JP2000154122A - Hair-restoring and growing composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair-restoring and growing composition exhibiting clear trichogenous effect. SOLUTION: This composition comprises a solution of teas and rice vinegar containing at least one kind of teas and rice vinegar as active ingredients. Prevention and treatment of thin hair are carried out by trichogenous effect obtained by using the composition. Green tea, oolong tea or black tea can be exemplified as teas.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a hair growth composition.

[0002]

2. Description of the Related Art Recently, hair-growing compositions containing a combination of α, α-trehalose and a water-soluble polymer as active ingredients have been proposed (for example, JP-A-7-53335, JP-A-8-20514). JP-A-8-40846 and JP-A-8-73321). In addition, as a component of a hair restorer, a component that keeps the scalp clean, a component that expands blood capillaries to promote blood circulation and facilitates nutrient distribution to hair roots, a component that directly supplies proteins and amino acids, Ingredients that suppress the responsible male hormone are used. However, there is still a strong demand for a new active ingredient having a preventive and curative effect on hair thinning.

[0003]

SUMMARY OF THE INVENTION The present invention provides a completely new type of an excellent hair growth and restorative composition which is effective in preventing and treating hair thinning.

[0004]

Means for Solving the Problems The inventors of the present invention have found that a composition containing tea rice vinegar as an active ingredient has an excellent hair-growth effect, and completed the present invention.

[0005] Tea rice vinegar which is an active ingredient of the present invention is:
It is as follows. Tea rice vinegar can be prepared by mixing tea and rice vinegar. Tea means tea including edible tea. Examples of teas include green tea, oolong tea, and black tea. These teas are prepared according to the purpose of taste, but any preparation method may be used. Furthermore, freshly picked tea leaves can also be used. Rice vinegar is one type of brewed vinegar described as vinegar / rice vinegar in the Japanese Food Composition Table. Rice vinegar is a type of brewed vinegar made from rice, and its components differ somewhat depending on the manufacturing conditions and the like. However, as described in the Japanese Food Composition Table, it is usually 4.5% acetic acid and carbohydrates. It contains components such as 5 g of carbohydrate and 0.7 g of ash.
Vinegar and cereal vinegar, and vinegar and fruit vinegar are remarkably different in that they have a high sugar content.

[0006] Tea rice vinegar is prepared as follows.
Tea is used for the purpose of the present invention by purchasing a product sold in a department store or a grocery store in a supermarket, or in a tea field, or growing in the wild or growing in a field. can do. Teas are usually prepared according to the purpose of taste.
For example, green tea (gyokuro, matcha, sencha, bancha, etc.), oolong tea, and black tea can be exemplified. Among teas, green tea (matcha, sencha) and black tea can be preferably used for the purpose of the present invention. Rice vinegar that is commercially available at grocery stores can be used.

The preparation is carried out at -10 to 60 ° C, usually at room temperature. The contaminants are removed from the tea, and then the tea and rice vinegar are crushed and mixed with a mixer or the like. The usage ratio of teas and rice vinegar (teas / rice vinegar) is not particularly limited, but is preferably 0.01 to 30, more preferably 0.1 to 30 g / g.
05 to 3. In addition, teas, including stems (for example, stems in which stems are remarkably mixed), can also be used for preparing tea rice vinegar. The pulverized mixture is transferred to a container such as a wide-mouthed bottle with a lid, and at room temperature for 0.5 to 30 days, preferably 3 to 20 days, more preferably 5 to 20 days.
The mixture is allowed to stand for 12 days, and if necessary, solids are removed by filtration or centrifugation to prepare a tea rice vinegar solution. In addition,
Depending on the preparation temperature, the temperature is adjusted to a short time if the temperature is high, and to a long time if the temperature is low, to select a period suitable for optimizing the effectiveness of the tea rice vinegar liquid. Can be.

The hair growth effect of the tea rice vinegar prepared as described above can be confirmed by the method (II) described below. The following two effects can be observed in a test on cut back skin of C3H mice (male, 8 weeks old) whose hair cycle is in a telogen state. (I) Hair growth effect: This is a test method using skin whose hair cycle is in a growth phase. This is a method utilizing the fact that the resting period is changed to the growing period by applying a depilatory cream treatment to the cut portion. Hair growth is also observed in the non-medicated area, in the water and in the alcohol-applied area, and the hair growth effect can be determined based on the difference in the area of hair growth and the rate of hair growth from the area to which the chemical is applied. (II) Hair growth effect: This is a test method using skin in which the resting state of the hair cycle continues. If the hair removal cream treatment is not performed, the rest period continues until about 14 weeks of age. In the skin during this period, no hair growth was observed in the non-medicated area or the water or alcohol applied area. The presence and extent of the hair growth effect (pause break effect) can be determined based on the hair growth area ratio of the drug application section.

