmaceuticals,
Oils, alcohol, pH adjusters, preservatives, antioxidants,
It is prepared by mixing a thickener, a coloring matter, a fragrance and the like as needed and appropriately blending them. The dosage form of the cosmetic of the present invention is not particularly limited, and may be various dosage forms such as lotion, milky lotion, cream, pack, powder, spray, ointment, dispersion, and detergent.

[0012]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, Eucomia (Eucom) according to the present invention will be described.
Mia) Test examples relating to the melanin production inhibitory effect of the extract of Tochu of the genus plant will be shown, and examples of prescriptions applied to cosmetics using the materials will be described. Needless to say.

<Example 1> Measurement of melanin production inhibitory effect Regarding the whitening effect of Tonaka, a test for inhibiting melanin production by mouse melanoma cells will be described. It goes without saying that the present invention is not limited to the examples described herein.

(1) Preparation of sample solution and culture solution As a water extract, 100 mg of Tochu dried extract (manufactured by Nippon Powder Chemical Co., Ltd.) was dissolved in 10 ml of PBS (-).
As a mixed solvent extract, a 50% aqueous ethanol solution 1
10 g of Tochu bark was added to 00 ml, extracted at 80 ° C. for 1 hour, and the extract was filtered and dried. Add 500 μl of dimethyl sulfoxide to 100 mg of the dried product, and further add PBS
(-) Dissolved in 9.5 ml. Kojic acid and arbutin were each dissolved in a PBS (-) solution using commercially available reagents. The culture solution was Eagle ME supplemented with 10% fetal bovine serum.
M (E-MEM) medium was used. The solution was sterilized and filtered through a 0.2 μm membrane filter.

(2) Cell culture Mouse melanoma cells B-16 F-10 cells were transferred to 15c
Planted in petri dishes of mφ. Planting amount is 4 × 10 ³
/ Cm ² . The day after planting, the extract solution prepared in (1) of Example 1 was brought to a dry matter concentration,

Addition was performed so that the concentration was as shown in Table 1, and the test was terminated three days after the addition.

(3) Evaluation method Cells grown in a 15 cm φ petri dish are collected by a cell scraper, put into a transparent centrifuge tube, and subjected to 1,000 rpm.
The cells were collected by centrifugation for 10 minutes. The color of the collected cell pellets was visually judged and displayed in five levels.

(Judgment criteria) 5: considerably black 4: black 3: slightly white 2: white 1: fairly white

[0018]

Table 1 shows the measurement results of the melanin production inhibitory effect test. The Tonaka extract showed a higher melanin production inhibitory effect than the control group.

[0019]

[Table 1]

<Example 2> [0020] Formulation example of a cosmetic formulation containing a Tonaka extract. (1) Cosmetic cream (% by weight) a) Beeswax {2.0 b) Stearyl alcohol} {5.0 c) stearic acid {8.0 d) squalane} ‥‥‥‥‥‥‥ 10.0 e) Self-emulsifying glyceryl monostearate ‥‥‥‥‥‥‥ 3.0 f) Polyoxyethylene cetyl ether (20EO) ‥‥ 1.0 g) Tochu Water extract ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 5.0 h) 1,3-butylene glycol ‥‥‥‥‥‥‥‥‥‥‥‥ 5.0 i) Potassium hydroxide ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 0.3 j) Preservative / antioxidant ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ appropriate amount k) Purified water ‥‥‥‥‥‥‥‥ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ Remaining process: Heat and dissolve steps a) to f) and keep at 80 ° C.
g) to k) are heated and melted, and kept at 80 ° C.
Add emulsification in addition to f) and cool with stirring to 40 ° C. (2) Emulsion (% by weight) a) Beeswax {0.5 b) Vaseline} {2.0 c) squalane {8.0 d) sorbitan sesquioleate} {0.8 e) Polyoxyethylene oleyl ether (20EO)} 1.2 f) Tochu 50% ethanol extract} {3.0 g) 1,3-butylene glycol {7.0 h) carboxyvinyl polymer} 2 i) Potassium hydroxide {0.1 j) Purified water} ‥‥‥‥‥‥ The rest k) Preservatives / oxidation Inhibitor {appropriate amount 1) Ethanol 7.0 Production method a ) To e) are heated and dissolved, and kept at 80 ° C.
f) to k) are heated and dissolved, and kept at 80 ° C., and a) to
Emulsify in addition to e) and cool to 50 ° C. with stirring. At 50 ° C add l) and cool to 40 ° C. (3) Lotion (% by weight) a) Tochu water extract {5.0 b) Glycerin} {5.0 c) polyoxyethylene sorbitan monolaurate (20EO) {1.0 d) ethanol} {6.0 e) Fragrance {appropriate amount f) Preservative / antioxidant} ‥‥‥‥‥‥‥‥‥‥‥‥ Appropriate amount g) Purified water ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ Remainder Production method Mix a) to g) And dissolve uniformly. (4) Packing agent (% by weight) a) Tochu 50% ethanol extract {3.0 b) Vinyl acetate resin emulsion} {15.0 c) polyvinyl alcohol {10.0 d) olive oil} 3.0 e) Glycerin {5.0 f) Titanium oxide} {8.0 g) kaolin {7.0 h) ethanol} ‥‥‥‥‥‥‥‥‥‥ 8.0 i) Perfume ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ Suitable amount j) Preservative / antioxidant ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ Appropriate amount k) Purified water ‥‥ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ mixed until balance process a) to k), stirred well and uniformly dispersed.

Example 3 Use Effect Test An effect test was carried out on the whitening effect of the cosmetic composition of the present invention by a use test. The usage test consisted of 20 women, each aged 30-50 years old, as panelists.
The test was carried out by applying the test cosmetic to the face after washing the face for months. As the test cosmetic, the cream, milky lotion, and lotion of Example 2 were used. As a control, a product obtained by replacing the Tochu extract with purified water from the cream, milky lotion, and lotion of Example 2 was used. The result

The results are shown in Table 2. The evaluation criteria were evaluated according to the following criteria. <Evaluation criteria for whitening effect>-Effective spots and freckles became less noticeable.・ Slightly effective stains and freckles have become less noticeable. -Invalid.

[0022]

[Table 2]

As apparent from the results in Table 2, Example 3
Was effective for the skin whitening effect.

[0024]

As described in detail above, the cosmetic of the present invention comprises:
It has excellent whitening effect, so the skin becomes black due to sunburn,
It can be widely applied for prevention and improvement of spots and freckles. The cosmetic of the present invention has high safety and can be used with confidence.

Claims (4)

[Claims] 1. An external preparation for skin comprising an extract of a plant of the genus Eucommia as an active ingredient. 2. The plant of the genus Eucommia is Eucommia ia ulmoides O.
iv. ) An external preparation for skin, characterized in that: 3. Eucommia ulmide
s Olive. An external preparation for skin comprising, as an active ingredient, the bark extract of (1). 4. The external preparation for skin according to claim 1, 2 or 3, which is a whitening cosmetic.