The rice vinegar for teas of the present invention can be used as it is, or can be used after being formulated into various dosage forms. Formulations include water diluent, aqueous solvent diluent, aqueous suspension,
Examples include liquid forms such as emulsions, creams, gels, aerosols, and the like. For use in these dosage forms, the components necessary for stabilizing the dosage form can be added.
As the aqueous solvent, ethyl alcohol and isopropyl alcohol (hereinafter, these two types of alcohols are collectively referred to as alcohols) can be used alone or in a mixture of both. It is also possible to use a mixture of types. The use amount (% by weight) of the alcohol in the liquid preparation using the alcohol and water as a solvent is preferably 1 to 85%. In this specification, the liquids are classified and described as follows according to the amount of alcohols used in the liquid preparation. Multi-aqueous solution: less than 20% of alcohol used. Middle aqueous solution: amount of alcohol used, 20% or more to 70
%Less than. Low aqueous solution: use amount of alcohol, 70% or more.

Further, the following substances can be added to the composition of the present invention as long as the effects of the tea vinegar are not impaired. Substances that promote blood circulation and improve blood flow and make it easier for nutrients to reach the hair root: assembly extract, α-tocopherol,
Vitamin E such as β-tocopherol, γ-tocopherol, δ-tocopherol, vitamin E acetate, vitamin E nicotinate, and derivatives thereof, cepharanthin, pepper agar tincture, ginseng extract, carpronium chloride, methyl nicotinate, benzyl nicotinate, hawthorn Extract, tincture tincture, salmon extract,
Touki extract, dialkyl monoamine derivatives such as diisopropylamine dichloroacetate, tincture tincture, and vanillyl amide nonanoate.

Substances that directly supply vitamins and nutrition to hair roots: pantothenic acid and its derivatives, D-pantothenyl alcohol, D-pantothenyl ethyl ether, pyridoxine hydrochloride, biotin, nicotinamide, soluble cystine, L-methionine, L-serine and milk protein hydrolyzate.

Substances that maintain scalp cleanliness by various actions: (Anti-inflammatory agent) Licorice extract, dipotassium glycyrrhizinate, glycyrrhetinic acid and its derivatives, diphenhydramine hydrochloride, hydrocortisone and chlorpheniramine maleate. (Keratolytic agent) salicylic acid, resorcinol, phenol,
Lactic acid and urea.

(Bactericide) Parabens such as hinoxythiol, orthomethoxycinnamaldehyde, methyl parahydroxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, isopropylmethylphenol, sorbic acid, benzalkonium chloride, chloride Benzethonium,
Tego-51 and parachlorometa-xylenol.

(Lipid metabolism promoting / antiseborrheic agent) Cashew, sulfur, S-carboxymethylcysteine, S-benzylcysteamine and thioxolone. (Humectant) Garlic extract, seaweed extract, propylene glycol, trichosaccharide, sodium pyrrolidone carboxylate, placenta extract, aloe extract, Maikai flower extract, ginkgo extract, shiitake extract, coltsfoot poppo extract, glycerin, lingin extract, bamboo ginseng extract Extract and saffron extract.

Substances that remove a major cause of thinning hair as antiandrogens: estriol, estrone, 17
β-estradiol, ethinylestradiol, estradiol and derivatives thereof, oxendrone and 4-androstene-3,17-dione-17-cyclic ethylene ketal and derivatives thereof.

A hydrophilic polymer having a hydrophilic group in the structural formula: natural, semi-synthetic or synthetic. Examples of the hydrophilic polymer that can be used in the present invention include the following. As a plant-based natural polymer, gum arabic, tragacanth gum, karaya gum, guar gum, roast bean gum, quince seed gum, tara gum, tamarind gum,
Pectin, alge colloid (Gusso extract), carrageenan and galactan.

Xanthan gum, succinoglucan, Zancote, Zanflow and
Pullulan. As an animal-derived polymer, chitosan or
A salt thereof, carboxymethyl chitin or a salt thereof, glycol chitin, chitin sulfate or a salt thereof, collagen, casein, albumin, and gelatin. As starch-based polymers, carboxymethyl starch and
Methyl hydroxypropyl starch. As a cellulosic polymer, methylhydroxypropylcellulose, hydroxyethylcellulose, cellulose sodium sulfate,
Hydroxypropyl cellulose and carboxymethyl cellulose sodium salt.

Alginate polymers such as sodium alginate, ammonium alginate, potassium alginate and propylene glycol alginate. Examples of the polyvinyl polymer include polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, and carboxyvinyl polymer (Carbopol). Sodium polyacrylate as an acrylic polymer. As mucopolysaccharides, hyaluronic acid and sodium hyaluronate, dermatan sulfate, sodium dermatan sulfate, heparan sulfate and sodium heparan sulfate. These hydrophilic polymers may be commercially available products or prepared by methods described in the literature.

A group consisting of monosaccharides, disaccharides and oligosaccharides (hereinafter the three groups are collectively referred to as saccharides) These saccharides are monosaccharides, disaccharides and oligosaccharides having a sugar chain length of 20 or less. If it is not particularly limited, for example, glucose, xylose, fructose, galactose, arabinose,
Mannose, sucrose, lactose, palatinose, maltose,
Cellobiose, raffinose, fructooligosaccharides, isomaltooligosaccharides, xylooligosaccharides, dextrins, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin (α, β, and γ cyclodextrins are collectively referred to as cyclodextrins. Do) or trehalose. These saccharides can be used alone or as a mixture of two or more. When these have isomers, they can be used either alone or as a mixture. All of these saccharides can be prepared and used according to a method described in the literature or a known method, or a commercially available product can be used. Among these saccharides, preferred are the following. brackets()
In the above, the preferred content in the liquid preparation is shown by weight%. Trehalose (0.1-5) and cyclodextrin (0.1-5).

Oils for improving feeling of use: white petrolatum,
Liquid paraffin, solid paraffin, ceresin, microcrystalline wax, cholesterol, squalane,
Horse fat, orb oil, rosehip oil, mink oil, jojoba oil, hardened castor oil, hardened coconut oil, hardened palm oil, beeswax, palmitoleic acid, linoleic acid, linolenic acid, oleic acid, stearic acid, palmitic acid, behenic acid , Lauric acid, stearyl alcohol, cetyl alcohol,
Lauryl alcohol and oleyl alcohol.

Surfactants: Cetyl isooctanoate, isopropyl myristate, ethyl caprate, ethyl caprylate, ethyl oleate, glyceryl monostearate, propylene glycol monooleate, glyceryl monooleate, sorbitan monocaprate, citric acid Esters such as glyceryl monostearate, diglyceryl distearate, and decaglyceryl monolaurate;
Nonionics such as silicone oils, polyol-modified silicones, silicone derivatives such as silicone resins, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyglycerin alkylphenyl ether, polyoxyethylene glycerin fatty acid esters, and polyoxyethylene hydrogenated castor oil Surfactant.

Anionic surfactants such as N-acyl amino acid salts, N-acyl sarcosine salts, edetates, lauryl sulfates, alkyl phosphates, acylmethyl taurates and the like. Cationic surfactant such as alkyltrimethylammonium, dialkyldimethylammonium, alkyl-N, N-dialkylaminoacetic acid ester. Amphoteric surfactants such as lecithin, betaine, imidazoline and amine oxide.

Colorant: Blue No. 1, Purple No. 401, Yellow No. 5, and Photosensitive Element 301. (10) Cooling stimulants: L-menthol, peppermint oil. (11) pH adjusters: L-aspartic acid, L-glutamic acid, arginine, citric acid, diisopropanolamine, phosphate buffer, hydrochloric acid, tartaric acid, acetic acid, potassium hydroxide, sodium hydroxide, lactic acid. (Buffer) amino acetic acid, citric acid, sodium citrate, Hind-Goyan buffer [sodium dihydrogen phosphate, disodium hydrogen phosphate,
Consisting of sodium chloride], Britton-Robinson buffer [composed of phosphoric acid, acetic acid, boric acid, sodium hydroxide], borax, boric acid, phosphoric acid, alkali metal salts of phosphoric acid (phosphoric acid Dipotassium hydrogen, disodium hydrogen phosphate, potassium dihydrogen phosphate, sodium dihydrogen phosphate), phosphate buffer, acetic acid, sodium acetate, sodium acetate buffer, sodium carbonate, sodium hydrogen carbonate.

(12) Inorganic pigment: bismuth oxychloride, carbon black, kaolin, calamine, clay, gunjo, magnesium silicate, talc, titanium white, red bengal, bentonite, mica, lithopone, zinc white, mica titanium, yellow iron oxide , Black iron oxide, chromium oxide, zirconium oxide, titanium oxide, magnesium oxide, zinc oxide, chromium hydroxide, calcium carbonate, magnesium carbonate, silicic anhydride, barium sulfate.

The amount of the tea rice vinegar is usually 1 to 95% by weight, preferably 2 to 40% by weight, more preferably 4 to 20% by weight, based on the weight of the composition. The hair growth composition of the present invention is used as follows. Usually, the hair growth composition is applied 1 to 3 times per day, preferably twice in the morning and evening.
Usually, 3 to 7 days of a week is applied for several weeks.
By continuing for about several months, it is possible to confirm the hair-growth effect, which is the object of the present invention.

[0026]

EXAMPLES The present invention will be described below with reference to examples, but the present invention is not limited to these examples. Matcha [purchased on the day before preparation at tea shop, iro, fragrant,
Matcha that is distributed under the name of "Isuzu" Matcha [purchased on the day before preparation at the tea shop, iro, fragrant,
Matcha distributed under the name of “Nama no Shiro” Sencha [purchased at the tea shop on the day of preparation, iro, fragrant sencha] Black tea [purchased on the day of preparation at the grocery store in department stores, iro, fragrant Black tea] Rice vinegar [Nakano vinegar shop. (Trademark) Mizkan pure rice vinegar. Acidity 4.5]

Preparation Example 1-1 Preparation of Matcha Rice Vinegar Liquid (1/20) Matcha (distributed under the name of "Isuzu") 15 g and rice vinegar 300
g with a juicer mixer for 5 minutes.
It was transferred to a glass wide-mouth bottle with an L lid and stored for one week. Then, the bleach was used as a filter cloth and filtered to prepare a matcha rice vinegar solution (1/20) as a filtrate. In the following test examples, preparation 1-1 is described.

Preparation Example 1-2 Preparation of Matcha Rice Vinegar Liquid (1/20) 15 g of matcha (distributed under the name of "Nama no Shira") and 300 g of rice vinegar
g with a juicer mixer for 5 minutes.
It was transferred to a glass wide-mouth bottle with an L lid and stored for one week. Then, the bleach was used as a filter cloth and filtered to prepare a matcha rice vinegar solution (1/20) as a filtrate. In the following test examples, preparation 1-2 is described.

Preparation Example 2 Preparation of Matcha Rice Vinegar Liquid (1/10) 15 g of matcha and 150 g of rice vinegar were mixed in a juicer mixer for 5 minutes.
After mixing for 1 minute, the mixture was transferred to a 1 L glass jar with lid and stored for 1 week. Then, the bleach was used as a filter cloth and filtered to prepare a matcha rice vinegar solution (1/10) as a filtrate. In the following test examples, it is described as Preparation 2.

Preparation Example 3 Preparation of Matcha Rice Vinegar (1/5) 30 g of matcha and 150 g of rice vinegar were mixed in a juicer mixer for 5 minutes.
After mixing for 1 minute, the mixture was transferred to a 1 L glass jar with lid and stored for 1 week. Then, the bleach was used as a filter cloth and filtered to prepare a matcha rice vinegar solution (1/5) as a filtrate. In the following test examples, it is described as Preparation 3.

Preparation Example 4 Preparation of Sencha Rice Vinegar Liquid (1/5) At room temperature, 30 g of sencha and 150 g of rice vinegar are ground and mixed with a juicer mixer for 5 minutes, and the mixture is transferred to a 1-L glass wide-mouth bottle with a lid. Stored for one week. Then, the bleach was used as a filter cloth and filtered, and as a filtrate, Sencha rice vinegar (1/1 /
5) was prepared. In the test examples below, preparation 4 is described. Various tea rice vinegar solutions shown in Table 1 of Table 1 were prepared by the operation according to Preparation Examples 1 to 4, and subjected to a test. The preparation number and the test number have a correspondence relationship as shown in Table 1.

[0032]

[Table 1] A): Tea consumption per 180g of rice vinegar

Test Example 1 Hair growth effect test 10 C3H / NeH mice (male, 8
Week) cut back with electric clippers, and on the left half,
For each animal, 0.1 ml was used as an application amount per application of one solution, and preparations 1 to 4 were applied once a day for 6 weeks on Monday to Saturday in a week. Was done. The application is started from the day after the shaving, and 42 days after the start,
The area of the hair growth portion was measured, the hair growth area ratio was calculated, and the evaluation points were determined according to the following criteria. The results are shown in Table 2 of Table 2.

Evaluation point Criterion 5 Hair growth of 60% or more of the surrounding non-sheared part. 4 Hair growth of 20% or more and less than 60% of the surrounding non-sheared part. 3 Hair growth of 10% or more and less than 20% of the surrounding non-sheared part. 2 Hair growth of 3% or more and less than 10% of the surrounding non-hair cut part. 1 Less than 3% hair growth of the surrounding non-sheared area.

[0035]

[Table 2]

[0036]

The hair growth effect obtained by using a composition containing a tea rice vinegar solution containing at least one kind of tea and rice vinegar as an active ingredient prevents hair thinning and
It is now possible to perform treatment.

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C083 AA111 AA112 AC102 CC37 EE22 FF01 4C088 AB45 AB74 AC04 AC05 BA08 BA09 CA25 MA07 NA14 ZA92

Claims (2)

[Claims] 1. A hair-growing composition comprising, as an active ingredient, a tea rice vinegar solution containing at least one kind of tea and rice vinegar. 2. The tea rice vinegar liquid wherein the crushed mixture of tea and rice vinegar is allowed to stand for 5 to 10 days.
The hair growth and restoration composition according to the above.